GAPDHS (glyceraldehyde-3-phosphate dehydrogenase, spermatogenic)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 26330
Gene name Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
Gene symbol GAPDHS
Synonyms (NCBI Gene)
GAPD2GAPDH-2GAPDSHEL-S-278HSD-35
Chromosome 19
Chromosome location 19q13.12
Summary This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adeni
miRNA miRNA information provided by mirtarbase database.
3
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (3)
miRTarBase ID miRNA Experiments Reference
MIRT018010 hsa-miR-335-5p Microarray 18185580
MIRT1999819 hsa-miR-3667-3p CLIP-seq
MIRT1999820 hsa-miR-4691-5p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0004365 Function Glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IBA
GO:0004365 Function Glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IEA
GO:0004365 Function Glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity TAS 10714828
GO:0005515 Function Protein binding IPI 16820410, 28514442, 32296183, 33961781
GO:0005634 Component Nucleus HDA 21630459
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
609169 24864 ENSG00000105679
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O14556
Protein name Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (EC 1.2.1.12) (Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2) (GAPDH-2) (Spermatogenic glyceraldehyde-3-phosphate dehydrogenase)
Protein function May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).
PDB 3H9E , 3PFW , 5C7L , 5C7O
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00044 Gp_dh_N 76 → 176 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Domain
PF02800 Gp_dh_C 229 → 386 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Testis specific.
Sequence
Sequence length 408
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Glycolysis / Gluconeogenesis
Metabolic pathways 		  Glycolysis
Gluconeogenesis
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Prostate cancer Uncertain significance rs193920833 RCV000149212
Show/Hide Text Mining Associations (7)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Asthenozoospermia Associate 32321348
Azoospermia Associate 23675907, 32321348
Lung Neoplasms Associate 34970420
Melanoma Associate 35149585
Neoplasm Metastasis Inhibit 35149585
Neoplasms Associate 35149585
Oligospermia Associate 32321348