Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	26354
Gene name Gene Name - the full gene name approved by the HGNC.	G protein nucleolar 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GNL3
Synonyms (NCBI Gene) Gene synonyms aliases	C77032, E2IG3, NNP47, NS, Nug1
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p21.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants e

Show/Hide all(217)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029281	hsa-miR-26b-5p	Microarray	19088304
MIRT047156	hsa-miR-183-5p	CLASH	23622248
MIRT039623	hsa-miR-615-3p	CLASH	23622248
MIRT039623	hsa-miR-615-3p	CLASH	23622248
MIRT237525	hsa-miR-495-5p	PAR-CLIP	20371350
MIRT550271	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT307996	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT307993	hsa-miR-369-3p	PAR-CLIP	20371350
MIRT550270	hsa-miR-5692b	PAR-CLIP	20371350
MIRT550269	hsa-miR-5692c	PAR-CLIP	20371350
MIRT550268	hsa-miR-6074	PAR-CLIP	20371350
MIRT550267	hsa-miR-4719	PAR-CLIP	20371350
MIRT237531	hsa-miR-3691-3p	PAR-CLIP	20371350
MIRT237521	hsa-miR-29b-1-5p	PAR-CLIP	20371350
MIRT237528	hsa-miR-1254	PAR-CLIP	20371350
MIRT237529	hsa-miR-3116	PAR-CLIP	20371350
MIRT237526	hsa-miR-661	PAR-CLIP	20371350
MIRT237532	hsa-miR-4423-5p	PAR-CLIP	20371350
MIRT307995	hsa-miR-374c-5p	PAR-CLIP	20371350
MIRT307994	hsa-miR-655-3p	PAR-CLIP	20371350
MIRT550266	hsa-miR-889-3p	PAR-CLIP	20371350
MIRT237523	hsa-miR-374a-5p	PAR-CLIP	20371350
MIRT237527	hsa-miR-374b-5p	PAR-CLIP	20371350
MIRT550265	hsa-miR-513b-5p	PAR-CLIP	20371350
MIRT550264	hsa-miR-6894-3p	PAR-CLIP	20371350
MIRT550263	hsa-miR-6514-3p	PAR-CLIP	20371350
MIRT237525	hsa-miR-495-5p	PAR-CLIP	20371350
MIRT550271	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT307996	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT307993	hsa-miR-369-3p	PAR-CLIP	20371350
MIRT550270	hsa-miR-5692b	PAR-CLIP	20371350
MIRT550269	hsa-miR-5692c	PAR-CLIP	20371350
MIRT550268	hsa-miR-6074	PAR-CLIP	20371350
MIRT550267	hsa-miR-4719	PAR-CLIP	20371350
MIRT237531	hsa-miR-3691-3p	PAR-CLIP	20371350
MIRT237521	hsa-miR-29b-1-5p	PAR-CLIP	20371350
MIRT237528	hsa-miR-1254	PAR-CLIP	20371350
MIRT237529	hsa-miR-3116	PAR-CLIP	20371350
MIRT237526	hsa-miR-661	PAR-CLIP	20371350
MIRT237532	hsa-miR-4423-5p	PAR-CLIP	20371350
MIRT307995	hsa-miR-374c-5p	PAR-CLIP	20371350
MIRT307994	hsa-miR-655-3p	PAR-CLIP	20371350
MIRT550266	hsa-miR-889-3p	PAR-CLIP	20371350
MIRT237523	hsa-miR-374a-5p	PAR-CLIP	20371350
MIRT237527	hsa-miR-374b-5p	PAR-CLIP	20371350
MIRT550265	hsa-miR-513b-5p	PAR-CLIP	20371350
MIRT550264	hsa-miR-6894-3p	PAR-CLIP	20371350
MIRT550263	hsa-miR-6514-3p	PAR-CLIP	20371350
MIRT237525	hsa-miR-495-5p	PAR-CLIP	21572407
MIRT550271	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT307996	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT307993	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT550270	hsa-miR-5692b	PAR-CLIP	21572407
MIRT550269	hsa-miR-5692c	PAR-CLIP	21572407
MIRT550268	hsa-miR-6074	PAR-CLIP	21572407
MIRT550267	hsa-miR-4719	PAR-CLIP	21572407
MIRT237531	hsa-miR-3691-3p	PAR-CLIP	21572407
MIRT237521	hsa-miR-29b-1-5p	PAR-CLIP	21572407
MIRT237528	hsa-miR-1254	PAR-CLIP	21572407
MIRT237529	hsa-miR-3116	PAR-CLIP	21572407
MIRT237526	hsa-miR-661	PAR-CLIP	21572407
MIRT237532	hsa-miR-4423-5p	PAR-CLIP	21572407
MIRT307995	hsa-miR-374c-5p	PAR-CLIP	21572407
MIRT307994	hsa-miR-655-3p	PAR-CLIP	21572407
MIRT550266	hsa-miR-889-3p	PAR-CLIP	21572407
MIRT237523	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT237527	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT550265	hsa-miR-513b-5p	PAR-CLIP	21572407
MIRT550264	hsa-miR-6894-3p	PAR-CLIP	21572407
MIRT550263	hsa-miR-6514-3p	PAR-CLIP	21572407
MIRT237525	hsa-miR-495-5p	PAR-CLIP	20371350
MIRT550271	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT307996	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT307993	hsa-miR-369-3p	PAR-CLIP	20371350
MIRT550270	hsa-miR-5692b	PAR-CLIP	20371350
MIRT550269	hsa-miR-5692c	PAR-CLIP	20371350
MIRT550268	hsa-miR-6074	PAR-CLIP	20371350
MIRT550267	hsa-miR-4719	PAR-CLIP	20371350
MIRT237531	hsa-miR-3691-3p	PAR-CLIP	20371350
MIRT237521	hsa-miR-29b-1-5p	PAR-CLIP	20371350
MIRT237528	hsa-miR-1254	PAR-CLIP	20371350
MIRT237529	hsa-miR-3116	PAR-CLIP	20371350
MIRT237526	hsa-miR-661	PAR-CLIP	20371350
MIRT237532	hsa-miR-4423-5p	PAR-CLIP	20371350
MIRT307995	hsa-miR-374c-5p	PAR-CLIP	20371350
MIRT307994	hsa-miR-655-3p	PAR-CLIP	20371350
MIRT550266	hsa-miR-889-3p	PAR-CLIP	20371350
MIRT237523	hsa-miR-374a-5p	PAR-CLIP	20371350
MIRT237527	hsa-miR-374b-5p	PAR-CLIP	20371350
MIRT550265	hsa-miR-513b-5p	PAR-CLIP	20371350
MIRT550264	hsa-miR-6894-3p	PAR-CLIP	20371350
MIRT550263	hsa-miR-6514-3p	PAR-CLIP	20371350
MIRT237525	hsa-miR-495-5p	PAR-CLIP	20371350
MIRT550271	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT307996	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT307993	hsa-miR-369-3p	PAR-CLIP	20371350
MIRT550270	hsa-miR-5692b	PAR-CLIP	20371350
MIRT550269	hsa-miR-5692c	PAR-CLIP	20371350
MIRT550268	hsa-miR-6074	PAR-CLIP	20371350
MIRT550267	hsa-miR-4719	PAR-CLIP	20371350
MIRT237531	hsa-miR-3691-3p	PAR-CLIP	20371350
MIRT237521	hsa-miR-29b-1-5p	PAR-CLIP	20371350
MIRT237528	hsa-miR-1254	PAR-CLIP	20371350
MIRT237529	hsa-miR-3116	PAR-CLIP	20371350
MIRT237526	hsa-miR-661	PAR-CLIP	20371350
MIRT237532	hsa-miR-4423-5p	PAR-CLIP	20371350
MIRT307995	hsa-miR-374c-5p	PAR-CLIP	20371350
MIRT307994	hsa-miR-655-3p	PAR-CLIP	20371350
MIRT550266	hsa-miR-889-3p	PAR-CLIP	20371350
MIRT237523	hsa-miR-374a-5p	PAR-CLIP	20371350
MIRT237527	hsa-miR-374b-5p	PAR-CLIP	20371350
MIRT550265	hsa-miR-513b-5p	PAR-CLIP	20371350
MIRT550264	hsa-miR-6894-3p	PAR-CLIP	20371350
MIRT550263	hsa-miR-6514-3p	PAR-CLIP	20371350
MIRT237525	hsa-miR-495-5p	PAR-CLIP	21572407
MIRT550271	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT307996	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT307993	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT550270	hsa-miR-5692b	PAR-CLIP	21572407
MIRT550269	hsa-miR-5692c	PAR-CLIP	21572407
MIRT550268	hsa-miR-6074	PAR-CLIP	21572407
MIRT550267	hsa-miR-4719	PAR-CLIP	21572407
MIRT237531	hsa-miR-3691-3p	PAR-CLIP	21572407
MIRT237521	hsa-miR-29b-1-5p	PAR-CLIP	21572407
MIRT237528	hsa-miR-1254	PAR-CLIP	21572407
MIRT237529	hsa-miR-3116	PAR-CLIP	21572407
MIRT237526	hsa-miR-661	PAR-CLIP	21572407
MIRT237532	hsa-miR-4423-5p	PAR-CLIP	21572407
MIRT307995	hsa-miR-374c-5p	PAR-CLIP	21572407
MIRT307994	hsa-miR-655-3p	PAR-CLIP	21572407
MIRT550266	hsa-miR-889-3p	PAR-CLIP	21572407
MIRT237523	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT237527	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT550265	hsa-miR-513b-5p	PAR-CLIP	21572407
MIRT550264	hsa-miR-6894-3p	PAR-CLIP	21572407
MIRT550263	hsa-miR-6514-3p	PAR-CLIP	21572407
MIRT1024663	hsa-miR-1273f	CLIP-seq
MIRT1024664	hsa-miR-143	CLIP-seq
MIRT1024665	hsa-miR-219-2-3p	CLIP-seq
MIRT1024666	hsa-miR-2964a-3p	CLIP-seq
MIRT1024667	hsa-miR-4708-5p	CLIP-seq
MIRT1024668	hsa-miR-4770	CLIP-seq
MIRT1024669	hsa-miR-511	CLIP-seq
MIRT1024663	hsa-miR-1273f	CLIP-seq
MIRT1024664	hsa-miR-143	CLIP-seq
MIRT1024665	hsa-miR-219-2-3p	CLIP-seq
MIRT2003901	hsa-miR-2909	CLIP-seq
MIRT1024666	hsa-miR-2964a-3p	CLIP-seq
MIRT2003902	hsa-miR-3162-5p	CLIP-seq
MIRT2003903	hsa-miR-374a	CLIP-seq
MIRT2003904	hsa-miR-374b	CLIP-seq
MIRT2003905	hsa-miR-374c	CLIP-seq
MIRT2003906	hsa-miR-3941	CLIP-seq
MIRT2003907	hsa-miR-4282	CLIP-seq
MIRT2003908	hsa-miR-466	CLIP-seq
MIRT2003909	hsa-miR-4672	CLIP-seq
MIRT1024667	hsa-miR-4708-5p	CLIP-seq
MIRT1024668	hsa-miR-4770	CLIP-seq
MIRT1024669	hsa-miR-511	CLIP-seq
MIRT2003910	hsa-miR-513b	CLIP-seq
MIRT2003911	hsa-miR-655	CLIP-seq
MIRT2003912	hsa-miR-889	CLIP-seq
MIRT2003903	hsa-miR-374a	CLIP-seq
MIRT2003904	hsa-miR-374b	CLIP-seq
MIRT2236667	hsa-miR-3919	CLIP-seq
MIRT2236668	hsa-miR-3925-5p	CLIP-seq
MIRT2003906	hsa-miR-3941	CLIP-seq
MIRT2236669	hsa-miR-4274	CLIP-seq
MIRT2003907	hsa-miR-4282	CLIP-seq
MIRT2236670	hsa-miR-4519	CLIP-seq
MIRT2236671	hsa-miR-4524	CLIP-seq
MIRT2003908	hsa-miR-466	CLIP-seq
MIRT2003909	hsa-miR-4672	CLIP-seq
MIRT2236672	hsa-miR-4773	CLIP-seq
MIRT2236673	hsa-miR-4789-5p	CLIP-seq
MIRT2236674	hsa-miR-4797-5p	CLIP-seq
MIRT2003910	hsa-miR-513b	CLIP-seq
MIRT2236675	hsa-miR-622	CLIP-seq
MIRT2003912	hsa-miR-889	CLIP-seq
MIRT1024663	hsa-miR-1273f	CLIP-seq
MIRT1024664	hsa-miR-143	CLIP-seq
MIRT1024665	hsa-miR-219-2-3p	CLIP-seq
MIRT1024666	hsa-miR-2964a-3p	CLIP-seq
MIRT2540586	hsa-miR-3662	CLIP-seq
MIRT2236667	hsa-miR-3919	CLIP-seq
MIRT2236668	hsa-miR-3925-5p	CLIP-seq
MIRT2236669	hsa-miR-4274	CLIP-seq
MIRT2236670	hsa-miR-4519	CLIP-seq
MIRT2236671	hsa-miR-4524	CLIP-seq
MIRT1024667	hsa-miR-4708-5p	CLIP-seq
MIRT2540587	hsa-miR-4720-3p	CLIP-seq
MIRT1024668	hsa-miR-4770	CLIP-seq
MIRT2236672	hsa-miR-4773	CLIP-seq
MIRT2236673	hsa-miR-4789-5p	CLIP-seq
MIRT2236674	hsa-miR-4797-5p	CLIP-seq
MIRT2540588	hsa-miR-4804-3p	CLIP-seq
MIRT1024669	hsa-miR-511	CLIP-seq
MIRT2236675	hsa-miR-622	CLIP-seq
MIRT1024663	hsa-miR-1273f	CLIP-seq
MIRT1024664	hsa-miR-143	CLIP-seq
MIRT1024665	hsa-miR-219-2-3p	CLIP-seq
MIRT1024666	hsa-miR-2964a-3p	CLIP-seq
MIRT2540586	hsa-miR-3662	CLIP-seq
MIRT2236667	hsa-miR-3919	CLIP-seq
MIRT2236668	hsa-miR-3925-5p	CLIP-seq
MIRT2236669	hsa-miR-4274	CLIP-seq
MIRT2236670	hsa-miR-4519	CLIP-seq
MIRT2236671	hsa-miR-4524	CLIP-seq
MIRT1024667	hsa-miR-4708-5p	CLIP-seq
MIRT2540587	hsa-miR-4720-3p	CLIP-seq
MIRT1024668	hsa-miR-4770	CLIP-seq
MIRT2236672	hsa-miR-4773	CLIP-seq
MIRT2236673	hsa-miR-4789-5p	CLIP-seq
MIRT2236674	hsa-miR-4797-5p	CLIP-seq
MIRT2540588	hsa-miR-4804-3p	CLIP-seq
MIRT1024669	hsa-miR-511	CLIP-seq
MIRT2236675	hsa-miR-622	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	16097049, 17932509, 19487455, 21132010, 21988832, 22641345, 24550003, 24965446, 26638075, 32296183
GO:0005525	Function	GTP binding	ISS
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005634	Component	Nucleus	ISS
GO:0005694	Component	Chromosome	IDA
GO:0005730	Component	Nucleolus	IBA	21873635
GO:0005730	Component	Nucleolus	IDA	22641345
GO:0005730	Component	Nucleolus	ISS
GO:0008283	Process	Cell population proliferation	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016604	Component	Nuclear body	IDA
GO:0017145	Process	Stem cell division	IDA	25522312
GO:0019827	Process	Stem cell population maintenance	IMP	25522312
GO:0030496	Component	Midbody	IDA
GO:0032206	Process	Positive regulation of telomere maintenance	IMP	22641345
GO:0033235	Process	Positive regulation of protein sumoylation	IMP	22641345
GO:0042127	Process	Regulation of cell population proliferation	ISS
GO:0048027	Function	MRNA 5'-UTR binding	IDA	16213212
GO:1902895	Process	Positive regulation of pri-miRNA transcription by RNA polymerase II	IMP	25569094
GO:1904816	Process	Positive regulation of protein localization to chromosome, telomeric region	IMP	22641345

MIM	HGNC	e!Ensembl
608011	29931	ENSG00000163938

Protein

UniProt ID

Q9BVP2

Protein name

Guanine nucleotide-binding protein-like 3 (E2-induced gene 3 protein) (Novel nucleolar protein 47) (NNP47) (Nucleolar GTP-binding protein 3) (Nucleostemin)

Protein function

May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).

PDB

8FKP , 8FKR , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ , 8FL0 , 8FL2 , 8FL3 , 8FL4 , 8INK , 8IPD , 8IPX , 8IPY , 8IR1 , 8IR3 , 8RL2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08701	GN3L_Grn1	16 → 89	GNL3L/Grn1 putative GTPase	Family
PF01926	MMR_HSR1	256 → 367	50S ribosome-binding GTPase	Family

Tissue specificity

TISSUE SPECIFICITY: Increased levels in lung tissue in cancer patients. {ECO:0000269|PubMed:16012751}.

Sequence

MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKRGHKKPRKDPGVPNSAPFKEAL
LREAELRKQRLEELKQQQKLDRQKELEKKRKLETNPDIKPSNVEPMEKEFGLCKTENKAK
SGKQNSKKLYCQELKKVIEASDVVLEVLDARDPLGCRCPQVEEAIVQSGQKKLVLILNKS
DLVPKENLESWLNYLKKELPTVVFRASTKPKDKGKITKRVKAKKNAAPFRSEVCFGKEGL
WKLLGGFQETCSKAIRVGVIGFPNVGKSSIINSLKQEQMCNVGVSMGLTRSMQVVPLDKQ
ITIIDSPSFIVSPLNSSSALALRSPASIEVVKPMEAASAILSQADARQVVLKYTVPGYRN
SLEFFTVLAQRRGMHQKGGIPNVEGAAKLLWSEWTGASLAYYCHPPTSWTPPPYFNESIV
VDMKSGFNLEELEKNNAQSIRAIKGPHLANSILFQSSGLTNGIIEEKDIHEELPKRKERK
QEEREDDKDSDQETVDEEVDENSSGMFAAEETGEALSEETTAGEQSTRSFILDKIIEEDD
AYDFSTDYV

Sequence length

549

Interactions

View interactions

	KEGG		Reactome
	Ribosome biogenesis in eukaryotes		Major pathway of rRNA processing in the nucleolus and cytosol

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Arthritis	Degenerative polyarthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	22763110

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Major Depressive Disorder		22472876	ClinVar

Show/Hide Text Mining Associations (33)

Disease Name	Relationship Type	References
Associations from Text Mining
Bipolar Disorder	Associate	29947131
Breast Neoplasms	Associate	24610951, 24650343, 24716972, 30817632
Carcinogenesis	Associate	16670719, 18419830, 26722529
Carcinoma Hepatocellular	Associate	26517370, 32051231
Carcinoma Squamous Cell	Associate	17970071
Colorectal Neoplasms	Associate	24762489
Colorectal Neoplasms	Stimulate	28849076
Disease	Associate	19318567
Esophageal Neoplasms	Associate	22050045
Head and Neck Neoplasms	Associate	17970071
Hematologic Neoplasms	Stimulate	35886999
Idiopathic Noncirrhotic Portal Hypertension	Associate	36312597
Immunologic Deficiency Syndromes	Associate	32051231
Kidney Neoplasms	Associate	32051231
Lung Neoplasms	Associate	22424632
Neoplasm Metastasis	Associate	22050045
Neoplasm Metastasis	Stimulate	28849076
Neoplasms	Associate	16670719, 17494866, 17970071, 18448670, 19318567, 19706044, 21132010, 21443540, 22050045, 22424632, 24628257, 24650343, 24716972, 25314067, 27374947, 28849076, 32051231, 34361059 View all (3 more)
Neoplasms	Stimulate	24769896, 30817632
Nervous System Neoplasms	Associate	18419830
Osteoarthritis	Associate	22763110, 24886551, 36167888
Osteoarthritis Knee	Associate	29942097
Pain	Associate	36167888
Phenylketonurias	Associate	36312597
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	24628257
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	24628257, 35886999
Schizophrenia	Associate	29947131
Sjogren's Syndrome	Associate	21655359
Squamous Cell Carcinoma of Head and Neck	Associate	17970071, 25314067
Stomach Neoplasms	Associate	24763828, 26722529
Triple Negative Breast Neoplasms	Associate	30817632
Urinary Bladder Neoplasms	Associate	19706044
Uterine Cervical Neoplasms	Associate	18419830

GNL3 (G protein nucleolar 3)