ATRNL1 (attractin like 1)

Gene

• Entrez ID: 26033
• Gene name: Attractin like 1
• Gene symbol: ATRNL1
• Synonyms (NCBI Gene): ALP, bA338L11.1, bA454H24.1
• Chromosome: 10
• Chromosome location: 10q25.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT026568	hsa-miR-192-5p	Microarray	19074876
MIRT529317	hsa-miR-548ac	PAR-CLIP	22012620
MIRT529316	hsa-miR-548bb-3p	PAR-CLIP	22012620
MIRT529315	hsa-miR-548d-3p	PAR-CLIP	22012620
MIRT529314	hsa-miR-548h-3p	PAR-CLIP	22012620
MIRT529313	hsa-miR-548z	PAR-CLIP	22012620
MIRT529312	hsa-miR-548as-3p	PAR-CLIP	22012620
MIRT529311	hsa-miR-4282	PAR-CLIP	22012620
MIRT529310	hsa-miR-6771-3p	PAR-CLIP	22012620
MIRT529309	hsa-miR-577	PAR-CLIP	22012620
MIRT529308	hsa-miR-3163	PAR-CLIP	22012620
MIRT529307	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT441141	hsa-miR-379-3p	HITS-CLIP	24374217
MIRT441141	hsa-miR-379-3p	HITS-CLIP	24374217
MIRT739749	hsa-miR-1227	HITS-CLIP	33718276
MIRT739750	hsa-miR-3180-5p	HITS-CLIP	33718276
MIRT529317	hsa-miR-548ac	PAR-CLIP	22012620
MIRT529316	hsa-miR-548bb-3p	PAR-CLIP	22012620
MIRT529315	hsa-miR-548d-3p	PAR-CLIP	22012620
MIRT529314	hsa-miR-548h-3p	PAR-CLIP	22012620
MIRT529313	hsa-miR-548z	PAR-CLIP	22012620
MIRT529312	hsa-miR-548as-3p	PAR-CLIP	22012620
MIRT529311	hsa-miR-4282	PAR-CLIP	22012620
MIRT529310	hsa-miR-6771-3p	PAR-CLIP	22012620
MIRT529309	hsa-miR-577	PAR-CLIP	22012620
MIRT529308	hsa-miR-3163	PAR-CLIP	22012620
MIRT529307	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT810477	hsa-miR-101	CLIP-seq
MIRT810478	hsa-miR-1228	CLIP-seq
MIRT810479	hsa-miR-1297	CLIP-seq
MIRT810480	hsa-miR-1305	CLIP-seq
MIRT810481	hsa-miR-194	CLIP-seq
MIRT810482	hsa-miR-200b	CLIP-seq
MIRT810483	hsa-miR-200c	CLIP-seq
MIRT810484	hsa-miR-21	CLIP-seq
MIRT810485	hsa-miR-23a	CLIP-seq
MIRT810486	hsa-miR-23b	CLIP-seq
MIRT810487	hsa-miR-23c	CLIP-seq
MIRT810488	hsa-miR-26a	CLIP-seq
MIRT810489	hsa-miR-26b	CLIP-seq
MIRT810490	hsa-miR-299-3p	CLIP-seq
MIRT810491	hsa-miR-3136-3p	CLIP-seq
MIRT810492	hsa-miR-3143	CLIP-seq
MIRT810493	hsa-miR-3145-3p	CLIP-seq
MIRT810494	hsa-miR-3161	CLIP-seq
MIRT810495	hsa-miR-3177-5p	CLIP-seq
MIRT810496	hsa-miR-3202	CLIP-seq
MIRT810497	hsa-miR-3612	CLIP-seq
MIRT810498	hsa-miR-3622b-5p	CLIP-seq
MIRT810499	hsa-miR-3653	CLIP-seq
MIRT810500	hsa-miR-3658	CLIP-seq
MIRT810501	hsa-miR-3692	CLIP-seq
MIRT810502	hsa-miR-3941	CLIP-seq
MIRT810503	hsa-miR-4266	CLIP-seq
MIRT810504	hsa-miR-4269	CLIP-seq
MIRT810505	hsa-miR-429	CLIP-seq
MIRT810506	hsa-miR-4330	CLIP-seq
MIRT810507	hsa-miR-4422	CLIP-seq
MIRT810508	hsa-miR-4443	CLIP-seq
MIRT810509	hsa-miR-4452	CLIP-seq
MIRT810510	hsa-miR-4465	CLIP-seq
MIRT810511	hsa-miR-4491	CLIP-seq
MIRT810512	hsa-miR-4494	CLIP-seq
MIRT810513	hsa-miR-4499	CLIP-seq
MIRT810514	hsa-miR-4511	CLIP-seq
MIRT810515	hsa-miR-4514	CLIP-seq
MIRT810516	hsa-miR-4533	CLIP-seq
MIRT810517	hsa-miR-4657	CLIP-seq
MIRT810518	hsa-miR-466	CLIP-seq
MIRT810519	hsa-miR-4672	CLIP-seq
MIRT810520	hsa-miR-4682	CLIP-seq
MIRT810521	hsa-miR-4687-3p	CLIP-seq
MIRT810522	hsa-miR-4692	CLIP-seq
MIRT810523	hsa-miR-4698	CLIP-seq
MIRT810524	hsa-miR-4699-3p	CLIP-seq
MIRT810525	hsa-miR-4700-3p	CLIP-seq
MIRT810526	hsa-miR-4731-3p	CLIP-seq
MIRT810527	hsa-miR-4742-5p	CLIP-seq
MIRT810528	hsa-miR-4801	CLIP-seq
MIRT810529	hsa-miR-485-5p	CLIP-seq
MIRT810530	hsa-miR-498	CLIP-seq
MIRT810531	hsa-miR-499-3p	CLIP-seq
MIRT810532	hsa-miR-499a-3p	CLIP-seq
MIRT810533	hsa-miR-499a-5p	CLIP-seq
MIRT810534	hsa-miR-520d-5p	CLIP-seq
MIRT810535	hsa-miR-524-5p	CLIP-seq
MIRT810536	hsa-miR-543	CLIP-seq
MIRT810537	hsa-miR-548b-3p	CLIP-seq
MIRT810538	hsa-miR-548c-3p	CLIP-seq
MIRT810539	hsa-miR-548m	CLIP-seq
MIRT810540	hsa-miR-590-5p	CLIP-seq
MIRT810541	hsa-miR-650	CLIP-seq
MIRT810542	hsa-miR-651	CLIP-seq
MIRT810543	hsa-miR-663b	CLIP-seq
MIRT1939556	hsa-miR-1179	CLIP-seq
MIRT1939557	hsa-miR-1266	CLIP-seq
MIRT1939558	hsa-miR-1301	CLIP-seq
MIRT810480	hsa-miR-1305	CLIP-seq
MIRT1939559	hsa-miR-19a	CLIP-seq
MIRT1939560	hsa-miR-19b	CLIP-seq
MIRT1939561	hsa-miR-3545-3p	CLIP-seq
MIRT1939562	hsa-miR-3607-3p	CLIP-seq
MIRT1939563	hsa-miR-3622a-3p	CLIP-seq
MIRT1939564	hsa-miR-3622b-3p	CLIP-seq
MIRT1939565	hsa-miR-3664-3p	CLIP-seq
MIRT1939566	hsa-miR-3922-5p	CLIP-seq
MIRT1939567	hsa-miR-4436a	CLIP-seq
MIRT1939568	hsa-miR-4518	CLIP-seq
MIRT1939569	hsa-miR-455-5p	CLIP-seq
MIRT1939570	hsa-miR-4660	CLIP-seq
MIRT1939571	hsa-miR-4668-3p	CLIP-seq
MIRT1939572	hsa-miR-4753-5p	CLIP-seq
MIRT1939573	hsa-miR-4796-3p	CLIP-seq
MIRT1939574	hsa-miR-4802-3p	CLIP-seq
MIRT1939575	hsa-miR-490-5p	CLIP-seq
MIRT1939576	hsa-miR-5047	CLIP-seq
MIRT1939577	hsa-miR-576-5p	CLIP-seq
MIRT2178805	hsa-miR-1182	CLIP-seq
MIRT2178806	hsa-miR-1264	CLIP-seq
MIRT810479	hsa-miR-1297	CLIP-seq
MIRT810488	hsa-miR-26a	CLIP-seq
MIRT810489	hsa-miR-26b	CLIP-seq
MIRT2178807	hsa-miR-3148	CLIP-seq
MIRT810499	hsa-miR-3653	CLIP-seq
MIRT2178808	hsa-miR-4278	CLIP-seq
MIRT810510	hsa-miR-4465	CLIP-seq
MIRT2178809	hsa-miR-450b-3p	CLIP-seq
MIRT2178810	hsa-miR-4668-5p	CLIP-seq
MIRT810523	hsa-miR-4698	CLIP-seq
MIRT2178811	hsa-miR-4716-3p	CLIP-seq
MIRT2178812	hsa-miR-4773	CLIP-seq
MIRT810530	hsa-miR-498	CLIP-seq
MIRT810531	hsa-miR-499-3p	CLIP-seq
MIRT810532	hsa-miR-499a-3p	CLIP-seq
MIRT2178813	hsa-miR-548a-3p	CLIP-seq
MIRT2178814	hsa-miR-548aa	CLIP-seq
MIRT2178815	hsa-miR-548e	CLIP-seq
MIRT2178816	hsa-miR-548f	CLIP-seq
MIRT2178817	hsa-miR-625	CLIP-seq
MIRT2178818	hsa-miR-635	CLIP-seq
MIRT2178819	hsa-miR-769-3p	CLIP-seq
MIRT2178820	hsa-miR-885-5p	CLIP-seq
MIRT2178821	hsa-miR-889	CLIP-seq
MIRT2384648	hsa-miR-323b-3p	CLIP-seq
MIRT810523	hsa-miR-4698	CLIP-seq
MIRT810531	hsa-miR-499-3p	CLIP-seq
MIRT810532	hsa-miR-499a-3p	CLIP-seq
MIRT2482326	hsa-miR-4536	CLIP-seq
MIRT2482326	hsa-miR-4536	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005112	Function	Notch binding	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0030246	Function	Carbohydrate binding	IEA

Other IDs

• MIM: 612869
• HGNC: 29063
• e!Ensembl: ENSG00000107518

Protein

• UniProt ID: Q5VV63
• Protein name: Attractin-like protein 1
• Protein function: May play a role in melanocortin signaling pathways that regulate energy homeostasis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00431	CUB	93 → 206	CUB domain	Domain
  PF07974	EGF_2	249 → 280	EGF-like domain	Domain
  PF13854	Kelch_5	352 → 392		Repeat
  PF13418	Kelch_4	466 → 518		Repeat
  PF13854	Kelch_5	579 → 614		Repeat
  PF00059	Lectin_C	765 → 874	Lectin C-type domain	Domain
  PF01437	PSI	889 → 939	Plexin repeat	Family
  PF01437	PSI	942 → 1012	Plexin repeat	Family

• Sequence:

  METGGRARTGTPQPAAPGVWRARPAGGGGGGASSWLLDGNSWLLCYGFLYLALYAQVSQS
  KPCERTGSCFSGRCVNSTCLCDPGWVGDQCQHCQGRFKLTEPSGYLTDGPINYKYKTKCT
  WLIEGYPNAVLRLRFNHFATECSWDHMYVYDGDSIYAPLIAVLSGLIVPEIRGNETVPEV
  VTTSGYALLHFFSDAAYNLTGFNIFYSINSCPNNCSGHGKCTTSVSVPSQVYCECDKYWK
  GEACDIPYCKANCGSPDHGYCDLTGEKLCVCNDSWQGPDCSLNVPSTESYWILPNVKPFS
  PSVGRASHKAVLHGKFMWVIGGYTFNYSSFQMVLNYNLESSIWNVGTPSRGPLQRYGHSL
  ALYQENIFMYGGRIETNDGNVTDELWVFNIHSQSWSTKTPTVLGHGQQYAVEGHSAHIME
  LDSRDVVMIIIFGYSAIYGYTSSIQEYHISSNTWLVPETKGAIVQGGYGHTSVYDEITKS
  IYVHGGYKALPGNKYGLVDDLYKYEVNTKTWTILKESGFARYLHSAVLINGAMLIFGGNT
  HNDTSLSNGAKCFSADFLAYDIACDEWKILPKPNLHRDVNRFGHSAVVINGSMYIFGGFS
  SVLLNDILVYKPPNCKAFRDEELCKNAGPGIKCVWNKNHCESWESGNTNNILRAKCPPKT
  AASDDRCYRYADCASCTANTNGCQWCDDKKCISANSNCSMSVKNYTKCHVRNEQICNKLT
  SCKSCSLNLNCQWDQRQQECQALPAHLCGEGWSHIGDACLRVNSSRENYDNAKLYCYNLS
  GNLASLTTSKEVEFVLDEIQKYTQQKVSPWVGLRKINISYWGWEDMSPFTNTTLQWLPGE
  PNDSGFCAYLERAAVAGLKANPCTSMANGLVCEKPVVSPNQNARPCKKPCSLRTSCSNCT
  SNGMECMWCSSTKRCVDSNAYIISFPYGQCLEWQTATCSPQNCSGLRTCGQCLEQPGCGW
  CNDPSNTGRGHCIEGSSRGPMKLIGMHHSEMVLDTNLCPKEKNYEWSFIQCPACQCNGHS
  TCINNNVCEQCKNLTTGKQCQDCMPGYYGDPTNGGQCTACTCSGHANICHLHTGKCFCTT
  KGIKGDQCQLCDSENRYVGNPLRGTCYYSLLIDYQFTFSLLQEDDRHHTAINFIANPEQS
  NKNLDISINASNNFNLNITWSVGSTAGTISGEETSIVSKNNIKEYRDSFSYEKFNFRSNP
  NITFYVYVSNFSWPIKIQIAFSQHNTIMDLVQFFVTFFSCFLSLLLVAAVVWKIKQTCWA
  SRRREQLLRERQQMASRPFASVDVALEVGAEQTEFLRGPLEGAPKPIAIEPCAGNRAAVL
  TVFLCLPRGSSGAPPPGQSGLAIASALIDISQQKASDSKDKTSGVRNRKHLSTRQGTCV

• Sequence length: 1379

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BONE REMODELING DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HUNTINGTON DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESTLESS LEGS SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma of the head and neck	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Congenital Abnormalities	Associate	30623622	★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Associate	30623622	★☆☆☆☆ Found in Text Mining only
Renal Insufficiency	Associate	32123936	★☆☆☆☆ Found in Text Mining only