PTPN18 (protein tyrosine phosphatase non-receptor type 18)

Gene

• Entrez ID: 26469
• Gene name: Protein tyrosine phosphatase non-receptor type 18
• Gene symbol: PTPN18
• Synonyms (NCBI Gene): BDP1, PTP-HSCF
• Chromosome: 2
• Chromosome location: 2q21.1
• Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051290	hsa-miR-16-5p	CLASH	23622248
MIRT1275140	hsa-miR-1228	CLIP-seq
MIRT1275141	hsa-miR-1231	CLIP-seq
MIRT1275142	hsa-miR-1257	CLIP-seq
MIRT1275143	hsa-miR-125a-3p	CLIP-seq
MIRT1275144	hsa-miR-125a-5p	CLIP-seq
MIRT1275145	hsa-miR-125b	CLIP-seq
MIRT1275146	hsa-miR-1270	CLIP-seq
MIRT1275147	hsa-miR-1275	CLIP-seq
MIRT1275148	hsa-miR-128	CLIP-seq
MIRT1275149	hsa-miR-1321	CLIP-seq
MIRT1275150	hsa-miR-144	CLIP-seq
MIRT1275151	hsa-miR-147	CLIP-seq
MIRT1275152	hsa-miR-216a	CLIP-seq
MIRT1275153	hsa-miR-216b	CLIP-seq
MIRT1275154	hsa-miR-24	CLIP-seq
MIRT1275155	hsa-miR-2467-5p	CLIP-seq
MIRT1275156	hsa-miR-27a	CLIP-seq
MIRT1275157	hsa-miR-27b	CLIP-seq
MIRT1275158	hsa-miR-3064-5p	CLIP-seq
MIRT1275159	hsa-miR-3065-3p	CLIP-seq
MIRT1275160	hsa-miR-3120-5p	CLIP-seq
MIRT1275161	hsa-miR-3126-5p	CLIP-seq
MIRT1275162	hsa-miR-3135	CLIP-seq
MIRT1275163	hsa-miR-3135b	CLIP-seq
MIRT1275164	hsa-miR-3176	CLIP-seq
MIRT1275165	hsa-miR-3177-5p	CLIP-seq
MIRT1275166	hsa-miR-3192	CLIP-seq
MIRT1275167	hsa-miR-331-3p	CLIP-seq
MIRT1275168	hsa-miR-342-3p	CLIP-seq
MIRT1275169	hsa-miR-346	CLIP-seq
MIRT1275170	hsa-miR-3616-3p	CLIP-seq
MIRT1275171	hsa-miR-3617	CLIP-seq
MIRT1275172	hsa-miR-3652	CLIP-seq
MIRT1275173	hsa-miR-3659	CLIP-seq
MIRT1275174	hsa-miR-3680	CLIP-seq
MIRT1275175	hsa-miR-3689a-3p	CLIP-seq
MIRT1275176	hsa-miR-3689c	CLIP-seq
MIRT1275177	hsa-miR-3691-3p	CLIP-seq
MIRT1275178	hsa-miR-3911	CLIP-seq
MIRT1275179	hsa-miR-3913-3p	CLIP-seq
MIRT1275180	hsa-miR-3922-3p	CLIP-seq
MIRT1275181	hsa-miR-3934	CLIP-seq
MIRT1275182	hsa-miR-3938	CLIP-seq
MIRT1275183	hsa-miR-4251	CLIP-seq
MIRT1275184	hsa-miR-4253	CLIP-seq
MIRT1275185	hsa-miR-4260	CLIP-seq
MIRT1275186	hsa-miR-4281	CLIP-seq
MIRT1275187	hsa-miR-4284	CLIP-seq
MIRT1275188	hsa-miR-4288	CLIP-seq
MIRT1275189	hsa-miR-4319	CLIP-seq
MIRT1275190	hsa-miR-432	CLIP-seq
MIRT1275191	hsa-miR-4324	CLIP-seq
MIRT1275192	hsa-miR-4419a	CLIP-seq
MIRT1275193	hsa-miR-4425	CLIP-seq
MIRT1275194	hsa-miR-4427	CLIP-seq
MIRT1275195	hsa-miR-4430	CLIP-seq
MIRT1275196	hsa-miR-4436b-5p	CLIP-seq
MIRT1275197	hsa-miR-4456	CLIP-seq
MIRT1275198	hsa-miR-4505	CLIP-seq
MIRT1275199	hsa-miR-4510	CLIP-seq
MIRT1275200	hsa-miR-4520a-3p	CLIP-seq
MIRT1275201	hsa-miR-4525	CLIP-seq
MIRT1275202	hsa-miR-4527	CLIP-seq
MIRT1275203	hsa-miR-4531	CLIP-seq
MIRT1275204	hsa-miR-4652-5p	CLIP-seq
MIRT1275205	hsa-miR-4658	CLIP-seq
MIRT1275206	hsa-miR-4665-5p	CLIP-seq
MIRT1275207	hsa-miR-4680-3p	CLIP-seq
MIRT1275208	hsa-miR-4683	CLIP-seq
MIRT1275209	hsa-miR-4693-3p	CLIP-seq
MIRT1275210	hsa-miR-4694-3p	CLIP-seq
MIRT1275211	hsa-miR-4712-3p	CLIP-seq
MIRT1275212	hsa-miR-4723-5p	CLIP-seq
MIRT1275213	hsa-miR-4731-5p	CLIP-seq
MIRT1275214	hsa-miR-4738-3p	CLIP-seq
MIRT1275215	hsa-miR-4739	CLIP-seq
MIRT1275216	hsa-miR-4743	CLIP-seq
MIRT1275217	hsa-miR-4756-5p	CLIP-seq
MIRT1275218	hsa-miR-4761-3p	CLIP-seq
MIRT1275219	hsa-miR-4798-3p	CLIP-seq
MIRT1275220	hsa-miR-539	CLIP-seq
MIRT1275221	hsa-miR-556-3p	CLIP-seq
MIRT1275222	hsa-miR-574-5p	CLIP-seq
MIRT1275223	hsa-miR-576-3p	CLIP-seq
MIRT1275224	hsa-miR-579	CLIP-seq
MIRT1275225	hsa-miR-615-5p	CLIP-seq
MIRT1275226	hsa-miR-620	CLIP-seq
MIRT1275227	hsa-miR-622	CLIP-seq
MIRT1275228	hsa-miR-625	CLIP-seq
MIRT1275229	hsa-miR-632	CLIP-seq
MIRT1275230	hsa-miR-637	CLIP-seq
MIRT1275231	hsa-miR-640	CLIP-seq
MIRT1275232	hsa-miR-641	CLIP-seq
MIRT1275233	hsa-miR-644	CLIP-seq
MIRT1275234	hsa-miR-764	CLIP-seq
MIRT1275235	hsa-miR-890	CLIP-seq
MIRT1275236	hsa-miR-942	CLIP-seq
MIRT1275237	hsa-miR-1273e	CLIP-seq
MIRT1275148	hsa-miR-128	CLIP-seq
MIRT1275150	hsa-miR-144	CLIP-seq
MIRT1275151	hsa-miR-147	CLIP-seq
MIRT1275238	hsa-miR-1827	CLIP-seq
MIRT1275239	hsa-miR-2278	CLIP-seq
MIRT1275156	hsa-miR-27a	CLIP-seq
MIRT1275157	hsa-miR-27b	CLIP-seq
MIRT1275240	hsa-miR-2964a-5p	CLIP-seq
MIRT1275241	hsa-miR-3122	CLIP-seq
MIRT1275242	hsa-miR-3150b-3p	CLIP-seq
MIRT1275169	hsa-miR-346	CLIP-seq
MIRT1275170	hsa-miR-3616-3p	CLIP-seq
MIRT1275174	hsa-miR-3680	CLIP-seq
MIRT1275175	hsa-miR-3689a-3p	CLIP-seq
MIRT1275176	hsa-miR-3689c	CLIP-seq
MIRT1275178	hsa-miR-3911	CLIP-seq
MIRT1275243	hsa-miR-3913-5p	CLIP-seq
MIRT1275244	hsa-miR-3929	CLIP-seq
MIRT1275182	hsa-miR-3938	CLIP-seq
MIRT1275184	hsa-miR-4253	CLIP-seq
MIRT1275245	hsa-miR-4274	CLIP-seq
MIRT1275188	hsa-miR-4288	CLIP-seq
MIRT1275246	hsa-miR-4419b	CLIP-seq
MIRT1275247	hsa-miR-4459	CLIP-seq
MIRT1275248	hsa-miR-4474-3p	CLIP-seq
MIRT1275249	hsa-miR-4478	CLIP-seq
MIRT1275200	hsa-miR-4520a-3p	CLIP-seq
MIRT1275250	hsa-miR-4649-3p	CLIP-seq
MIRT1275251	hsa-miR-4689	CLIP-seq
MIRT1275210	hsa-miR-4694-3p	CLIP-seq
MIRT1275252	hsa-miR-4710	CLIP-seq
MIRT1275253	hsa-miR-4716-5p	CLIP-seq
MIRT1275254	hsa-miR-4722-5p	CLIP-seq
MIRT1275255	hsa-miR-4728-5p	CLIP-seq
MIRT1275256	hsa-miR-4749-3p	CLIP-seq
MIRT1275218	hsa-miR-4761-3p	CLIP-seq
MIRT1275257	hsa-miR-4784	CLIP-seq
MIRT1275258	hsa-miR-4792	CLIP-seq
MIRT1275219	hsa-miR-4798-3p	CLIP-seq
MIRT1275259	hsa-miR-485-5p	CLIP-seq
MIRT1275260	hsa-miR-512-3p	CLIP-seq
MIRT1275221	hsa-miR-556-3p	CLIP-seq
MIRT1275229	hsa-miR-632	CLIP-seq
MIRT1275233	hsa-miR-644	CLIP-seq
MIRT1275261	hsa-miR-654-3p	CLIP-seq
MIRT1275262	hsa-miR-940	CLIP-seq
MIRT2081007	hsa-miR-1208	CLIP-seq
MIRT1275140	hsa-miR-1228	CLIP-seq
MIRT1275141	hsa-miR-1231	CLIP-seq
MIRT2081008	hsa-miR-1254	CLIP-seq
MIRT2081009	hsa-miR-1285	CLIP-seq
MIRT2081010	hsa-miR-15a	CLIP-seq
MIRT2081011	hsa-miR-15b	CLIP-seq
MIRT2081012	hsa-miR-16	CLIP-seq
MIRT1275238	hsa-miR-1827	CLIP-seq
MIRT2081013	hsa-miR-195	CLIP-seq
MIRT2081014	hsa-miR-198	CLIP-seq
MIRT2081015	hsa-miR-214	CLIP-seq
MIRT2081016	hsa-miR-223	CLIP-seq
MIRT1275154	hsa-miR-24	CLIP-seq
MIRT1275240	hsa-miR-2964a-5p	CLIP-seq
MIRT1275158	hsa-miR-3064-5p	CLIP-seq
MIRT1275159	hsa-miR-3065-3p	CLIP-seq
MIRT2081017	hsa-miR-3116	CLIP-seq
MIRT1275160	hsa-miR-3120-5p	CLIP-seq
MIRT2081018	hsa-miR-3187-5p	CLIP-seq
MIRT1275169	hsa-miR-346	CLIP-seq
MIRT2081019	hsa-miR-3612	CLIP-seq
MIRT2081020	hsa-miR-3619-5p	CLIP-seq
MIRT1275175	hsa-miR-3689a-3p	CLIP-seq
MIRT1275176	hsa-miR-3689c	CLIP-seq
MIRT2081021	hsa-miR-424	CLIP-seq
MIRT2081022	hsa-miR-4278	CLIP-seq
MIRT1275187	hsa-miR-4284	CLIP-seq
MIRT2081023	hsa-miR-4291	CLIP-seq
MIRT1275197	hsa-miR-4456	CLIP-seq
MIRT1275248	hsa-miR-4474-3p	CLIP-seq
MIRT2081024	hsa-miR-450b-5p	CLIP-seq
MIRT2081025	hsa-miR-4514	CLIP-seq
MIRT2081026	hsa-miR-452	CLIP-seq
MIRT2081027	hsa-miR-4633-5p	CLIP-seq
MIRT2081028	hsa-miR-4645-5p	CLIP-seq
MIRT2081029	hsa-miR-4655-5p	CLIP-seq
MIRT2081030	hsa-miR-4656	CLIP-seq
MIRT2081031	hsa-miR-4663	CLIP-seq
MIRT2081032	hsa-miR-4673	CLIP-seq
MIRT2081033	hsa-miR-4676-3p	CLIP-seq
MIRT2081034	hsa-miR-4687-3p	CLIP-seq
MIRT2081035	hsa-miR-4692	CLIP-seq
MIRT2081036	hsa-miR-4697-3p	CLIP-seq
MIRT2081037	hsa-miR-4704-3p	CLIP-seq
MIRT2081038	hsa-miR-4711-5p	CLIP-seq
MIRT2081039	hsa-miR-4716-3p	CLIP-seq
MIRT1275253	hsa-miR-4716-5p	CLIP-seq
MIRT1275254	hsa-miR-4722-5p	CLIP-seq
MIRT1275255	hsa-miR-4728-5p	CLIP-seq
MIRT1275213	hsa-miR-4731-5p	CLIP-seq
MIRT2081040	hsa-miR-4756-3p	CLIP-seq
MIRT2081041	hsa-miR-497	CLIP-seq
MIRT2081042	hsa-miR-507	CLIP-seq
MIRT2081043	hsa-miR-520a-5p	CLIP-seq
MIRT2081044	hsa-miR-525-5p	CLIP-seq
MIRT2081045	hsa-miR-532-5p	CLIP-seq
MIRT2081046	hsa-miR-557	CLIP-seq
MIRT2081047	hsa-miR-570	CLIP-seq
MIRT2081048	hsa-miR-587	CLIP-seq
MIRT2081049	hsa-miR-612	CLIP-seq
MIRT1275225	hsa-miR-615-5p	CLIP-seq
MIRT1275230	hsa-miR-637	CLIP-seq
MIRT1275231	hsa-miR-640	CLIP-seq
MIRT2081050	hsa-miR-650	CLIP-seq
MIRT1275261	hsa-miR-654-3p	CLIP-seq
MIRT2081051	hsa-miR-661	CLIP-seq
MIRT2081052	hsa-miR-761	CLIP-seq
MIRT2081053	hsa-miR-873	CLIP-seq
MIRT2081054	hsa-miR-922	CLIP-seq
MIRT1275262	hsa-miR-940	CLIP-seq
MIRT1275140	hsa-miR-1228	CLIP-seq
MIRT1275141	hsa-miR-1231	CLIP-seq
MIRT1275146	hsa-miR-1270	CLIP-seq
MIRT1275147	hsa-miR-1275	CLIP-seq
MIRT1275150	hsa-miR-144	CLIP-seq
MIRT1275238	hsa-miR-1827	CLIP-seq
MIRT2081014	hsa-miR-198	CLIP-seq
MIRT1275152	hsa-miR-216a	CLIP-seq
MIRT1275153	hsa-miR-216b	CLIP-seq
MIRT1275154	hsa-miR-24	CLIP-seq
MIRT1275240	hsa-miR-2964a-5p	CLIP-seq
MIRT1275159	hsa-miR-3065-3p	CLIP-seq
MIRT1275160	hsa-miR-3120-5p	CLIP-seq
MIRT1275241	hsa-miR-3122	CLIP-seq
MIRT1275165	hsa-miR-3177-5p	CLIP-seq
MIRT2306977	hsa-miR-323-5p	CLIP-seq
MIRT1275168	hsa-miR-342-3p	CLIP-seq
MIRT1275169	hsa-miR-346	CLIP-seq
MIRT1275175	hsa-miR-3689a-3p	CLIP-seq
MIRT1275176	hsa-miR-3689c	CLIP-seq
MIRT1275243	hsa-miR-3913-5p	CLIP-seq
MIRT1275244	hsa-miR-3929	CLIP-seq
MIRT1275185	hsa-miR-4260	CLIP-seq
MIRT2306978	hsa-miR-4279	CLIP-seq
MIRT1275187	hsa-miR-4284	CLIP-seq
MIRT1275188	hsa-miR-4288	CLIP-seq
MIRT1275246	hsa-miR-4419b	CLIP-seq
MIRT2306979	hsa-miR-4421	CLIP-seq
MIRT1275197	hsa-miR-4456	CLIP-seq
MIRT1275247	hsa-miR-4459	CLIP-seq
MIRT1275248	hsa-miR-4474-3p	CLIP-seq
MIRT1275249	hsa-miR-4478	CLIP-seq
MIRT1275201	hsa-miR-4525	CLIP-seq
MIRT1275250	hsa-miR-4649-3p	CLIP-seq
MIRT1275204	hsa-miR-4652-5p	CLIP-seq
MIRT1275206	hsa-miR-4665-5p	CLIP-seq
MIRT1275208	hsa-miR-4683	CLIP-seq
MIRT2081034	hsa-miR-4687-3p	CLIP-seq
MIRT2306980	hsa-miR-4691-5p	CLIP-seq
MIRT1275253	hsa-miR-4716-5p	CLIP-seq
MIRT1275254	hsa-miR-4722-5p	CLIP-seq
MIRT1275212	hsa-miR-4723-5p	CLIP-seq
MIRT1275255	hsa-miR-4728-5p	CLIP-seq
MIRT2081040	hsa-miR-4756-3p	CLIP-seq
MIRT1275259	hsa-miR-485-5p	CLIP-seq
MIRT2081043	hsa-miR-520a-5p	CLIP-seq
MIRT2081044	hsa-miR-525-5p	CLIP-seq
MIRT1275223	hsa-miR-576-3p	CLIP-seq
MIRT1275224	hsa-miR-579	CLIP-seq
MIRT1275226	hsa-miR-620	CLIP-seq
MIRT1275228	hsa-miR-625	CLIP-seq
MIRT2306981	hsa-miR-626	CLIP-seq
MIRT1275229	hsa-miR-632	CLIP-seq
MIRT2306982	hsa-miR-647	CLIP-seq
MIRT1275261	hsa-miR-654-3p	CLIP-seq
MIRT2306983	hsa-miR-876-3p	CLIP-seq
MIRT1275262	hsa-miR-940	CLIP-seq
MIRT1275144	hsa-miR-125a-5p	CLIP-seq
MIRT1275145	hsa-miR-125b	CLIP-seq
MIRT1275183	hsa-miR-4251	CLIP-seq
MIRT1275189	hsa-miR-4319	CLIP-seq
MIRT1275152	hsa-miR-216a	CLIP-seq
MIRT1275159	hsa-miR-3065-3p	CLIP-seq
MIRT1275140	hsa-miR-1228	CLIP-seq
MIRT2457424	hsa-miR-148a	CLIP-seq
MIRT2457425	hsa-miR-148b	CLIP-seq
MIRT2457426	hsa-miR-152	CLIP-seq
MIRT2457427	hsa-miR-1825	CLIP-seq
MIRT1275238	hsa-miR-1827	CLIP-seq
MIRT1275152	hsa-miR-216a	CLIP-seq
MIRT1275153	hsa-miR-216b	CLIP-seq
MIRT2457428	hsa-miR-2355-3p	CLIP-seq
MIRT1275159	hsa-miR-3065-3p	CLIP-seq
MIRT1275241	hsa-miR-3122	CLIP-seq
MIRT1275175	hsa-miR-3689a-3p	CLIP-seq
MIRT1275176	hsa-miR-3689c	CLIP-seq
MIRT1275243	hsa-miR-3913-5p	CLIP-seq
MIRT1275244	hsa-miR-3929	CLIP-seq
MIRT1275246	hsa-miR-4419b	CLIP-seq
MIRT1275247	hsa-miR-4459	CLIP-seq
MIRT1275249	hsa-miR-4478	CLIP-seq
MIRT2457429	hsa-miR-4646-3p	CLIP-seq
MIRT1275250	hsa-miR-4649-3p	CLIP-seq
MIRT1275254	hsa-miR-4722-5p	CLIP-seq
MIRT1275255	hsa-miR-4728-5p	CLIP-seq
MIRT1275259	hsa-miR-485-5p	CLIP-seq
MIRT1275262	hsa-miR-940	CLIP-seq
MIRT1275140	hsa-miR-1228	CLIP-seq
MIRT1275237	hsa-miR-1273e	CLIP-seq
MIRT1275238	hsa-miR-1827	CLIP-seq
MIRT1275152	hsa-miR-216a	CLIP-seq
MIRT1275153	hsa-miR-216b	CLIP-seq
MIRT1275159	hsa-miR-3065-3p	CLIP-seq
MIRT1275241	hsa-miR-3122	CLIP-seq
MIRT1275175	hsa-miR-3689a-3p	CLIP-seq
MIRT1275176	hsa-miR-3689c	CLIP-seq
MIRT1275243	hsa-miR-3913-5p	CLIP-seq
MIRT1275244	hsa-miR-3929	CLIP-seq
MIRT1275246	hsa-miR-4419b	CLIP-seq
MIRT1275247	hsa-miR-4459	CLIP-seq
MIRT1275249	hsa-miR-4478	CLIP-seq
MIRT1275250	hsa-miR-4649-3p	CLIP-seq
MIRT1275254	hsa-miR-4722-5p	CLIP-seq
MIRT1275255	hsa-miR-4728-5p	CLIP-seq
MIRT1275259	hsa-miR-485-5p	CLIP-seq
MIRT1275262	hsa-miR-940	CLIP-seq
MIRT1275140	hsa-miR-1228	CLIP-seq
MIRT2689074	hsa-miR-1269	CLIP-seq
MIRT2689075	hsa-miR-1269b	CLIP-seq
MIRT1275237	hsa-miR-1273e	CLIP-seq
MIRT2081009	hsa-miR-1285	CLIP-seq
MIRT2689076	hsa-miR-1288	CLIP-seq
MIRT1275238	hsa-miR-1827	CLIP-seq
MIRT1275152	hsa-miR-216a	CLIP-seq
MIRT1275153	hsa-miR-216b	CLIP-seq
MIRT2457428	hsa-miR-2355-3p	CLIP-seq
MIRT1275159	hsa-miR-3065-3p	CLIP-seq
MIRT1275241	hsa-miR-3122	CLIP-seq
MIRT2689077	hsa-miR-3138	CLIP-seq
MIRT2081018	hsa-miR-3187-5p	CLIP-seq
MIRT1275175	hsa-miR-3689a-3p	CLIP-seq
MIRT1275176	hsa-miR-3689c	CLIP-seq
MIRT2689078	hsa-miR-378g	CLIP-seq
MIRT1275243	hsa-miR-3913-5p	CLIP-seq
MIRT1275244	hsa-miR-3929	CLIP-seq
MIRT1275246	hsa-miR-4419b	CLIP-seq
MIRT1275247	hsa-miR-4459	CLIP-seq
MIRT2689079	hsa-miR-4470	CLIP-seq
MIRT1275249	hsa-miR-4478	CLIP-seq
MIRT2689080	hsa-miR-4486	CLIP-seq
MIRT2689081	hsa-miR-4515	CLIP-seq
MIRT2457429	hsa-miR-4646-3p	CLIP-seq
MIRT1275250	hsa-miR-4649-3p	CLIP-seq
MIRT1275254	hsa-miR-4722-5p	CLIP-seq
MIRT1275255	hsa-miR-4728-5p	CLIP-seq
MIRT2689082	hsa-miR-4740-5p	CLIP-seq
MIRT2689083	hsa-miR-4800-5p	CLIP-seq
MIRT1275259	hsa-miR-485-5p	CLIP-seq
MIRT2081049	hsa-miR-612	CLIP-seq
MIRT1275227	hsa-miR-622	CLIP-seq
MIRT1275262	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001825	Process	Blastocyst formation	IEA
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	EXP	25081058
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0004726	Function	Non-membrane spanning protein tyrosine phosphatase activity	IEA
GO:0004726	Function	Non-membrane spanning protein tyrosine phosphatase activity	TAS	8950995
GO:0005515	Function	Protein binding	IPI	9422760, 25081058, 35152348
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006470	Process	Protein dephosphorylation	TAS	8950995
GO:0016787	Function	Hydrolase activity	IEA
GO:1901185	Process	Negative regulation of ERBB signaling pathway	TAS

Other IDs

• MIM: 606587
• HGNC: 9649
• e!Ensembl: ENSG00000072135

Protein

• UniProt ID: Q99952
• Protein name: Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase)
• Protein function: Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
• PDB: 2OC3, 4GFU, 4GFV, 4NND
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00102	Y_phosphatase	56 → 290	Protein-tyrosine phosphatase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain, colon and several tumor-derived cell lines. {ECO:0000269|PubMed:8950995}.
• Sequence:

  MSRSLDSARSFLERLEARGGREGAVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKN
  RYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVW
  EFGVKVILMACREIENGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNEDIMLRTLKVTF
  QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLC
  TVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTLQNAS
  PHYQNIKENCAPLYDDALFLRTPQALLAIPRPPGGVLRSISVPGSPGHAMADTYAVVQKR
  GAPAGAGSGTQTGTGTGTGARSAEEAPLYSKVTPRAQRPGAHAEDARGTLPGRVPADQSP
  AGSGAYEDVAGGAQTGGLGFNLRIGRPKGPRDPPAEWTRV

• Sequence length: 460

Pathways

Reactome:

Downregulation of ERBB2 signaling
Interleukin-37 signaling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Breast Neoplasms	Associate	25081058	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Inhibit	35982039	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	29742497	★☆☆☆☆ Found in Text Mining only
Cleft Palate	Associate	32241273	★☆☆☆☆ Found in Text Mining only
Gastrointestinal Stromal Tumors	Associate	25349971, 30149002	★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Associate	32027948	★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Inhibit	35982039	★☆☆☆☆ Found in Text Mining only