ERC2 (ELKS/RAB6-interacting/CAST family member 2)

Gene

• Entrez ID: 26059
• Gene name: ELKS/RAB6-interacting/CAST family member 2
• Gene symbol: ERC2
• Synonyms (NCBI Gene): CAST, CAST1, ELKSL, SPBC110, Spc110
• Chromosome: 3
• Chromosome location: 3p14.3
• Summary: This gene encodes a protein that belongs to the Rab3-interacting molecule (RIM)-binding protein family. Members of this protein family form part of the cytomatrix at the active zone (CAZ) complex and function as regulators of neurotransmitter release. Alt

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT968322	hsa-miR-1182	CLIP-seq
MIRT968323	hsa-miR-1208	CLIP-seq
MIRT968324	hsa-miR-1243	CLIP-seq
MIRT968325	hsa-miR-1538	CLIP-seq
MIRT968326	hsa-miR-297	CLIP-seq
MIRT968327	hsa-miR-299-5p	CLIP-seq
MIRT968328	hsa-miR-3125	CLIP-seq
MIRT968329	hsa-miR-3202	CLIP-seq
MIRT968330	hsa-miR-323-3p	CLIP-seq
MIRT968331	hsa-miR-34c-3p	CLIP-seq
MIRT968332	hsa-miR-361-5p	CLIP-seq
MIRT968333	hsa-miR-3654	CLIP-seq
MIRT968334	hsa-miR-380	CLIP-seq
MIRT968335	hsa-miR-3916	CLIP-seq
MIRT968336	hsa-miR-4257	CLIP-seq
MIRT968337	hsa-miR-4438	CLIP-seq
MIRT968338	hsa-miR-4495	CLIP-seq
MIRT968339	hsa-miR-4533	CLIP-seq
MIRT968340	hsa-miR-4659a-3p	CLIP-seq
MIRT968341	hsa-miR-4659b-3p	CLIP-seq
MIRT968342	hsa-miR-4731-3p	CLIP-seq
MIRT968343	hsa-miR-4745-3p	CLIP-seq
MIRT968344	hsa-miR-4747-3p	CLIP-seq
MIRT968345	hsa-miR-4801	CLIP-seq
MIRT968346	hsa-miR-5095	CLIP-seq
MIRT968347	hsa-miR-517b	CLIP-seq
MIRT968348	hsa-miR-539	CLIP-seq
MIRT968349	hsa-miR-548c-3p	CLIP-seq
MIRT968350	hsa-miR-567	CLIP-seq
MIRT968351	hsa-miR-587	CLIP-seq
MIRT968352	hsa-miR-659	CLIP-seq
MIRT968353	hsa-miR-9	CLIP-seq
MIRT1987027	hsa-miR-4307	CLIP-seq
MIRT1987028	hsa-miR-4728-3p	CLIP-seq
MIRT968323	hsa-miR-1208	CLIP-seq
MIRT2221421	hsa-miR-1827	CLIP-seq
MIRT2221422	hsa-miR-2682	CLIP-seq
MIRT2221423	hsa-miR-3145-3p	CLIP-seq
MIRT2221424	hsa-miR-323b-5p	CLIP-seq
MIRT2221425	hsa-miR-329	CLIP-seq
MIRT2221426	hsa-miR-34a	CLIP-seq
MIRT2221427	hsa-miR-34c-5p	CLIP-seq
MIRT2221428	hsa-miR-3612	CLIP-seq
MIRT2221429	hsa-miR-362-3p	CLIP-seq
MIRT2221430	hsa-miR-3661	CLIP-seq
MIRT2221431	hsa-miR-3919	CLIP-seq
MIRT2221432	hsa-miR-4266	CLIP-seq
MIRT2221433	hsa-miR-449a	CLIP-seq
MIRT2221434	hsa-miR-449b	CLIP-seq
MIRT2221435	hsa-miR-449c	CLIP-seq
MIRT2221436	hsa-miR-4695-5p	CLIP-seq
MIRT2221437	hsa-miR-4716-5p	CLIP-seq
MIRT2221438	hsa-miR-4756-3p	CLIP-seq
MIRT2221439	hsa-miR-4779	CLIP-seq
MIRT2221440	hsa-miR-631	CLIP-seq
MIRT2221441	hsa-miR-650	CLIP-seq
MIRT2525059	hsa-miR-128	CLIP-seq
MIRT2525060	hsa-miR-27a	CLIP-seq
MIRT2525061	hsa-miR-27b	CLIP-seq
MIRT2525062	hsa-miR-499-3p	CLIP-seq
MIRT2525063	hsa-miR-499a-3p	CLIP-seq
MIRT2680244	hsa-miR-181a	CLIP-seq
MIRT2680245	hsa-miR-181b	CLIP-seq
MIRT2680246	hsa-miR-181c	CLIP-seq
MIRT2680247	hsa-miR-181d	CLIP-seq
MIRT2680248	hsa-miR-23a	CLIP-seq
MIRT2680249	hsa-miR-23b	CLIP-seq
MIRT2680250	hsa-miR-23c	CLIP-seq
MIRT2680251	hsa-miR-365	CLIP-seq
MIRT2680252	hsa-miR-4262	CLIP-seq
MIRT1987027	hsa-miR-4307	CLIP-seq
MIRT2680253	hsa-miR-4698	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12923177, 20195357
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0016082	Process	Synaptic vesicle priming	IEA
GO:0030426	Component	Growth cone	ISS
GO:0042734	Component	Presynaptic membrane	ISS
GO:0042995	Component	Cell projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0048786	Component	Presynaptic active zone	IEA
GO:0048786	Component	Presynaptic active zone	TAS	15217342
GO:0048790	Process	Maintenance of presynaptic active zone structure	IBA
GO:0098793	Component	Presynapse	IEA
GO:0098831	Component	Presynaptic active zone cytoplasmic component	IBA
GO:0098831	Component	Presynaptic active zone cytoplasmic component	IEA
GO:0098882	Function	Structural constituent of presynaptic active zone	IBA
GO:0098882	Function	Structural constituent of presynaptic active zone	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098982	Component	GABA-ergic synapse	IEA
GO:0099509	Process	Regulation of presynaptic cytosolic calcium ion concentration	IEA
GO:0150037	Process	Regulation of calcium-dependent activation of synaptic vesicle fusion	IEA

Other IDs

• MIM: 617250
• HGNC: 31922
• e!Ensembl: ENSG00000187672

Protein

• UniProt ID: O15083
• Protein name: ERC protein 2
• Protein function: Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10174	Cast	150 → 911	RIM-binding protein of the cytomatrix active zone	Coiled-coil

• Sequence:

  MYGSARTITNLEGSPSRSPRLPRSPRLGHRRTSSGGGGGTGKTLSMENIQSLNAAYATSG
  PMYLSDHEGVASTTYPKGTMTLGRATNRAVYGGRVTAMGSSPNIASAGLSHTDVLSYTDQ
  HGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMN
  SIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNH
  LLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNA
  RDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREEL
  HRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIK
  QIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTA
  KEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERK
  INVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERL
  KEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKR
  DSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECG
  KAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNA
  QLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANL
  RIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQ
  LKQQTQNRMKLMADNYDDDHHHYHHHHHHHHHRSPGRSQHSNHRPSPDQDDEEGIWA

• Sequence length: 957