Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	26206
Gene name Gene Name - the full gene name approved by the HGNC.	Sperm associated antigen 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SPAG8
Synonyms (NCBI Gene) Gene synonyms aliases	BS-84, CILD28, CT142, HSD-1, SMP1, SPAG3, hSMP-1
Disease Acronyms (UniProt) Disease acronyms from UniProt database	CILD28
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targete

Show/Hide all(18)

miRTarBase ID	miRNA	Experiments
MIRT1381748	hsa-miR-1208	CLIP-seq
MIRT1381749	hsa-miR-3607-3p	CLIP-seq
MIRT1381750	hsa-miR-3686	CLIP-seq
MIRT1381751	hsa-miR-4420	CLIP-seq
MIRT1381752	hsa-miR-4426	CLIP-seq
MIRT1381753	hsa-miR-4647	CLIP-seq
MIRT1381754	hsa-miR-4662b	CLIP-seq
MIRT1381755	hsa-miR-548ac	CLIP-seq
MIRT1381756	hsa-miR-548ae	CLIP-seq
MIRT1381757	hsa-miR-548aj	CLIP-seq
MIRT1381758	hsa-miR-548am	CLIP-seq
MIRT1381759	hsa-miR-548d-3p	CLIP-seq
MIRT1381760	hsa-miR-548x	CLIP-seq
MIRT1381761	hsa-miR-548z	CLIP-seq
MIRT1381762	hsa-miR-892a	CLIP-seq
MIRT1557086	hsa-miR-2861	CLIP-seq
MIRT1381751	hsa-miR-4420	CLIP-seq
MIRT2114211	hsa-miR-587	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005819	Component	Spindle	IEA
GO:0007049	Process	Cell cycle	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007338	Process	Single fertilization	IEA
GO:0008017	Function	Microtubule binding	IEA
GO:0008150	Process	Biological_process	ND
GO:0016020	Component	Membrane	NAS	8788182
GO:0030154	Process	Cell differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635

MIM	HGNC	e!Ensembl
605731	14105	ENSG00000137098

Protein

UniProt ID

Q99932

Protein name

Sperm-associated antigen 8 (HSD-1) (Sperm membrane protein 1) (SMP-1) (Sperm membrane protein BS-84)

Protein function

Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau

PDB

7UNG , 8J07

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed in testis (germ cells), but not in liver, kidney, prostate and small intestine. Expressed in airway epithelial cells (PubMed:36191189). {ECO:0000269|PubMed:36191189, ECO:0000269|PubMed:8788182}.

Sequence

METNESTEGSRSRSRSLDIQPSSEGLGPTSEPFPSSDDSPRSALAAATAAAAAAASAAAA
TAAFTTAKAAALSTKTPAPCSEFMEPSSDPSLLGEPCAGPGFTHNIAHGSLGFEPVYVSC
IAQDTCTTTDHSSNPGPVPGSSSGPVLGSSSGAGHGSGSGSGPGCGSVPGSGSGPGPGSG
PGSGPGHGSGSHPGPASGPGPDTGPDSELSPCIPPGFRNLVADRVPNYTSWSQHCPWEPQ
KQPPWEFLQVLEPGARGLWKPPDIKGKLMVCYETLPRGQCLLYNWEEERATNHLDQVPSM
QDGSESFFFRHGHRGLLTMQLKSPMPSSTTQKDSYQPPGNVYWPLRGKREAMLEMLLQHQ
ICKEVQAEQEPTRKLFEVESVTHHDYRMELAQAGTPAPTKPHDYRQEQPETFWIQRAPQL
PGVSNIRTLDTPFRKNCSFSTPVPLSLGKLLPYEPENYPYQLGEISSLPCPGGRLGGGGG
RMTPF

Sequence length

485

Interactions

View interactions

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Acromesomelic dysplasia	ACROMESOMELIC DYSPLASIA, MAROTEAUX TYPE	rs863223287, rs28936683, rs121909350, rs121909351, rs28931582, rs28929479, rs121912739, rs879255257, rs863225041, rs863225042, rs745854387, rs1057519324, rs1057519335, rs1057519334, rs1057519333 View all (12 more)	15146390
Epilepsy	EPILEPSY, FAMILIAL FOCAL, WITH VARIABLE FOCI 2	rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670 View all (165 more)

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.		GWAS, CBGDA

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Frontotemporal Dementia	Associate	22343411
Neoplasms	Associate	28797028

SPAG8 (sperm associated antigen 8)