Gene Gene information from NCBI Gene database.
Entrez ID 26135
Gene name SERPINE1 mRNA binding protein 1
Gene symbol SERBP1
Synonyms (NCBI Gene)
CGI-55CHD3IPHABP4LHero45PAI-RBP1PAIRBP1
Chromosome 1
Chromosome location 1p31.3
miRNA miRNA information provided by mirtarbase database.
1440
miRTarBase ID miRNA Experiments Reference
MIRT002315 hsa-miR-26a-5p ImmunoprecipitaionLuciferase reporter assayWestern blot 17637574
MIRT025598 hsa-miR-10a-5p Sequencing 20371350
MIRT002315 hsa-miR-26a-5p Other 19011087
MIRT031433 hsa-miR-16-5p Proteomics 18668040
MIRT052014 hsa-let-7b-5p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
SOX17 Repression 24407731
USF1 Activation 18234320
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding EXP 34631798
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IEA
GO:0003730 Function MRNA 3'-UTR binding IBA
GO:0003730 Function MRNA 3'-UTR binding IDA 11001948
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607378 17860 ENSG00000142864
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NC51
Protein name SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein)
Protein function Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, seque
PDB 4V6X , 6Z6M , 6Z6N , 8K2C , 8UKB , 8XSX , 8XSY , 8XSZ , 8Y0W , 8Y0X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16174 IHABP4_N 5 152 Intracellular hyaluronan-binding protein 4 N-terminal Family
PF04774 HABP4_PAI-RBP1 189 313 Hyaluronan / mRNA binding family Family
Tissue specificity TISSUE SPECIFICITY: Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain. {ECO:0000269|PubMed:12505151}.
Sequence
Sequence length 408
Interactions View interactions