Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2645
Gene name Gene Name - the full gene name approved by the HGNC.	Glucokinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GCK
Synonyms (NCBI Gene) Gene synonyms aliases	FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2, PNDM1
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7p13
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited b

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SNP ID	Visualize variation	Clinical significance	Consequence
rs77440690	C>T	Uncertain-significance, conflicting-interpretations-of-pathogenicity, likely-benign	Intron variant, genic upstream transcript variant
rs104894010	A>G	Pathogenic	Missense variant, coding sequence variant, genic upstream transcript variant
rs104894012	C>T	Pathogenic	Missense variant, coding sequence variant
rs104894014	G>A	Pathogenic	Missense variant, coding sequence variant
rs104894016	C>G,T	Pathogenic	Missense variant, coding sequence variant, 5 prime UTR variant
rs193921338	G>A,T	Likely-pathogenic	Missense variant, coding sequence variant
rs193921340	A>G,T	Likely-pathogenic	Missense variant, coding sequence variant
rs193922259	T>A	Likely-pathogenic	Coding sequence variant, genic upstream transcript variant, stop gained
rs193922261	C>G,T	Likely-pathogenic	Missense variant, coding sequence variant, genic upstream transcript variant
rs193922262	C>A,G	Likely-pathogenic	Stop gained, missense variant, coding sequence variant, 5 prime UTR variant
rs193922263	G>A	Likely-pathogenic	Missense variant, coding sequence variant, 5 prime UTR variant
rs193922264	C>T	Likely-pathogenic, uncertain-significance	Missense variant, coding sequence variant, 5 prime UTR variant
rs193922265	G>A,C,T	Likely-pathogenic, uncertain-significance	Missense variant, coding sequence variant, 5 prime UTR variant
rs193922266	A>C,T	Likely-pathogenic, uncertain-significance	Initiator codon variant, coding sequence variant, missense variant
rs193922267	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs193922268	A>G	Likely-pathogenic	Missense variant, coding sequence variant
rs193922269	C>A	Likely-pathogenic	Missense variant, coding sequence variant
rs193922271	G>C,T	Likely-pathogenic	Missense variant, coding sequence variant
rs193922272	T>C	Likely-pathogenic	Missense variant, coding sequence variant
rs193922273	A>G,T	Likely-pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs193922274	GAGACCAGGGCCGCGCCCCGGCCACTGCCCTCCTCCGACTCGATGAAGGTGATCTCGCAGCTGGGCGTCAGCCTGCGCAC>TGTAA	Likely-pathogenic	Coding sequence variant, inframe indel
rs193922275	GC>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs193922277	A>G	Likely-pathogenic	Missense variant, coding sequence variant
rs193922278	A>T	Likely-pathogenic	Missense variant, coding sequence variant
rs193922279	C>T	Likely-pathogenic	Missense variant, coding sequence variant, genic upstream transcript variant
rs193922280	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs193922281	G>C	Likely-pathogenic	Missense variant, coding sequence variant
rs193922282	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs193922283	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs193922284	TT>-	Likely-pathogenic	Coding sequence variant, frameshift variant, intron variant
rs193922286	G>T	Likely-pathogenic, uncertain-significance	Missense variant, coding sequence variant, genic upstream transcript variant
rs193922287	G>A	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant, genic upstream transcript variant
rs193922289	C>T	Pathogenic	Missense variant, coding sequence variant, genic upstream transcript variant
rs193922290	T>A	Likely-pathogenic	Missense variant, coding sequence variant, genic upstream transcript variant
rs193922291	T>A	Likely-pathogenic	Coding sequence variant, genic upstream transcript variant, stop gained
rs193922292	A>C,G	Likely-pathogenic	Missense variant, coding sequence variant, genic upstream transcript variant
rs193922295	G>-	Likely-pathogenic	Coding sequence variant, genic upstream transcript variant, frameshift variant
rs193922296	C>T	Likely-pathogenic	Missense variant, coding sequence variant, genic upstream transcript variant
rs193922297	A>G,T	Likely-pathogenic, pathogenic, uncertain-significance	Missense variant, coding sequence variant, genic upstream transcript variant
rs193922301	T>C	Likely-pathogenic	Missense variant, coding sequence variant, genic upstream transcript variant
rs193922302	C>T	Likely-pathogenic	Synonymous variant, coding sequence variant, genic upstream transcript variant
rs193922308	G>C,T	Likely-pathogenic	Synonymous variant, missense variant, coding sequence variant, genic upstream transcript variant
rs193922325	A>C,T	Likely-pathogenic, uncertain-significance	Missense variant, coding sequence variant, genic upstream transcript variant
rs193922329	G>A	Likely-pathogenic, pathogenic	Coding sequence variant, genic upstream transcript variant, stop gained
rs193929374	G>A,C	Pathogenic	Missense variant, coding sequence variant, 5 prime UTR variant
rs193929375	C>A	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant
rs267601516	C>T	Pathogenic	Missense variant, coding sequence variant, genic upstream transcript variant
rs556581174	G>A,C,T	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant, stop gained, 5 prime UTR variant, synonymous variant
rs587780343	C>A,T	Likely-pathogenic	Coding sequence variant, 5 prime UTR variant, missense variant
rs753795627	A>C,T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs758737171	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs759072800	C>G,T	Likely-pathogenic, uncertain-significance	Genic upstream transcript variant, coding sequence variant, missense variant
rs762263694	G>A	Pathogenic, pathogenic-likely-pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant
rs764232985	C>G,T	Likely-pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant
rs777870079	G>A,T	Likely-pathogenic	Coding sequence variant, stop gained, missense variant
rs780612692	G>A,T	Pathogenic	Coding sequence variant, stop gained, genic upstream transcript variant, synonymous variant
rs781260712	C>A	Pathogenic	Genic upstream transcript variant, splice donor variant
rs794727236	C>T	Pathogenic	Coding sequence variant, missense variant, genic upstream transcript variant
rs797045595	GGATGGAGTACATCTGG>-	Pathogenic	Coding sequence variant, genic upstream transcript variant, frameshift variant
rs876661320	A>G	Likely-pathogenic	Coding sequence variant, missense variant, genic upstream transcript variant
rs878853246	G>A	Pathogenic	Coding sequence variant, stop gained, genic upstream transcript variant
rs886041690	->G	Pathogenic	Genic upstream transcript variant, coding sequence variant, frameshift variant
rs886042015	->C	Pathogenic	Coding sequence variant, frameshift variant
rs1057520109	C>A,T	Pathogenic, likely-pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant
rs1057521092	C>T	Likely-pathogenic	Missense variant, 5 prime UTR variant, coding sequence variant
rs1057521094	C>T	Pathogenic-likely-pathogenic	Genic upstream transcript variant, splice acceptor variant
rs1057524900	G>A,T	Likely-pathogenic	Missense variant, coding sequence variant
rs1057524901	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1057524902	A>C,T	Pathogenic	Splice donor variant
rs1057524906	A>G	Uncertain-significance, likely-pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant
rs1064793134	C>T	Likely-pathogenic	Missense variant, 5 prime UTR variant, coding sequence variant
rs1064793428	->GG	Pathogenic	Genic upstream transcript variant, coding sequence variant, frameshift variant
rs1064793998	C>T	Pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant
rs1064794268	T>G	Uncertain-significance, likely-pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant
rs1064795242	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1064796410	A>-	Pathogenic	Genic upstream transcript variant, coding sequence variant, frameshift variant
rs1131691416	C>G,T	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant
rs1131691483	C>A	Likely-pathogenic	Stop gained, genic upstream transcript variant, coding sequence variant
rs1131691505	CAGCGCGCG>-	Uncertain-significance, likely-pathogenic	Inframe deletion, 5 prime UTR variant, coding sequence variant
rs1281712444	G>A	Pathogenic	Genic upstream transcript variant, stop gained, coding sequence variant
rs1286804191	G>A	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant
rs1350717554	C>G,T	Pathogenic	Coding sequence variant, missense variant
rs1400535021	C>-,CC	Pathogenic, likely-pathogenic	Frameshift variant, coding sequence variant
rs1444739794	A>G	Likely-pathogenic	Coding sequence variant, missense variant, genic upstream transcript variant
rs1486280029	G>A,T	Pathogenic, likely-pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant
rs1554334433	->CCG	Pathogenic	Coding sequence variant, inframe insertion
rs1554334579	G>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1554334610	AGCACATGTGCGCAGCG>-	Pathogenic	Initiator codon variant, 5 prime UTR variant, coding sequence variant, frameshift variant
rs1554335564	A>G	Pathogenic	Genic upstream transcript variant, splice donor variant
rs1554335566	C>T	Likely-pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant
rs1554335570	C>T	Likely-pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant
rs1554335585	C>-	Pathogenic	Genic upstream transcript variant, coding sequence variant, frameshift variant
rs1554335612	T>A	Likely-pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant
rs1554335616	G>C,T	Likely-pathogenic, uncertain-significance	Genic upstream transcript variant, coding sequence variant, missense variant
rs1554335751	A>G	Pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant
rs1554335752	A>-	Pathogenic	Genic upstream transcript variant, coding sequence variant, frameshift variant
rs1554335761	C>T	Likely-pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant
rs1554335913	C>T	Pathogenic	Genic upstream transcript variant, splice donor variant
rs1554335954	A>C,G,T	Pathogenic, likely-pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant
rs1554335966	T>C	Pathogenic	Splice acceptor variant, genic upstream transcript variant
rs1562711915	C>A	Pathogenic	Coding sequence variant, stop gained
rs1562719029	C>-	Pathogenic	Genic upstream transcript variant, coding sequence variant, frameshift variant
rs1562719705	G>A	Pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant
rs1583590393	C>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1583591809	G>T	Likely-pathogenic	Coding sequence variant, stop gained
rs1583601110	CCACCCGGCCCACCT>-	Pathogenic	Coding sequence variant, genic upstream transcript variant, intron variant, splice donor variant
rs1583601365	G>T	Pathogenic	Coding sequence variant, genic upstream transcript variant, stop gained

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018730	hsa-miR-335-5p	Microarray	18185580
MIRT721960	hsa-miR-4524b-3p	HITS-CLIP	19536157
MIRT496313	hsa-miR-6733-3p	HITS-CLIP	19536157
MIRT721959	hsa-miR-6072	HITS-CLIP	19536157
MIRT721958	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT721957	hsa-miR-4744	HITS-CLIP	19536157
MIRT721956	hsa-miR-4509	HITS-CLIP	19536157
MIRT721955	hsa-miR-6758-3p	HITS-CLIP	19536157
MIRT721954	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT721953	hsa-miR-3909	HITS-CLIP	19536157
MIRT721952	hsa-miR-6852-3p	HITS-CLIP	19536157
MIRT721951	hsa-miR-4799-5p	HITS-CLIP	19536157
MIRT721950	hsa-miR-4263	HITS-CLIP	19536157
MIRT721949	hsa-miR-576-5p	HITS-CLIP	19536157
MIRT612962	hsa-miR-8485	HITS-CLIP	19536157
MIRT612961	hsa-miR-329-3p	HITS-CLIP	19536157
MIRT612960	hsa-miR-362-3p	HITS-CLIP	19536157
MIRT612959	hsa-miR-603	HITS-CLIP	19536157
MIRT612958	hsa-miR-4789-3p	HITS-CLIP	19536157
MIRT674566	hsa-miR-5580-3p	HITS-CLIP	19536157
MIRT612957	hsa-miR-3941	HITS-CLIP	19536157
MIRT674565	hsa-miR-3924	HITS-CLIP	19536157
MIRT496317	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT612962	hsa-miR-8485	HITS-CLIP	21572407
MIRT612961	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT612960	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT612959	hsa-miR-603	HITS-CLIP	21572407
MIRT612958	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT496314	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT612957	hsa-miR-3941	HITS-CLIP	21572407
MIRT612956	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT612955	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT612962	hsa-miR-8485	HITS-CLIP	23824327
MIRT612961	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612960	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612959	hsa-miR-603	HITS-CLIP	23824327
MIRT612958	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT674566	hsa-miR-5580-3p	HITS-CLIP	23824327
MIRT612957	hsa-miR-3941	HITS-CLIP	23824327
MIRT674565	hsa-miR-3924	HITS-CLIP	23824327
MIRT612962	hsa-miR-8485	HITS-CLIP	23824327
MIRT612961	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612960	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612959	hsa-miR-603	HITS-CLIP	23824327
MIRT612958	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT496314	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT612957	hsa-miR-3941	HITS-CLIP	23824327
MIRT612956	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612955	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT496317	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT493787	hsa-miR-8080	PAR-CLIP	20371350
MIRT493786	hsa-miR-6087	PAR-CLIP	20371350
MIRT493785	hsa-miR-4533	PAR-CLIP	20371350
MIRT493784	hsa-miR-3202	PAR-CLIP	20371350
MIRT493783	hsa-miR-92b-5p	PAR-CLIP	20371350
MIRT493782	hsa-miR-3191-3p	PAR-CLIP	20371350
MIRT493781	hsa-miR-6795-5p	PAR-CLIP	20371350
MIRT493780	hsa-miR-6887-5p	PAR-CLIP	20371350
MIRT496317	hsa-miR-1277-5p	PAR-CLIP	22291592
MIRT496316	hsa-miR-3163	PAR-CLIP	22291592
MIRT496315	hsa-miR-1295b-3p	PAR-CLIP	22291592
MIRT496314	hsa-miR-5011-5p	PAR-CLIP	22291592
MIRT496313	hsa-miR-6733-3p	PAR-CLIP	22291592
MIRT496312	hsa-miR-4302	PAR-CLIP	22291592
MIRT496311	hsa-miR-568	PAR-CLIP	22291592
MIRT493787	hsa-miR-8080	PAR-CLIP	23592263
MIRT493786	hsa-miR-6087	PAR-CLIP	23592263
MIRT493785	hsa-miR-4533	PAR-CLIP	23592263
MIRT493784	hsa-miR-3202	PAR-CLIP	23592263
MIRT493783	hsa-miR-92b-5p	PAR-CLIP	23592263
MIRT493782	hsa-miR-3191-3p	PAR-CLIP	23592263
MIRT493781	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT493780	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT493779	hsa-miR-6079	PAR-CLIP	23592263
MIRT440581	hsa-miR-409-3p	HITS-CLIP	24374217
MIRT440581	hsa-miR-409-3p	HITS-CLIP	24374217
MIRT721960	hsa-miR-4524b-3p	HITS-CLIP	19536157
MIRT496313	hsa-miR-6733-3p	HITS-CLIP	19536157
MIRT721959	hsa-miR-6072	HITS-CLIP	19536157
MIRT721958	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT721957	hsa-miR-4744	HITS-CLIP	19536157
MIRT721956	hsa-miR-4509	HITS-CLIP	19536157
MIRT721955	hsa-miR-6758-3p	HITS-CLIP	19536157
MIRT721954	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT721953	hsa-miR-3909	HITS-CLIP	19536157
MIRT721952	hsa-miR-6852-3p	HITS-CLIP	19536157
MIRT721951	hsa-miR-4799-5p	HITS-CLIP	19536157
MIRT721950	hsa-miR-4263	HITS-CLIP	19536157
MIRT721949	hsa-miR-576-5p	HITS-CLIP	19536157
MIRT612962	hsa-miR-8485	HITS-CLIP	19536157
MIRT612961	hsa-miR-329-3p	HITS-CLIP	19536157
MIRT612960	hsa-miR-362-3p	HITS-CLIP	19536157
MIRT612959	hsa-miR-603	HITS-CLIP	19536157
MIRT612958	hsa-miR-4789-3p	HITS-CLIP	19536157
MIRT674566	hsa-miR-5580-3p	HITS-CLIP	19536157
MIRT612957	hsa-miR-3941	HITS-CLIP	19536157
MIRT674565	hsa-miR-3924	HITS-CLIP	19536157
MIRT496317	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT612962	hsa-miR-8485	HITS-CLIP	21572407
MIRT612961	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT612960	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT612959	hsa-miR-603	HITS-CLIP	21572407
MIRT612958	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT496314	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT612957	hsa-miR-3941	HITS-CLIP	21572407
MIRT612956	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT612955	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT612962	hsa-miR-8485	HITS-CLIP	23824327
MIRT612961	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612960	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612959	hsa-miR-603	HITS-CLIP	23824327
MIRT612958	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT674566	hsa-miR-5580-3p	HITS-CLIP	23824327
MIRT612957	hsa-miR-3941	HITS-CLIP	23824327
MIRT674565	hsa-miR-3924	HITS-CLIP	23824327
MIRT612962	hsa-miR-8485	HITS-CLIP	23824327
MIRT612961	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612960	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612959	hsa-miR-603	HITS-CLIP	23824327
MIRT612958	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT496314	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT612957	hsa-miR-3941	HITS-CLIP	23824327
MIRT612956	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612955	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT496317	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT493787	hsa-miR-8080	PAR-CLIP	20371350
MIRT493786	hsa-miR-6087	PAR-CLIP	20371350
MIRT493785	hsa-miR-4533	PAR-CLIP	20371350
MIRT493784	hsa-miR-3202	PAR-CLIP	20371350
MIRT493783	hsa-miR-92b-5p	PAR-CLIP	20371350
MIRT493782	hsa-miR-3191-3p	PAR-CLIP	20371350
MIRT493781	hsa-miR-6795-5p	PAR-CLIP	20371350
MIRT493780	hsa-miR-6887-5p	PAR-CLIP	20371350
MIRT496317	hsa-miR-1277-5p	PAR-CLIP	22291592
MIRT496316	hsa-miR-3163	PAR-CLIP	22291592
MIRT496315	hsa-miR-1295b-3p	PAR-CLIP	22291592
MIRT496314	hsa-miR-5011-5p	PAR-CLIP	22291592
MIRT496313	hsa-miR-6733-3p	PAR-CLIP	22291592
MIRT496312	hsa-miR-4302	PAR-CLIP	22291592
MIRT496311	hsa-miR-568	PAR-CLIP	22291592
MIRT493787	hsa-miR-8080	PAR-CLIP	23592263
MIRT493786	hsa-miR-6087	PAR-CLIP	23592263
MIRT493785	hsa-miR-4533	PAR-CLIP	23592263
MIRT493784	hsa-miR-3202	PAR-CLIP	23592263
MIRT493783	hsa-miR-92b-5p	PAR-CLIP	23592263
MIRT493782	hsa-miR-3191-3p	PAR-CLIP	23592263
MIRT493781	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT493780	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT493779	hsa-miR-6079	PAR-CLIP	23592263
MIRT1014693	hsa-miR-1200	CLIP-seq
MIRT1014694	hsa-miR-1913	CLIP-seq
MIRT1014695	hsa-miR-1976	CLIP-seq
MIRT1014696	hsa-miR-296-5p	CLIP-seq
MIRT1014697	hsa-miR-3127-3p	CLIP-seq
MIRT1014698	hsa-miR-3170	CLIP-seq
MIRT1014699	hsa-miR-3189-3p	CLIP-seq
MIRT1014700	hsa-miR-324-3p	CLIP-seq
MIRT1014701	hsa-miR-4258	CLIP-seq
MIRT1014702	hsa-miR-4260	CLIP-seq
MIRT1014703	hsa-miR-4265	CLIP-seq
MIRT1014704	hsa-miR-4296	CLIP-seq
MIRT1014705	hsa-miR-4322	CLIP-seq
MIRT1014706	hsa-miR-4324	CLIP-seq
MIRT1014707	hsa-miR-4417	CLIP-seq
MIRT1014708	hsa-miR-4650-5p	CLIP-seq
MIRT1014709	hsa-miR-4659a-3p	CLIP-seq
MIRT1014710	hsa-miR-4659b-3p	CLIP-seq
MIRT1014711	hsa-miR-4722-3p	CLIP-seq
MIRT1014712	hsa-miR-4738-5p	CLIP-seq
MIRT1014713	hsa-miR-4755-3p	CLIP-seq
MIRT1014714	hsa-miR-486-3p	CLIP-seq
MIRT1014715	hsa-miR-544b	CLIP-seq
MIRT1014716	hsa-miR-3126-5p	CLIP-seq
MIRT1014717	hsa-miR-3160-3p	CLIP-seq
MIRT1014718	hsa-miR-4300	CLIP-seq
MIRT1014719	hsa-miR-4419a	CLIP-seq
MIRT1014720	hsa-miR-4510	CLIP-seq
MIRT1014721	hsa-miR-4699-5p	CLIP-seq
MIRT1014712	hsa-miR-4738-5p	CLIP-seq
MIRT1014722	hsa-miR-4747-3p	CLIP-seq
MIRT1014723	hsa-miR-548a-3p	CLIP-seq
MIRT1014724	hsa-miR-548ae	CLIP-seq
MIRT1014725	hsa-miR-548aj	CLIP-seq
MIRT1014726	hsa-miR-548am	CLIP-seq
MIRT1014727	hsa-miR-548e	CLIP-seq
MIRT1014728	hsa-miR-548f	CLIP-seq
MIRT1014729	hsa-miR-548x	CLIP-seq
MIRT1014730	hsa-miR-920	CLIP-seq
MIRT2233958	hsa-miR-2115	CLIP-seq
MIRT2233959	hsa-miR-3180-5p	CLIP-seq
MIRT2233960	hsa-miR-520a-5p	CLIP-seq
MIRT2233961	hsa-miR-525-5p	CLIP-seq

Transcription factors

Show/Hide all(4)

Transcription factor	Regulation	Reference
HIF1A	Unknown	14612449
HNF4A	Unknown	14612449
PDX1	Activation	8866550
USF1	Activation	9677331

Show/Hide all(65)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001678	Process	Intracellular glucose homeostasis	IBA
GO:0001678	Process	Intracellular glucose homeostasis	IEA
GO:0001678	Process	Intracellular glucose homeostasis	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0004340	Function	Glucokinase activity	IBA
GO:0004340	Function	Glucokinase activity	IDA	8446612, 12941786, 16173921, 22611063
GO:0004340	Function	Glucokinase activity	IEA
GO:0004340	Function	Glucokinase activity	IMP	18322640, 19146401
GO:0004340	Function	Glucokinase activity	TAS
GO:0004396	Function	Hexokinase activity	IEA
GO:0005515	Function	Protein binding	IPI	11522786, 16173921, 32296183
GO:0005524	Function	ATP binding	IDA	8446612, 12941786, 16173921
GO:0005524	Function	ATP binding	IEA
GO:0005536	Function	D-glucose binding	IDA	8446612, 12941786, 16173921
GO:0005536	Function	D-glucose binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006006	Process	Glucose metabolic process	IBA
GO:0006006	Process	Glucose metabolic process	IEA
GO:0006006	Process	Glucose metabolic process	IEA
GO:0006007	Process	Glucose catabolic process	IMP	12941786
GO:0006096	Process	Glycolytic process	IBA
GO:0006096	Process	Glycolytic process	IEA
GO:0006110	Process	Regulation of glycolytic process	NAS	9570959
GO:0006163	Process	Purine nucleotide metabolic process	IEA
GO:0006739	Process	NADP+ metabolic process	IEA
GO:0008865	Function	Fructokinase activity	IBA
GO:0008865	Function	Fructokinase activity	IEA
GO:0009749	Process	Response to glucose	ISS
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016773	Function	Phosphotransferase activity, alcohol group as acceptor	IEA
GO:0019158	Function	Mannokinase activity	IBA
GO:0019158	Function	Mannokinase activity	IEA
GO:0019318	Process	Hexose metabolic process	IEA
GO:0032024	Process	Positive regulation of insulin secretion	IEA
GO:0032024	Process	Positive regulation of insulin secretion	IEA
GO:0032024	Process	Positive regulation of insulin secretion	IMP	8132752, 8878425
GO:0032869	Process	Cellular response to insulin stimulus	ISS
GO:0042593	Process	Glucose homeostasis	IEA
GO:0042593	Process	Glucose homeostasis	IEA
GO:0042593	Process	Glucose homeostasis	IMP	8132752, 20668700
GO:0043266	Process	Regulation of potassium ion transport	IEA
GO:0044320	Process	Cellular response to leptin stimulus	ISS
GO:0045721	Process	Negative regulation of gluconeogenesis	IMP	8878425
GO:0045725	Process	Positive regulation of glycogen biosynthetic process	IMP	8878425
GO:0046496	Process	Nicotinamide nucleotide metabolic process	IEA
GO:0046835	Process	Carbohydrate phosphorylation	IEA
GO:0050796	Process	Regulation of insulin secretion	IBA
GO:0050796	Process	Regulation of insulin secretion	IEA
GO:0050796	Process	Regulation of insulin secretion	IMP	20668700
GO:0051156	Process	Glucose 6-phosphate metabolic process	IBA
GO:0051156	Process	Glucose 6-phosphate metabolic process	IMP	18322640, 19146401
GO:0061621	Process	Canonical glycolysis	TAS
GO:0070509	Process	Calcium ion import	IEA
GO:0141089	Function	Glucose sensor activity	ISS

MIM	HGNC	e!Ensembl
138079	4195	ENSG00000106633

Protein

UniProt ID

P35557

Protein name

Hexokinase-4 (HK4) (EC 2.7.1.1) (Glucokinase) (Hexokinase type IV) (HK IV) (Hexokinase-D)

Protein function

Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively) (PubMed:11916951, PubMed:15277402, PubMed:1708218

PDB

1V4S , 1V4T , 3A0I , 3F9M , 3FGU , 3FR0 , 3GOI , 3H1V , 3ID8 , 3IDH , 3IMX , 3QIC , 3S41 , 3VEV , 3VEY , 3VF6 , 4DCH , 4DHY , 4ISE , 4ISF , 4ISG , 4IWV , 4IXC , 4L3Q , 4LC9 , 4MLE , 4MLH , 4NO7 , 4RCH , 5V4W , 5V4X , 6E0E , 6E0I , 7T78 , 7T79

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00349	Hexokinase_1	15 → 215	Hexokinase	Domain
PF03727	Hexokinase_2	221 → 455	Hexokinase	Domain

Sequence

MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ

Sequence length

465

Interactions

View interactions

	KEGG		Reactome
	Glycolysis / Gluconeogenesis Galactose metabolism Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism Neomycin, kanamycin and gentamicin biosynthesis Metabolic pathways Carbon metabolism Biosynthesis of nucleotide sugars Insulin signaling pathway Insulin secretion Prolactin signaling pathway Glucagon signaling pathway Type II diabetes mellitus Maturity onset diabetes of the young Central carbon metabolism in cancer		Regulation of Glucokinase by Glucokinase Regulatory Protein Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) Glycolysis

Show/Hide Causal Diseases (5)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Diabetes Mellitus	Maturity-onset diabetes of the young type 2, Gestational diabetes, permanent neonatal diabetes mellitus, Type 2 diabetes mellitus, Maturity-onset diabetes of the young type 3, diabetes mellitus	rs193922259, rs1415041911, rs193922275, rs777870079, rs1554334872, rs1057524904, rs587780346, rs80356654, rs148311934, rs1375656631, rs193922282, rs886042610, rs193922300, rs193921338, rs193922340 View all (102 more)	N/A
Hyperinsulinism	hyperinsulinism due to glucokinase deficiency	rs80356655, rs104894014, rs104894015, rs1350717554, rs104894010, rs1400535021, rs104894012	N/A
Mason type diabetes	maturity onset diabetes mellitus in young	rs193922340, rs1131691483, rs1562717053, rs1554335132, rs1583601365, rs1554335752, rs1064796410, rs193922330, rs193922259, rs1554335441, rs193922275, rs1583590393, rs1554334872, rs1057524904, rs193922264 View all (82 more)	N/A
Monogenic Diabetes	monogenic diabetes	rs193922340, rs193922313, rs1583590393, rs193922264, rs193922289, rs556581174, rs794727839, rs1554335966, rs193929375, rs777870079, rs1057520109, rs1562718043, rs587780346, rs1554335132, rs1375656631 View all (93 more)	N/A
Pancytopenia-developmental delay syndrome	pancytopenia-developmental delay syndrome	rs193922340	N/A

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Gout	Gout	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (72)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
6q24 Related Transient Neonatal Diabetes Mellitus	Associate	25015100
Acute Coronary Syndrome	Associate	31605429
Acute Kidney Injury	Associate	39696008
Adenocarcinoma	Stimulate	38082365
Anodontia	Associate	27197745
Beckwith Wiedemann Syndrome	Associate	39382384
Carbohydrate Metabolism Inborn Errors	Associate	1502186
Carcinoma Hepatocellular	Associate	33594203, 33920410, 39215018
Cardiovascular Diseases	Associate	36151532
Cataract	Associate	34385667
Cerulean cataract	Associate	24244580
Chemical and Drug Induced Liver Injury	Associate	36901746
Cognition Disorders	Associate	28387648
Colorectal Neoplasms	Associate	34608882
Colorectal Neoplasms	Inhibit	9292708
Congenital Hereditary and Neonatal Diseases and Abnormalities	Associate	25015100
Congenital Hyperinsulinism	Associate	16938872, 19617908, 19884385, 21454522, 23274908, 23275527, 23345197, 24890200, 25008049, 26283387, 26399329, 28842611, 29425029, 31094068, 34635134 View all (7 more)
Coronary Artery Disease	Associate	34165031
Coronary Artery Disease	Inhibit	36151532
Coronary Disease	Associate	24696842
Deafness	Associate	34630320
Diabetes Gestational	Associate	18271687, 20682688, 22773699, 27173344, 27554451, 28072873, 28371533, 29412391, 32482198, 33953693
Diabetes Mellitus	Associate	10347805, 1502186, 16059790, 16173921, 16938872, 18297260, 18382660, 19073768, 19884385, 19903754, 21437567, 21720051, 22298776, 22341299, 22446163 View all (50 more)
Diabetes Mellitus	Inhibit	19564454
Diabetes Mellitus Permanent Neonatal	Associate	19496967, 19884385, 24606082, 25755231, 31197960, 31441606, 32971462, 35228227
Diabetes Mellitus Transient Neonatal 1	Associate	21437567, 25755231, 33148726
Diabetes Mellitus Type 1	Associate	19309449, 21437567, 23799006, 24606082, 25082184, 29412391, 30465894, 31638168, 36418577
Diabetes Mellitus Type 2	Associate	10347805, 11112984, 15016359, 1502186, 16059790, 16173921, 16936201, 16938872, 17503332, 18271687, 18297260, 18382660, 18498634, 19309449, 19533084 View all (84 more)
Diabetes Mellitus Type 2	Stimulate	34101350
Disease	Associate	35177841
Dyslipidemias	Associate	31605429, 31924263
Epilepsy	Associate	26399329, 31094068
Epileptic Syndromes	Associate	22291974, 24890200
Fetal Alcohol Spectrum Disorders	Associate	26399329
Fetal Macrosomia	Associate	31094068, 32533152
Frailty	Inhibit	40035195
Genetic Diseases Inborn	Associate	32792356
Glucose Intolerance	Associate	1502186, 18411240, 19564454, 8376578
Glycosuria	Associate	28593615
Heart Failure	Associate	36151532
Hemochromatosis	Associate	24890200
Hepatitis B Chronic	Associate	34630320
Hepatitis C	Stimulate	35055105
Hyperglycemia	Stimulate	16059790
Hyperglycemia	Associate	17186458, 18556336, 19309449, 19411616, 19564454, 19903754, 20628598, 20858683, 21420961, 22761713, 22773699, 30592380, 31197960, 31576961, 32531870 View all (11 more)
Hyperglycemia	Inhibit	23985558
Hyperglycemic Hyperosmolar Nonketotic Coma	Associate	31197960, 8376578
Hyperinsulinism	Associate	19053014, 19336674, 20185807, 23271955, 25555642, 29493090, 35674212, 36384957, 36384997, 37725835, 39382384
Hyperuricemia	Associate	35365700
Hypoglycemia	Associate	17082186, 19053014, 19336674, 19564454, 19884385, 22291974, 22298776, 22341299, 29704611, 31094068, 34635134, 35228227, 35293603, 35370948, 36384957
hypoglycemic encephalopathy	Associate	19884385, 23271955
Inflammation	Associate	36901746
Insulin Resistance	Associate	11112984, 20628598, 26634513, 32556615
Intellectual Disability	Associate	19053014
Ketosis	Associate	21437567
Kidney Failure Chronic	Associate	20144192
Liver Diseases	Associate	36400171
Mason Type Diabetes	Associate	10347805, 16173921, 18322640, 19617908, 21454522, 22289546, 22493702, 30912798, 31028668, 32533685, 33450726, 34085361, 34630320, 35228227, 36342518, 37101203, 8376578 View all (2 more)
Maturity Onset Diabetes of the Young Type 2	Associate	16173921, 18271687, 18322640, 18382660, 18411240, 22291974, 22341299, 22761713, 23139355, 23778137, 24092492, 24578721, 24606082, 28371533, 28387648 View all (19 more)
Maturity Onset Diabetes of the Young Type 4	Associate	23271955
Meningioma	Associate	8132752
Mental Disorders	Associate	35381380
Metabolic Diseases	Associate	24890200, 39215018
Metabolic Syndrome	Associate	35177841, 38201907
Neoplasms	Associate	33920410
Neoplasms Adipose Tissue	Associate	24890200
Obesity	Associate	18483479, 25060389, 27377425, 31924263, 35370948
Pancreatic Neoplasms	Associate	20845477
Peripheral Arterial Disease	Associate	36151532
Prediabetic State	Associate	22289546, 28158221, 29412391, 31882596
Stroke	Associate	36151532
Warburg Sjo Fledelius syndrome	Associate	36400171

GCK (glucokinase)