Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	26149
Gene name	Zinc finger protein 658
Gene symbol	ZNF658
Synonyms (NCBI Gene)	-
Chromosome	9
Chromosome location	9q21.11

Show/Hide all (22)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023238	hsa-miR-122-5p	Microarray	17612493
MIRT1534068	hsa-miR-219-2-3p	CLIP-seq
MIRT1534069	hsa-miR-2964a-3p	CLIP-seq
MIRT1534070	hsa-miR-3130-3p	CLIP-seq
MIRT1534071	hsa-miR-3661	CLIP-seq
MIRT1534072	hsa-miR-375	CLIP-seq
MIRT1534073	hsa-miR-4717-3p	CLIP-seq
MIRT1534074	hsa-miR-4793-3p	CLIP-seq
MIRT1534075	hsa-miR-544	CLIP-seq
MIRT1534076	hsa-miR-619	CLIP-seq
MIRT1534077	hsa-miR-631	CLIP-seq
MIRT2161536	hsa-miR-3920	CLIP-seq
MIRT2161537	hsa-miR-4263	CLIP-seq
MIRT2161538	hsa-miR-4502	CLIP-seq
MIRT2161539	hsa-miR-4799-5p	CLIP-seq
MIRT2161540	hsa-miR-548a-3p	CLIP-seq
MIRT2161541	hsa-miR-548e	CLIP-seq
MIRT2161542	hsa-miR-548f	CLIP-seq
MIRT2161543	hsa-miR-576-5p	CLIP-seq
MIRT2380376	hsa-miR-2052	CLIP-seq
MIRT2380377	hsa-miR-4700-3p	CLIP-seq
MIRT2380378	hsa-miR-711	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	25582195
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042254	Process	Ribosome biogenesis	IMP	25582195
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	25582195
GO:0046872	Function	Metal ion binding	IEA
GO:0071294	Process	Cellular response to zinc ion	IMP	25582195
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IEA

MIM	HGNC	e!Ensembl
616290	25226	ENSG00000274349

Q5TYW1

Protein name

Zinc finger protein 658

Protein function

Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5'-C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3') found in

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	7 → 48	KRAB box	Family
PF00096	zf-C2H2	440 → 462	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	518 → 540	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	546 → 568	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	574 → 596	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	602 → 624	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	630 → 652	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	658 → 680	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	686 → 708	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	714 → 736	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	742 → 764	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	770 → 792	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	798 → 820	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	826 → 848	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	854 → 876	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	882 → 903	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	910 → 932	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	938 → 960	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	966 → 988	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	994 → 1016	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	1022 → 1045	Zinc finger, C2H2 type	Domain

Sequence

MNMSQASVSFQDVTVEFTREEWQHLGPVERTLYRDVMLENYSHLISVGYCITKPKVISKL
EKGEEPWSLEDEFLNQRYPGYFKVDHIKGIREKQEKPLWQEIFISDADKTLSKEGQKVLE
KPFNLEIAPELSEKISCKCDSHRMNLPVASQLIISERKYSRKKTEYMNVCEKLQLDIKHE
KAHAEEKSYEHGENAKAFSYKKDQHWKFQTLEESFECDGSGQGLYDKTICITPQSFLTGE
KSCKDDEFRKNFDKITLFNHMRTDTRGKCSDLNEYGTSCDKTTAVEYNKVHMAMTHYECN
ERGINFSRKSPLTQSQRTITGWSAFESNKCEENFSQSSAHIVHQKTQAGDKFGEHNECTD
ALYQKLDFTAHQRIHTEDKFYLSDEHGKCRKSFYRKAHLIQHQRPHSGEKTYQYEECAKS
FCSSSHPIQHPGTYVGFKLYECNECGKAFCQNSNLSKHLRIHTKEKPCDNNGCGRSYKSP
LIGHQKTDAEMELCGGSEYGKTSHLKGHQRILMGEKPYECIECGKTFSKTSHLRAHQRIH
TGEKPYECVECEKTFSHKTHLSVHQRVHTGEKPYECNDCGKSFTYNSALRAHQRIHTGEK
PYECSDCEKTFAHNSALRAHHRIHTGEKPYECNECGRSFAHISVLKAHQRIHTGEKPYEC
NECGRSFTYNSALRAHQRIHTGRKPYECSDCEKTFAHNSALKIHQRIHTGEKPYECNECE
KTFAHNSALRAHQNIHTGEKLYECSECGKTFFQKTRLSTHRRIHTGEKPYECSKCGKTFS
QKSYLSGHERIHTGEKPYECNVCGKTFVYKAALIVHQRIHTGEKPYECNQCGKTFSQRTH
LCAHQRIHTGEKPYECNECGKTFADNSALRAHHRIHTGEKPYECNDCGKTFSKTSHLRAH
LRTRSGEKPYECSECGKTFSEKSYVSAHQRVHTGEKPYECNVCGKPFAHNSTLRVHQRIH
TGEKSYECNDCGKTFSQKSHLSAHQRIHTGEKPYECNECGKAFAQNSTLRVHQRIHTGEK
PYECDECGKTFVRKAALRVHHTRMHTREKTLACNGFGKS

Sequence length

1059

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

ZNF658 (zinc finger protein 658)