Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
26147
Gene name Gene Name - the full gene name approved by the HGNC.
PHD finger protein 19
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PHF19
Synonyms (NCBI Gene) Gene synonyms aliases
MTF2L1, PCL3, TDRD19B
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q33.2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002687 hsa-miR-124-3p Microarray 15685193
MIRT016585 hsa-miR-193b-3p Microarray 20304954
MIRT002687 hsa-miR-124-3p Microarray 15685193
MIRT002687 hsa-miR-124-3p Microarray 18668037
MIRT025582 hsa-miR-34a-5p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0003677 Function DNA binding IBA
GO:0003682 Function Chromatin binding IBA
GO:0005515 Function Protein binding IPI 23104054, 23160351, 23455924, 32296183, 32814053
GO:0005634 Component Nucleus IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609740 24566 ENSG00000119403
Protein
UniProt ID Q5T6S3
Protein name PHD finger protein 19 (Polycomb-like protein 3) (hPCL3)
Protein function Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:15563832, PubMed:18691976, PubMed:23104054, PubMed:2316
PDB 2E5Q , 4BD3 , 6NQ3 , 6WAU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18104 Tudor_2 43 78 Jumonji domain-containing protein 2A Tudor domain Domain
PF00628 PHD 98 151 PHD-finger Domain
PF14061 Mtf2_C 531 578 Polycomb-like MTF2 factor 2 Domain
Tissue specificity TISSUE SPECIFICITY: Isoform 1 is expressed in thymus, heart, lung and kidney. Isoform 2 is predominantly expressed in placenta, skeletal muscle and kidney, whereas isoform 1 is predominantly expressed in liver and peripheral blood leukocytes. Overexpresse
Sequence
MENRALDPGTRDSYGATSHLPNKGALAKVKNNFKDLMSKLTEGQYVLCRWTDGLYYLGKI
KRVSSSKQSCLVTFEDNS
KYWVLWKDIQHAGVPGEEPKCNICLGKTSGPLNEILICGKCG
LGYHQQCHIPIAGSADQPLLTPWFCRRCIFA
LAVRKGGALKKGAIARTLQAVKMVLSYQP
EELEWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEACTQCLNEPMMFGDRFYL
FFCSVCNQGPEYIERLPLRWVDVVHLALYNLGVQSKKKYFDFEEILAFVNHHWELLQLGK
LTSTPVTDRGPHLLNALNSYKSRFLCGKEIKKKKCIFRLRIRVPPNPPGKLLPDKGLLPN
ENSASSELRKRGKSKPGLLPHEFQQQKRRVYRRKRSKFLLEDAIPSSDFTSAWSTNHHLA
SIFDFTLDEIQSLKSASSGQTFFSDVDSTDAASTSGSASTSLSYDSRWTVGSRKRKLAAK
AYMPLRAKRWAAELDGRCPSDSSAEGASVPERPDEGIDSHTFESISEDDSSLSHLKSSIT
NYFGAAGRLACGEKYQVLARRVTPEGKVQYLVEWEGTT
PY
Sequence length 580
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Polycomb repressive complex   PRC2 methylates histones and DNA
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Dermatitis Atopic dermatitis N/A N/A GWAS
Eczema Eczema N/A N/A GWAS
Rheumatoid arthritis Rheumatoid arthritis N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 18648537, 19714643, 34910834
Astrocytoma Associate 24260522
Carcinogenesis Stimulate 33894670
Carcinoma Hepatocellular Associate 35069553
Glioblastoma Associate 24260522
Meningioma Associate 32949309
Multiple Myeloma Associate 32060406, 33894670
Multiple Myeloma Stimulate 34390275
Neoplasm Metastasis Inhibit 32155117
Neoplasms Inhibit 32149111