LHX6 (LIM homeobox 6)

Gene

• Entrez ID: 26468
• Gene name: LIM homeobox 6
• Gene symbol: LHX6
• Synonyms (NCBI Gene): LHX6.1, hLHX6
• Chromosome: 9
• Chromosome location: 9q33.2
• Summary: This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein has tandem LIM domains as well as a DNA-binding homeodomain. The protein functions as a transcription factor

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016904	hsa-miR-335-5p	Microarray	18185580
MIRT028799	hsa-miR-26b-5p	Microarray	19088304
MIRT572716	hsa-miR-218-2-3p	PAR-CLIP	20371350
MIRT572715	hsa-miR-892c-5p	PAR-CLIP	20371350
MIRT572714	hsa-miR-506-5p	PAR-CLIP	20371350
MIRT572712	hsa-miR-3919	PAR-CLIP	20371350
MIRT572713	hsa-miR-4756-3p	PAR-CLIP	20371350
MIRT572711	hsa-miR-5690	PAR-CLIP	20371350
MIRT572710	hsa-miR-1273f	PAR-CLIP	20371350
MIRT572709	hsa-miR-8069	PAR-CLIP	20371350
MIRT572708	hsa-miR-218-1-3p	PAR-CLIP	20371350
MIRT572716	hsa-miR-218-2-3p	PAR-CLIP	20371350
MIRT572715	hsa-miR-892c-5p	PAR-CLIP	20371350
MIRT572714	hsa-miR-506-5p	PAR-CLIP	20371350
MIRT572712	hsa-miR-3919	PAR-CLIP	20371350
MIRT572713	hsa-miR-4756-3p	PAR-CLIP	20371350
MIRT572711	hsa-miR-5690	PAR-CLIP	20371350
MIRT572710	hsa-miR-1273f	PAR-CLIP	20371350
MIRT572709	hsa-miR-8069	PAR-CLIP	20371350
MIRT572708	hsa-miR-218-1-3p	PAR-CLIP	20371350
MIRT755546	hsa-miR-1290	Luciferase reporter assay, Western blotting, qRT-PCR	34729246
MIRT1109045	hsa-miR-1245b-5p	CLIP-seq
MIRT1109046	hsa-miR-1266	CLIP-seq
MIRT1109047	hsa-miR-1285	CLIP-seq
MIRT1109048	hsa-miR-1295	CLIP-seq
MIRT1109049	hsa-miR-1913	CLIP-seq
MIRT1109050	hsa-miR-3142	CLIP-seq
MIRT1109051	hsa-miR-3157-3p	CLIP-seq
MIRT1109052	hsa-miR-3187-5p	CLIP-seq
MIRT1109053	hsa-miR-324-3p	CLIP-seq
MIRT1109054	hsa-miR-3664-3p	CLIP-seq
MIRT1109055	hsa-miR-4492	CLIP-seq
MIRT1109056	hsa-miR-4498	CLIP-seq
MIRT1109057	hsa-miR-4505	CLIP-seq
MIRT1109058	hsa-miR-4518	CLIP-seq
MIRT1109059	hsa-miR-4757-5p	CLIP-seq
MIRT1109060	hsa-miR-612	CLIP-seq
MIRT1109061	hsa-miR-762	CLIP-seq
MIRT2030144	hsa-miR-1293	CLIP-seq
MIRT2030145	hsa-miR-3682-3p	CLIP-seq
MIRT2030146	hsa-miR-4483	CLIP-seq
MIRT2261028	hsa-miR-330-3p	CLIP-seq
MIRT2261029	hsa-miR-380	CLIP-seq
MIRT2261030	hsa-miR-4495	CLIP-seq
MIRT2261031	hsa-miR-488	CLIP-seq
MIRT2261032	hsa-miR-548m	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
PITX2	Activation	23229549

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	NAS	10393337
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32814053, 33961781, 35140242
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007399	Process	Nervous system development	IEA
GO:0021799	Process	Cerebral cortex radially oriented cell migration	ISS
GO:0021800	Process	Cerebral cortex tangential migration	ISS
GO:0021853	Process	Cerebral cortex GABAergic interneuron migration	ISS
GO:0021884	Process	Forebrain neuron development	IBA
GO:0030154	Process	Cell differentiation	IEA
GO:0030182	Process	Neuron differentiation	IBA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048469	Process	Cell maturation	ISS
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 608215
• HGNC: 21735
• e!Ensembl: ENSG00000106852

Protein

• UniProt ID: Q9UPM6
• Protein name: LIM/homeobox protein Lhx6 (LIM homeobox protein 6) (LIM/homeobox protein Lhx6.1)
• Protein function: Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron prec
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00412	LIM	70 → 127	LIM domain	Domain
  PF00412	LIM	131 → 188	LIM domain	Domain
  PF00046	Homeodomain	220 → 276	Homeodomain	Domain

• Sequence:

  MAQPGSGCKATTRCLEGTAPPAMAQSDAEALAGALDKDEGQASPCTPSTPSVCSPPSAAS
  SVPSAGKNICSSCGLEILDRYLLKVNNLIWHVRCLECSVCRTSLRQQNSCYIKNKEIFCK
  MDYFSRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVL
  CRIHYDTMIENLKRAAENGNGLTLEGAVPSEQDSQPKPAKRARTSFTAEQLQVMQAQFAQ
  DNNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKKHTPQHPVPPSGAPPSRLPSALSDD
  IHYTPFSSPERARMVTLHGYIESQVQCGQVHCRLPYTAPPVHLKADMDGPLSNRGEKVIL
  FQY

• Sequence length: 363