Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	26052
Gene name	Dynamin 3
Gene symbol	DNM3
Synonyms (NCBI Gene)	Dyna III
Chromosome	1
Chromosome location	1q24.3
Summary	This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing resu

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022316	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT032198	hsa-let-7b-5p	Proteomics	18668040
MIRT942403	hsa-miR-1237	CLIP-seq
MIRT942404	hsa-miR-1248	CLIP-seq
MIRT942405	hsa-miR-1278	CLIP-seq
MIRT942406	hsa-miR-1297	CLIP-seq
MIRT942407	hsa-miR-26a	CLIP-seq
MIRT942408	hsa-miR-26b	CLIP-seq
MIRT942409	hsa-miR-3686	CLIP-seq
MIRT942410	hsa-miR-410	CLIP-seq
MIRT942411	hsa-miR-4432	CLIP-seq
MIRT942412	hsa-miR-4465	CLIP-seq
MIRT942413	hsa-miR-4672	CLIP-seq
MIRT942414	hsa-miR-4719	CLIP-seq
MIRT942415	hsa-miR-4742-3p	CLIP-seq
MIRT942416	hsa-miR-4778-3p	CLIP-seq
MIRT942417	hsa-miR-570	CLIP-seq
MIRT942418	hsa-miR-579	CLIP-seq
MIRT942405	hsa-miR-1278	CLIP-seq
MIRT942406	hsa-miR-1297	CLIP-seq
MIRT942407	hsa-miR-26a	CLIP-seq
MIRT942408	hsa-miR-26b	CLIP-seq
MIRT942419	hsa-miR-3137	CLIP-seq
MIRT942420	hsa-miR-3165	CLIP-seq
MIRT942421	hsa-miR-3182	CLIP-seq
MIRT942422	hsa-miR-3529	CLIP-seq
MIRT942423	hsa-miR-3653	CLIP-seq
MIRT942424	hsa-miR-3658	CLIP-seq
MIRT942425	hsa-miR-3682-5p	CLIP-seq
MIRT942409	hsa-miR-3686	CLIP-seq
MIRT942426	hsa-miR-379	CLIP-seq
MIRT942427	hsa-miR-3925-3p	CLIP-seq
MIRT942428	hsa-miR-4257	CLIP-seq
MIRT942429	hsa-miR-4307	CLIP-seq
MIRT942430	hsa-miR-4451	CLIP-seq
MIRT942431	hsa-miR-4456	CLIP-seq
MIRT942412	hsa-miR-4465	CLIP-seq
MIRT942432	hsa-miR-4477a	CLIP-seq
MIRT942433	hsa-miR-4517	CLIP-seq
MIRT942434	hsa-miR-4650-3p	CLIP-seq
MIRT942435	hsa-miR-4699-3p	CLIP-seq
MIRT942436	hsa-miR-520a-5p	CLIP-seq
MIRT942437	hsa-miR-525-5p	CLIP-seq
MIRT942438	hsa-miR-576-3p	CLIP-seq
MIRT942439	hsa-miR-766	CLIP-seq
MIRT1979018	hsa-miR-128	CLIP-seq
MIRT1979019	hsa-miR-3074-3p	CLIP-seq
MIRT1979020	hsa-miR-515-5p	CLIP-seq
MIRT1979021	hsa-miR-548p	CLIP-seq
MIRT2214161	hsa-miR-4729	CLIP-seq
MIRT2214162	hsa-miR-499-3p	CLIP-seq
MIRT2214163	hsa-miR-499a-3p	CLIP-seq
MIRT2214164	hsa-miR-513a-5p	CLIP-seq
MIRT2214165	hsa-miR-1292	CLIP-seq
MIRT2214166	hsa-miR-132	CLIP-seq
MIRT2214167	hsa-miR-212	CLIP-seq
MIRT2214168	hsa-miR-300	CLIP-seq
MIRT2214169	hsa-miR-381	CLIP-seq
MIRT2214170	hsa-miR-4328	CLIP-seq
MIRT2214171	hsa-miR-4471	CLIP-seq
MIRT2214172	hsa-miR-4646-5p	CLIP-seq
MIRT2214173	hsa-miR-4666-3p	CLIP-seq
MIRT2214174	hsa-miR-4774-5p	CLIP-seq
MIRT2214175	hsa-miR-548g	CLIP-seq
MIRT2214176	hsa-miR-587	CLIP-seq
MIRT2387049	hsa-miR-3691-5p	CLIP-seq
MIRT2442113	hsa-miR-142-5p	CLIP-seq
MIRT2442114	hsa-miR-340	CLIP-seq
MIRT2518528	hsa-miR-105	CLIP-seq
MIRT2518529	hsa-miR-140-3p	CLIP-seq
MIRT2518530	hsa-miR-148a	CLIP-seq
MIRT2518531	hsa-miR-148b	CLIP-seq
MIRT2518532	hsa-miR-152	CLIP-seq
MIRT2518533	hsa-miR-299-3p	CLIP-seq
MIRT2518534	hsa-miR-3129-3p	CLIP-seq
MIRT2518535	hsa-miR-3136-5p	CLIP-seq
MIRT2518536	hsa-miR-3153	CLIP-seq
MIRT2518537	hsa-miR-4439	CLIP-seq
MIRT2518538	hsa-miR-4513	CLIP-seq
MIRT2518539	hsa-miR-4648	CLIP-seq
MIRT2518540	hsa-miR-4654	CLIP-seq
MIRT2518541	hsa-miR-4662a-5p	CLIP-seq
MIRT2518542	hsa-miR-4666-5p	CLIP-seq
MIRT2518543	hsa-miR-4668-5p	CLIP-seq
MIRT2518544	hsa-miR-4769-5p	CLIP-seq
MIRT2518545	hsa-miR-4789-3p	CLIP-seq
MIRT2518546	hsa-miR-4793-5p	CLIP-seq
MIRT2518547	hsa-miR-556-3p	CLIP-seq
MIRT2518548	hsa-miR-943	CLIP-seq
MIRT2679374	hsa-miR-3185	CLIP-seq

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Transcription factor	Regulation	Reference
TWIST1	Activation	18033314

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IEA
GO:0003924	Function	GTPase activity	ISS
GO:0005515	Function	Protein binding	IPI	15252009
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IBA
GO:0005874	Component	Microtubule	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0006897	Process	Endocytosis	IEA
GO:0006897	Process	Endocytosis	ISS
GO:0007416	Process	Synapse assembly	ISS
GO:0008017	Function	Microtubule binding	IBA
GO:0014069	Component	Postsynaptic density	ISS
GO:0016185	Process	Synaptic vesicle budding from presynaptic endocytic zone membrane	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0042802	Function	Identical protein binding	IPI	26302298
GO:0043197	Component	Dendritic spine	ISS
GO:0045202	Component	Synapse	IBA
GO:0046847	Process	Filopodium assembly	ISS
GO:0048471	Component	Perinuclear region of cytoplasm	ISS
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0098793	Component	Presynapse	IEA

MIM	HGNC	e!Ensembl
611445	29125	ENSG00000197959

Q9UQ16

Protein name

Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin)

Protein function

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity).

PDB

3L43 , 5A3F

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00350	Dynamin_N	34 → 207	Dynamin family	Domain
PF01031	Dynamin_M	216 → 502	Dynamin central region	Family
PF00169	PH	526 → 630	PH domain	Domain
PF02212	GED	654 → 745	Dynamin GTPase effector domain	Family

Sequence

MGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRG
SGIVTRRPLVLQLVTSKAEYAEFLHCKGKKFTDFDEVRLEIEAETDRVTGMNKGISSIPI
NLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPANTD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYVGVVNRSQK
DIDGKKDIKAAMLAERKFFLSHPAYRHIADRMGTPHLQKVLNQQLTNHIRDTLPNFRNKL
QGQLLSIEHEVEAYKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVDTLELSGGA
KINRIFHERFPFEIVKMEFNEKELRREISYAIKNIHGIRTGLFTPDMAFEAIVKKQIVKL
KGPSLKSVDLVIQELINTVKKCTKKLANFPRLCEETERIVANHIREREGKTKDQVLLLID
IQVSYINTNHEDFIGFANAQQRSSQVHKKTTVGNQGTNLPPSRQIVIRKGWLTISNIGIM
KGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQR
NVYKDYRFLELACDSQEDVDSWKASLLRAGVYPDKSVAENDENGQAENFSMDPQLERQVE
TIRNLVDSYMSIINKCIRDLIPKTIMHLMINNVKDFINSELLAQLYSSEDQNTLMEESAE
QAQRRDEMLRMYQALKEALGIIGDISTATVSTPAPPPVDDSWIQHSRRSPPPSPTTQRRP
TLSAPLARPTSGRGPAPAIPSPGPHSGAPPVPFRPGPLPPFPSSSDSFGAPPQVPSRPTR
APPSVPSRRPPPSPTRPTIIRPLESSLLD

Sequence length

869

Interactions

View interactions

	KEGG		Reactome
	Phospholipase D signaling pathway Endocytosis Synaptic vesicle cycle Endocrine and other factor-regulated calcium reabsorption Bacterial invasion of epithelial cells		Toll Like Receptor 4 (TLR4) Cascade MHC class II antigen presentation Recycling pathway of L1 Clathrin-mediated endocytosis

DNM3 (dynamin 3)