Gene Gene information from NCBI Gene database.
Entrez ID 2619
Gene name Growth arrest specific 1
Gene symbol GAS1
Synonyms (NCBI Gene)
-
Chromosome 9
Chromosome location 9q21.33
Summary Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
518
miRTarBase ID miRNA Experiments Reference
MIRT020112 hsa-miR-130b-3p Sequencing 20371350
MIRT025001 hsa-miR-183-5p Sequencing 20371350
MIRT025257 hsa-miR-34a-5p Sequencing 20371350
MIRT025983 hsa-miR-148a-3p Sequencing 20371350
MIRT025257 hsa-miR-34a-5p Luciferase reporter assayqRT-PCRWestern blot 24220341
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21357679
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IDA 8127893
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
139185 4165 ENSG00000180447
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P54826
Protein name Growth arrest-specific protein 1 (GAS-1)
Protein function Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). {ECO:0000250|UniProtKB:Q01721, ECO:0000269|PubM
PDB 7RHQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02351 GDNF 166 243 GDNF/GAS1 domain Domain
Sequence
MVAALLGGGGEARGGTVPGAWLCLMALLQLLGSAPRGSGLAHGRRLICWQALLQCQGEPE
CSYAYNQYAEACAPVLAQHGGGDAPGAAAAAFPASAASFSSRWRCPSHCISALIQLNHTR
RGPALEDCDCAQDENCKSTKRAIEPCLPRTSGGGAGGPGAGGVMGCTEARRRCDRDSRCN
LALSRYLTYCGKVFNGLRCTDECRTVIEDMLAMPKAALLNDCVCDGLERPICESVKENMA
RLC
FGAELGNGPGSSGSDGGLDDYYDEDYDDEQRTGGAGGEQPLDDDDGVPHPPRPGSGA
AASGGRGDLPYGPGRRSSGGGGRLAPRGAWTPLASILLLLLGPLF
Sequence length 345
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Hedgehog signaling pathway   Ligand-receptor interactions
Activation of SMO
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
9
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
GAS1-related disorder Uncertain significance; Likely benign rs1265547559, rs373433865, rs757870606, rs1156483505, rs2489905633, rs917196227, rs201726102 RCV003402420
RCV003919334
RCV004753714
RCV003974404
RCV003899876
RCV003967157
RCV003925839
Holoprosencephaly 1 Uncertain significance rs387907165, rs387907166 RCV000024280
RCV000024281
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Cap Myopathy Associate 18974881
Carcinoma Basal Cell Associate 31988301
Carcinoma Hepatocellular Associate 39174588
Carcinoma Intraductal Noninfiltrating Associate 32050925
Carcinoma Papillary Inhibit 15619007
Colorectal Neoplasms Associate 33397428
Drug Related Side Effects and Adverse Reactions Associate 26215053
Esophageal Neoplasms Associate 34716287
Glioblastoma Stimulate 37609818
Glioma Stimulate 37609818