Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	26173
Gene name Gene Name - the full gene name approved by the HGNC.	Integrator complex subunit 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	INTS1
Synonyms (NCBI Gene) Gene synonyms aliases	INT1, NDCAGF, NET28
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7p22.3
Summary Summary of gene provided in NCBI Entrez Gene.	INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Ba

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SNP ID	Visualize variation	Clinical significance	Consequence
rs200649090	G>A	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs770569947	T>G	Likely-pathogenic	Splice acceptor variant
rs1030646527	T>A,C	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs1162809128	G>A	Pathogenic	Coding sequence variant, missense variant, genic downstream transcript variant
rs1284335313	G>A	Pathogenic	Genic downstream transcript variant, stop gained, coding sequence variant
rs1286686353	G>T	Pathogenic	Genic downstream transcript variant, non coding transcript variant, stop gained, coding sequence variant
rs1357982637	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant, non coding transcript variant
rs1562487424	->G	Pathogenic	Genic downstream transcript variant, coding sequence variant, non coding transcript variant, frameshift variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT052201	hsa-let-7b-5p	CLASH	23622248
MIRT039713	hsa-miR-615-3p	CLASH	23622248
MIRT039713	hsa-miR-615-3p	CLASH	23622248
MIRT039214	hsa-miR-769-5p	CLASH	23622248
MIRT039110	hsa-miR-769-3p	CLASH	23622248
MIRT037241	hsa-miR-877-5p	CLASH	23622248
MIRT440446	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440446	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1067906	hsa-miR-3191	CLIP-seq
MIRT1067907	hsa-miR-3917	CLIP-seq
MIRT1067908	hsa-miR-4532	CLIP-seq
MIRT1067909	hsa-miR-4707-5p	CLIP-seq
MIRT1067910	hsa-miR-634	CLIP-seq
MIRT1067907	hsa-miR-3917	CLIP-seq
MIRT1067910	hsa-miR-634	CLIP-seq
MIRT2451891	hsa-miR-1203	CLIP-seq
MIRT2451892	hsa-miR-1538	CLIP-seq
MIRT2451893	hsa-miR-1915	CLIP-seq
MIRT2451894	hsa-miR-4685-5p	CLIP-seq
MIRT2451895	hsa-miR-4745-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001832	Process	Blastocyst growth	IEA
GO:0001833	Process	Inner cell mass cell proliferation	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005634	Component	Nucleus	IDA	29471365, 39032490
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	32647223
GO:0005654	Component	Nucleoplasm	TAS
GO:0007566	Process	Embryo implantation	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016180	Process	SnRNA processing	IDA	16239144
GO:0016180	Process	SnRNA processing	NAS	16239144
GO:0031965	Component	Nuclear membrane	IEA
GO:0032039	Component	Integrator complex	IBA
GO:0032039	Component	Integrator complex	IDA	16239144, 29471365, 36920904, 39032490
GO:0032039	Component	Integrator complex	IEA
GO:0032039	Component	Integrator complex	NAS	33548203
GO:0034243	Process	Regulation of transcription elongation by RNA polymerase II	NAS	32697989
GO:0034474	Process	U2 snRNA 3'-end processing	IBA
GO:0034474	Process	U2 snRNA 3'-end processing	IEA
GO:0034474	Process	U2 snRNA 3'-end processing	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0160232	Component	INTAC complex	IDA	33243860, 34004147, 34762484, 36869814, 38570683
GO:0160240	Process	RNA polymerase II transcription initiation surveillance	IDA	33243860, 34004147, 38570683

MIM	HGNC	e!Ensembl
611345	24555	ENSG00000164880

Protein

UniProt ID

Q8N201

Protein name

Integrator complex subunit 1 (Int1)

Protein function

Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a

PDB

7CUN , 7PKS , 7YCX , 8RBX , 8RBZ , 8RC4 , 8YJB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12432	DUF3677	350 → 430	Protein of unknown function (DUF3677)	Family

Sequence

MNRAKPTTVRRPSAAAKPSGHPPPGDFIALGSKGQANESKTASTLLKPAPSGLPSERKRD
AAAALSSASALTGLTKRPKLSSTPPLSALGRLAEAAVAEKRAISPSIKEPSVVPIEVLPT
VLLDEIEAAELEGNDDRIEGVLCGAVKQLKVTRAKPDSTLYLSLMYLAKIKPNIFATEGV
IEALCSLLRRDASINFKAKGNSLVSVLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIW
VDSPHCKTFVDNIQTAFNTRMPPRSVLLQGEAGRVAGDLGAGSSPHPSLTEEEDSQTELL
IAEEKLSPEQEGQLMPRYEELAESVEEYVLDMLRDQLNRRQPIDNVSRNLLRLLTSTCGY
KEVRLLAVQKLEMWLQNPKLTRPAQDLLMSVCMNCNTHGSEDMDVISHLIKIRLKPKVLL
NHFMLCIRELLSAHKDNLGTTIKLVIFNELSSARNPNNMQVLYTALQHSSELAPKFLAMV
FQDLLTNKDDYLRASRALLREIIKQTKHEINFQAFCLGLMQERKEPQYLEMEFKERFVVH
ITDVLAVSMMLGITAQVKEAGIAWDKGEKRNLEVLRSFQNQIAAIQRDAVWWLHTVVPSI
SKLAPKDYVHCLHKVLFTEQPETYYKWDNWPPESDRNFFLRLCSEVPILEDTLMRILVIG
LSRELPLGPADAMELADHLVKRAAAVQADDVEVLKVGRTQLIDAVLNLCTYHHPENIQLP
PGYQPPNLAISTLYWKAWPLLLVVAAFNPENIGLAAWEEYPTLKMLMEMVMTNNYSYPPC
TLTDEETRTEMLNRELQTAQREKQEILAFEGHLAAASTKQTITESSSLLLSQLTSLDPQG
PPRRPPPHILDQVKSLNQSLRLGHLLCRSRNPDFLLHIIQRQASSQSMPWLADLVQSSEG
SLDVLPVQCLCEFLLHDAVDDAASGEEDDEGESKEQKAKKRQRQQKQRQLLGRLQDLLLG
PKADEQTTCEVLDYFLRRLGSSQVASRVLAMKGLSLVLSEGSLRDGEEKEPPMEEDVGDT
DVLQGYQWLLRDLPRLPLFDSVRSTTALALQQAIHMETDPQTISAYLIYLSQHTPVEEQA
QHSDLALDVARLVVERSTIMSHLFSKLSPSAASDAVLSALLSIFSRYVRRMRQSKEGEEV
YSWSESQDQVFLRWSSGETATMHILVVHAMVILLTLGPPRADDSEFQALLDIWFPEEKPL
PTAFLVDTSEEALLLPDWLKLRMIRSEVLRLVDAALQDLEPQQLLLFVQSFGIPVSSMSK
LLQFLDQAVAHDPQTLEQNIMDKNYMAHLVEVQHERGASGGQTFHSLLTASLPPRRDSTE
APKPKSSPEQPIGQGRIRVGTQLRVLGPEDDLAGMFLQIFPLSPDPRWQSSSPRPVALAL
QQALGQELARVVQGSPEVPGITVRVLQALATLLSSPHGGALVMSMHRSHFLACPLLRQLC
QYQRCVPQDTGFSSLFLKVLLQMLQWLDSPGVEGGPLRAQLRMLASQASAGRRLSDVRGG
LLRLAEALAFRQDLEVVSSTVRAVIATLRSGEQCSVEPDLISKVLQGLIEVRSPHLEELL
TAFFSATADAASPFPACKPVVVVSSLLLQEEEPLAGGKPGADGGSLEAVRLGPSSGLLVD
WLEMLDPEVVSSCPDLQLRLLFSRRKGKGQAQVPSFRPYLLTLFTHQSSWPTLHQCIRVL
LGKSREQRFDPSASLDFLWACIHVPRIWQGRDQRTPQKRREELVLRVQGPELISLVELIL
AEAETRSQDGDTAACSLIQARLPLLLSCCCGDDESVRKVTEHLSGCIQQWGDSVLGRRCR
DLLLQLYLQRPELRVPVPEVLLHSEGAASSSVCKLDGLIHRFITLLADTSDSRALENRGA
DASMACRKLAVAHPLLLLRHLPMIAALLHGRTHLNFQEFRQQNHLSCFLHVLGLLELLQP
HVFRSEHQGALWDCLLSFIRLLLNYRKSSRHLAAFINKFVQFIHKYITYNAPAAISFLQK
HADPLHDLSFDNSDLVMLKSLLAGLSLPSRDDRTDRGLDEEGEEESSAGSLPLVSVSLFT
PLTAAEMAPYMKRLSRGQTVEDLLEVLSDIDEMSRRRPEILSFFSTNLQRLMSSAEECCR
NLAFSLALRSMQNSPSIAAAFLPTFMYCLGSQDFEVVQTALRNLPEYALLCQEHAAVLLH
RAFLVGMYGQMDPSAQISEALRILHMEAVM

Sequence length

2190

Interactions

View interactions

	Reactome
			RNA polymerase II transcribes snRNA genes

INTS1 (integrator complex subunit 1)