AK5 (adenylate kinase 5)

Gene

• Entrez ID: 26289
• Gene name: Adenylate kinase 5
• Gene symbol: AK5
• Synonyms (NCBI Gene): AK6
• Chromosome: 1
• Chromosome location: 1p31.1
• Summary: This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT775146	hsa-miR-1273g	CLIP-seq
MIRT775147	hsa-miR-2114	CLIP-seq
MIRT775148	hsa-miR-323-5p	CLIP-seq
MIRT775149	hsa-miR-3689d	CLIP-seq
MIRT775150	hsa-miR-3911	CLIP-seq
MIRT775151	hsa-miR-4266	CLIP-seq
MIRT775152	hsa-miR-4434	CLIP-seq
MIRT775153	hsa-miR-4447	CLIP-seq
MIRT775154	hsa-miR-4472	CLIP-seq
MIRT775155	hsa-miR-4488	CLIP-seq
MIRT775156	hsa-miR-4516	CLIP-seq
MIRT775157	hsa-miR-4531	CLIP-seq
MIRT775158	hsa-miR-4695-5p	CLIP-seq
MIRT775159	hsa-miR-4697-5p	CLIP-seq
MIRT775160	hsa-miR-4779	CLIP-seq
MIRT775161	hsa-miR-541	CLIP-seq
MIRT775162	hsa-miR-651	CLIP-seq
MIRT775163	hsa-miR-654-5p	CLIP-seq
MIRT775164	hsa-miR-876-3p	CLIP-seq
MIRT775165	hsa-miR-144	CLIP-seq
MIRT775166	hsa-miR-3123	CLIP-seq
MIRT775167	hsa-miR-329	CLIP-seq
MIRT775168	hsa-miR-362-3p	CLIP-seq
MIRT775169	hsa-miR-3691-3p	CLIP-seq
MIRT775170	hsa-miR-3925-5p	CLIP-seq
MIRT775171	hsa-miR-3976	CLIP-seq
MIRT775172	hsa-miR-4645-3p	CLIP-seq
MIRT775173	hsa-miR-4662a-5p	CLIP-seq
MIRT775174	hsa-miR-495	CLIP-seq
MIRT2443428	hsa-miR-1231	CLIP-seq
MIRT2443429	hsa-miR-3616-5p	CLIP-seq
MIRT2443430	hsa-miR-3647-5p	CLIP-seq
MIRT775150	hsa-miR-3911	CLIP-seq
MIRT2443431	hsa-miR-4288	CLIP-seq
MIRT775152	hsa-miR-4434	CLIP-seq
MIRT775156	hsa-miR-4516	CLIP-seq
MIRT775157	hsa-miR-4531	CLIP-seq
MIRT2443432	hsa-miR-4795-5p	CLIP-seq
MIRT2443433	hsa-miR-573	CLIP-seq
MIRT2443434	hsa-miR-595	CLIP-seq
MIRT2443435	hsa-miR-632	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004017	Function	AMP kinase activity	IEA
GO:0004017	Function	AMP kinase activity	TAS	10215863
GO:0004550	Function	Nucleoside diphosphate kinase activity	IBA
GO:0004550	Function	Nucleoside diphosphate kinase activity	IDA	23416111
GO:0004550	Function	Nucleoside diphosphate kinase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS	10215863
GO:0006139	Process	Nucleobase-containing compound metabolic process	IEA
GO:0006172	Process	ADP biosynthetic process	TAS	10215863
GO:0006173	Process	DADP biosynthetic process	TAS	10215863
GO:0009220	Process	Pyrimidine ribonucleotide biosynthetic process	TAS	10215863
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019205	Function	Nucleobase-containing compound kinase activity	IEA
GO:0034451	Component	Centriolar satellite	IDA
GO:0046034	Process	ATP metabolic process	IEA
GO:0046940	Process	Nucleoside monophosphate phosphorylation	IEA

Other IDs

• MIM: 608009
• HGNC: 365
• e!Ensembl: ENSG00000154027

Protein

• UniProt ID: Q9Y6K8
• Protein name: Adenylate kinase isoenzyme 5 (AK 5) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 5)
• Protein function: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, th
• PDB: 2BWJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00406	ADK	137 → 294		Domain
  PF00406	ADK	381 → 537		Domain

• Tissue specificity: TISSUE SPECIFICITY: Brain specific. {ECO:0000269|PubMed:10215863}.
• Sequence:

  MNTNDAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKWDTFV
  SQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDLSETAELIE
  EYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKW
  SLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICTPDLV
  VFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDA
  DRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNV
  FGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESE
  RSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDP
  QLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHK
  INAEGTPEDVFLQLCTAIDSIF

• Sequence length: 562

Pathways

KEGG:

Purine metabolism
Thiamine metabolism
Metabolic pathways
Nucleotide metabolism
Biosynthesis of cofactors

Reactome:

Interconversion of nucleotide di- and triphosphates

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Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
Bipolar Disorder	Bipolar I disorder	N/A	N/A	GWAS
Diabetes	Type 2 diabetes (age of onset)	N/A	N/A	GWAS
Lung adenocarcinoma	Lung adenocarcinoma, Lung adenocarcinoma (conditioned on cigarettes per day)	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Alzheimer Disease	Associate	25311278
Amnesia	Associate	33843981
Anorexia	Stimulate	33843981
Celiac Disease	Associate	28505210
Colonic Neoplasms	Associate	34135408
Colorectal Neoplasms	Associate	34135408
Depressive Disorder	Associate	33843981
Encephalitis	Associate	33843981
Glioma	Associate	40715243
Heart Failure	Associate	31059043
Hyperglycemia	Inhibit	21556322
Limbic Encephalitis	Associate	33843981
Neoplasm Metastasis	Associate	34135408
Neoplasms	Associate	31799658
Seizures	Associate	33843981
Stomach Neoplasms	Associate	31799658
Weight Loss	Associate	33843981