IL1RAPL2 (interleukin 1 receptor accessory protein like 2)

Gene

• Entrez ID: 26280
• Gene name: Interleukin 1 receptor accessory protein like 2
• Gene symbol: IL1RAPL2
• Synonyms (NCBI Gene): IL-1R9, IL1R9, IL1RAPL-2, TIGIRR-1
• Chromosome: X
• Chromosome location: Xq22.3
• Summary: The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2015301	hsa-miR-3125	CLIP-seq
MIRT2015302	hsa-miR-3916	CLIP-seq
MIRT2015303	hsa-miR-4257	CLIP-seq
MIRT2015301	hsa-miR-3125	CLIP-seq
MIRT2015302	hsa-miR-3916	CLIP-seq
MIRT2015303	hsa-miR-4257	CLIP-seq
MIRT2247654	hsa-miR-4659a-3p	CLIP-seq
MIRT2247655	hsa-miR-4659b-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004896	Function	Cytokine receptor activity	IEA
GO:0004908	Function	Interleukin-1 receptor activity	TAS	10757639
GO:0004910	Function	Interleukin-1, type II, blocking receptor activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IBA
GO:0007399	Process	Nervous system development	IEA
GO:0007417	Process	Central nervous system development	TAS	10757639
GO:0009986	Component	Cell surface	IBA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IEA
GO:0061809	Function	NAD+ nucleosidase activity, cyclic ADP-ribose generating	IEA
GO:0098978	Component	Glutamatergic synapse	IDA	21926414
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IMP	21926414
GO:1905606	Process	Regulation of presynapse assembly	IDA	21926414
GO:1905606	Process	Regulation of presynapse assembly	IEA
GO:1905606	Process	Regulation of presynapse assembly	IMP	21926414

Other IDs

• MIM: 300277
• HGNC: 5997
• e!Ensembl: ENSG00000189108

Protein

• UniProt ID: Q9NP60
• Protein name: X-linked interleukin-1 receptor accessory protein-like 2 (IL-1 receptor accessory protein-like 2) (IL-1-RAPL-2) (IL-1RAPL-2) (IL1RAPL-2) (EC 3.2.2.6) (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R-9) (IL-1R9) (Three immunoglobulin domain-co
• PDB: 7FD3, 7SZL
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF18452	Ig_6	90 → 141	Immunoglobulin domain	Domain
  PF13895	Ig_2	143 → 231	Immunoglobulin domain	Domain
  PF00047	ig	249 → 345	Immunoglobulin domain	Domain
  PF01582	TIR	402 → 575	TIR domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected at low levels in fetal and adult brain, in particular in the frontal lobe, temporal lobe and cerebellum. Detected at very low levels in skin, liver, fetal ovary and in placenta. {ECO:0000269|PubMed:10882729, ECO:0000269|PubMed
• Sequence:

  MKPPFLLALVVCSVVSTNLKMVSKRNSVDGCIDWSVDLKTYMALAGEPVRVKCALFYSYI
  RTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRN
  STYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWY
  KECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPP
  KPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEI
  RLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKDLIYKIELAGG
  LGAIFLLLVLLVVIYKCYNIELMLFYRQHFGADETNDDNKEYDAYLSYTKVDQDTLDCDN
  PEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRLIIVLTPDYIL
  RRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKRSIKLLSLIKWKGSK
  SSKLNSKFWKHLVYEMPIKKKEMLPRCHVLDSAEQGLFGELQPIPSIAMTSTSATLVSSQ
  ADLPEFHPSDSMQIRHCCRGYKHEIPATTLPVPSLGNHHTYCNLPLTLLNGQLPLNNTLK
  DTQEFHRNSSLLPLSSKELSFTSDIW

• Sequence length: 686

Pathways

Reactome:

Receptor-type tyrosine-protein phosphatases