Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2648
Gene name Gene Name - the full gene name approved by the HGNC.	Lysine acetyltransferase 2A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	KAT2A
Synonyms (NCBI Gene) Gene synonyms aliases	GCN5, GCN5L2, PCAF-b, hGCN5
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q21.2
Summary Summary of gene provided in NCBI Entrez Gene.	KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-

Show/Hide all(159)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022532	hsa-miR-124-3p	Microarray	18668037
MIRT023698	hsa-miR-1-3p	Microarray	18668037
MIRT049612	hsa-miR-92a-3p	qRT-PCR	23622248
MIRT050843	hsa-miR-17-5p	CLASH	23622248
MIRT049612	hsa-miR-92a-3p	CLASH	23622248
MIRT047064	hsa-miR-183-5p	CLASH	23622248
MIRT043446	hsa-miR-331-3p	CLASH	23622248
MIRT039857	hsa-miR-615-3p	CLASH	23622248
MIRT437521	hsa-miR-19b-3p	Immunoprecipitaion	22382630
MIRT1078613	hsa-miR-155	CLIP-seq
MIRT1078614	hsa-miR-365	CLIP-seq
MIRT1078615	hsa-miR-4475	CLIP-seq
MIRT1078616	hsa-miR-4755-3p	CLIP-seq
MIRT1078617	hsa-miR-4790-3p	CLIP-seq
MIRT1078616	hsa-miR-4755-3p	CLIP-seq
MIRT2251467	hsa-miR-1275	CLIP-seq
MIRT2251468	hsa-miR-1287	CLIP-seq
MIRT2251469	hsa-miR-3135b	CLIP-seq
MIRT2251470	hsa-miR-3175	CLIP-seq
MIRT2251471	hsa-miR-3622b-5p	CLIP-seq
MIRT2251472	hsa-miR-3660	CLIP-seq
MIRT2251473	hsa-miR-3910	CLIP-seq
MIRT2251474	hsa-miR-4292	CLIP-seq
MIRT2251475	hsa-miR-4525	CLIP-seq
MIRT2251476	hsa-miR-4526	CLIP-seq
MIRT2251477	hsa-miR-4638-3p	CLIP-seq
MIRT2251478	hsa-miR-4640-3p	CLIP-seq
MIRT2251479	hsa-miR-4665-5p	CLIP-seq
MIRT2251480	hsa-miR-4723-5p	CLIP-seq
MIRT2251481	hsa-miR-4773	CLIP-seq
MIRT2251482	hsa-miR-512-3p	CLIP-seq
MIRT2251483	hsa-miR-625	CLIP-seq
MIRT2251484	hsa-miR-637	CLIP-seq
MIRT2554675	hsa-miR-1203	CLIP-seq
MIRT2554676	hsa-miR-1205	CLIP-seq
MIRT2554677	hsa-miR-122	CLIP-seq
MIRT2554678	hsa-miR-1226	CLIP-seq
MIRT2251467	hsa-miR-1275	CLIP-seq
MIRT2554679	hsa-miR-1276	CLIP-seq
MIRT2554680	hsa-miR-128	CLIP-seq
MIRT2554681	hsa-miR-1285	CLIP-seq
MIRT2554682	hsa-miR-1286	CLIP-seq
MIRT2251468	hsa-miR-1287	CLIP-seq
MIRT2554683	hsa-miR-1302	CLIP-seq
MIRT2554684	hsa-miR-1587	CLIP-seq
MIRT2554685	hsa-miR-198	CLIP-seq
MIRT2554686	hsa-miR-2110	CLIP-seq
MIRT2554687	hsa-miR-3127-3p	CLIP-seq
MIRT2251469	hsa-miR-3135b	CLIP-seq
MIRT2554688	hsa-miR-3144-5p	CLIP-seq
MIRT2554689	hsa-miR-3150a-3p	CLIP-seq
MIRT2554690	hsa-miR-3184	CLIP-seq
MIRT2554691	hsa-miR-3187-5p	CLIP-seq
MIRT2554692	hsa-miR-3191	CLIP-seq
MIRT2554693	hsa-miR-342-5p	CLIP-seq
MIRT2251471	hsa-miR-3622b-5p	CLIP-seq
MIRT2554694	hsa-miR-3652	CLIP-seq
MIRT2554695	hsa-miR-3662	CLIP-seq
MIRT2554696	hsa-miR-3663-5p	CLIP-seq
MIRT2554697	hsa-miR-377	CLIP-seq
MIRT2251473	hsa-miR-3910	CLIP-seq
MIRT2554698	hsa-miR-423-5p	CLIP-seq
MIRT2554699	hsa-miR-4277	CLIP-seq
MIRT2251474	hsa-miR-4292	CLIP-seq
MIRT2554700	hsa-miR-4298	CLIP-seq
MIRT2554701	hsa-miR-4308	CLIP-seq
MIRT2554702	hsa-miR-4313	CLIP-seq
MIRT2554703	hsa-miR-4328	CLIP-seq
MIRT2554704	hsa-miR-4430	CLIP-seq
MIRT2554705	hsa-miR-4468	CLIP-seq
MIRT2554706	hsa-miR-4488	CLIP-seq
MIRT2554707	hsa-miR-4492	CLIP-seq
MIRT2554708	hsa-miR-4493	CLIP-seq
MIRT2554709	hsa-miR-4498	CLIP-seq
MIRT2554710	hsa-miR-4505	CLIP-seq
MIRT2554711	hsa-miR-4539	CLIP-seq
MIRT2251477	hsa-miR-4638-3p	CLIP-seq
MIRT2554712	hsa-miR-4640-5p	CLIP-seq
MIRT2554713	hsa-miR-4650-5p	CLIP-seq
MIRT2554714	hsa-miR-4652-5p	CLIP-seq
MIRT2554715	hsa-miR-4656	CLIP-seq
MIRT2554716	hsa-miR-4664-5p	CLIP-seq
MIRT2251479	hsa-miR-4665-5p	CLIP-seq
MIRT2554717	hsa-miR-4674	CLIP-seq
MIRT2554718	hsa-miR-4675	CLIP-seq
MIRT2554719	hsa-miR-4697-5p	CLIP-seq
MIRT2554720	hsa-miR-4701-5p	CLIP-seq
MIRT2554721	hsa-miR-4722-5p	CLIP-seq
MIRT2554722	hsa-miR-4726-5p	CLIP-seq
MIRT2554723	hsa-miR-4741	CLIP-seq
MIRT2554724	hsa-miR-4751	CLIP-seq
MIRT1078616	hsa-miR-4755-3p	CLIP-seq
MIRT2251481	hsa-miR-4773	CLIP-seq
MIRT2554725	hsa-miR-4786-3p	CLIP-seq
MIRT2554726	hsa-miR-493	CLIP-seq
MIRT2251482	hsa-miR-512-3p	CLIP-seq
MIRT2554727	hsa-miR-513c	CLIP-seq
MIRT2554728	hsa-miR-514b-5p	CLIP-seq
MIRT2554729	hsa-miR-518d-5p	CLIP-seq
MIRT2554730	hsa-miR-519b-5p	CLIP-seq
MIRT2554731	hsa-miR-519c-5p	CLIP-seq
MIRT2554732	hsa-miR-520c-5p	CLIP-seq
MIRT2554733	hsa-miR-526a	CLIP-seq
MIRT2554734	hsa-miR-550a	CLIP-seq
MIRT2554735	hsa-miR-558	CLIP-seq
MIRT2554736	hsa-miR-588	CLIP-seq
MIRT2554737	hsa-miR-612	CLIP-seq
MIRT2554738	hsa-miR-635	CLIP-seq
MIRT2251484	hsa-miR-637	CLIP-seq
MIRT2554739	hsa-miR-647	CLIP-seq
MIRT2554740	hsa-miR-661	CLIP-seq
MIRT2554741	hsa-miR-762	CLIP-seq
MIRT2554676	hsa-miR-1205	CLIP-seq
MIRT2251467	hsa-miR-1275	CLIP-seq
MIRT2554679	hsa-miR-1276	CLIP-seq
MIRT2554680	hsa-miR-128	CLIP-seq
MIRT2554682	hsa-miR-1286	CLIP-seq
MIRT2251468	hsa-miR-1287	CLIP-seq
MIRT2554683	hsa-miR-1302	CLIP-seq
MIRT2554684	hsa-miR-1587	CLIP-seq
MIRT2554685	hsa-miR-198	CLIP-seq
MIRT2554686	hsa-miR-2110	CLIP-seq
MIRT2554687	hsa-miR-3127-3p	CLIP-seq
MIRT2251469	hsa-miR-3135b	CLIP-seq
MIRT2554688	hsa-miR-3144-5p	CLIP-seq
MIRT2554689	hsa-miR-3150a-3p	CLIP-seq
MIRT2554692	hsa-miR-3191	CLIP-seq
MIRT2554693	hsa-miR-342-5p	CLIP-seq
MIRT2251471	hsa-miR-3622b-5p	CLIP-seq
MIRT2554697	hsa-miR-377	CLIP-seq
MIRT2251473	hsa-miR-3910	CLIP-seq
MIRT2554700	hsa-miR-4298	CLIP-seq
MIRT2554702	hsa-miR-4313	CLIP-seq
MIRT2554703	hsa-miR-4328	CLIP-seq
MIRT2554707	hsa-miR-4492	CLIP-seq
MIRT2554708	hsa-miR-4493	CLIP-seq
MIRT2554709	hsa-miR-4498	CLIP-seq
MIRT2554710	hsa-miR-4505	CLIP-seq
MIRT2554711	hsa-miR-4539	CLIP-seq
MIRT2251477	hsa-miR-4638-3p	CLIP-seq
MIRT2554712	hsa-miR-4640-5p	CLIP-seq
MIRT2554713	hsa-miR-4650-5p	CLIP-seq
MIRT2554714	hsa-miR-4652-5p	CLIP-seq
MIRT2554715	hsa-miR-4656	CLIP-seq
MIRT2554716	hsa-miR-4664-5p	CLIP-seq
MIRT2251479	hsa-miR-4665-5p	CLIP-seq
MIRT2554717	hsa-miR-4674	CLIP-seq
MIRT2554718	hsa-miR-4675	CLIP-seq
MIRT2554721	hsa-miR-4722-5p	CLIP-seq
MIRT2554722	hsa-miR-4726-5p	CLIP-seq
MIRT2554723	hsa-miR-4741	CLIP-seq
MIRT1078616	hsa-miR-4755-3p	CLIP-seq
MIRT2251481	hsa-miR-4773	CLIP-seq
MIRT2554726	hsa-miR-493	CLIP-seq
MIRT2251482	hsa-miR-512-3p	CLIP-seq
MIRT2554734	hsa-miR-550a	CLIP-seq
MIRT2554735	hsa-miR-558	CLIP-seq
MIRT2554738	hsa-miR-635	CLIP-seq
MIRT2554741	hsa-miR-762	CLIP-seq

Show/Hide all(70)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000123	Component	Histone acetyltransferase complex	IDA	29973595, 31527837
GO:0001701	Process	In utero embryonic development	IEA
GO:0001756	Process	Somitogenesis	IEA
GO:0001816	Process	Cytokine production	ISS
GO:0001843	Process	Neural tube closure	IEA
GO:0003682	Function	Chromatin binding	IDA	29211711
GO:0003713	Function	Transcription coactivator activity	IDA	11564863, 29211711, 29973595, 31527837
GO:0004402	Function	Histone acetyltransferase activity	IDA	10373431, 11564863, 29211711, 31527837
GO:0004402	Function	Histone acetyltransferase activity	TAS
GO:0005515	Function	Protein binding	IPI	17664281, 20562830, 20972224, 21725360, 24502362, 27796307, 29174768, 29232376, 29973595, 31527837
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005634	Component	Nucleus	IDA	11564863, 27796307, 29211711
GO:0005654	Component	Nucleoplasm	TAS
GO:0005671	Component	Ada2/Gcn5/Ada3 transcription activator complex	IDA	18838386
GO:0005694	Component	Chromosome	IEA
GO:0005813	Component	Centrosome	IDA	27796307
GO:0006338	Process	Chromatin remodeling	TAS	8552087
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	8552087
GO:0007507	Process	Heart development	ISS
GO:0007616	Process	Long-term memory	ISS
GO:0008134	Function	Transcription factor binding	IPI	17301242
GO:0008283	Process	Cell population proliferation	IEA
GO:0010484	Function	H3 histone acetyltransferase activity	IDA	18838386
GO:0014070	Process	Response to organic cyclic compound	IEA
GO:0016032	Process	Viral process	IEA
GO:0016573	Process	Histone acetylation	IDA	29973595, 31527837
GO:0016578	Process	Histone deubiquitination	IDA	18206972
GO:0016579	Process	Protein deubiquitination	TAS
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0018393	Process	Internal peptidyl-lysine acetylation	IDA	27796307, 29174768
GO:0019903	Function	Protein phosphatase binding	IEA
GO:0021537	Process	Telencephalon development	IEA
GO:0022037	Process	Metencephalon development	IEA
GO:0030901	Process	Midbrain development	IEA
GO:0030914	Component	STAGA complex	IDA	11564863
GO:0031346	Process	Positive regulation of cell projection organization	IEA
GO:0031647	Process	Regulation of protein stability	IMP	20562830
GO:0031667	Process	Response to nutrient levels	IEA
GO:0033276	Component	Transcription factor TFTC complex	IDA	10373431
GO:0035066	Process	Positive regulation of histone acetylation	IEA
GO:0035264	Process	Multicellular organism growth	IEA
GO:0042826	Function	Histone deacetylase binding	IPI	12887892
GO:0043966	Process	Histone H3 acetylation	IDA	10373431, 11564863, 18838386, 29211711
GO:0043983	Process	Histone H4-K12 acetylation	IEA
GO:0043997	Function	Histone acetyltransferase activity (H4-K12 specific)	IEA
GO:0044154	Process	Histone H3-K14 acetylation	IEA
GO:0045252	Component	Oxoglutarate dehydrogenase complex	IDA	29211711
GO:0045589	Process	Regulation of regulatory T cell differentiation	ISS
GO:0045722	Process	Positive regulation of gluconeogenesis	IEA
GO:0045815	Process	Positive regulation of gene expression, epigenetic	TAS
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	29973595, 31527837
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	29211711
GO:0046600	Process	Negative regulation of centriole replication	IDA	27796307
GO:0048167	Process	Regulation of synaptic plasticity	ISS
GO:0048312	Process	Intracellular distribution of mitochondria	IEA
GO:0050863	Process	Regulation of T cell activation	ISS
GO:0060173	Process	Limb development	ISS
GO:0061035	Process	Regulation of cartilage development	ISS
GO:0061733	Function	Peptide-lysine-N-acetyltransferase activity	IDA	27796307, 29174768
GO:0071356	Process	Cellular response to tumor necrosis factor	IEA
GO:0071929	Process	Alpha-tubulin acetylation	IEA
GO:0072686	Component	Mitotic spindle	IEA
GO:0106077	Process	Histone succinylation	IDA	29211711
GO:0106078	Function	Histone succinyltransferase activity	IDA	29211711
GO:0106227	Process	Peptidyl-lysine glutarylation	IDA	31542297
GO:0106229	Function	Histone glutaryltransferase activity	IDA	31542297
GO:1903010	Process	Regulation of bone development	ISS
GO:1990090	Process	Cellular response to nerve growth factor stimulus	IEA
GO:2000036	Process	Regulation of stem cell population maintenance	ISS
GO:2000727	Process	Positive regulation of cardiac muscle cell differentiation	IEA

MIM	HGNC	e!Ensembl
602301	4201	ENSG00000108773

Protein

UniProt ID

Q92830

Protein name

Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine ace

Protein function

Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase, succinyltransferase or malonyltransferase, depending on the context (PubMed:29211711, PubMed:35995428). Acts as a histone lysine succinyltransferase: cataly

PDB

1F68 , 1Z4R , 3D7C , 5H84 , 5H86 , 5MLJ , 5TRL , 5TRM , 6J3P , 8E6O , 8H65 , 8H66 , 8H6C , 8H6D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06466	PCAF_N	86 → 336	PCAF (P300/CBP-associated factor) N-terminal domain	Domain
PF00583	Acetyltransf_1	517 → 627	Acetyltransferase (GNAT) family	Family
PF00439	Bromodomain	737 → 820	Bromodomain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in all tissues tested. {ECO:0000269|PubMed:8684459}.

Sequence

MAEPSQAPTPAPAAQPRPLQSPAPAPTPTPAPSPASAPIPTPTPAPAPAPAAAPAGSTGT
GGPGVGSGGAGSGGDPARPGLSQQQRASQRKAQVRGLPRAKKLEKLGVFSACKANETCKC
NGWKNPKPPTAPRMDLQQPAANLSELCRSCEHPLADHVSHLENVSEDEINRLLGMVVDVE
NLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGSLGSPPFEKPNIEQGVLNFVQ
YKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQAEDVATYKVNYTRWLCYCH
VPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTHFPKFL
SMLEEEIYGANSPIWESGFTMPPSEGTQLVPRPASVSAAVVPSTPIFSPSMGGGSNSSLS
LDSAGAEPMPGEKRTLPENLTLEDAKRLRVMGDIPMELVNEVMLTITDPAAMLGPETSLL
SANAARDETARLEERRGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSHQLPRMPKEYIA
RLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKE
YHIKHNILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIP
YTELSHIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLG
KEKGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTE
RLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK

Sequence length

837

Interactions

View interactions

	KEGG		Reactome
	Viral life cycle - HIV-1 Notch signaling pathway Thyroid hormone signaling pathway Human T-cell leukemia virus 1 infection Viral carcinogenesis		Pre-NOTCH Transcription and Translation NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway B-WICH complex positively regulates rRNA expression Ub-specific processing proteases RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537	29212778

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Inflammatory Bowel Disease	Inflammatory Bowel Disease			GWAS

Show/Hide Text Mining Associations (36)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	38168564
Aortic Aneurysm Abdominal	Associate	26767057
Arrhythmogenic Right Ventricular Dysplasia	Stimulate	35712781
Breast Neoplasms	Associate	33827682
Carcinogenesis	Associate	32883234, 38007639, 38168564
Carcinoma Hepatocellular	Associate	21367571, 30021196, 32393195
Carcinoma Pancreatic Ductal	Associate	23696899
Colitis Ulcerative	Associate	26278503, 28751935
Colonic Neoplasms	Stimulate	26637399
Colorectal Neoplasms	Stimulate	26637399
Crohn Disease	Associate	26278503
Embolism Fat	Associate	35712781
Glioma	Associate	26378521
Hamartoma Syndrome Multiple	Associate	30894545
Heart Failure	Associate	35712781
Hepatitis B	Associate	33809336
Inflammation	Inhibit	27216891
Inflammation	Associate	34718330
Inflammatory Bowel Diseases	Associate	26278503
Leukemia	Associate	27760321, 33223444
Leukemia Myeloid Acute	Associate	27760321, 33223444
Lung Neoplasms	Associate	25770212, 31613681, 36142846
Lupus Erythematosus Systemic	Associate	34718330
Lymphoma Large B Cell Diffuse	Associate	37789275
Melanoma	Associate	37415153
Metabolic Diseases	Associate	19491097
Neoplasm Metastasis	Associate	28608921, 30333255, 38058677
Neoplasms	Associate	21725360, 24668547, 26637399, 28592290, 28751935, 30021196, 30079588, 30333255, 30753595, 30894545, 31828117, 33223444, 33279621, 33827682, 37789275, 38007639 View all (1 more)
Ovarian Neoplasms	Associate	35639349
Periodontitis	Associate	27216891
Prostatic Neoplasms	Associate	28592290, 30333255
Spinocerebellar Ataxias	Associate	24129567, 33626063
Stomach Neoplasms	Associate	24668547, 30274785
Testicular Germ Cell Tumor	Associate	38007639
Urethral Neoplasms	Associate	28678170
Uterine Cervical Neoplasms	Associate	30079588

KAT2A (lysine acetyltransferase 2A)