Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
26135
Gene name Gene Name - the full gene name approved by the HGNC.
SERPINE1 mRNA binding protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SERBP1
Synonyms (NCBI Gene) Gene synonyms aliases
CGI-55, CHD3IP, HABP4L, Hero45, PAI-RBP1, PAIRBP1
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p31.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002315 hsa-miR-26a-5p Immunoprecipitaion, Luciferase reporter assay, Western blot 17637574
MIRT025598 hsa-miR-10a-5p Sequencing 20371350
MIRT002315 hsa-miR-26a-5p Other 19011087
MIRT031433 hsa-miR-16-5p Proteomics 18668040
MIRT052014 hsa-let-7b-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
SOX17 Repression 24407731
USF1 Activation 18234320
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IBA 21873635
GO:0003730 Function MRNA 3'-UTR binding IBA 21873635
GO:0003730 Function MRNA 3'-UTR binding IDA 11001948
GO:0005515 Function Protein binding IPI 12505151, 16879614, 24965446, 32296183, 32814053
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607378 17860 ENSG00000142864
Protein
UniProt ID Q8NC51
Protein name SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein)
Protein function Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, seque
PDB 4V6X , 6Z6M , 6Z6N , 8K2C , 8UKB , 8XSX , 8XSY , 8XSZ , 8Y0W , 8Y0X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16174 IHABP4_N 5 152 Intracellular hyaluronan-binding protein 4 N-terminal Family
PF04774 HABP4_PAI-RBP1 189 313 Hyaluronan / mRNA binding family Family
Tissue specificity TISSUE SPECIFICITY: Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain. {ECO:0000269|PubMed:12505151}.
Sequence
Sequence length 408
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
21364753
Unknown
Disease term Disease name Evidence References Source
Inflammatory Bowel Disease Inflammatory Bowel Disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Astrocytoma Associate 23737970
Breast Neoplasms Associate 23236990
Calcinosis Cutis Stimulate 34436734
Carcinogenesis Associate 36213507
Carcinoma Hepatocellular Associate 28369267
Cerebral Infarction Associate 37240062
Glioblastoma Associate 23737970
Glioblastoma Stimulate 34436734
Glioma Associate 27340667
Leukemia Stimulate 34436734