Gene Gene information from NCBI Gene database.
Entrez ID 26051
Gene name Protein phosphatase 1 regulatory subunit 16B
Gene symbol PPP1R16B
Synonyms (NCBI Gene)
ANKRD4TIMAP
Chromosome 20
Chromosome location 20q11.23
Summary The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta
miRNA miRNA information provided by mirtarbase database.
351
miRTarBase ID miRNA Experiments Reference
MIRT052173 hsa-let-7b-5p CLASH 23622248
MIRT711119 hsa-miR-34a-3p HITS-CLIP 19536157
MIRT711118 hsa-miR-3614-3p HITS-CLIP 19536157
MIRT711117 hsa-miR-1207-3p HITS-CLIP 19536157
MIRT711115 hsa-miR-6849-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
GO ID Ontology Definition Evidence Reference
GO:0001938 Process Positive regulation of endothelial cell proliferation IMP 25007873
GO:0004857 Function Enzyme inhibitor activity IBA
GO:0005515 Function Protein binding IPI 16263087, 18586956, 25007873, 25416956, 26497934, 27107012, 28330616, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005634 Component Nucleus IDA 12055102, 18586956
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613275 15850 ENSG00000101445
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96T49
Protein name Protein phosphatase 1 regulatory inhibitor subunit 16B (Ankyrin repeat domain-containing protein 4) (CAAX box protein TIMAP) (TGF-beta-inhibited membrane-associated protein) (hTIMAP)
Protein function Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956). Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell pro
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12796 Ank_2 72 164 Ankyrin repeats (3 copies) Repeat
PF00023 Ank 261 293 Ankyrin repeat Repeat
Sequence
MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGR
RKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLL
LSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVN
SDGNMPYDLCEDEPTL
DVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANG
YLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPID
LCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRK
EYEGEAILWQRSAAEDQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFPTKIPRGEL
DMPVENGLRAPVSAYQYALANGDVWKVHEVPDYSMAYGNPGVADATPPWSSYKEQSPQTL
LELKRQRAAAKLLSHPFLSTHLGSSMARTGESSSEGKAPLIGGRTSPYSSNGTSVYYTVT
SGDPPLLKFKAPIEEMEEKVHGCCRIS
Sequence length 567
Interactions View interactions