DECR2 (2,4-dienoyl-CoA reductase 2)

Gene

• Entrez ID: 26063
• Gene name: 2,4-dienoyl-CoA reductase 2
• Gene symbol: DECR2
• Synonyms (NCBI Gene): PDCR, SDR17C1
• Chromosome: 16
• Chromosome location: 16p13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT931749	hsa-miR-101	CLIP-seq
MIRT931750	hsa-miR-1207-3p	CLIP-seq
MIRT931751	hsa-miR-144	CLIP-seq
MIRT931752	hsa-miR-3121-3p	CLIP-seq
MIRT931753	hsa-miR-3135b	CLIP-seq
MIRT931754	hsa-miR-3619-3p	CLIP-seq
MIRT931755	hsa-miR-4265	CLIP-seq
MIRT931756	hsa-miR-4296	CLIP-seq
MIRT931757	hsa-miR-4322	CLIP-seq
MIRT931758	hsa-miR-4417	CLIP-seq
MIRT931759	hsa-miR-4640-5p	CLIP-seq
MIRT931760	hsa-miR-4660	CLIP-seq
MIRT931761	hsa-miR-4726-5p	CLIP-seq
MIRT931762	hsa-miR-4751	CLIP-seq
MIRT931763	hsa-miR-4755-3p	CLIP-seq
MIRT931764	hsa-miR-582-5p	CLIP-seq
MIRT931765	hsa-miR-765	CLIP-seq
MIRT931766	hsa-miR-885-3p	CLIP-seq
MIRT2211208	hsa-miR-1197	CLIP-seq
MIRT2211209	hsa-miR-1286	CLIP-seq
MIRT2211210	hsa-miR-3150a-3p	CLIP-seq
MIRT2211211	hsa-miR-3153	CLIP-seq
MIRT2211212	hsa-miR-3175	CLIP-seq
MIRT2211213	hsa-miR-3675-5p	CLIP-seq
MIRT2211214	hsa-miR-4259	CLIP-seq
MIRT2211215	hsa-miR-4260	CLIP-seq
MIRT2211216	hsa-miR-4302	CLIP-seq
MIRT2211217	hsa-miR-4436a	CLIP-seq
MIRT2211218	hsa-miR-4728-5p	CLIP-seq
MIRT2211219	hsa-miR-4780	CLIP-seq
MIRT2211220	hsa-miR-491-5p	CLIP-seq
MIRT2211221	hsa-miR-571	CLIP-seq
MIRT2211222	hsa-miR-591	CLIP-seq
MIRT2211223	hsa-miR-939	CLIP-seq
MIRT2515083	hsa-miR-1231	CLIP-seq
MIRT2515084	hsa-miR-338-3p	CLIP-seq
MIRT2515085	hsa-miR-3655	CLIP-seq
MIRT2515086	hsa-miR-4288	CLIP-seq
MIRT2515087	hsa-miR-4640-3p	CLIP-seq
MIRT2515088	hsa-miR-632	CLIP-seq
MIRT2515083	hsa-miR-1231	CLIP-seq
MIRT2515084	hsa-miR-338-3p	CLIP-seq
MIRT2515085	hsa-miR-3655	CLIP-seq
MIRT2515086	hsa-miR-4288	CLIP-seq
MIRT2515088	hsa-miR-632	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 33961781
GO:0005777	Component	Peroxisome	IBA
GO:0005777	Component	Peroxisome	IEA
GO:0005778	Component	Peroxisomal membrane	IEA
GO:0005778	Component	Peroxisomal membrane	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IBA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006636	Process	Unsaturated fatty acid biosynthetic process	IDA	11514237
GO:0008670	Function	2,4-dienoyl-CoA reductase (NADPH) activity	IBA
GO:0008670	Function	2,4-dienoyl-CoA reductase (NADPH) activity	IDA	11514237
GO:0008670	Function	2,4-dienoyl-CoA reductase (NADPH) activity	IEA
GO:0009062	Process	Fatty acid catabolic process	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0019166	Function	Trans-2-enoyl-CoA reductase (NADPH) activity	EXP	11514237
GO:0019166	Function	Trans-2-enoyl-CoA reductase (NADPH) activity	IDA	10811639
GO:0033540	Process	Fatty acid beta-oxidation using acyl-CoA oxidase	TAS
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0051020	Function	GTPase binding	IEA

Other IDs

• MIM: 615839
• HGNC: 2754
• e!Ensembl: ENSG00000242612

Protein

• UniProt ID: Q9NUI1
• Protein name: Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (pDCR) (EC 1.3.1.124) (2,4-dienoyl-CoA reductase 2) (Short chain dehydrogenase/reductase family 17C member 1)
• Protein function: Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yi
• PDB: 4FC6, 4FC7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13561	adh_short_C2	33 → 271		Domain

• Sequence:

  MAQPPPDVEGDDCLPAYRHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASR
  SLPRVLTAARKLAGATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLC
  PAGALSFNAFKTVMDIDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGS
  AKAAVDAMTRHLAVEWGPQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLG
  NKTEIAHSVLYLASPLASYVTGAVLVADGGAWLTFPNGVKGLPDFASFSAKL

• Sequence length: 292

Pathways

KEGG:

Peroxisome

Reactome:

Beta-oxidation of very long chain fatty acids
Peroxisomal protein import