HSPB8 (heat shock protein family B (small) member 8)

Gene

• Entrez ID: 26353
• Gene name: Heat shock protein family B (small) member 8
• Gene symbol: HSPB8
• Synonyms (NCBI Gene): CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HMND2, HSP22, HSPB8-N1, HSPB8-N2, MFM13
• Chromosome: 12
• Chromosome location: 12q24.23
• Summary: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-posi

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs35909818	C>A,G,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs55826713	G>T	Conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs60924821	TAATAA>-,TAA,TAATAATAA,TAATAATAATAA,TAATAATAATAATAA,TAATAATAATAATAATAA,TAATAATAATAATAATAATAA	Uncertain-significance, conflicting-interpretations-of-pathogenicity	3 prime UTR variant
rs373049356	C>T	Conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs1565930588	TACTCAACATTTGG>-	Likely-pathogenic	Frameshift variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT036507	hsa-miR-1226-3p	CLASH	23622248
MIRT502215	hsa-miR-1296-3p	PAR-CLIP	24398324
MIRT502214	hsa-miR-4491	PAR-CLIP	24398324
MIRT502213	hsa-miR-4657	PAR-CLIP	24398324
MIRT502212	hsa-miR-128-3p	PAR-CLIP	24398324
MIRT502211	hsa-miR-216a-3p	PAR-CLIP	24398324
MIRT502210	hsa-miR-3681-3p	PAR-CLIP	24398324
MIRT502209	hsa-miR-194-3p	PAR-CLIP	24398324
MIRT502208	hsa-miR-4645-5p	PAR-CLIP	24398324
MIRT502207	hsa-miR-4673	PAR-CLIP	24398324
MIRT502206	hsa-miR-4755-3p	PAR-CLIP	24398324
MIRT502204	hsa-miR-6828-5p	PAR-CLIP	24398324
MIRT502205	hsa-miR-671-5p	PAR-CLIP	24398324
MIRT502203	hsa-miR-193b-5p	PAR-CLIP	24398324
MIRT502202	hsa-miR-3190-3p	PAR-CLIP	24398324
MIRT502200	hsa-miR-6742-5p	PAR-CLIP	24398324
MIRT502201	hsa-miR-6079	PAR-CLIP	24398324
MIRT502199	hsa-miR-3170	PAR-CLIP	24398324
MIRT502198	hsa-miR-6855-5p	PAR-CLIP	24398324
MIRT502197	hsa-miR-6833-5p	PAR-CLIP	24398324
MIRT502215	hsa-miR-1296-3p	PAR-CLIP	24398324
MIRT502214	hsa-miR-4491	PAR-CLIP	24398324
MIRT502213	hsa-miR-4657	PAR-CLIP	24398324
MIRT502212	hsa-miR-128-3p	PAR-CLIP	24398324
MIRT502211	hsa-miR-216a-3p	PAR-CLIP	24398324
MIRT502210	hsa-miR-3681-3p	PAR-CLIP	24398324
MIRT502209	hsa-miR-194-3p	PAR-CLIP	24398324
MIRT502208	hsa-miR-4645-5p	PAR-CLIP	24398324
MIRT502207	hsa-miR-4673	PAR-CLIP	24398324
MIRT502206	hsa-miR-4755-3p	PAR-CLIP	24398324
MIRT502204	hsa-miR-6828-5p	PAR-CLIP	24398324
MIRT502205	hsa-miR-671-5p	PAR-CLIP	24398324
MIRT502203	hsa-miR-193b-5p	PAR-CLIP	24398324
MIRT502202	hsa-miR-3190-3p	PAR-CLIP	24398324
MIRT502200	hsa-miR-6742-5p	PAR-CLIP	24398324
MIRT502201	hsa-miR-6079	PAR-CLIP	24398324
MIRT502199	hsa-miR-3170	PAR-CLIP	24398324
MIRT502198	hsa-miR-6855-5p	PAR-CLIP	24398324
MIRT502197	hsa-miR-6833-5p	PAR-CLIP	24398324
MIRT1056468	hsa-miR-1200	CLIP-seq
MIRT1056469	hsa-miR-1208	CLIP-seq
MIRT1056470	hsa-miR-1231	CLIP-seq
MIRT1056471	hsa-miR-124	CLIP-seq
MIRT1056472	hsa-miR-1273e	CLIP-seq
MIRT1056473	hsa-miR-1273g	CLIP-seq
MIRT1056474	hsa-miR-128	CLIP-seq
MIRT1056475	hsa-miR-1285	CLIP-seq
MIRT1056476	hsa-miR-1287	CLIP-seq
MIRT1056477	hsa-miR-1295	CLIP-seq
MIRT1056478	hsa-miR-1321	CLIP-seq
MIRT1056479	hsa-miR-146a	CLIP-seq
MIRT1056480	hsa-miR-146b-5p	CLIP-seq
MIRT1056481	hsa-miR-1910	CLIP-seq
MIRT1056482	hsa-miR-1914	CLIP-seq
MIRT1056483	hsa-miR-19a	CLIP-seq
MIRT1056484	hsa-miR-19b	CLIP-seq
MIRT1056485	hsa-miR-203	CLIP-seq
MIRT1056486	hsa-miR-2052	CLIP-seq
MIRT1056487	hsa-miR-2110	CLIP-seq
MIRT1056488	hsa-miR-2276	CLIP-seq
MIRT1056489	hsa-miR-2392	CLIP-seq
MIRT1056490	hsa-miR-2467-3p	CLIP-seq
MIRT1056491	hsa-miR-296-3p	CLIP-seq
MIRT1056492	hsa-miR-298	CLIP-seq
MIRT1056493	hsa-miR-299-3p	CLIP-seq
MIRT1056494	hsa-miR-3120-5p	CLIP-seq
MIRT1056495	hsa-miR-3121-5p	CLIP-seq
MIRT1056496	hsa-miR-3122	CLIP-seq
MIRT1056497	hsa-miR-3126-3p	CLIP-seq
MIRT1056498	hsa-miR-3127-3p	CLIP-seq
MIRT1056499	hsa-miR-3134	CLIP-seq
MIRT1056500	hsa-miR-3135b	CLIP-seq
MIRT1056501	hsa-miR-3143	CLIP-seq
MIRT1056502	hsa-miR-3144-5p	CLIP-seq
MIRT1056503	hsa-miR-3150a-3p	CLIP-seq
MIRT1056504	hsa-miR-3155	CLIP-seq
MIRT1056505	hsa-miR-3155b	CLIP-seq
MIRT1056506	hsa-miR-3162-5p	CLIP-seq
MIRT1056507	hsa-miR-3176	CLIP-seq
MIRT1056508	hsa-miR-3187-5p	CLIP-seq
MIRT1056509	hsa-miR-3190	CLIP-seq
MIRT1056510	hsa-miR-3191	CLIP-seq
MIRT1056511	hsa-miR-3200-5p	CLIP-seq
MIRT1056512	hsa-miR-33a	CLIP-seq
MIRT1056513	hsa-miR-33b	CLIP-seq
MIRT1056514	hsa-miR-3607-3p	CLIP-seq
MIRT1056515	hsa-miR-3616-3p	CLIP-seq
MIRT1056516	hsa-miR-3649	CLIP-seq
MIRT1056517	hsa-miR-3660	CLIP-seq
MIRT1056518	hsa-miR-3686	CLIP-seq
MIRT1056519	hsa-miR-3689a-3p	CLIP-seq
MIRT1056520	hsa-miR-3689c	CLIP-seq
MIRT1056521	hsa-miR-3690	CLIP-seq
MIRT1056522	hsa-miR-3713	CLIP-seq
MIRT1056523	hsa-miR-378g	CLIP-seq
MIRT1056524	hsa-miR-3913-5p	CLIP-seq
MIRT1056525	hsa-miR-3914	CLIP-seq
MIRT1056526	hsa-miR-3919	CLIP-seq
MIRT1056527	hsa-miR-3922-3p	CLIP-seq
MIRT1056528	hsa-miR-4254	CLIP-seq
MIRT1056529	hsa-miR-4258	CLIP-seq
MIRT1056530	hsa-miR-4261	CLIP-seq
MIRT1056531	hsa-miR-4300	CLIP-seq
MIRT1056532	hsa-miR-4325	CLIP-seq
MIRT1056533	hsa-miR-4420	CLIP-seq
MIRT1056534	hsa-miR-4434	CLIP-seq
MIRT1056535	hsa-miR-4436b-3p	CLIP-seq
MIRT1056536	hsa-miR-4438	CLIP-seq
MIRT1056537	hsa-miR-4469	CLIP-seq
MIRT1056538	hsa-miR-4486	CLIP-seq
MIRT1056539	hsa-miR-450b-5p	CLIP-seq
MIRT1056540	hsa-miR-4516	CLIP-seq
MIRT1056541	hsa-miR-452	CLIP-seq
MIRT1056542	hsa-miR-4526	CLIP-seq
MIRT1056543	hsa-miR-4531	CLIP-seq
MIRT1056544	hsa-miR-4534	CLIP-seq
MIRT1056545	hsa-miR-455-3p	CLIP-seq
MIRT1056546	hsa-miR-4633-3p	CLIP-seq
MIRT1056547	hsa-miR-4638-3p	CLIP-seq
MIRT1056548	hsa-miR-4652-5p	CLIP-seq
MIRT1056549	hsa-miR-4662a-3p	CLIP-seq
MIRT1056550	hsa-miR-4668-3p	CLIP-seq
MIRT1056551	hsa-miR-4676-3p	CLIP-seq
MIRT1056552	hsa-miR-4682	CLIP-seq
MIRT1056553	hsa-miR-4685-5p	CLIP-seq
MIRT1056554	hsa-miR-4704-5p	CLIP-seq
MIRT1056555	hsa-miR-4717-5p	CLIP-seq
MIRT1056556	hsa-miR-4731-3p	CLIP-seq
MIRT1056557	hsa-miR-4739	CLIP-seq
MIRT1056558	hsa-miR-4756-3p	CLIP-seq
MIRT1056559	hsa-miR-4756-5p	CLIP-seq
MIRT1056560	hsa-miR-4776-3p	CLIP-seq
MIRT1056561	hsa-miR-4789-5p	CLIP-seq
MIRT1056562	hsa-miR-4801	CLIP-seq
MIRT1056563	hsa-miR-484	CLIP-seq
MIRT1056564	hsa-miR-506	CLIP-seq
MIRT1056565	hsa-miR-507	CLIP-seq
MIRT1056566	hsa-miR-516b	CLIP-seq
MIRT1056567	hsa-miR-539	CLIP-seq
MIRT1056568	hsa-miR-543	CLIP-seq
MIRT1056569	hsa-miR-548a-5p	CLIP-seq
MIRT1056570	hsa-miR-548ab	CLIP-seq
MIRT1056571	hsa-miR-548ak	CLIP-seq
MIRT1056572	hsa-miR-548b-5p	CLIP-seq
MIRT1056573	hsa-miR-548c-3p	CLIP-seq
MIRT1056574	hsa-miR-548c-5p	CLIP-seq
MIRT1056575	hsa-miR-548d-5p	CLIP-seq
MIRT1056576	hsa-miR-548g	CLIP-seq
MIRT1056577	hsa-miR-548h	CLIP-seq
MIRT1056578	hsa-miR-548i	CLIP-seq
MIRT1056579	hsa-miR-548j	CLIP-seq
MIRT1056580	hsa-miR-548k	CLIP-seq
MIRT1056581	hsa-miR-548l	CLIP-seq
MIRT1056582	hsa-miR-548w	CLIP-seq
MIRT1056583	hsa-miR-548y	CLIP-seq
MIRT1056584	hsa-miR-557	CLIP-seq
MIRT1056585	hsa-miR-559	CLIP-seq
MIRT1056586	hsa-miR-563	CLIP-seq
MIRT1056587	hsa-miR-580	CLIP-seq
MIRT1056588	hsa-miR-589	CLIP-seq
MIRT1056589	hsa-miR-605	CLIP-seq
MIRT1056590	hsa-miR-612	CLIP-seq
MIRT1056591	hsa-miR-626	CLIP-seq
MIRT1056592	hsa-miR-629	CLIP-seq
MIRT1056593	hsa-miR-642a	CLIP-seq
MIRT1056594	hsa-miR-642b	CLIP-seq
MIRT1056595	hsa-miR-659	CLIP-seq
MIRT1056596	hsa-miR-660	CLIP-seq
MIRT1056597	hsa-miR-891b	CLIP-seq
MIRT1056598	hsa-miR-920	CLIP-seq
MIRT1056468	hsa-miR-1200	CLIP-seq
MIRT1056469	hsa-miR-1208	CLIP-seq
MIRT1056471	hsa-miR-124	CLIP-seq
MIRT2012971	hsa-miR-1261	CLIP-seq
MIRT1056472	hsa-miR-1273e	CLIP-seq
MIRT1056473	hsa-miR-1273g	CLIP-seq
MIRT1056474	hsa-miR-128	CLIP-seq
MIRT1056475	hsa-miR-1285	CLIP-seq
MIRT1056476	hsa-miR-1287	CLIP-seq
MIRT1056477	hsa-miR-1295	CLIP-seq
MIRT1056478	hsa-miR-1321	CLIP-seq
MIRT1056479	hsa-miR-146a	CLIP-seq
MIRT1056480	hsa-miR-146b-5p	CLIP-seq
MIRT1056481	hsa-miR-1910	CLIP-seq
MIRT1056482	hsa-miR-1914	CLIP-seq
MIRT1056490	hsa-miR-2467-3p	CLIP-seq
MIRT1056492	hsa-miR-298	CLIP-seq
MIRT1056493	hsa-miR-299-3p	CLIP-seq
MIRT2012972	hsa-miR-3074-3p	CLIP-seq
MIRT1056495	hsa-miR-3121-5p	CLIP-seq
MIRT1056497	hsa-miR-3126-3p	CLIP-seq
MIRT1056499	hsa-miR-3134	CLIP-seq
MIRT1056500	hsa-miR-3135b	CLIP-seq
MIRT1056504	hsa-miR-3155	CLIP-seq
MIRT1056505	hsa-miR-3155b	CLIP-seq
MIRT1056506	hsa-miR-3162-5p	CLIP-seq
MIRT1056507	hsa-miR-3176	CLIP-seq
MIRT1056508	hsa-miR-3187-5p	CLIP-seq
MIRT1056509	hsa-miR-3190	CLIP-seq
MIRT1056515	hsa-miR-3616-3p	CLIP-seq
MIRT1056517	hsa-miR-3660	CLIP-seq
MIRT2012973	hsa-miR-3667-5p	CLIP-seq
MIRT2012974	hsa-miR-3675-5p	CLIP-seq
MIRT1056523	hsa-miR-378g	CLIP-seq
MIRT1056527	hsa-miR-3922-3p	CLIP-seq
MIRT1056530	hsa-miR-4261	CLIP-seq
MIRT1056534	hsa-miR-4434	CLIP-seq
MIRT1056535	hsa-miR-4436b-3p	CLIP-seq
MIRT1056536	hsa-miR-4438	CLIP-seq
MIRT2012975	hsa-miR-4448	CLIP-seq
MIRT2012976	hsa-miR-4450	CLIP-seq
MIRT1056538	hsa-miR-4486	CLIP-seq
MIRT2012977	hsa-miR-4511	CLIP-seq
MIRT1056540	hsa-miR-4516	CLIP-seq
MIRT1056541	hsa-miR-452	CLIP-seq
MIRT1056542	hsa-miR-4526	CLIP-seq
MIRT1056543	hsa-miR-4531	CLIP-seq
MIRT1056544	hsa-miR-4534	CLIP-seq
MIRT1056545	hsa-miR-455-3p	CLIP-seq
MIRT1056547	hsa-miR-4638-3p	CLIP-seq
MIRT1056551	hsa-miR-4676-3p	CLIP-seq
MIRT1056553	hsa-miR-4685-5p	CLIP-seq
MIRT1056554	hsa-miR-4704-5p	CLIP-seq
MIRT1056555	hsa-miR-4717-5p	CLIP-seq
MIRT1056556	hsa-miR-4731-3p	CLIP-seq
MIRT1056557	hsa-miR-4739	CLIP-seq
MIRT1056559	hsa-miR-4756-5p	CLIP-seq
MIRT1056560	hsa-miR-4776-3p	CLIP-seq
MIRT1056561	hsa-miR-4789-5p	CLIP-seq
MIRT2012978	hsa-miR-4795-3p	CLIP-seq
MIRT1056562	hsa-miR-4801	CLIP-seq
MIRT1056563	hsa-miR-484	CLIP-seq
MIRT1056564	hsa-miR-506	CLIP-seq
MIRT1056567	hsa-miR-539	CLIP-seq
MIRT2012979	hsa-miR-548b-3p	CLIP-seq
MIRT1056586	hsa-miR-563	CLIP-seq
MIRT1056587	hsa-miR-580	CLIP-seq
MIRT2012980	hsa-miR-587	CLIP-seq
MIRT1056588	hsa-miR-589	CLIP-seq
MIRT1056590	hsa-miR-612	CLIP-seq
MIRT1056594	hsa-miR-642b	CLIP-seq
MIRT1056595	hsa-miR-659	CLIP-seq
MIRT1056596	hsa-miR-660	CLIP-seq
MIRT1056469	hsa-miR-1208	CLIP-seq
MIRT1056471	hsa-miR-124	CLIP-seq
MIRT2245227	hsa-miR-1278	CLIP-seq
MIRT1056474	hsa-miR-128	CLIP-seq
MIRT1056475	hsa-miR-1285	CLIP-seq
MIRT1056476	hsa-miR-1287	CLIP-seq
MIRT1056477	hsa-miR-1295	CLIP-seq
MIRT1056478	hsa-miR-1321	CLIP-seq
MIRT1056479	hsa-miR-146a	CLIP-seq
MIRT1056480	hsa-miR-146b-5p	CLIP-seq
MIRT1056481	hsa-miR-1910	CLIP-seq
MIRT1056482	hsa-miR-1914	CLIP-seq
MIRT1056486	hsa-miR-2052	CLIP-seq
MIRT1056487	hsa-miR-2110	CLIP-seq
MIRT1056488	hsa-miR-2276	CLIP-seq
MIRT1056489	hsa-miR-2392	CLIP-seq
MIRT1056490	hsa-miR-2467-3p	CLIP-seq
MIRT1056491	hsa-miR-296-3p	CLIP-seq
MIRT1056492	hsa-miR-298	CLIP-seq
MIRT2012972	hsa-miR-3074-3p	CLIP-seq
MIRT1056496	hsa-miR-3122	CLIP-seq
MIRT1056497	hsa-miR-3126-3p	CLIP-seq
MIRT1056498	hsa-miR-3127-3p	CLIP-seq
MIRT1056500	hsa-miR-3135b	CLIP-seq
MIRT1056501	hsa-miR-3143	CLIP-seq
MIRT1056502	hsa-miR-3144-5p	CLIP-seq
MIRT1056503	hsa-miR-3150a-3p	CLIP-seq
MIRT1056504	hsa-miR-3155	CLIP-seq
MIRT1056505	hsa-miR-3155b	CLIP-seq
MIRT1056506	hsa-miR-3162-5p	CLIP-seq
MIRT1056508	hsa-miR-3187-5p	CLIP-seq
MIRT1056509	hsa-miR-3190	CLIP-seq
MIRT1056510	hsa-miR-3191	CLIP-seq
MIRT1056511	hsa-miR-3200-5p	CLIP-seq
MIRT1056515	hsa-miR-3616-3p	CLIP-seq
MIRT2012973	hsa-miR-3667-5p	CLIP-seq
MIRT2012974	hsa-miR-3675-5p	CLIP-seq
MIRT1056519	hsa-miR-3689a-3p	CLIP-seq
MIRT1056520	hsa-miR-3689c	CLIP-seq
MIRT1056523	hsa-miR-378g	CLIP-seq
MIRT1056524	hsa-miR-3913-5p	CLIP-seq
MIRT1056526	hsa-miR-3919	CLIP-seq
MIRT2245228	hsa-miR-425	CLIP-seq
MIRT1056529	hsa-miR-4258	CLIP-seq
MIRT1056530	hsa-miR-4261	CLIP-seq
MIRT1056531	hsa-miR-4300	CLIP-seq
MIRT1056533	hsa-miR-4420	CLIP-seq
MIRT1056534	hsa-miR-4434	CLIP-seq
MIRT1056535	hsa-miR-4436b-3p	CLIP-seq
MIRT2012976	hsa-miR-4450	CLIP-seq
MIRT1056538	hsa-miR-4486	CLIP-seq
MIRT1056539	hsa-miR-450b-5p	CLIP-seq
MIRT1056540	hsa-miR-4516	CLIP-seq
MIRT1056541	hsa-miR-452	CLIP-seq
MIRT1056543	hsa-miR-4531	CLIP-seq
MIRT1056545	hsa-miR-455-3p	CLIP-seq
MIRT1056547	hsa-miR-4638-3p	CLIP-seq
MIRT2245229	hsa-miR-4640-5p	CLIP-seq
MIRT1056548	hsa-miR-4652-5p	CLIP-seq
MIRT1056549	hsa-miR-4662a-3p	CLIP-seq
MIRT1056550	hsa-miR-4668-3p	CLIP-seq
MIRT1056551	hsa-miR-4676-3p	CLIP-seq
MIRT1056552	hsa-miR-4682	CLIP-seq
MIRT1056553	hsa-miR-4685-5p	CLIP-seq
MIRT1056554	hsa-miR-4704-5p	CLIP-seq
MIRT2245230	hsa-miR-4712-5p	CLIP-seq
MIRT1056555	hsa-miR-4717-5p	CLIP-seq
MIRT2245231	hsa-miR-4726-5p	CLIP-seq
MIRT1056556	hsa-miR-4731-3p	CLIP-seq
MIRT1056557	hsa-miR-4739	CLIP-seq
MIRT1056558	hsa-miR-4756-3p	CLIP-seq
MIRT1056559	hsa-miR-4756-5p	CLIP-seq
MIRT1056560	hsa-miR-4776-3p	CLIP-seq
MIRT1056561	hsa-miR-4789-5p	CLIP-seq
MIRT1056562	hsa-miR-4801	CLIP-seq
MIRT1056563	hsa-miR-484	CLIP-seq
MIRT1056564	hsa-miR-506	CLIP-seq
MIRT1056565	hsa-miR-507	CLIP-seq
MIRT1056567	hsa-miR-539	CLIP-seq
MIRT1056568	hsa-miR-543	CLIP-seq
MIRT1056569	hsa-miR-548a-5p	CLIP-seq
MIRT1056570	hsa-miR-548ab	CLIP-seq
MIRT1056571	hsa-miR-548ak	CLIP-seq
MIRT1056572	hsa-miR-548b-5p	CLIP-seq
MIRT1056573	hsa-miR-548c-3p	CLIP-seq
MIRT1056574	hsa-miR-548c-5p	CLIP-seq
MIRT1056575	hsa-miR-548d-5p	CLIP-seq
MIRT1056577	hsa-miR-548h	CLIP-seq
MIRT1056578	hsa-miR-548i	CLIP-seq
MIRT1056579	hsa-miR-548j	CLIP-seq
MIRT1056580	hsa-miR-548k	CLIP-seq
MIRT1056581	hsa-miR-548l	CLIP-seq
MIRT1056582	hsa-miR-548w	CLIP-seq
MIRT1056583	hsa-miR-548y	CLIP-seq
MIRT1056584	hsa-miR-557	CLIP-seq
MIRT1056585	hsa-miR-559	CLIP-seq
MIRT1056587	hsa-miR-580	CLIP-seq
MIRT1056588	hsa-miR-589	CLIP-seq
MIRT1056589	hsa-miR-605	CLIP-seq
MIRT1056590	hsa-miR-612	CLIP-seq
MIRT1056594	hsa-miR-642b	CLIP-seq
MIRT1056596	hsa-miR-660	CLIP-seq
MIRT2245232	hsa-miR-770-5p	CLIP-seq
MIRT1056597	hsa-miR-891b	CLIP-seq
MIRT1056598	hsa-miR-920	CLIP-seq
MIRT1056509	hsa-miR-3190	CLIP-seq
MIRT1056553	hsa-miR-4685-5p	CLIP-seq
MIRT1056554	hsa-miR-4704-5p	CLIP-seq
MIRT1056594	hsa-miR-642b	CLIP-seq
MIRT1056487	hsa-miR-2110	CLIP-seq
MIRT1056489	hsa-miR-2392	CLIP-seq
MIRT1056502	hsa-miR-3144-5p	CLIP-seq
MIRT1056503	hsa-miR-3150a-3p	CLIP-seq
MIRT1056510	hsa-miR-3191	CLIP-seq
MIRT2245229	hsa-miR-4640-5p	CLIP-seq
MIRT1056548	hsa-miR-4652-5p	CLIP-seq
MIRT2245231	hsa-miR-4726-5p	CLIP-seq
MIRT1056468	hsa-miR-1200	CLIP-seq
MIRT1056469	hsa-miR-1208	CLIP-seq
MIRT1056470	hsa-miR-1231	CLIP-seq
MIRT1056471	hsa-miR-124	CLIP-seq
MIRT1056472	hsa-miR-1273e	CLIP-seq
MIRT1056473	hsa-miR-1273g	CLIP-seq
MIRT1056475	hsa-miR-1285	CLIP-seq
MIRT1056476	hsa-miR-1287	CLIP-seq
MIRT1056478	hsa-miR-1321	CLIP-seq
MIRT1056479	hsa-miR-146a	CLIP-seq
MIRT1056480	hsa-miR-146b-5p	CLIP-seq
MIRT1056481	hsa-miR-1910	CLIP-seq
MIRT1056482	hsa-miR-1914	CLIP-seq
MIRT1056490	hsa-miR-2467-3p	CLIP-seq
MIRT1056492	hsa-miR-298	CLIP-seq
MIRT1056493	hsa-miR-299-3p	CLIP-seq
MIRT1056494	hsa-miR-3120-5p	CLIP-seq
MIRT1056495	hsa-miR-3121-5p	CLIP-seq
MIRT1056497	hsa-miR-3126-3p	CLIP-seq
MIRT1056499	hsa-miR-3134	CLIP-seq
MIRT1056500	hsa-miR-3135b	CLIP-seq
MIRT1056501	hsa-miR-3143	CLIP-seq
MIRT1056502	hsa-miR-3144-5p	CLIP-seq
MIRT1056504	hsa-miR-3155	CLIP-seq
MIRT1056505	hsa-miR-3155b	CLIP-seq
MIRT1056506	hsa-miR-3162-5p	CLIP-seq
MIRT1056507	hsa-miR-3176	CLIP-seq
MIRT1056508	hsa-miR-3187-5p	CLIP-seq
MIRT1056509	hsa-miR-3190	CLIP-seq
MIRT1056515	hsa-miR-3616-3p	CLIP-seq
MIRT1056523	hsa-miR-378g	CLIP-seq
MIRT1056527	hsa-miR-3922-3p	CLIP-seq
MIRT1056529	hsa-miR-4258	CLIP-seq
MIRT1056530	hsa-miR-4261	CLIP-seq
MIRT1056532	hsa-miR-4325	CLIP-seq
MIRT1056534	hsa-miR-4434	CLIP-seq
MIRT1056535	hsa-miR-4436b-3p	CLIP-seq
MIRT1056536	hsa-miR-4438	CLIP-seq
MIRT1056538	hsa-miR-4486	CLIP-seq
MIRT1056540	hsa-miR-4516	CLIP-seq
MIRT1056541	hsa-miR-452	CLIP-seq
MIRT1056543	hsa-miR-4531	CLIP-seq
MIRT1056544	hsa-miR-4534	CLIP-seq
MIRT1056545	hsa-miR-455-3p	CLIP-seq
MIRT1056546	hsa-miR-4633-3p	CLIP-seq
MIRT1056547	hsa-miR-4638-3p	CLIP-seq
MIRT1056551	hsa-miR-4676-3p	CLIP-seq
MIRT1056553	hsa-miR-4685-5p	CLIP-seq
MIRT1056554	hsa-miR-4704-5p	CLIP-seq
MIRT1056556	hsa-miR-4731-3p	CLIP-seq
MIRT1056557	hsa-miR-4739	CLIP-seq
MIRT1056559	hsa-miR-4756-5p	CLIP-seq
MIRT1056560	hsa-miR-4776-3p	CLIP-seq
MIRT1056561	hsa-miR-4789-5p	CLIP-seq
MIRT1056562	hsa-miR-4801	CLIP-seq
MIRT1056563	hsa-miR-484	CLIP-seq
MIRT1056564	hsa-miR-506	CLIP-seq
MIRT1056566	hsa-miR-516b	CLIP-seq
MIRT1056567	hsa-miR-539	CLIP-seq
MIRT1056568	hsa-miR-543	CLIP-seq
MIRT1056586	hsa-miR-563	CLIP-seq
MIRT1056587	hsa-miR-580	CLIP-seq
MIRT1056588	hsa-miR-589	CLIP-seq
MIRT1056590	hsa-miR-612	CLIP-seq
MIRT1056591	hsa-miR-626	CLIP-seq
MIRT1056594	hsa-miR-642b	CLIP-seq
MIRT1056595	hsa-miR-659	CLIP-seq
MIRT1056468	hsa-miR-1200	CLIP-seq
MIRT1056469	hsa-miR-1208	CLIP-seq
MIRT1056470	hsa-miR-1231	CLIP-seq
MIRT1056471	hsa-miR-124	CLIP-seq
MIRT1056472	hsa-miR-1273e	CLIP-seq
MIRT1056475	hsa-miR-1285	CLIP-seq
MIRT1056476	hsa-miR-1287	CLIP-seq
MIRT1056478	hsa-miR-1321	CLIP-seq
MIRT1056479	hsa-miR-146a	CLIP-seq
MIRT1056480	hsa-miR-146b-5p	CLIP-seq
MIRT1056481	hsa-miR-1910	CLIP-seq
MIRT1056482	hsa-miR-1914	CLIP-seq
MIRT1056490	hsa-miR-2467-3p	CLIP-seq
MIRT1056492	hsa-miR-298	CLIP-seq
MIRT1056494	hsa-miR-3120-5p	CLIP-seq
MIRT1056495	hsa-miR-3121-5p	CLIP-seq
MIRT1056497	hsa-miR-3126-3p	CLIP-seq
MIRT1056499	hsa-miR-3134	CLIP-seq
MIRT1056500	hsa-miR-3135b	CLIP-seq
MIRT1056501	hsa-miR-3143	CLIP-seq
MIRT1056504	hsa-miR-3155	CLIP-seq
MIRT1056505	hsa-miR-3155b	CLIP-seq
MIRT1056506	hsa-miR-3162-5p	CLIP-seq
MIRT1056507	hsa-miR-3176	CLIP-seq
MIRT1056508	hsa-miR-3187-5p	CLIP-seq
MIRT1056509	hsa-miR-3190	CLIP-seq
MIRT1056511	hsa-miR-3200-5p	CLIP-seq
MIRT1056514	hsa-miR-3607-3p	CLIP-seq
MIRT1056515	hsa-miR-3616-3p	CLIP-seq
MIRT1056518	hsa-miR-3686	CLIP-seq
MIRT1056523	hsa-miR-378g	CLIP-seq
MIRT1056527	hsa-miR-3922-3p	CLIP-seq
MIRT1056529	hsa-miR-4258	CLIP-seq
MIRT1056530	hsa-miR-4261	CLIP-seq
MIRT1056532	hsa-miR-4325	CLIP-seq
MIRT1056534	hsa-miR-4434	CLIP-seq
MIRT1056535	hsa-miR-4436b-3p	CLIP-seq
MIRT1056536	hsa-miR-4438	CLIP-seq
MIRT1056537	hsa-miR-4469	CLIP-seq
MIRT1056538	hsa-miR-4486	CLIP-seq
MIRT1056540	hsa-miR-4516	CLIP-seq
MIRT1056541	hsa-miR-452	CLIP-seq
MIRT1056543	hsa-miR-4531	CLIP-seq
MIRT1056544	hsa-miR-4534	CLIP-seq
MIRT1056545	hsa-miR-455-3p	CLIP-seq
MIRT1056546	hsa-miR-4633-3p	CLIP-seq
MIRT1056547	hsa-miR-4638-3p	CLIP-seq
MIRT1056551	hsa-miR-4676-3p	CLIP-seq
MIRT1056552	hsa-miR-4682	CLIP-seq
MIRT1056553	hsa-miR-4685-5p	CLIP-seq
MIRT1056554	hsa-miR-4704-5p	CLIP-seq
MIRT1056556	hsa-miR-4731-3p	CLIP-seq
MIRT1056557	hsa-miR-4739	CLIP-seq
MIRT1056559	hsa-miR-4756-5p	CLIP-seq
MIRT1056560	hsa-miR-4776-3p	CLIP-seq
MIRT1056561	hsa-miR-4789-5p	CLIP-seq
MIRT1056562	hsa-miR-4801	CLIP-seq
MIRT1056563	hsa-miR-484	CLIP-seq
MIRT1056564	hsa-miR-506	CLIP-seq
MIRT1056566	hsa-miR-516b	CLIP-seq
MIRT1056567	hsa-miR-539	CLIP-seq
MIRT1056568	hsa-miR-543	CLIP-seq
MIRT1056587	hsa-miR-580	CLIP-seq
MIRT1056588	hsa-miR-589	CLIP-seq
MIRT1056590	hsa-miR-612	CLIP-seq
MIRT1056591	hsa-miR-626	CLIP-seq
MIRT1056593	hsa-miR-642a	CLIP-seq
MIRT1056594	hsa-miR-642b	CLIP-seq
MIRT1056595	hsa-miR-659	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004672	Function	Protein kinase activity	IDA	14985082
GO:0005515	Function	Protein binding	IPI	14594798, 16189514, 18006506, 21516116, 22366786, 23414517, 25036637, 25416956, 26496610, 28144995, 28514442, 31273097, 32296183, 32707033, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	19464326
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	19464326, 28144995
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0034620	Process	Cellular response to unfolded protein	IBA
GO:0034620	Process	Cellular response to unfolded protein	IEA
GO:0034620	Process	Cellular response to unfolded protein	IMP	18006506
GO:0042802	Function	Identical protein binding	IPI	14594798
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0042803	Function	Protein homodimerization activity	IPI	18006506
GO:0101031	Component	Protein folding chaperone complex	IBA
GO:0101031	Component	Protein folding chaperone complex	IDA	18006506
GO:1905337	Process	Positive regulation of aggrephagy	IMP	18006506

Other IDs

• MIM: 608014
• HGNC: 30171
• e!Ensembl: ENSG00000152137

Protein

• UniProt ID: Q9UJY1
• Protein name: Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Heat shock protein family B member 8) (Protein kinase H11) (Small stress protein-like protein HSP22)
• Protein function: Involved in the chaperone-assisted selective autophagy (CASA), a crucial process for protein quality control, particularly in mechanical strained cells and tissues such as muscle. Displays temperature-dependent chaperone activity. {ECO:0000250|U
• PDB: 8S7A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00011	HSP20	93 → 180	Hsp20/alpha crystallin family	Family

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in skeletal muscle and heart. {ECO:0000269|PubMed:11470154}.
• Sequence:

  MADGQMPFSCHYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAW
  PGTLRSGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVE
  VSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGES
  SFNNELPQDSQEVTCT

• Sequence length: 196

Pathways

Reactome:

HSF1-dependent transactivation

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Charcot-Marie-Tooth disease	Pathogenic	rs104894345	RCV000192250
Charcot-Marie-Tooth disease axonal type 2L	Likely pathogenic; Pathogenic	rs2500054710, rs104894351, rs104894345, rs2500054682, rs1565929090, rs1954727878	RCV002290198 RCV001216811 RCV000002737 RCV002472046 RCV000678501 RCV001249293
Distal myopathy	Likely pathogenic	rs1565930588	RCV000708586
HSPB8-related neuromuscular disorder	Likely pathogenic; Pathogenic	rs1954727678	RCV004004919
Myopathy, autophagic vacuolar, infantile-onset	Likely pathogenic; Pathogenic	rs2500054710	RCV004587340
Myopathy, myofibrillar, 13, with rimmed vacuoles	Likely pathogenic; Pathogenic	rs2500054710, rs1954727878, rs1954727678, rs1954727159	RCV005055397 RCV005055453 RCV005235551 RCV005055454
Neuronopathy, distal hereditary motor, type 2A	Pathogenic; Likely pathogenic	rs104894345, rs104894351, rs1565929080, rs1954727678	RCV000002735 RCV000002736 RCV000678500 RCV001254712

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Cervical cancer	Benign	rs1133026	RCV005893071
Charcot-Marie-Tooth disease type 2	Uncertain significance; Conflicting classifications of pathogenicity	rs886049028, rs60924821	RCV000342451 RCV000314864 RCV000349752
Distal spinal muscular atrophy	Uncertain significance; Conflicting classifications of pathogenicity	rs886049028, rs60924821	RCV004576943 RCV004576944 RCV004576945
HSPB8-related disorder	Likely benign; Benign	rs1448722290, rs949273182, rs143010542, rs1401613594	RCV003921768 RCV003901601 RCV003892790 RCV003920391
Intellectual disability, autosomal dominant 46	Conflicting classifications of pathogenicity	rs60924821	RCV005860063
Malignant tumor of esophagus	Benign	rs1133026	RCV005893070
Ovarian serous cystadenocarcinoma	Conflicting classifications of pathogenicity	rs368810689	RCV005896767
Peripheral neuropathy	Uncertain significance	rs1463622153	RCV003229923

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	35029906, 37322027
Amyotrophic Lateral Sclerosis	Associate	31152038
Atherosclerosis	Inhibit	36934244
Autistic Disorder	Associate	18378158
Brain Diseases	Associate	18378158
Brain Infarction	Associate	39736019
Breast Neoplasms	Associate	18229450, 28060751, 29345254, 30596229
Carcinogenesis	Associate	33885248
Carcinoma Hepatocellular	Associate	28456666
Cerebral Infarction	Associate	39736019
Charcot Marie Tooth Disease	Associate	20157854
Charcot Marie Tooth disease Type 2I	Associate	26718575, 36854646
Cholangiocarcinoma	Associate	34606781
Congenital thrombotic disease due to Protein C deficiency	Inhibit	31273254
Demyelinating Diseases	Associate	26694816
Distal Hereditary Motor Neuropathy Type II	Associate	17663003, 20157854, 21985219, 28000086, 35328016, 36854646
Distal Myopathies	Associate	26718575
Fused Kidney	Associate	34487489
Genetic Diseases Inborn	Associate	20157854
Glioblastoma	Associate	21678403
Glioma	Associate	33885248
Hematologic Neoplasms	Associate	21914495
Hereditary Sensory and Motor Neuropathy	Associate	35328016
Inflammation	Associate	35513867
Inherited Peripheral Neuropathy	Associate	35328016
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	21914495
Lymphoma	Associate	21914495
Melanoma	Associate	17173073, 36400750
Motor Neuron Disease	Associate	20157854
Multiple Sclerosis	Stimulate	26694816
Multiple Sclerosis	Associate	30014472
Muscular Diseases	Associate	26718575
Myofibrillar Myopathy	Associate	26718575
Neoplasm Metastasis	Associate	31273254
Neoplasms	Inhibit	12832417
Neoplasms	Associate	21914495, 25798051, 28456666, 33885248, 34606781, 36400750
Nervous System Diseases	Associate	21329698
Neurodegenerative Diseases	Associate	36574942
Neuromuscular Diseases	Associate	26718575, 37411010
Neuronopathy Distal Hereditary Motor Type I	Associate	26718575
Neuronopathy Distal Hereditary Motor Type V	Associate	17663003
Neurotoxicity Syndromes	Associate	36574942
Peripheral Nervous System Diseases	Associate	20157854, 26718575, 35328016
Prostatic Neoplasms	Associate	32264916
Sarcoma	Inhibit	12832417
Spastic paraplegia 17	Associate	17663003
Spinal Cord Diseases	Associate	30014472
Squamous Cell Carcinoma of Head and Neck	Associate	33456497
Stroke	Associate	39736019
Vacuolar myopathy	Associate	26718575
Vacuolar Neuromyopathy	Associate	36854646