Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	26094
Gene name	DDB1 and CUL4 associated factor 4
Gene symbol	DCAF4
Synonyms (NCBI Gene)	WDR21WDR21A
Chromosome	14
Chromosome location	14q24.2
Summary	This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

166

Show/Hide all (166)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030411	hsa-miR-24-3p	Microarray	19748357
MIRT445126	hsa-miR-18a-5p	PAR-CLIP	22100165
MIRT445125	hsa-miR-18b-5p	PAR-CLIP	22100165
MIRT445124	hsa-miR-4735-3p	PAR-CLIP	22100165
MIRT445123	hsa-miR-181a-5p	PAR-CLIP	22100165
MIRT445122	hsa-miR-181b-5p	PAR-CLIP	22100165
MIRT445121	hsa-miR-181c-5p	PAR-CLIP	22100165
MIRT445120	hsa-miR-181d-5p	PAR-CLIP	22100165
MIRT445119	hsa-miR-4262	PAR-CLIP	22100165
MIRT445118	hsa-miR-875-3p	PAR-CLIP	22100165
MIRT445117	hsa-miR-6128	PAR-CLIP	22100165
MIRT445116	hsa-miR-4533	PAR-CLIP	22100165
MIRT445115	hsa-miR-3202	PAR-CLIP	22100165
MIRT445114	hsa-miR-636	PAR-CLIP	22100165
MIRT445113	hsa-miR-1299	PAR-CLIP	22100165
MIRT445112	hsa-miR-516b-5p	PAR-CLIP	22100165
MIRT445111	hsa-miR-4782-5p	PAR-CLIP	22100165
MIRT445109	hsa-miR-5706	PAR-CLIP	22100165
MIRT445110	hsa-miR-1273e	PAR-CLIP	22100165
MIRT445126	hsa-miR-18a-5p	PAR-CLIP	22100165
MIRT445125	hsa-miR-18b-5p	PAR-CLIP	22100165
MIRT445124	hsa-miR-4735-3p	PAR-CLIP	22100165
MIRT445123	hsa-miR-181a-5p	PAR-CLIP	22100165
MIRT445122	hsa-miR-181b-5p	PAR-CLIP	22100165
MIRT445121	hsa-miR-181c-5p	PAR-CLIP	22100165
MIRT445120	hsa-miR-181d-5p	PAR-CLIP	22100165
MIRT445119	hsa-miR-4262	PAR-CLIP	22100165
MIRT445118	hsa-miR-875-3p	PAR-CLIP	22100165
MIRT445117	hsa-miR-6128	PAR-CLIP	22100165
MIRT445116	hsa-miR-4533	PAR-CLIP	22100165
MIRT445115	hsa-miR-3202	PAR-CLIP	22100165
MIRT445114	hsa-miR-636	PAR-CLIP	22100165
MIRT445113	hsa-miR-1299	PAR-CLIP	22100165
MIRT445112	hsa-miR-516b-5p	PAR-CLIP	22100165
MIRT445111	hsa-miR-4782-5p	PAR-CLIP	22100165
MIRT445109	hsa-miR-5706	PAR-CLIP	22100165
MIRT445110	hsa-miR-1273e	PAR-CLIP	22100165
MIRT445126	hsa-miR-18a-5p	PAR-CLIP	22100165
MIRT445125	hsa-miR-18b-5p	PAR-CLIP	22100165
MIRT445124	hsa-miR-4735-3p	PAR-CLIP	22100165
MIRT445123	hsa-miR-181a-5p	PAR-CLIP	22100165
MIRT445122	hsa-miR-181b-5p	PAR-CLIP	22100165
MIRT445121	hsa-miR-181c-5p	PAR-CLIP	22100165
MIRT445120	hsa-miR-181d-5p	PAR-CLIP	22100165
MIRT445119	hsa-miR-4262	PAR-CLIP	22100165
MIRT445118	hsa-miR-875-3p	PAR-CLIP	22100165
MIRT445117	hsa-miR-6128	PAR-CLIP	22100165
MIRT445116	hsa-miR-4533	PAR-CLIP	22100165
MIRT445115	hsa-miR-3202	PAR-CLIP	22100165
MIRT445114	hsa-miR-636	PAR-CLIP	22100165
MIRT445113	hsa-miR-1299	PAR-CLIP	22100165
MIRT445112	hsa-miR-516b-5p	PAR-CLIP	22100165
MIRT445111	hsa-miR-4782-5p	PAR-CLIP	22100165
MIRT445109	hsa-miR-5706	PAR-CLIP	22100165
MIRT445110	hsa-miR-1273e	PAR-CLIP	22100165
MIRT445126	hsa-miR-18a-5p	PAR-CLIP	22100165
MIRT445125	hsa-miR-18b-5p	PAR-CLIP	22100165
MIRT445124	hsa-miR-4735-3p	PAR-CLIP	22100165
MIRT445123	hsa-miR-181a-5p	PAR-CLIP	22100165
MIRT445122	hsa-miR-181b-5p	PAR-CLIP	22100165
MIRT445121	hsa-miR-181c-5p	PAR-CLIP	22100165
MIRT445120	hsa-miR-181d-5p	PAR-CLIP	22100165
MIRT445119	hsa-miR-4262	PAR-CLIP	22100165
MIRT445118	hsa-miR-875-3p	PAR-CLIP	22100165
MIRT445117	hsa-miR-6128	PAR-CLIP	22100165
MIRT445116	hsa-miR-4533	PAR-CLIP	22100165
MIRT445115	hsa-miR-3202	PAR-CLIP	22100165
MIRT445114	hsa-miR-636	PAR-CLIP	22100165
MIRT445113	hsa-miR-1299	PAR-CLIP	22100165
MIRT445112	hsa-miR-516b-5p	PAR-CLIP	22100165
MIRT445111	hsa-miR-4782-5p	PAR-CLIP	22100165
MIRT445109	hsa-miR-5706	PAR-CLIP	22100165
MIRT445110	hsa-miR-1273e	PAR-CLIP	22100165
MIRT924992	hsa-miR-141	CLIP-seq
MIRT924993	hsa-miR-200a	CLIP-seq
MIRT924994	hsa-miR-3155	CLIP-seq
MIRT924995	hsa-miR-3155b	CLIP-seq
MIRT924996	hsa-miR-3529	CLIP-seq
MIRT924997	hsa-miR-379	CLIP-seq
MIRT924998	hsa-miR-4427	CLIP-seq
MIRT924999	hsa-miR-4438	CLIP-seq
MIRT925000	hsa-miR-4451	CLIP-seq
MIRT925001	hsa-miR-4650-3p	CLIP-seq
MIRT925002	hsa-miR-4753-3p	CLIP-seq
MIRT925003	hsa-miR-484	CLIP-seq
MIRT925004	hsa-miR-942	CLIP-seq
MIRT925005	hsa-miR-1200	CLIP-seq
MIRT924992	hsa-miR-141	CLIP-seq
MIRT925006	hsa-miR-181a	CLIP-seq
MIRT925007	hsa-miR-181b	CLIP-seq
MIRT925008	hsa-miR-181c	CLIP-seq
MIRT925009	hsa-miR-181d	CLIP-seq
MIRT924993	hsa-miR-200a	CLIP-seq
MIRT925010	hsa-miR-3065-3p	CLIP-seq
MIRT925011	hsa-miR-3074-5p	CLIP-seq
MIRT925012	hsa-miR-3124-3p	CLIP-seq
MIRT924994	hsa-miR-3155	CLIP-seq
MIRT924995	hsa-miR-3155b	CLIP-seq
MIRT924996	hsa-miR-3529	CLIP-seq
MIRT925013	hsa-miR-3671	CLIP-seq
MIRT924997	hsa-miR-379	CLIP-seq
MIRT925014	hsa-miR-4291	CLIP-seq
MIRT925015	hsa-miR-4324	CLIP-seq
MIRT924998	hsa-miR-4427	CLIP-seq
MIRT924999	hsa-miR-4438	CLIP-seq
MIRT925000	hsa-miR-4451	CLIP-seq
MIRT925001	hsa-miR-4650-3p	CLIP-seq
MIRT925003	hsa-miR-484	CLIP-seq
MIRT925016	hsa-miR-543	CLIP-seq
MIRT925017	hsa-miR-544b	CLIP-seq
MIRT925012	hsa-miR-3124-3p	CLIP-seq
MIRT1974006	hsa-miR-3667-3p	CLIP-seq
MIRT925005	hsa-miR-1200	CLIP-seq
MIRT924992	hsa-miR-141	CLIP-seq
MIRT2209570	hsa-miR-15a	CLIP-seq
MIRT2209571	hsa-miR-15b	CLIP-seq
MIRT2209572	hsa-miR-16	CLIP-seq
MIRT925006	hsa-miR-181a	CLIP-seq
MIRT925007	hsa-miR-181b	CLIP-seq
MIRT925008	hsa-miR-181c	CLIP-seq
MIRT925009	hsa-miR-181d	CLIP-seq
MIRT2209573	hsa-miR-18a	CLIP-seq
MIRT2209574	hsa-miR-18b	CLIP-seq
MIRT2209575	hsa-miR-195	CLIP-seq
MIRT924993	hsa-miR-200a	CLIP-seq
MIRT2209576	hsa-miR-2392	CLIP-seq
MIRT925010	hsa-miR-3065-3p	CLIP-seq
MIRT925011	hsa-miR-3074-5p	CLIP-seq
MIRT925012	hsa-miR-3124-3p	CLIP-seq
MIRT924994	hsa-miR-3155	CLIP-seq
MIRT924995	hsa-miR-3155b	CLIP-seq
MIRT2209577	hsa-miR-3177-5p	CLIP-seq
MIRT2209578	hsa-miR-3605-5p	CLIP-seq
MIRT2209579	hsa-miR-378g	CLIP-seq
MIRT2209580	hsa-miR-424	CLIP-seq
MIRT925014	hsa-miR-4291	CLIP-seq
MIRT925015	hsa-miR-4324	CLIP-seq
MIRT924998	hsa-miR-4427	CLIP-seq
MIRT924999	hsa-miR-4438	CLIP-seq
MIRT2209581	hsa-miR-4477b	CLIP-seq
MIRT2209582	hsa-miR-450b-3p	CLIP-seq
MIRT2209583	hsa-miR-4524	CLIP-seq
MIRT2209584	hsa-miR-4713-3p	CLIP-seq
MIRT2209585	hsa-miR-4768-5p	CLIP-seq
MIRT2209586	hsa-miR-4778-3p	CLIP-seq
MIRT925003	hsa-miR-484	CLIP-seq
MIRT2209587	hsa-miR-497	CLIP-seq
MIRT2209588	hsa-miR-503	CLIP-seq
MIRT2209589	hsa-miR-516b	CLIP-seq
MIRT925016	hsa-miR-543	CLIP-seq
MIRT925017	hsa-miR-544b	CLIP-seq
MIRT2209590	hsa-miR-548an	CLIP-seq
MIRT2209591	hsa-miR-638	CLIP-seq
MIRT2209592	hsa-miR-646	CLIP-seq
MIRT2209593	hsa-miR-769-3p	CLIP-seq
MIRT925004	hsa-miR-942	CLIP-seq
MIRT2209579	hsa-miR-378g	CLIP-seq
MIRT2513271	hsa-miR-4437	CLIP-seq
MIRT2513272	hsa-miR-4674	CLIP-seq
MIRT2209586	hsa-miR-4778-3p	CLIP-seq
MIRT2513273	hsa-miR-668	CLIP-seq
MIRT2679059	hsa-miR-1229	CLIP-seq
MIRT2209579	hsa-miR-378g	CLIP-seq
MIRT2513271	hsa-miR-4437	CLIP-seq
MIRT2513272	hsa-miR-4674	CLIP-seq
MIRT2209586	hsa-miR-4778-3p	CLIP-seq

Show/Hide all (5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19966799, 28514442, 30945288, 32814053, 33961781
GO:0005654	Component	Nucleoplasm	TAS
GO:0016567	Process	Protein ubiquitination	IEA
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IBA
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IDA	16949367

MIM	HGNC	e!Ensembl
616372	20229	ENSG00000119599

Q8WV16

Protein name

DDB1- and CUL4-associated factor 4 (WD repeat-containing protein 21A)

Protein function

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

PDB

3I8C

Family and domains

Sequence

MNKSRWQSRRRHGRRSHQQNPWFRLRDSEDRSDSRAAQPAHDSGHGDDESPSTSSGTAGT
SSVPELPGFYFDPEKKRYFRLLPGHNNCNPLTKESIRQKEMESKRLRLLQEEDRRKKIAR
MGFNASSMLRKSQLGFLNVTNYCHLAHELRLSCMERKKVQIRSMDPSALASDRFNLILAD
TNSDRLFTVNDVKVGGSKYGIINLQSLKTPTLKVFMHENLYFTNRKVNSVCWASLNHLDS
HILLCLMGLAETPGCATLLPASLFVNSHPGIDRPGMLCSFRIPGAWSCAWSLNIQANNCF
STGLSRRVLLTNVVTGHRQSFGTNSDVLAQQFALMAPLLFNGCRSGEIFAIDLRCGNQGK
GWKATRLFHDSAVTSVRILQDEQYLMASDMAGKIKLWDLRTTKCVRQYEGHVNEYAYLPL
HVHEEEGILVAVGQDCYTRIWSLHDARLLRTIPSPYPASKADIPSVAFSSRLGGSRGAPG
LLMAVGQDLYCYSYS

Sequence length

495

Interactions

View interactions

	Reactome
			Neddylation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (43)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Adrenocortical carcinoma, hereditary	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BILIARY TRACT CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CERVICAL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CLEAR CELL RENAL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Likely benign	ClinVar GWAS catalog	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
ENDOMETRIAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR NEGATIVE BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Likely benign	ClinVar GWAS catalog	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
LUNG ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Likely benign	ClinVar GWAS catalog	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-HODGKINS LYMPHOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN ENDOMETRIOID CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN SEROUS CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCREATIC CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Telomere length, mean leukocyte	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Stimulate	28336923	★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Associate	32014991	★★★★★ ★☆☆☆☆ Found in Text Mining only

DCAF4 (DDB1 and CUL4 associated factor 4)