GC (GC vitamin D binding protein)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2638
Gene name Gene Name - the full gene name approved by the HGNC.
GC vitamin D binding protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GC
Synonyms (NCBI Gene) Gene synonyms aliases
DBP, DBP-maf, DBP/GC, GRD3, Gc-MAF, GcMAF, HEL-S-51, VDB, VDBG, VDBP
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q13.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
miRTarBase ID miRNA Experiments Reference
MIRT016788 hsa-miR-335-5p Microarray 18185580
MIRT2233845 hsa-miR-3663-5p CLIP-seq
MIRT2233846 hsa-miR-3973 CLIP-seq
MIRT2233847 hsa-miR-520g CLIP-seq
MIRT2233848 hsa-miR-520h CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
TP53 Unknown 8642300
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(23)
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0003779 Function Actin binding IPI 12119014
GO:0005499 Function Vitamin D binding IBA
GO:0005499 Function Vitamin D binding IEA
GO:0005499 Function Vitamin D binding TAS 1696927
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
139200 4187 ENSG00000145321
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P02774
Protein name Vitamin D-binding protein (DBP) (VDB) (Gc protein-derived macrophage activating factor) (Gc-MAF) (GcMAF) (Gc-globulin) (Group-specific component) (Gc) (Vitamin D-binding protein-macrophage activating factor) (DBP-maf)
Protein function Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
PDB 1J78 , 1J7E , 1KW2 , 1KXP , 1LOT , 1MA9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00273 Serum_albumin 27 → 199 Serum albumin family Domain
PF00273 Serum_albumin 218 → 385 Serum albumin family Domain
PF09164 VitD-bind_III 405 → 469 Vitamin D binding protein, domain III Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine. {ECO:0000269|PubMed:20079467, ECO:0000269|PubMed:2416779, ECO:0000305|PubMed:16302727}.
Sequence
Sequence length 474
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Vitamin D (calciferol) metabolism
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (4)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
chronic obstructive pulmonary disease Chronic obstructive pulmonary disease N/A N/A ClinVar
Mental Depression Major depressive disorder N/A N/A GWAS
Oligodendroglioma Oligodendroglioma N/A N/A GWAS
Periodontitis periodontitis N/A N/A ClinVar
Show/Hide Text Mining Associations (145)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 30716477
Adenoma Associate 36701139
Airway Obstruction Associate 32546996
Aphasia Primary Progressive Associate 20805994
Arthritis Associate 22771520
Arthritis Infectious Associate 32569219
Arthritis Juvenile Associate 22771520
Arthritis Rheumatoid Associate 30662913, 31491989
Arthritis Rheumatoid Inhibit 33584536
Asthma Associate 21810276, 24447085, 24745702, 30548492, 31541492, 37407930, 39894560