ARHGEF26 (Rho guanine nucleotide exchange factor 26)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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26084 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Rho guanine nucleotide exchange factor 26 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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ARHGEF26 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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CSGEF, HMFN1864, SGEF |
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Chromosome
Chromosome number
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3 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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3q25.2 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | Q96DR7 | |||||||||||||||
| Protein name | Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) | |||||||||||||||
| Protein function | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of | |||||||||||||||
| PDB | 6MYE , 7YKG | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver. {ECO:0000269|PubMed:12697679, ECO:0000269|PubMed:15133129}. | |||||||||||||||
| Sequence |
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| Sequence length | 871 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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