Gene Gene information from NCBI Gene database.
Entrez ID 260425
Gene name Membrane associated guanylate kinase, WW and PDZ domain containing 3
Gene symbol MAGI3
Synonyms (NCBI Gene)
MAGI-3dJ730K3.2
Chromosome 1
Chromosome location 1p13.2
miRNA miRNA information provided by mirtarbase database.
446
miRTarBase ID miRNA Experiments Reference
MIRT685132 hsa-miR-6771-3p HITS-CLIP 23313552
MIRT685131 hsa-miR-3675-3p HITS-CLIP 23313552
MIRT522674 hsa-miR-6849-3p HITS-CLIP 23313552
MIRT685130 hsa-miR-3190-5p HITS-CLIP 23313552
MIRT540547 hsa-miR-4786-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0004385 Function GMP kinase activity NAS 10748157
GO:0005109 Function Frizzled binding IEA
GO:0005515 Function Protein binding IPI 16316992, 16964398, 20353789, 23873930
GO:0005524 Function ATP binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
615943 29647 ENSG00000081026
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5TCQ9
Protein name Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (Membrane-associated guanylate kinase inverted 3) (MAGI-3)
Protein function Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins sugg
PDB 3SOE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00625 Guanylate_kin 122 196 Guanylate kinase Domain
PF00397 WW 295 324 WW domain Domain
PF00397 WW 341 370 WW domain Domain
PF00595 PDZ 410 490 PDZ domain Domain
PF00595 PDZ 725 807 PDZ domain Domain
PF00595 PDZ 851 935 PDZ domain Domain
PF00595 PDZ 1021 1100 PDZ domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10748157}.
Sequence
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVV
SGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQ
FQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLES
GTYDGNFYGTPKPPAE
PSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEE
EDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWE
MAYTDTGMIYFIDHNTKTTTWLDP
RLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDH
LNQKTQFENP
VEEAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGF
GFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLV
PVNQYVNLTL
CRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQ
NGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQK
VKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSP
TKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPP
NTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIP
VKGKSHKQVLDLMTTAARNGHVLLTVR
RKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEV
PARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVG
DHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVI
AEEEHHGPPSGTNSARQSPALQHRP
MGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCY
PVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGIT
HTRAIELIQAGGNKVLLLLR
PGTGLIPDHGDWDINNPSSSNVIYDEQSPLPPSSHFASIF
EESHVPVIEESLRVQICEKAEELKDIVPEKKSTLNENQPEIKHQSLLQKNVSKRDPPSSH
GHSNKKNLLKVENGVTRRGRSVSPKKPASQHSEEHLDKIPSPLKNNPKRRPRDQSLSPSK
GENKSCQVSTRAGSGQDQCRKSRGRSASPKKQQKIEGSKAPSNAEAKLLEGKSRRIAGYT
GSNAEQIPDGKEKSDVIRKDAKQNQLEKSRTRSPEKKIKRMVEKSLPSKMTNKTTSKEVS
ENEKGKKVTTGETSSSNDKIGENVQLSEKRLKQEPEEKVVSNKTEDHKGKELEAADKNKE
TGRFKPESSSPVKKTLITPGPWKVPSGNKVTGTIGMAEKRQ
Sequence length 1481
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Rap1 signaling pathway  
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Arthrogryposis multiplex congenita Uncertain significance rs753459456 RCV000855514
Fetal akinesia deformation sequence 1 Uncertain significance rs753459456 RCV000855514
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Arthritis Juvenile Associate 36362342
Arthritis Rheumatoid Associate 33740106
Breast Neoplasms Associate 27205883, 29362392
Cardiomyopathies Associate 33288658
Colitis Ulcerative Inhibit 28545409
Crohn Disease Associate 28545409
Inflammation Associate 28545409
Inflammatory Bowel Diseases Associate 28545409
Lung Neoplasms Associate 30590402
Muscular Dystrophy Duchenne Associate 33740106