Gene Gene information from NCBI Gene database.
Entrez ID 2648
Gene name Lysine acetyltransferase 2A
Gene symbol KAT2A
Synonyms (NCBI Gene)
GCN5GCN5L2PCAF-bhGCN5
Chromosome 17
Chromosome location 17q21.2
Summary KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-
miRNA miRNA information provided by mirtarbase database.
159
miRTarBase ID miRNA Experiments Reference
MIRT022532 hsa-miR-124-3p Microarray 18668037
MIRT023698 hsa-miR-1-3p Microarray 18668037
MIRT049612 hsa-miR-92a-3p qRT-PCR 23622248
MIRT050843 hsa-miR-17-5p CLASH 23622248
MIRT049612 hsa-miR-92a-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
117
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 18838386
GO:0000123 Component Histone acetyltransferase complex IDA 29973595, 31527837
GO:0000123 Component Histone acetyltransferase complex IEA
GO:0000124 Component SAGA complex IDA 11564863
GO:0000124 Component SAGA complex IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602301 4201 ENSG00000108773
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92830
Protein name Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine ace
Protein function Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase, succinyltransferase or malonyltransferase, depending on the context (PubMed:29211711, PubMed:35995428). Acts as a histone lysine succinyltransferase: cataly
PDB 1F68 , 1Z4R , 3D7C , 5H84 , 5H86 , 5MLJ , 5TRL , 5TRM , 6J3P , 8E6O , 8H65 , 8H66 , 8H6C , 8H6D
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06466 PCAF_N 86 336 PCAF (P300/CBP-associated factor) N-terminal domain Domain
PF00583 Acetyltransf_1 517 627 Acetyltransferase (GNAT) family Family
PF00439 Bromodomain 737 820 Bromodomain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in all tissues tested. {ECO:0000269|PubMed:8684459}.
Sequence
MAEPSQAPTPAPAAQPRPLQSPAPAPTPTPAPSPASAPIPTPTPAPAPAPAAAPAGSTGT
GGPGVGSGGAGSGGDPARPGLSQQQRASQRKAQVRGLPRAKKLEKLGVFSACKANETCKC
NGWKNPKPPTAPRMDLQQPAANLSELCRSCEHPLADHVSHLENVSEDEINRLLGMVVDVE
NLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGSLGSPPFEKPNIEQGVLNFVQ
YKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQAEDVATYKVNYTRWLCYCH
VPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEK
FRVEKDKLVPEKRTLILTHFPKFL
SMLEEEIYGANSPIWESGFTMPPSEGTQLVPRPASVSAAVVPSTPIFSPSMGGGSNSSLS
LDSAGAEPMPGEKRTLPENLTLEDAKRLRVMGDIPMELVNEVMLTITDPAAMLGPETSLL
SANAARDETARLEERRGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSHQLPRMPKEYIA
RLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKE
YHIKHNILYFLTYADEYAIGYFKKQGF
SKDIKVPKSRYLGYIKDYEGATLMECELNPRIP
YTELSHIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLG
KEKGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTE
RLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASA
LEKFFYFKLKEGGLIDK
Sequence length 837
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Viral life cycle - HIV-1
Notch signaling pathway
Thyroid hormone signaling pathway
Human T-cell leukemia virus 1 infection
Viral carcinogenesis
  Pre-NOTCH Transcription and Translation
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Notch-HLH transcription pathway
B-WICH complex positively regulates rRNA expression
Ub-specific processing proteases
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
See cases Likely pathogenic rs2544066740 RCV003388299
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Familial cancer of breast Benign rs35184688 RCV005922989
Ovarian serous cystadenocarcinoma Benign rs147034250 RCV005911794
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 38168564
Aortic Aneurysm Abdominal Associate 26767057
Arrhythmogenic Right Ventricular Dysplasia Stimulate 35712781
Breast Neoplasms Associate 33827682
Carcinogenesis Associate 32883234, 38007639, 38168564
Carcinoma Hepatocellular Associate 21367571, 30021196, 32393195
Carcinoma Pancreatic Ductal Associate 23696899
Colitis Ulcerative Associate 26278503, 28751935
Colonic Neoplasms Stimulate 26637399
Colorectal Neoplasms Stimulate 26637399