Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	26052
Gene name Gene Name - the full gene name approved by the HGNC.	Dynamin 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DNM3
Synonyms (NCBI Gene) Gene synonyms aliases	Dyna III
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q24.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing resu

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022316	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT032198	hsa-let-7b-5p	Proteomics	18668040
MIRT942403	hsa-miR-1237	CLIP-seq
MIRT942404	hsa-miR-1248	CLIP-seq
MIRT942405	hsa-miR-1278	CLIP-seq
MIRT942406	hsa-miR-1297	CLIP-seq
MIRT942407	hsa-miR-26a	CLIP-seq
MIRT942408	hsa-miR-26b	CLIP-seq
MIRT942409	hsa-miR-3686	CLIP-seq
MIRT942410	hsa-miR-410	CLIP-seq
MIRT942411	hsa-miR-4432	CLIP-seq
MIRT942412	hsa-miR-4465	CLIP-seq
MIRT942413	hsa-miR-4672	CLIP-seq
MIRT942414	hsa-miR-4719	CLIP-seq
MIRT942415	hsa-miR-4742-3p	CLIP-seq
MIRT942416	hsa-miR-4778-3p	CLIP-seq
MIRT942417	hsa-miR-570	CLIP-seq
MIRT942418	hsa-miR-579	CLIP-seq
MIRT942405	hsa-miR-1278	CLIP-seq
MIRT942406	hsa-miR-1297	CLIP-seq
MIRT942407	hsa-miR-26a	CLIP-seq
MIRT942408	hsa-miR-26b	CLIP-seq
MIRT942419	hsa-miR-3137	CLIP-seq
MIRT942420	hsa-miR-3165	CLIP-seq
MIRT942421	hsa-miR-3182	CLIP-seq
MIRT942422	hsa-miR-3529	CLIP-seq
MIRT942423	hsa-miR-3653	CLIP-seq
MIRT942424	hsa-miR-3658	CLIP-seq
MIRT942425	hsa-miR-3682-5p	CLIP-seq
MIRT942409	hsa-miR-3686	CLIP-seq
MIRT942426	hsa-miR-379	CLIP-seq
MIRT942427	hsa-miR-3925-3p	CLIP-seq
MIRT942428	hsa-miR-4257	CLIP-seq
MIRT942429	hsa-miR-4307	CLIP-seq
MIRT942430	hsa-miR-4451	CLIP-seq
MIRT942431	hsa-miR-4456	CLIP-seq
MIRT942412	hsa-miR-4465	CLIP-seq
MIRT942432	hsa-miR-4477a	CLIP-seq
MIRT942433	hsa-miR-4517	CLIP-seq
MIRT942434	hsa-miR-4650-3p	CLIP-seq
MIRT942435	hsa-miR-4699-3p	CLIP-seq
MIRT942436	hsa-miR-520a-5p	CLIP-seq
MIRT942437	hsa-miR-525-5p	CLIP-seq
MIRT942438	hsa-miR-576-3p	CLIP-seq
MIRT942439	hsa-miR-766	CLIP-seq
MIRT1979018	hsa-miR-128	CLIP-seq
MIRT1979019	hsa-miR-3074-3p	CLIP-seq
MIRT1979020	hsa-miR-515-5p	CLIP-seq
MIRT1979021	hsa-miR-548p	CLIP-seq
MIRT2214161	hsa-miR-4729	CLIP-seq
MIRT2214162	hsa-miR-499-3p	CLIP-seq
MIRT2214163	hsa-miR-499a-3p	CLIP-seq
MIRT2214164	hsa-miR-513a-5p	CLIP-seq
MIRT2214165	hsa-miR-1292	CLIP-seq
MIRT2214166	hsa-miR-132	CLIP-seq
MIRT2214167	hsa-miR-212	CLIP-seq
MIRT2214168	hsa-miR-300	CLIP-seq
MIRT2214169	hsa-miR-381	CLIP-seq
MIRT2214170	hsa-miR-4328	CLIP-seq
MIRT2214171	hsa-miR-4471	CLIP-seq
MIRT2214172	hsa-miR-4646-5p	CLIP-seq
MIRT2214173	hsa-miR-4666-3p	CLIP-seq
MIRT2214174	hsa-miR-4774-5p	CLIP-seq
MIRT2214175	hsa-miR-548g	CLIP-seq
MIRT2214176	hsa-miR-587	CLIP-seq
MIRT2387049	hsa-miR-3691-5p	CLIP-seq
MIRT2442113	hsa-miR-142-5p	CLIP-seq
MIRT2442114	hsa-miR-340	CLIP-seq
MIRT2518528	hsa-miR-105	CLIP-seq
MIRT2518529	hsa-miR-140-3p	CLIP-seq
MIRT2518530	hsa-miR-148a	CLIP-seq
MIRT2518531	hsa-miR-148b	CLIP-seq
MIRT2518532	hsa-miR-152	CLIP-seq
MIRT2518533	hsa-miR-299-3p	CLIP-seq
MIRT2518534	hsa-miR-3129-3p	CLIP-seq
MIRT2518535	hsa-miR-3136-5p	CLIP-seq
MIRT2518536	hsa-miR-3153	CLIP-seq
MIRT2518537	hsa-miR-4439	CLIP-seq
MIRT2518538	hsa-miR-4513	CLIP-seq
MIRT2518539	hsa-miR-4648	CLIP-seq
MIRT2518540	hsa-miR-4654	CLIP-seq
MIRT2518541	hsa-miR-4662a-5p	CLIP-seq
MIRT2518542	hsa-miR-4666-5p	CLIP-seq
MIRT2518543	hsa-miR-4668-5p	CLIP-seq
MIRT2518544	hsa-miR-4769-5p	CLIP-seq
MIRT2518545	hsa-miR-4789-3p	CLIP-seq
MIRT2518546	hsa-miR-4793-5p	CLIP-seq
MIRT2518547	hsa-miR-556-3p	CLIP-seq
MIRT2518548	hsa-miR-943	CLIP-seq
MIRT2679374	hsa-miR-3185	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
TWIST1	Activation	18033314

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000266	Process	Mitochondrial fission	IBA	21873635
GO:0003374	Process	Dynamin family protein polymerization involved in mitochondrial fission	IBA	21873635
GO:0003924	Function	GTPase activity	IBA	21873635
GO:0003924	Function	GTPase activity	ISS
GO:0005515	Function	Protein binding	IPI	15252009
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005794	Component	Golgi apparatus	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0006897	Process	Endocytosis	ISS
GO:0007416	Process	Synapse assembly	ISS
GO:0008017	Function	Microtubule binding	IBA	21873635
GO:0014069	Component	Postsynaptic density	IBA	21873635
GO:0014069	Component	Postsynaptic density	ISS
GO:0015630	Component	Microtubule cytoskeleton	IBA	21873635
GO:0016020	Component	Membrane	IBA	21873635
GO:0016185	Process	Synaptic vesicle budding from presynaptic endocytic zone membrane	IBA	21873635
GO:0030424	Component	Axon	IBA	21873635
GO:0031410	Component	Cytoplasmic vesicle	IBA	21873635
GO:0031623	Process	Receptor internalization	IBA	21873635
GO:0031798	Function	Type 1 metabotropic glutamate receptor binding	IEA
GO:0031802	Function	Type 5 metabotropic glutamate receptor binding	IEA
GO:0031966	Component	Mitochondrial membrane	IBA	21873635
GO:0043083	Component	Synaptic cleft	IEA
GO:0043197	Component	Dendritic spine	ISS
GO:0044327	Component	Dendritic spine head	IBA	21873635
GO:0046847	Process	Filopodium assembly	ISS
GO:0048471	Component	Perinuclear region of cytoplasm	ISS
GO:0050803	Process	Regulation of synapse structure or activity	IBA	21873635
GO:0050998	Function	Nitric-oxide synthase binding	IEA
GO:0051491	Process	Positive regulation of filopodium assembly	IEA
GO:0061002	Process	Negative regulation of dendritic spine morphogenesis	IEA
GO:0061025	Process	Membrane fusion	IBA	21873635
GO:0061828	Component	Apical tubulobulbar complex	IEA
GO:0061829	Component	Basal tubulobulbar complex	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0098793	Component	Presynapse	IEA
GO:0098844	Component	Postsynaptic endocytic zone membrane	IBA	21873635
GO:0098884	Process	Postsynaptic neurotransmitter receptor internalization	IBA	21873635
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099173	Process	Postsynapse organization	IEA
GO:0099186	Function	Structural constituent of postsynapse	IEA
GO:1903423	Process	Positive regulation of synaptic vesicle recycling	IEA

MIM	HGNC	e!Ensembl
611445	29125	ENSG00000197959

Protein

UniProt ID

Q9UQ16

Protein name

Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin)

Protein function

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity).

PDB

3L43 , 5A3F

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00350	Dynamin_N	34 → 207	Dynamin family	Domain
PF01031	Dynamin_M	216 → 502	Dynamin central region	Family
PF00169	PH	526 → 630	PH domain	Domain
PF02212	GED	654 → 745	Dynamin GTPase effector domain	Family

Sequence

MGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRG
SGIVTRRPLVLQLVTSKAEYAEFLHCKGKKFTDFDEVRLEIEAETDRVTGMNKGISSIPI
NLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPANTD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYVGVVNRSQK
DIDGKKDIKAAMLAERKFFLSHPAYRHIADRMGTPHLQKVLNQQLTNHIRDTLPNFRNKL
QGQLLSIEHEVEAYKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVDTLELSGGA
KINRIFHERFPFEIVKMEFNEKELRREISYAIKNIHGIRTGLFTPDMAFEAIVKKQIVKL
KGPSLKSVDLVIQELINTVKKCTKKLANFPRLCEETERIVANHIREREGKTKDQVLLLID
IQVSYINTNHEDFIGFANAQQRSSQVHKKTTVGNQGTNLPPSRQIVIRKGWLTISNIGIM
KGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQR
NVYKDYRFLELACDSQEDVDSWKASLLRAGVYPDKSVAENDENGQAENFSMDPQLERQVE
TIRNLVDSYMSIINKCIRDLIPKTIMHLMINNVKDFINSELLAQLYSSEDQNTLMEESAE
QAQRRDEMLRMYQALKEALGIIGDISTATVSTPAPPPVDDSWIQHSRRSPPPSPTTQRRP
TLSAPLARPTSGRGPAPAIPSPGPHSGAPPVPFRPGPLPPFPSSSDSFGAPPQVPSRPTR
APPSVPSRRPPPSPTRPTIIRPLESSLLD

Sequence length

869

Interactions

View interactions

	KEGG		Reactome
	Phospholipase D signaling pathway Endocytosis Synaptic vesicle cycle Endocrine and other factor-regulated calcium reabsorption Bacterial invasion of epithelial cells		Toll Like Receptor 4 (TLR4) Cascade MHC class II antigen presentation Recycling pathway of L1 Clathrin-mediated endocytosis

Show/Hide Unknown Diseases (7)

Disease term	Disease name	Evidence	Source
Unknown
Neuroticism	Neuroticism		GWAS
Moyamoya Disease	Moyamoya Disease		GWAS
Metabolic Syndrome	Metabolic Syndrome		GWAS
Diabetes	Diabetes		GWAS
Uterine Fibroids	Uterine Fibroids		GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA
Endometriosis	Endometriosis		GWAS

Show/Hide Text Mining Associations (20)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	27993161, 33499882
Carcinoma Hepatocellular	Inhibit	26784388
Carcinoma Hepatocellular	Associate	32573516
Cognition Disorders	Associate	21548129
Glioblastoma	Associate	24440977
Language Development Disorders	Associate	33141070
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	29733872
Multiple Sclerosis	Associate	37380766
Mycosis Fungoides	Associate	36400759
Neoplasm Invasiveness	Inhibit	26784388
Neoplasm Metastasis	Inhibit	26784388
Neurodegenerative Diseases	Associate	24673776
Noncommunicable Diseases	Associate	33141070
Obesity	Associate	29145611
Obsessive Compulsive Disorder	Associate	27023174
Osteoporosis	Associate	29145611
Ovarian Neoplasms	Associate	34027641, 36528667
Pituitary Neoplasms	Associate	33622874
Sezary Syndrome	Associate	26930587
Stomach Neoplasms	Inhibit	26784388

DNM3 (dynamin 3)