Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2634
Gene name	Guanylate binding protein 2
Gene symbol	GBP2
Synonyms (NCBI Gene)	-
Chromosome	1
Chromosome location	1p22.2
Summary	This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may

Show/Hide all (61)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017798	hsa-miR-335-5p	Microarray	18185580
MIRT029407	hsa-miR-26b-5p	Microarray	19088304
MIRT573882	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT573881	hsa-miR-4709-5p	PAR-CLIP	20371350
MIRT573880	hsa-miR-6806-5p	PAR-CLIP	20371350
MIRT573882	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT573881	hsa-miR-4709-5p	PAR-CLIP	20371350
MIRT573880	hsa-miR-6806-5p	PAR-CLIP	20371350
MIRT756350	hsa-miR-221-3p	Luciferase reporter assayWestern blottingqRT-PCR	38450521
MIRT2537618	hsa-miR-1178	CLIP-seq
MIRT2537619	hsa-miR-1269	CLIP-seq
MIRT2537620	hsa-miR-1269b	CLIP-seq
MIRT2537621	hsa-miR-2110	CLIP-seq
MIRT2537622	hsa-miR-3117-5p	CLIP-seq
MIRT2537623	hsa-miR-3150a-3p	CLIP-seq
MIRT2537624	hsa-miR-3175	CLIP-seq
MIRT2537625	hsa-miR-3189-3p	CLIP-seq
MIRT2537626	hsa-miR-4268	CLIP-seq
MIRT2537627	hsa-miR-4300	CLIP-seq
MIRT2537628	hsa-miR-4419a	CLIP-seq
MIRT2537629	hsa-miR-4448	CLIP-seq
MIRT2537630	hsa-miR-4487	CLIP-seq
MIRT2537631	hsa-miR-4510	CLIP-seq
MIRT2537632	hsa-miR-4520a-3p	CLIP-seq
MIRT2537633	hsa-miR-4529-3p	CLIP-seq
MIRT2537634	hsa-miR-4638-3p	CLIP-seq
MIRT2537635	hsa-miR-4670-3p	CLIP-seq
MIRT2537636	hsa-miR-4714-5p	CLIP-seq
MIRT2537637	hsa-miR-4742-5p	CLIP-seq
MIRT2537638	hsa-miR-514	CLIP-seq
MIRT2537639	hsa-miR-514b-3p	CLIP-seq
MIRT2537640	hsa-miR-578	CLIP-seq
MIRT2537641	hsa-miR-635	CLIP-seq
MIRT2537642	hsa-miR-920	CLIP-seq
MIRT2537643	hsa-miR-939	CLIP-seq
MIRT2537618	hsa-miR-1178	CLIP-seq
MIRT2537619	hsa-miR-1269	CLIP-seq
MIRT2537620	hsa-miR-1269b	CLIP-seq
MIRT2537621	hsa-miR-2110	CLIP-seq
MIRT2537622	hsa-miR-3117-5p	CLIP-seq
MIRT2537623	hsa-miR-3150a-3p	CLIP-seq
MIRT2537624	hsa-miR-3175	CLIP-seq
MIRT2537625	hsa-miR-3189-3p	CLIP-seq
MIRT2537626	hsa-miR-4268	CLIP-seq
MIRT2537627	hsa-miR-4300	CLIP-seq
MIRT2537628	hsa-miR-4419a	CLIP-seq
MIRT2537629	hsa-miR-4448	CLIP-seq
MIRT2537630	hsa-miR-4487	CLIP-seq
MIRT2537631	hsa-miR-4510	CLIP-seq
MIRT2537632	hsa-miR-4520a-3p	CLIP-seq
MIRT2537633	hsa-miR-4529-3p	CLIP-seq
MIRT2537634	hsa-miR-4638-3p	CLIP-seq
MIRT2537635	hsa-miR-4670-3p	CLIP-seq
MIRT2537636	hsa-miR-4714-5p	CLIP-seq
MIRT2537637	hsa-miR-4742-5p	CLIP-seq
MIRT2537638	hsa-miR-514	CLIP-seq
MIRT2537639	hsa-miR-514b-3p	CLIP-seq
MIRT2537640	hsa-miR-578	CLIP-seq
MIRT2537641	hsa-miR-635	CLIP-seq
MIRT2537642	hsa-miR-920	CLIP-seq
MIRT2537643	hsa-miR-939	CLIP-seq

Show/Hide all (49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	31091448
GO:0000139	Component	Golgi membrane	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0002218	Process	Activation of innate immune response	ISS
GO:0002376	Process	Immune system process	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IEA
GO:0004866	Function	Endopeptidase inhibitor activity	IDA	31091448
GO:0005515	Function	Protein binding	IPI	18985028, 21151871, 28514442, 33961781
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IEA
GO:0005525	Function	GTP binding	TAS	1715024
GO:0005634	Component	Nucleus	IDA	17266443, 21151871
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	21151871
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA	31091448
GO:0005794	Component	Golgi apparatus	IDA	17266443
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006955	Process	Immune response	TAS	1715024
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IBA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031410	Component	Cytoplasmic vesicle	ISS
GO:0034504	Process	Protein localization to nucleus	IDA	21151871
GO:0042742	Process	Defense response to bacterium	ISS
GO:0042802	Function	Identical protein binding	IPI	21151871
GO:0042803	Function	Protein homodimerization activity	IDA	21151871
GO:0042832	Process	Defense response to protozoan	IBA
GO:0045087	Process	Innate immune response	IEA
GO:0046718	Process	Symbiont entry into host cell	IDA	9641677
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	17266443
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050830	Process	Defense response to Gram-positive bacterium	IBA
GO:0051604	Process	Protein maturation	IDA	31091448
GO:0051607	Process	Defense response to virus	IDA	31091448
GO:0051715	Process	Cytolysis in another organism	ISS
GO:0071222	Process	Cellular response to lipopolysaccharide	ISS
GO:0071346	Process	Cellular response to type II interferon	IBA
GO:0071346	Process	Cellular response to type II interferon	IDA	17266443
GO:0071347	Process	Cellular response to interleukin-1	IEP	17266443
GO:0071356	Process	Cellular response to tumor necrosis factor	IEP	17266443
GO:0140639	Process	Positive regulation of pyroptotic inflammatory response	ISS
GO:0140678	Function	Molecular function inhibitor activity	IDA	31091448
GO:0140973	Process	Positive regulation of AIM2 inflammasome complex assembly	ISS

MIM	HGNC	e!Ensembl
600412	4183	ENSG00000162645

P32456

Protein name

Guanylate-binding protein 2 (EC 3.6.5.-) (GTP-binding protein 2) (GBP-2) (HuGBP-2) (Guanine nucleotide-binding protein 2) (Interferon-induced guanylate-binding protein 2)

Protein function

Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:31091448). Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major react

PDB

6VKJ , 7E58 , 7M1S

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02263	GBP	18 → 280	Guanylate-binding protein, N-terminal domain	Domain
PF02841	GBP_C	282 → 578	Guanylate-binding protein, C-terminal domain	Domain

Sequence

MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
KKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAI
LLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTL
RDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPA
PKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVN
AISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSER
EAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDV
KQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSL
SEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQL
MAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPICNIL

Sequence length

591

Interactions

View interactions

	KEGG		Reactome
	NOD-like receptor signaling pathway		Interferon gamma signaling Interferon alpha/beta signaling

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Inherited susceptibility to mycobacterial diseases	Likely risk allele	rs753229736	RCV002290425

Show/Hide Text Mining Associations (30)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acidosis	Associate	34993253
Breast Neoplasms	Associate	31311202, 35233733, 37784054
Carcinogenesis	Associate	35730811, 39251636
Carcinoma Hepatocellular	Associate	35730811, 37551111, 39251636
Carcinoma Non Small Cell Lung	Associate	37784054
Carcinoma Renal Cell	Stimulate	36660930
Coronary Artery Disease	Associate	37924005
COVID 19	Associate	39337460
Dermatomyositis	Associate	32846838
Diabetic Nephropathies	Associate	37622120
Inflammation	Associate	37622120
Lupus Erythematosus Systemic	Stimulate	20617533
Lupus Nephritis	Associate	36115937
Melanoma	Associate	33688507, 37784054
Mouth Diseases	Stimulate	31600201
Neoplasms	Associate	35730811, 36660930, 37784054
Osteosarcoma	Associate	38169731
Ovarian Diseases	Associate	22246450
Ovarian Neoplasms	Associate	27806724
Pancreatic Neoplasms	Associate	34993253
Rectal Neoplasms	Associate	35730811
Respiratory Distress Syndrome	Associate	34418997
Sarcoma	Associate	33316779
Severe Acute Respiratory Syndrome	Associate	16124062
Sjogren's Syndrome	Stimulate	20617533
Stomach Neoplasms	Associate	37784054
Tuberculosis Pleural	Associate	38288122
Tuberculosis Pulmonary	Associate	39337460
Urethral Neoplasms	Associate	37784054
Urinary Bladder Neoplasms	Associate	34708131

GBP2 (guanylate binding protein 2)