Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	26037
Gene name	Signal induced proliferation associated 1 like 1
Gene symbol	SIPA1L1
Synonyms (NCBI Gene)	E6TP1SPAR1
Chromosome	14
Chromosome location	14q24.2

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miRTarBase ID	miRNA	Experiments	Reference
MIRT049597	hsa-miR-92a-3p	CLASH	23622248
MIRT715899	hsa-miR-539-5p	HITS-CLIP	19536157
MIRT715898	hsa-miR-4434	HITS-CLIP	19536157
MIRT715897	hsa-miR-4516	HITS-CLIP	19536157
MIRT715896	hsa-miR-5703	HITS-CLIP	19536157
MIRT715895	hsa-miR-5581-3p	HITS-CLIP	19536157
MIRT715894	hsa-miR-4531	HITS-CLIP	19536157
MIRT726571	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT726570	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT726569	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT726568	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT734963	hsa-miR-204-5p	Luciferase reporter assayWestern blottingImmunofluorescenceqRT-PCRIn situ hybridizationFlow cytometry	33138854
MIRT715899	hsa-miR-539-5p	HITS-CLIP	19536157
MIRT715898	hsa-miR-4434	HITS-CLIP	19536157
MIRT715897	hsa-miR-4516	HITS-CLIP	19536157
MIRT715896	hsa-miR-5703	HITS-CLIP	19536157
MIRT715895	hsa-miR-5581-3p	HITS-CLIP	19536157
MIRT715894	hsa-miR-4531	HITS-CLIP	19536157
MIRT1349692	hsa-miR-1185	CLIP-seq
MIRT1349693	hsa-miR-125a-3p	CLIP-seq
MIRT1349694	hsa-miR-1283	CLIP-seq
MIRT1349695	hsa-miR-18a	CLIP-seq
MIRT1349696	hsa-miR-18b	CLIP-seq
MIRT1349697	hsa-miR-219-5p	CLIP-seq
MIRT1349698	hsa-miR-2276	CLIP-seq
MIRT1349699	hsa-miR-3160-5p	CLIP-seq
MIRT1349700	hsa-miR-3194-3p	CLIP-seq
MIRT1349701	hsa-miR-3605-5p	CLIP-seq
MIRT1349702	hsa-miR-3665	CLIP-seq
MIRT1349703	hsa-miR-3679-5p	CLIP-seq
MIRT1349704	hsa-miR-3682-3p	CLIP-seq
MIRT1349705	hsa-miR-3714	CLIP-seq
MIRT1349706	hsa-miR-3907	CLIP-seq
MIRT1349707	hsa-miR-3921	CLIP-seq
MIRT1349708	hsa-miR-4445	CLIP-seq
MIRT1349709	hsa-miR-4476	CLIP-seq
MIRT1349710	hsa-miR-4649-3p	CLIP-seq
MIRT1349711	hsa-miR-4653-5p	CLIP-seq
MIRT1349712	hsa-miR-4735-3p	CLIP-seq
MIRT1349713	hsa-miR-4736	CLIP-seq
MIRT1349714	hsa-miR-4747-5p	CLIP-seq
MIRT1349715	hsa-miR-4772-3p	CLIP-seq
MIRT1349716	hsa-miR-4782-3p	CLIP-seq
MIRT1349717	hsa-miR-4786-3p	CLIP-seq
MIRT1349718	hsa-miR-486-3p	CLIP-seq
MIRT1349719	hsa-miR-508-3p	CLIP-seq
MIRT1349720	hsa-miR-548an	CLIP-seq
MIRT1349721	hsa-miR-653	CLIP-seq
MIRT1349722	hsa-miR-671-5p	CLIP-seq
MIRT1349723	hsa-miR-891b	CLIP-seq
MIRT1349724	hsa-miR-940	CLIP-seq
MIRT1349692	hsa-miR-1185	CLIP-seq
MIRT1349693	hsa-miR-125a-3p	CLIP-seq
MIRT1349694	hsa-miR-1283	CLIP-seq
MIRT1349695	hsa-miR-18a	CLIP-seq
MIRT1349696	hsa-miR-18b	CLIP-seq
MIRT1349697	hsa-miR-219-5p	CLIP-seq
MIRT1349698	hsa-miR-2276	CLIP-seq
MIRT1349699	hsa-miR-3160-5p	CLIP-seq
MIRT1349700	hsa-miR-3194-3p	CLIP-seq
MIRT1349701	hsa-miR-3605-5p	CLIP-seq
MIRT1349702	hsa-miR-3665	CLIP-seq
MIRT1349703	hsa-miR-3679-5p	CLIP-seq
MIRT1349704	hsa-miR-3682-3p	CLIP-seq
MIRT1349705	hsa-miR-3714	CLIP-seq
MIRT1349706	hsa-miR-3907	CLIP-seq
MIRT1349707	hsa-miR-3921	CLIP-seq
MIRT1349708	hsa-miR-4445	CLIP-seq
MIRT1349709	hsa-miR-4476	CLIP-seq
MIRT1349710	hsa-miR-4649-3p	CLIP-seq
MIRT1349711	hsa-miR-4653-5p	CLIP-seq
MIRT1349712	hsa-miR-4735-3p	CLIP-seq
MIRT1349713	hsa-miR-4736	CLIP-seq
MIRT1349714	hsa-miR-4747-5p	CLIP-seq
MIRT1349715	hsa-miR-4772-3p	CLIP-seq
MIRT1349716	hsa-miR-4782-3p	CLIP-seq
MIRT1349717	hsa-miR-4786-3p	CLIP-seq
MIRT1349718	hsa-miR-486-3p	CLIP-seq
MIRT1349719	hsa-miR-508-3p	CLIP-seq
MIRT1349720	hsa-miR-548an	CLIP-seq
MIRT1349721	hsa-miR-653	CLIP-seq
MIRT1349722	hsa-miR-671-5p	CLIP-seq
MIRT1349723	hsa-miR-891b	CLIP-seq
MIRT1349724	hsa-miR-940	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	15778465, 21653829, 22117215, 36931259
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0014069	Component	Postsynaptic density	IEA
GO:0014069	Component	Postsynaptic density	ISS
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0043005	Component	Neuron projection	IEA
GO:0043087	Process	Regulation of GTPase activity	ISS
GO:0043197	Component	Dendritic spine	ISS
GO:0045202	Component	Synapse	IEA
GO:0046875	Function	Ephrin receptor binding	IEA
GO:0048013	Process	Ephrin receptor signaling pathway	IEA
GO:0048013	Process	Ephrin receptor signaling pathway	ISS
GO:0048167	Process	Regulation of synaptic plasticity	ISS
GO:0050770	Process	Regulation of axonogenesis	IEA
GO:0050770	Process	Regulation of axonogenesis	ISS
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA
GO:0061001	Process	Regulation of dendritic spine morphogenesis	ISS
GO:0090630	Process	Activation of GTPase activity	ISS

MIM	HGNC	e!Ensembl
617504	20284	ENSG00000197555

O43166

Protein name

Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)

Protein function

Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02145	Rap_GAP	628 → 810	Rap/ran-GAP	Family
PF11881	SPAR_C	1504 → 1749	C-terminal domain of SPAR protein	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:9858596}.

Sequence

MTSLKRSQTERPLATDRASVVGTDGTPKVHTDDFYMRRFRSQNGSLGSSVMAPVGPPRSE
GSHHITSTPGVPKMGVRARIADWPPRKENIKESSRSSQEIETSSCLDSLSSKSSPVSQGS
SVSLNSNDSAMLKSIQNTLKNKTRPSENMDSRFLMPEAYPSSPRKALRRIRQRSNSDITI
SELDVDSFDECISPTYKTGPSLHREYGSTSSIDKQGTSGESFFDLLKGYKDDKSDRGPTP
TKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLKRRSKSETGDSSIFRKLR
NAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTT
TGASAAAVASLVSGPLSHSASFSSPMGSTEDLNSKGSLSMDQGDDKSNELVMSCPYFRNE
IGGEGERKISLSKSNSGSFSGCESASFESTLSSHCTNAGVAVLEVPKENLVLHLDRVKRY
IVEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRREKPDEMKENGSPYNYRIIFR
TSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVVPELNVQCLRLAFNTPKVTEQLM
KLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQ
LDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGA
QPFSPKNIRSHFQHVFVIVRVHNPCSDSVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVF
RDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASK
KKEKSKPYPGAELSSMGAIVWAVRAEDYNKAMELDCLLGISNEFIVLIEQETKSVVFNCS
CRDVIGWTSTDTSLKIFYERGECVSVGSFINIEEIKEIVKRLQFVSKGCESVEMTLRRNG
LGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTV
KVVIIPPHDDCTPRRSCSETYRMPVMEYKMNEGVSYEFKFPFRNNNKWQRNASKGPHSPQ
VPSQVQSPMTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMA
LARSQCRNSPSNLSSSSDTGSVGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDIGGSGKS
TPSWQRSEDSIADQMAYSYRGPQDFNSFVLEQHEYTEPTCHLPAVSKVLPAFRESPSGRL
MRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESELNSYNYLQ
GTSADSGIDTTSYGPSHGSTASLGAATSSPRSGPGKEKVAPLWHSSSEVISMADRTLETE
SHGLDRKTESSLSLDIHSKSQAGSTPLTRENSTFSINDAASHTSTMSSRHSASPVVFTSA
RSSPKEELHPAAPSQLAPSFSSSSSSSSGPRSFYPRQGATSKYLIGWKKPEGTINSVGFM
DTRKRHQSDGNEIAHTRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESPTPESQKSFKF
HALSSPQSPFPSTPTSRRALHRTLSDESIYNSQREHFFTSRASLLDQALPNDVLFSSTYP
SLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLMPLPDTAADLDWS
NLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEDQALAQMKPYSSSKDSSPTLASK
VDQLEGMLKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQNASDKLKKFTEWVFNT
IDMS

Sequence length

1804

Interactions

View interactions

	KEGG
	Rap1 signaling pathway

SIPA1L1 (signal induced proliferation associated 1 like 1)