Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
260425
Gene name Gene Name - the full gene name approved by the HGNC.
Membrane associated guanylate kinase, WW and PDZ domain containing 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MAGI3
Synonyms (NCBI Gene) Gene synonyms aliases
MAGI-3, dJ730K3.2
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p13.2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT685132 hsa-miR-6771-3p HITS-CLIP 23313552
MIRT685131 hsa-miR-3675-3p HITS-CLIP 23313552
MIRT522674 hsa-miR-6849-3p HITS-CLIP 23313552
MIRT685130 hsa-miR-3190-5p HITS-CLIP 23313552
MIRT540547 hsa-miR-4786-5p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004385 Function Guanylate kinase activity NAS 10748157
GO:0005515 Function Protein binding IPI 16316992, 16964398, 20353789, 23873930
GO:0005524 Function ATP binding IEA
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
615943 29647 ENSG00000081026
Protein
UniProt ID Q5TCQ9
Protein name Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (Membrane-associated guanylate kinase inverted 3) (MAGI-3)
Protein function Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins sugg
PDB 3SOE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00625 Guanylate_kin 122 196 Guanylate kinase Domain
PF00397 WW 295 324 WW domain Domain
PF00397 WW 341 370 WW domain Domain
PF00595 PDZ 410 490 PDZ domain Domain
PF00595 PDZ 725 807 PDZ domain Domain
PF00595 PDZ 851 935 PDZ domain Domain
PF00595 PDZ 1021 1100 PDZ domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10748157}.
Sequence
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVV
SGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQ
FQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLES
GTYDGNFYGTPKPPAE
PSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEE
EDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWE
MAYTDTGMIYFIDHNTKTTTWLDP
RLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDH
LNQKTQFENP
VEEAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGF
GFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLV
PVNQYVNLTL
CRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQ
NGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQK
VKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSP
TKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPP
NTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIP
VKGKSHKQVLDLMTTAARNGHVLLTVR
RKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEV
PARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVG
DHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVI
AEEEHHGPPSGTNSARQSPALQHRP
MGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCY
PVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGIT
HTRAIELIQAGGNKVLLLLR
PGTGLIPDHGDWDINNPSSSNVIYDEQSPLPPSSHFASIF
EESHVPVIEESLRVQICEKAEELKDIVPEKKSTLNENQPEIKHQSLLQKNVSKRDPPSSH
GHSNKKNLLKVENGVTRRGRSVSPKKPASQHSEEHLDKIPSPLKNNPKRRPRDQSLSPSK
GENKSCQVSTRAGSGQDQCRKSRGRSASPKKQQKIEGSKAPSNAEAKLLEGKSRRIAGYT
GSNAEQIPDGKEKSDVIRKDAKQNQLEKSRTRSPEKKIKRMVEKSLPSKMTNKTTSKEVS
ENEKGKKVTTGETSSSNDKIGENVQLSEKRLKQEPEEKVVSNKTEDHKGKELEAADKNKE
TGRFKPESSSPVKKTLITPGPWKVPSGNKVTGTIGMAEKRQ
Sequence length 1481
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Rap1 signaling pathway  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
29059683
Diabetes mellitus Diabetes Mellitus, Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
25936594
Rheumatoid arthritis Rheumatoid Arthritis rs587776843 19503088
Unknown
Disease term Disease name Evidence References Source
Alopecia Areata Alopecia Areata GWAS
Hypothyroidism Hypothyroidism GWAS
Bulimia Bulimia GWAS
Myasthenia Gravis Myasthenia Gravis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Juvenile Associate 36362342
Arthritis Rheumatoid Associate 33740106
Breast Neoplasms Associate 27205883, 29362392
Cardiomyopathies Associate 33288658
Colitis Ulcerative Inhibit 28545409
Crohn Disease Associate 28545409
Inflammation Associate 28545409
Inflammatory Bowel Diseases Associate 28545409
Lung Neoplasms Associate 30590402
Muscular Dystrophy Duchenne Associate 33740106