Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	26037
Gene name Gene Name - the full gene name approved by the HGNC.	Signal induced proliferation associated 1 like 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SIPA1L1
Synonyms (NCBI Gene) Gene synonyms aliases	E6TP1, SPAR1
Chromosome Chromosome number	14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	14q24.2

Show/Hide all(84)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049597	hsa-miR-92a-3p	CLASH	23622248
MIRT715899	hsa-miR-539-5p	HITS-CLIP	19536157
MIRT715898	hsa-miR-4434	HITS-CLIP	19536157
MIRT715897	hsa-miR-4516	HITS-CLIP	19536157
MIRT715896	hsa-miR-5703	HITS-CLIP	19536157
MIRT715895	hsa-miR-5581-3p	HITS-CLIP	19536157
MIRT715894	hsa-miR-4531	HITS-CLIP	19536157
MIRT726571	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT726570	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT726569	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT726568	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT734963	hsa-miR-204-5p	Luciferase reporter assay, Western blotting, Immunofluorescence, qRT-PCR, In situ hybridization, Flow cytometry	33138854
MIRT715899	hsa-miR-539-5p	HITS-CLIP	19536157
MIRT715898	hsa-miR-4434	HITS-CLIP	19536157
MIRT715897	hsa-miR-4516	HITS-CLIP	19536157
MIRT715896	hsa-miR-5703	HITS-CLIP	19536157
MIRT715895	hsa-miR-5581-3p	HITS-CLIP	19536157
MIRT715894	hsa-miR-4531	HITS-CLIP	19536157
MIRT1349692	hsa-miR-1185	CLIP-seq
MIRT1349693	hsa-miR-125a-3p	CLIP-seq
MIRT1349694	hsa-miR-1283	CLIP-seq
MIRT1349695	hsa-miR-18a	CLIP-seq
MIRT1349696	hsa-miR-18b	CLIP-seq
MIRT1349697	hsa-miR-219-5p	CLIP-seq
MIRT1349698	hsa-miR-2276	CLIP-seq
MIRT1349699	hsa-miR-3160-5p	CLIP-seq
MIRT1349700	hsa-miR-3194-3p	CLIP-seq
MIRT1349701	hsa-miR-3605-5p	CLIP-seq
MIRT1349702	hsa-miR-3665	CLIP-seq
MIRT1349703	hsa-miR-3679-5p	CLIP-seq
MIRT1349704	hsa-miR-3682-3p	CLIP-seq
MIRT1349705	hsa-miR-3714	CLIP-seq
MIRT1349706	hsa-miR-3907	CLIP-seq
MIRT1349707	hsa-miR-3921	CLIP-seq
MIRT1349708	hsa-miR-4445	CLIP-seq
MIRT1349709	hsa-miR-4476	CLIP-seq
MIRT1349710	hsa-miR-4649-3p	CLIP-seq
MIRT1349711	hsa-miR-4653-5p	CLIP-seq
MIRT1349712	hsa-miR-4735-3p	CLIP-seq
MIRT1349713	hsa-miR-4736	CLIP-seq
MIRT1349714	hsa-miR-4747-5p	CLIP-seq
MIRT1349715	hsa-miR-4772-3p	CLIP-seq
MIRT1349716	hsa-miR-4782-3p	CLIP-seq
MIRT1349717	hsa-miR-4786-3p	CLIP-seq
MIRT1349718	hsa-miR-486-3p	CLIP-seq
MIRT1349719	hsa-miR-508-3p	CLIP-seq
MIRT1349720	hsa-miR-548an	CLIP-seq
MIRT1349721	hsa-miR-653	CLIP-seq
MIRT1349722	hsa-miR-671-5p	CLIP-seq
MIRT1349723	hsa-miR-891b	CLIP-seq
MIRT1349724	hsa-miR-940	CLIP-seq
MIRT1349692	hsa-miR-1185	CLIP-seq
MIRT1349693	hsa-miR-125a-3p	CLIP-seq
MIRT1349694	hsa-miR-1283	CLIP-seq
MIRT1349695	hsa-miR-18a	CLIP-seq
MIRT1349696	hsa-miR-18b	CLIP-seq
MIRT1349697	hsa-miR-219-5p	CLIP-seq
MIRT1349698	hsa-miR-2276	CLIP-seq
MIRT1349699	hsa-miR-3160-5p	CLIP-seq
MIRT1349700	hsa-miR-3194-3p	CLIP-seq
MIRT1349701	hsa-miR-3605-5p	CLIP-seq
MIRT1349702	hsa-miR-3665	CLIP-seq
MIRT1349703	hsa-miR-3679-5p	CLIP-seq
MIRT1349704	hsa-miR-3682-3p	CLIP-seq
MIRT1349705	hsa-miR-3714	CLIP-seq
MIRT1349706	hsa-miR-3907	CLIP-seq
MIRT1349707	hsa-miR-3921	CLIP-seq
MIRT1349708	hsa-miR-4445	CLIP-seq
MIRT1349709	hsa-miR-4476	CLIP-seq
MIRT1349710	hsa-miR-4649-3p	CLIP-seq
MIRT1349711	hsa-miR-4653-5p	CLIP-seq
MIRT1349712	hsa-miR-4735-3p	CLIP-seq
MIRT1349713	hsa-miR-4736	CLIP-seq
MIRT1349714	hsa-miR-4747-5p	CLIP-seq
MIRT1349715	hsa-miR-4772-3p	CLIP-seq
MIRT1349716	hsa-miR-4782-3p	CLIP-seq
MIRT1349717	hsa-miR-4786-3p	CLIP-seq
MIRT1349718	hsa-miR-486-3p	CLIP-seq
MIRT1349719	hsa-miR-508-3p	CLIP-seq
MIRT1349720	hsa-miR-548an	CLIP-seq
MIRT1349721	hsa-miR-653	CLIP-seq
MIRT1349722	hsa-miR-671-5p	CLIP-seq
MIRT1349723	hsa-miR-891b	CLIP-seq
MIRT1349724	hsa-miR-940	CLIP-seq

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005096	Function	GTPase activator activity	IBA	21873635
GO:0005575	Component	Cellular_component	ND
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0008150	Process	Biological_process	ND
GO:0014069	Component	Postsynaptic density	ISS
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0031532	Process	Actin cytoskeleton reorganization	ISS
GO:0043087	Process	Regulation of GTPase activity	ISS
GO:0043197	Component	Dendritic spine	ISS
GO:0046875	Function	Ephrin receptor binding	IEA
GO:0048013	Process	Ephrin receptor signaling pathway	ISS
GO:0048167	Process	Regulation of synaptic plasticity	ISS
GO:0048814	Process	Regulation of dendrite morphogenesis	IEA
GO:0050770	Process	Regulation of axonogenesis	ISS
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA
GO:0061001	Process	Regulation of dendritic spine morphogenesis	ISS
GO:0090630	Process	Activation of GTPase activity	IBA	21873635
GO:0090630	Process	Activation of GTPase activity	ISS

MIM	HGNC	e!Ensembl
617504	20284	ENSG00000197555

Protein

UniProt ID

O43166

Protein name

Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)

Protein function

Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02145	Rap_GAP	628 → 810	Rap/ran-GAP	Family
PF11881	SPAR_C	1504 → 1749	C-terminal domain of SPAR protein	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:9858596}.

Sequence

MTSLKRSQTERPLATDRASVVGTDGTPKVHTDDFYMRRFRSQNGSLGSSVMAPVGPPRSE
GSHHITSTPGVPKMGVRARIADWPPRKENIKESSRSSQEIETSSCLDSLSSKSSPVSQGS
SVSLNSNDSAMLKSIQNTLKNKTRPSENMDSRFLMPEAYPSSPRKALRRIRQRSNSDITI
SELDVDSFDECISPTYKTGPSLHREYGSTSSIDKQGTSGESFFDLLKGYKDDKSDRGPTP
TKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLKRRSKSETGDSSIFRKLR
NAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTT
TGASAAAVASLVSGPLSHSASFSSPMGSTEDLNSKGSLSMDQGDDKSNELVMSCPYFRNE
IGGEGERKISLSKSNSGSFSGCESASFESTLSSHCTNAGVAVLEVPKENLVLHLDRVKRY
IVEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRREKPDEMKENGSPYNYRIIFR
TSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVVPELNVQCLRLAFNTPKVTEQLM
KLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQ
LDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGA
QPFSPKNIRSHFQHVFVIVRVHNPCSDSVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVF
RDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASK
KKEKSKPYPGAELSSMGAIVWAVRAEDYNKAMELDCLLGISNEFIVLIEQETKSVVFNCS
CRDVIGWTSTDTSLKIFYERGECVSVGSFINIEEIKEIVKRLQFVSKGCESVEMTLRRNG
LGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTV
KVVIIPPHDDCTPRRSCSETYRMPVMEYKMNEGVSYEFKFPFRNNNKWQRNASKGPHSPQ
VPSQVQSPMTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMA
LARSQCRNSPSNLSSSSDTGSVGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDIGGSGKS
TPSWQRSEDSIADQMAYSYRGPQDFNSFVLEQHEYTEPTCHLPAVSKVLPAFRESPSGRL
MRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESELNSYNYLQ
GTSADSGIDTTSYGPSHGSTASLGAATSSPRSGPGKEKVAPLWHSSSEVISMADRTLETE
SHGLDRKTESSLSLDIHSKSQAGSTPLTRENSTFSINDAASHTSTMSSRHSASPVVFTSA
RSSPKEELHPAAPSQLAPSFSSSSSSSSGPRSFYPRQGATSKYLIGWKKPEGTINSVGFM
DTRKRHQSDGNEIAHTRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESPTPESQKSFKF
HALSSPQSPFPSTPTSRRALHRTLSDESIYNSQREHFFTSRASLLDQALPNDVLFSSTYP
SLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLMPLPDTAADLDWS
NLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEDQALAQMKPYSSSKDSSPTLASK
VDQLEGMLKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQNASDKLKKFTEWVFNT
IDMS

Sequence length

1804

Interactions

View interactions

	KEGG
	Rap1 signaling pathway

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Arthritis	Juvenile arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	19565504
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)

Show/Hide Unknown Diseases (7)

Disease term	Disease name	References	Source
Unknown
Heart failure	Heart Failure, Diastolic	29556499	ClinVar
Neuroticism	Neuroticism		GWAS
Schizophrenia	Schizophrenia		GWAS
Hypertension	Hypertension		GWAS
Oligodendroglioma	Oligodendroglioma		GWAS
Otosclerosis	Otosclerosis		GWAS
Myocardial Infarction	Myocardial Infarction		GWAS

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining
Meningioma	Associate	9858596

SIPA1L1 (signal induced proliferation associated 1 like 1)