FBXW8 (F-box and WD repeat domain containing 8)

Gene

• Entrez ID: 26259
• Gene name: F-box and WD repeat domain containing 8
• Gene symbol: FBXW8
• Synonyms (NCBI Gene): FBW6, FBW8, FBX29, FBXO29, FBXW6
• Chromosome: 12
• Chromosome location: 12q24.22
• Summary: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cul

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT643228	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT643227	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT643226	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT643225	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT643224	hsa-miR-604	HITS-CLIP	23824327
MIRT643223	hsa-miR-6762-3p	HITS-CLIP	23824327
MIRT643222	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT643221	hsa-miR-647	HITS-CLIP	23824327
MIRT643220	hsa-miR-6842-3p	HITS-CLIP	23824327
MIRT633402	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT633401	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT633400	hsa-miR-940	HITS-CLIP	23824327
MIRT633399	hsa-miR-3929	HITS-CLIP	23824327
MIRT633398	hsa-miR-4419b	HITS-CLIP	23824327
MIRT633397	hsa-miR-4478	HITS-CLIP	23824327
MIRT633396	hsa-miR-4742-5p	HITS-CLIP	23824327
MIRT633395	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT633394	hsa-miR-1827	HITS-CLIP	23824327
MIRT633393	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT633392	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT633391	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT633390	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT633389	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT633388	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT633387	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT633386	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT633385	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT633384	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT633383	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT633382	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT633381	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT633380	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT633379	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT633378	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT633377	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT633376	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT633375	hsa-miR-3689c	HITS-CLIP	23824327
MIRT633374	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT633373	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT633372	hsa-miR-1304-5p	HITS-CLIP	23824327
MIRT633371	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT633370	hsa-miR-3122	HITS-CLIP	23824327
MIRT633369	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT633368	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT633367	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT633366	hsa-miR-665	HITS-CLIP	23824327
MIRT633394	hsa-miR-1827	PAR-CLIP	26701625
MIRT633394	hsa-miR-1827	PAR-CLIP	26701625
MIRT643228	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT643227	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT643226	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT643225	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT643224	hsa-miR-604	HITS-CLIP	23824327
MIRT643223	hsa-miR-6762-3p	HITS-CLIP	23824327
MIRT643222	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT643221	hsa-miR-647	HITS-CLIP	23824327
MIRT643220	hsa-miR-6842-3p	HITS-CLIP	23824327
MIRT633402	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT633401	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT633400	hsa-miR-940	HITS-CLIP	23824327
MIRT633399	hsa-miR-3929	HITS-CLIP	23824327
MIRT633398	hsa-miR-4419b	HITS-CLIP	23824327
MIRT633397	hsa-miR-4478	HITS-CLIP	23824327
MIRT633396	hsa-miR-4742-5p	HITS-CLIP	23824327
MIRT633395	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT633394	hsa-miR-1827	HITS-CLIP	23824327
MIRT633393	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT633392	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT633391	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT633390	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT633389	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT633388	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT633387	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT633386	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT633385	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT633384	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT633383	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT633382	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT633381	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT633380	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT633379	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT633378	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT633377	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT633376	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT633375	hsa-miR-3689c	HITS-CLIP	23824327
MIRT633374	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT633373	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT633372	hsa-miR-1304-5p	HITS-CLIP	23824327
MIRT633371	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT633370	hsa-miR-3122	HITS-CLIP	23824327
MIRT633369	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT633368	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT633367	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT633366	hsa-miR-665	HITS-CLIP	23824327
MIRT993580	hsa-miR-1229	CLIP-seq
MIRT993581	hsa-miR-1289	CLIP-seq
MIRT993582	hsa-miR-1304	CLIP-seq
MIRT993583	hsa-miR-3198	CLIP-seq
MIRT993584	hsa-miR-33a	CLIP-seq
MIRT993585	hsa-miR-33b	CLIP-seq
MIRT993586	hsa-miR-4294	CLIP-seq
MIRT993587	hsa-miR-4309	CLIP-seq
MIRT993588	hsa-miR-4778-5p	CLIP-seq
MIRT993589	hsa-miR-544	CLIP-seq
MIRT993590	hsa-miR-579	CLIP-seq
MIRT993591	hsa-miR-653	CLIP-seq
MIRT993592	hsa-miR-1200	CLIP-seq
MIRT993593	hsa-miR-1207-3p	CLIP-seq
MIRT993594	hsa-miR-1207-5p	CLIP-seq
MIRT993580	hsa-miR-1229	CLIP-seq
MIRT993595	hsa-miR-1257	CLIP-seq
MIRT993596	hsa-miR-125a-5p	CLIP-seq
MIRT993597	hsa-miR-125b	CLIP-seq
MIRT993598	hsa-miR-1293	CLIP-seq
MIRT993582	hsa-miR-1304	CLIP-seq
MIRT993599	hsa-miR-2110	CLIP-seq
MIRT993600	hsa-miR-2113	CLIP-seq
MIRT993601	hsa-miR-2116	CLIP-seq
MIRT993602	hsa-miR-218	CLIP-seq
MIRT993603	hsa-miR-223	CLIP-seq
MIRT993604	hsa-miR-2355-5p	CLIP-seq
MIRT993605	hsa-miR-3126-5p	CLIP-seq
MIRT993606	hsa-miR-3140-3p	CLIP-seq
MIRT993607	hsa-miR-3155	CLIP-seq
MIRT993608	hsa-miR-3155b	CLIP-seq
MIRT993609	hsa-miR-3160-3p	CLIP-seq
MIRT993610	hsa-miR-3173-3p	CLIP-seq
MIRT993611	hsa-miR-3184	CLIP-seq
MIRT993612	hsa-miR-3186-5p	CLIP-seq
MIRT993613	hsa-miR-3194-3p	CLIP-seq
MIRT993614	hsa-miR-3197	CLIP-seq
MIRT993615	hsa-miR-3200-5p	CLIP-seq
MIRT993616	hsa-miR-339-5p	CLIP-seq
MIRT993617	hsa-miR-3545-5p	CLIP-seq
MIRT993618	hsa-miR-3650	CLIP-seq
MIRT993619	hsa-miR-3672	CLIP-seq
MIRT993620	hsa-miR-3679-3p	CLIP-seq
MIRT993621	hsa-miR-3975	CLIP-seq
MIRT993622	hsa-miR-423-5p	CLIP-seq
MIRT993623	hsa-miR-4271	CLIP-seq
MIRT993624	hsa-miR-4300	CLIP-seq
MIRT993625	hsa-miR-4302	CLIP-seq
MIRT993626	hsa-miR-4303	CLIP-seq
MIRT993627	hsa-miR-4319	CLIP-seq
MIRT993628	hsa-miR-4324	CLIP-seq
MIRT993629	hsa-miR-4419a	CLIP-seq
MIRT993630	hsa-miR-4435	CLIP-seq
MIRT993631	hsa-miR-4438	CLIP-seq
MIRT993632	hsa-miR-4446-5p	CLIP-seq
MIRT993633	hsa-miR-4474-3p	CLIP-seq
MIRT993634	hsa-miR-4483	CLIP-seq
MIRT993635	hsa-miR-4487	CLIP-seq
MIRT993636	hsa-miR-4489	CLIP-seq
MIRT993637	hsa-miR-4510	CLIP-seq
MIRT993638	hsa-miR-4533	CLIP-seq
MIRT993639	hsa-miR-4536	CLIP-seq
MIRT993640	hsa-miR-4662a-5p	CLIP-seq
MIRT993641	hsa-miR-4676-5p	CLIP-seq
MIRT993642	hsa-miR-4677-5p	CLIP-seq
MIRT993643	hsa-miR-4690-3p	CLIP-seq
MIRT993644	hsa-miR-4693-5p	CLIP-seq
MIRT993645	hsa-miR-4695-5p	CLIP-seq
MIRT993646	hsa-miR-4697-3p	CLIP-seq
MIRT993647	hsa-miR-4725-3p	CLIP-seq
MIRT993648	hsa-miR-4732-3p	CLIP-seq
MIRT993649	hsa-miR-4734	CLIP-seq
MIRT993650	hsa-miR-4736	CLIP-seq
MIRT993651	hsa-miR-4746-3p	CLIP-seq
MIRT993652	hsa-miR-4747-5p	CLIP-seq
MIRT993653	hsa-miR-4755-5p	CLIP-seq
MIRT993654	hsa-miR-4763-3p	CLIP-seq
MIRT993588	hsa-miR-4778-5p	CLIP-seq
MIRT993655	hsa-miR-4786-5p	CLIP-seq
MIRT993656	hsa-miR-484	CLIP-seq
MIRT993657	hsa-miR-491-5p	CLIP-seq
MIRT993658	hsa-miR-518d-5p	CLIP-seq
MIRT993659	hsa-miR-519b-5p	CLIP-seq
MIRT993660	hsa-miR-519c-5p	CLIP-seq
MIRT993661	hsa-miR-520c-5p	CLIP-seq
MIRT993662	hsa-miR-526a	CLIP-seq
MIRT993589	hsa-miR-544	CLIP-seq
MIRT993663	hsa-miR-544b	CLIP-seq
MIRT993664	hsa-miR-548c-3p	CLIP-seq
MIRT993665	hsa-miR-558	CLIP-seq
MIRT993666	hsa-miR-575	CLIP-seq
MIRT993590	hsa-miR-579	CLIP-seq
MIRT993667	hsa-miR-636	CLIP-seq
MIRT993591	hsa-miR-653	CLIP-seq
MIRT993668	hsa-miR-663b	CLIP-seq
MIRT993669	hsa-miR-670	CLIP-seq
MIRT993670	hsa-miR-760	CLIP-seq
MIRT993671	hsa-miR-769-5p	CLIP-seq
MIRT993672	hsa-miR-876-3p	CLIP-seq
MIRT993673	hsa-miR-920	CLIP-seq
MIRT1994694	hsa-miR-1273e	CLIP-seq
MIRT993598	hsa-miR-1293	CLIP-seq
MIRT993599	hsa-miR-2110	CLIP-seq
MIRT1994695	hsa-miR-2964a-3p	CLIP-seq
MIRT1994696	hsa-miR-302f	CLIP-seq
MIRT993610	hsa-miR-3173-3p	CLIP-seq
MIRT1994697	hsa-miR-3545-3p	CLIP-seq
MIRT1994698	hsa-miR-3664-3p	CLIP-seq
MIRT993621	hsa-miR-3975	CLIP-seq
MIRT993623	hsa-miR-4271	CLIP-seq
MIRT1994699	hsa-miR-4307	CLIP-seq
MIRT1994700	hsa-miR-4433	CLIP-seq
MIRT1994701	hsa-miR-4459	CLIP-seq
MIRT993634	hsa-miR-4483	CLIP-seq
MIRT993638	hsa-miR-4533	CLIP-seq
MIRT1994702	hsa-miR-4680-5p	CLIP-seq
MIRT993645	hsa-miR-4695-5p	CLIP-seq
MIRT1994703	hsa-miR-4722-5p	CLIP-seq
MIRT993647	hsa-miR-4725-3p	CLIP-seq
MIRT993652	hsa-miR-4747-5p	CLIP-seq
MIRT1994704	hsa-miR-4768-3p	CLIP-seq
MIRT993657	hsa-miR-491-5p	CLIP-seq
MIRT1994705	hsa-miR-510	CLIP-seq
MIRT1994706	hsa-miR-512-5p	CLIP-seq
MIRT993663	hsa-miR-544b	CLIP-seq
MIRT2228799	hsa-miR-1246	CLIP-seq
MIRT1994694	hsa-miR-1273e	CLIP-seq
MIRT2228800	hsa-miR-1290	CLIP-seq
MIRT2228801	hsa-miR-1292	CLIP-seq
MIRT2228802	hsa-miR-19a	CLIP-seq
MIRT2228803	hsa-miR-19b	CLIP-seq
MIRT993601	hsa-miR-2116	CLIP-seq
MIRT1994695	hsa-miR-2964a-3p	CLIP-seq
MIRT1994696	hsa-miR-302f	CLIP-seq
MIRT2228804	hsa-miR-31	CLIP-seq
MIRT2228805	hsa-miR-3135b	CLIP-seq
MIRT2228806	hsa-miR-3167	CLIP-seq
MIRT2228807	hsa-miR-3202	CLIP-seq
MIRT1994697	hsa-miR-3545-3p	CLIP-seq
MIRT2228808	hsa-miR-3646	CLIP-seq
MIRT2228809	hsa-miR-3652	CLIP-seq
MIRT2228810	hsa-miR-3662	CLIP-seq
MIRT1994698	hsa-miR-3664-3p	CLIP-seq
MIRT2228811	hsa-miR-3926	CLIP-seq
MIRT2228812	hsa-miR-3936	CLIP-seq
MIRT2228813	hsa-miR-3978	CLIP-seq
MIRT2228814	hsa-miR-4315	CLIP-seq
MIRT2228815	hsa-miR-4328	CLIP-seq
MIRT2228816	hsa-miR-4430	CLIP-seq
MIRT1994700	hsa-miR-4433	CLIP-seq
MIRT1994701	hsa-miR-4459	CLIP-seq
MIRT2228817	hsa-miR-4471	CLIP-seq
MIRT993633	hsa-miR-4474-3p	CLIP-seq
MIRT993638	hsa-miR-4533	CLIP-seq
MIRT2228818	hsa-miR-4646-5p	CLIP-seq
MIRT2228819	hsa-miR-4660	CLIP-seq
MIRT993642	hsa-miR-4677-5p	CLIP-seq
MIRT1994702	hsa-miR-4680-5p	CLIP-seq
MIRT993645	hsa-miR-4695-5p	CLIP-seq
MIRT2228820	hsa-miR-4698	CLIP-seq
MIRT1994703	hsa-miR-4722-5p	CLIP-seq
MIRT1994704	hsa-miR-4768-3p	CLIP-seq
MIRT993655	hsa-miR-4786-5p	CLIP-seq
MIRT2228821	hsa-miR-4790-5p	CLIP-seq
MIRT2228822	hsa-miR-493	CLIP-seq
MIRT1994705	hsa-miR-510	CLIP-seq
MIRT1994706	hsa-miR-512-5p	CLIP-seq
MIRT2228823	hsa-miR-548s	CLIP-seq
MIRT2228824	hsa-miR-583	CLIP-seq
MIRT993668	hsa-miR-663b	CLIP-seq
MIRT993671	hsa-miR-769-5p	CLIP-seq
MIRT993672	hsa-miR-876-3p	CLIP-seq
MIRT2228825	hsa-miR-876-5p	CLIP-seq
MIRT2228826	hsa-miR-885-3p	CLIP-seq
MIRT2228827	hsa-miR-891b	CLIP-seq
MIRT993606	hsa-miR-3140-3p	CLIP-seq
MIRT993591	hsa-miR-653	CLIP-seq
MIRT993593	hsa-miR-1207-3p	CLIP-seq
MIRT993598	hsa-miR-1293	CLIP-seq
MIRT993599	hsa-miR-2110	CLIP-seq
MIRT993610	hsa-miR-3173-3p	CLIP-seq
MIRT993621	hsa-miR-3975	CLIP-seq
MIRT993623	hsa-miR-4271	CLIP-seq
MIRT993634	hsa-miR-4483	CLIP-seq
MIRT993638	hsa-miR-4533	CLIP-seq
MIRT993645	hsa-miR-4695-5p	CLIP-seq
MIRT993647	hsa-miR-4725-3p	CLIP-seq
MIRT993652	hsa-miR-4747-5p	CLIP-seq
MIRT993657	hsa-miR-491-5p	CLIP-seq
MIRT993593	hsa-miR-1207-3p	CLIP-seq
MIRT993598	hsa-miR-1293	CLIP-seq
MIRT993599	hsa-miR-2110	CLIP-seq
MIRT993610	hsa-miR-3173-3p	CLIP-seq
MIRT993621	hsa-miR-3975	CLIP-seq
MIRT993623	hsa-miR-4271	CLIP-seq
MIRT993634	hsa-miR-4483	CLIP-seq
MIRT993638	hsa-miR-4533	CLIP-seq
MIRT993645	hsa-miR-4695-5p	CLIP-seq
MIRT993647	hsa-miR-4725-3p	CLIP-seq
MIRT993652	hsa-miR-4747-5p	CLIP-seq
MIRT993657	hsa-miR-491-5p	CLIP-seq
MIRT1994694	hsa-miR-1273e	CLIP-seq
MIRT1994695	hsa-miR-2964a-3p	CLIP-seq
MIRT1994696	hsa-miR-302f	CLIP-seq
MIRT2532375	hsa-miR-320e	CLIP-seq
MIRT1994697	hsa-miR-3545-3p	CLIP-seq
MIRT1994698	hsa-miR-3664-3p	CLIP-seq
MIRT993623	hsa-miR-4271	CLIP-seq
MIRT1994700	hsa-miR-4433	CLIP-seq
MIRT1994701	hsa-miR-4459	CLIP-seq
MIRT2532376	hsa-miR-4495	CLIP-seq
MIRT993640	hsa-miR-4662a-5p	CLIP-seq
MIRT993641	hsa-miR-4676-5p	CLIP-seq
MIRT1994702	hsa-miR-4680-5p	CLIP-seq
MIRT2532377	hsa-miR-4684-5p	CLIP-seq
MIRT993645	hsa-miR-4695-5p	CLIP-seq
MIRT1994703	hsa-miR-4722-5p	CLIP-seq
MIRT993647	hsa-miR-4725-3p	CLIP-seq
MIRT1994704	hsa-miR-4768-3p	CLIP-seq
MIRT2532378	hsa-miR-4794	CLIP-seq
MIRT1994705	hsa-miR-510	CLIP-seq
MIRT1994706	hsa-miR-512-5p	CLIP-seq
MIRT993664	hsa-miR-548c-3p	CLIP-seq
MIRT993666	hsa-miR-575	CLIP-seq
MIRT993596	hsa-miR-125a-5p	CLIP-seq
MIRT993597	hsa-miR-125b	CLIP-seq
MIRT1994694	hsa-miR-1273e	CLIP-seq
MIRT1994695	hsa-miR-2964a-3p	CLIP-seq
MIRT1994696	hsa-miR-302f	CLIP-seq
MIRT2532375	hsa-miR-320e	CLIP-seq
MIRT1994697	hsa-miR-3545-3p	CLIP-seq
MIRT1994698	hsa-miR-3664-3p	CLIP-seq
MIRT993627	hsa-miR-4319	CLIP-seq
MIRT1994700	hsa-miR-4433	CLIP-seq
MIRT1994701	hsa-miR-4459	CLIP-seq
MIRT2532376	hsa-miR-4495	CLIP-seq
MIRT993640	hsa-miR-4662a-5p	CLIP-seq
MIRT993641	hsa-miR-4676-5p	CLIP-seq
MIRT1994702	hsa-miR-4680-5p	CLIP-seq
MIRT2532377	hsa-miR-4684-5p	CLIP-seq
MIRT993645	hsa-miR-4695-5p	CLIP-seq
MIRT1994703	hsa-miR-4722-5p	CLIP-seq
MIRT993648	hsa-miR-4732-3p	CLIP-seq
MIRT1994704	hsa-miR-4768-3p	CLIP-seq
MIRT2532378	hsa-miR-4794	CLIP-seq
MIRT1994705	hsa-miR-510	CLIP-seq
MIRT1994706	hsa-miR-512-5p	CLIP-seq
MIRT993663	hsa-miR-544b	CLIP-seq
MIRT993664	hsa-miR-548c-3p	CLIP-seq
MIRT993666	hsa-miR-575	CLIP-seq
MIRT993669	hsa-miR-670	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15070733, 17314511, 18498745, 21572988, 24362026, 27705803, 33961781
GO:0005737	Component	Cytoplasm	IDA	17205132, 18498745
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA	21572988
GO:0005794	Component	Golgi apparatus	IEA
GO:0005814	Component	Centriole	IBA
GO:0005829	Component	Cytosol	IDA	18498745
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	17636018
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	18498745
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0007030	Process	Golgi organization	IGI	21572988
GO:0007030	Process	Golgi organization	ISS
GO:0008283	Process	Cell population proliferation	IDA	24362026
GO:0008286	Process	Insulin receptor signaling pathway	IDA	38056462
GO:0016567	Process	Protein ubiquitination	IBA
GO:0016567	Process	Protein ubiquitination	IDA	24362026
GO:0016567	Process	Protein ubiquitination	IEA
GO:0019005	Component	SCF ubiquitin ligase complex	IEA
GO:0031467	Component	Cul7-RING ubiquitin ligase complex	IBA
GO:0031467	Component	Cul7-RING ubiquitin ligase complex	IDA	17205132, 18498745, 21572988, 24362026
GO:0031467	Component	Cul7-RING ubiquitin ligase complex	IEA
GO:0032436	Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA
GO:0036064	Component	Ciliary basal body	IBA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	17205132
GO:0045727	Process	Positive regulation of translation	IMP	28106072
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IDA	18498745
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IDA	18498745
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	21572988
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050775	Process	Positive regulation of dendrite morphogenesis	IDA	21572988
GO:0050775	Process	Positive regulation of dendrite morphogenesis	ISS
GO:0060271	Process	Cilium assembly	IBA
GO:0060716	Process	Labyrinthine layer blood vessel development	IEA
GO:1990393	Component	3M complex	IDA	24793695
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IDA	17205132, 18498745, 24362026
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IEA
GO:2000059	Process	Negative regulation of ubiquitin-dependent protein catabolic process	IDA	39032648

Other IDs

• MIM: 609073
• HGNC: 13597
• e!Ensembl: ENSG00000174989

Protein

• UniProt ID: Q8N3Y1
• Protein name: F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)
• Protein function: Substrate-recognition component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17205132, PubMed:18498745, PubMed:21572988, PubMed:24362026, Pu
• PDB: 7Z8B
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00646	F-box	117 → 161	F-box domain	Domain

• Sequence:

  MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPEVGSGRGEQASGDPALAQRLL
  EGAGRPPAARATRAEGQDVASRSRSPLAREGAGGGEQLVDQLIRDLNEMNDVPFFDIQLP
  YELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLI
  FQECRAKEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTW
  DYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDA
  RIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVA
  VAAAGDLMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLE
  AGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSA
  VQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRN
  ADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV

• Sequence length: 598

Pathways

KEGG:

Ubiquitin mediated proteolysis

Reactome:

Neddylation
Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Cervical cancer	Benign	rs147289806	RCV005910454
Familial cancer of breast	Benign	rs147289806	RCV005910453
Lung cancer	Uncertain significance	rs139880165	RCV005926933
Sarcoma	Uncertain significance	rs139880165	RCV005926931
Thyroid cancer, nonmedullary, 1	Uncertain significance; Benign	rs139880165, rs147289806	RCV005926932 RCV005910455
Uveal melanoma	Uncertain significance	rs139880165	RCV005926930

Associations from Text Mining
Disease Name	Relationship Type	References
Cognition Disorders	Associate	22504421
Dementia	Associate	22504421
Pancreatic Neoplasms	Associate	24362026