Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	26022
Gene name Gene Name - the full gene name approved by the HGNC.	Transmembrane protein 98
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TMEM98
Synonyms (NCBI Gene) Gene synonyms aliases	TADA1
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q11.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a transmembrane protein. A missense mutation in this gene result in Nanophthalmos 4 (NNO4). Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2014]

Show/Hide all(3)

SNP ID	Visualize variation	Clinical significance	Consequence
rs587777690	G>C,T	Pathogenic	Coding sequence variant, missense variant
rs869312733	A>C	Pathogenic	Missense variant, coding sequence variant
rs869312734	AGAATGAAGACTGGATCGAAGATGCCTCGTAAGG>-	Pathogenic	Coding sequence variant, splice donor variant, intron variant

Show/Hide all(163)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044487	hsa-miR-320a	CLASH	23622248
MIRT044487	hsa-miR-320a	CLASH	23622248
MIRT043661	hsa-miR-342-3p	CLASH	23622248
MIRT042183	hsa-miR-484	CLASH	23622248
MIRT344723	hsa-miR-577	HITS-CLIP	19536157
MIRT560531	hsa-miR-548at-5p	PAR-CLIP	20371350
MIRT560530	hsa-miR-561-3p	PAR-CLIP	20371350
MIRT560529	hsa-miR-3617-5p	PAR-CLIP	20371350
MIRT560528	hsa-miR-641	PAR-CLIP	20371350
MIRT560527	hsa-miR-302f	PAR-CLIP	20371350
MIRT560526	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT560525	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT560524	hsa-miR-5702	PAR-CLIP	20371350
MIRT560523	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT560522	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT560521	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT560520	hsa-miR-937-5p	PAR-CLIP	20371350
MIRT560519	hsa-miR-627-5p	PAR-CLIP	20371350
MIRT560518	hsa-miR-33a-5p	PAR-CLIP	20371350
MIRT560517	hsa-miR-33b-5p	PAR-CLIP	20371350
MIRT560516	hsa-miR-8081	PAR-CLIP	20371350
MIRT344723	hsa-miR-577	HITS-CLIP	19536157
MIRT560531	hsa-miR-548at-5p	PAR-CLIP	20371350
MIRT560530	hsa-miR-561-3p	PAR-CLIP	20371350
MIRT560529	hsa-miR-3617-5p	PAR-CLIP	20371350
MIRT560528	hsa-miR-641	PAR-CLIP	20371350
MIRT560527	hsa-miR-302f	PAR-CLIP	20371350
MIRT560526	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT560525	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT560524	hsa-miR-5702	PAR-CLIP	20371350
MIRT560523	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT560522	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT560521	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT560520	hsa-miR-937-5p	PAR-CLIP	20371350
MIRT560519	hsa-miR-627-5p	PAR-CLIP	20371350
MIRT560518	hsa-miR-33a-5p	PAR-CLIP	20371350
MIRT560517	hsa-miR-33b-5p	PAR-CLIP	20371350
MIRT560516	hsa-miR-8081	PAR-CLIP	20371350
MIRT1439807	hsa-miR-1207-5p	CLIP-seq
MIRT1439808	hsa-miR-1909	CLIP-seq
MIRT1439809	hsa-miR-205	CLIP-seq
MIRT1439810	hsa-miR-4467	CLIP-seq
MIRT1439811	hsa-miR-4685-5p	CLIP-seq
MIRT1439812	hsa-miR-4763-3p	CLIP-seq
MIRT1439813	hsa-miR-1305	CLIP-seq
MIRT1439814	hsa-miR-4328	CLIP-seq
MIRT1439815	hsa-miR-455-3p	CLIP-seq
MIRT2353003	hsa-miR-2355-3p	CLIP-seq
MIRT2353004	hsa-miR-3182	CLIP-seq
MIRT2353005	hsa-miR-3647-3p	CLIP-seq
MIRT2353006	hsa-miR-3909	CLIP-seq
MIRT2353007	hsa-miR-4766-5p	CLIP-seq
MIRT2353008	hsa-miR-676	CLIP-seq
MIRT2646609	hsa-miR-1183	CLIP-seq
MIRT1439807	hsa-miR-1207-5p	CLIP-seq
MIRT2646610	hsa-miR-1226	CLIP-seq
MIRT1439813	hsa-miR-1305	CLIP-seq
MIRT2646611	hsa-miR-151-3p	CLIP-seq
MIRT1439808	hsa-miR-1909	CLIP-seq
MIRT2646612	hsa-miR-1976	CLIP-seq
MIRT1439809	hsa-miR-205	CLIP-seq
MIRT2646613	hsa-miR-22	CLIP-seq
MIRT2646614	hsa-miR-24	CLIP-seq
MIRT2646615	hsa-miR-2467-3p	CLIP-seq
MIRT2646616	hsa-miR-3148	CLIP-seq
MIRT2646617	hsa-miR-3154	CLIP-seq
MIRT2646618	hsa-miR-3176	CLIP-seq
MIRT2646619	hsa-miR-320e	CLIP-seq
MIRT2646620	hsa-miR-3678-3p	CLIP-seq
MIRT2646621	hsa-miR-370	CLIP-seq
MIRT2646622	hsa-miR-3922-3p	CLIP-seq
MIRT2646623	hsa-miR-3925-3p	CLIP-seq
MIRT2646624	hsa-miR-4252	CLIP-seq
MIRT2646625	hsa-miR-4284	CLIP-seq
MIRT1439814	hsa-miR-4328	CLIP-seq
MIRT2646626	hsa-miR-4434	CLIP-seq
MIRT2646627	hsa-miR-4463	CLIP-seq
MIRT1439810	hsa-miR-4467	CLIP-seq
MIRT2646628	hsa-miR-4496	CLIP-seq
MIRT2646629	hsa-miR-4499	CLIP-seq
MIRT2646630	hsa-miR-450b-5p	CLIP-seq
MIRT2646631	hsa-miR-4516	CLIP-seq
MIRT2646632	hsa-miR-4531	CLIP-seq
MIRT2646633	hsa-miR-4539	CLIP-seq
MIRT1439815	hsa-miR-455-3p	CLIP-seq
MIRT2646634	hsa-miR-4635	CLIP-seq
MIRT2646635	hsa-miR-4637	CLIP-seq
MIRT2646636	hsa-miR-4642	CLIP-seq
MIRT2646637	hsa-miR-4645-3p	CLIP-seq
MIRT2646638	hsa-miR-4663	CLIP-seq
MIRT2646639	hsa-miR-4680-5p	CLIP-seq
MIRT1439811	hsa-miR-4685-5p	CLIP-seq
MIRT2646640	hsa-miR-4691-3p	CLIP-seq
MIRT2646641	hsa-miR-4733-3p	CLIP-seq
MIRT1439812	hsa-miR-4763-3p	CLIP-seq
MIRT2646642	hsa-miR-483-5p	CLIP-seq
MIRT2646643	hsa-miR-501-3p	CLIP-seq
MIRT2646644	hsa-miR-502-3p	CLIP-seq
MIRT2646645	hsa-miR-526b	CLIP-seq
MIRT2646646	hsa-miR-542-5p	CLIP-seq
MIRT2646647	hsa-miR-548g	CLIP-seq
MIRT2646648	hsa-miR-548n	CLIP-seq
MIRT2646649	hsa-miR-570	CLIP-seq
MIRT2646650	hsa-miR-578	CLIP-seq
MIRT2646651	hsa-miR-583	CLIP-seq
MIRT2646652	hsa-miR-618	CLIP-seq
MIRT2646653	hsa-miR-766	CLIP-seq
MIRT2646654	hsa-miR-891b	CLIP-seq
MIRT2646609	hsa-miR-1183	CLIP-seq
MIRT1439807	hsa-miR-1207-5p	CLIP-seq
MIRT2646610	hsa-miR-1226	CLIP-seq
MIRT1439813	hsa-miR-1305	CLIP-seq
MIRT2646611	hsa-miR-151-3p	CLIP-seq
MIRT1439808	hsa-miR-1909	CLIP-seq
MIRT2646612	hsa-miR-1976	CLIP-seq
MIRT1439809	hsa-miR-205	CLIP-seq
MIRT2646613	hsa-miR-22	CLIP-seq
MIRT2646614	hsa-miR-24	CLIP-seq
MIRT2646615	hsa-miR-2467-3p	CLIP-seq
MIRT2646616	hsa-miR-3148	CLIP-seq
MIRT2646617	hsa-miR-3154	CLIP-seq
MIRT2646618	hsa-miR-3176	CLIP-seq
MIRT2646619	hsa-miR-320e	CLIP-seq
MIRT2646620	hsa-miR-3678-3p	CLIP-seq
MIRT2646621	hsa-miR-370	CLIP-seq
MIRT2646622	hsa-miR-3922-3p	CLIP-seq
MIRT2646623	hsa-miR-3925-3p	CLIP-seq
MIRT2646624	hsa-miR-4252	CLIP-seq
MIRT2646625	hsa-miR-4284	CLIP-seq
MIRT1439814	hsa-miR-4328	CLIP-seq
MIRT2646626	hsa-miR-4434	CLIP-seq
MIRT2646627	hsa-miR-4463	CLIP-seq
MIRT1439810	hsa-miR-4467	CLIP-seq
MIRT2646628	hsa-miR-4496	CLIP-seq
MIRT2646629	hsa-miR-4499	CLIP-seq
MIRT2646630	hsa-miR-450b-5p	CLIP-seq
MIRT2646631	hsa-miR-4516	CLIP-seq
MIRT2646632	hsa-miR-4531	CLIP-seq
MIRT2646633	hsa-miR-4539	CLIP-seq
MIRT1439815	hsa-miR-455-3p	CLIP-seq
MIRT2646634	hsa-miR-4635	CLIP-seq
MIRT2646635	hsa-miR-4637	CLIP-seq
MIRT2646636	hsa-miR-4642	CLIP-seq
MIRT2646637	hsa-miR-4645-3p	CLIP-seq
MIRT2646638	hsa-miR-4663	CLIP-seq
MIRT2646639	hsa-miR-4680-5p	CLIP-seq
MIRT1439811	hsa-miR-4685-5p	CLIP-seq
MIRT2646640	hsa-miR-4691-3p	CLIP-seq
MIRT2693578	hsa-miR-4693-3p	CLIP-seq
MIRT2646641	hsa-miR-4733-3p	CLIP-seq
MIRT1439812	hsa-miR-4763-3p	CLIP-seq
MIRT2646642	hsa-miR-483-5p	CLIP-seq
MIRT2646643	hsa-miR-501-3p	CLIP-seq
MIRT2646644	hsa-miR-502-3p	CLIP-seq
MIRT2646645	hsa-miR-526b	CLIP-seq
MIRT2646646	hsa-miR-542-5p	CLIP-seq
MIRT2646647	hsa-miR-548g	CLIP-seq
MIRT2646648	hsa-miR-548n	CLIP-seq
MIRT2646650	hsa-miR-578	CLIP-seq
MIRT2646651	hsa-miR-583	CLIP-seq
MIRT2646652	hsa-miR-618	CLIP-seq
MIRT2646653	hsa-miR-766	CLIP-seq
MIRT2646654	hsa-miR-891b	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005615	Component	Extracellular space	IDA	25946230
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005886	Component	Plasma membrane	IDA	25946230
GO:0010955	Process	Negative regulation of protein processing	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0031642	Process	Negative regulation of myelination	ISS
GO:0045063	Process	T-helper 1 cell differentiation	ISS
GO:0048715	Process	Negative regulation of oligodendrocyte differentiation	ISS
GO:0070062	Component	Extracellular exosome	IDA	25946230
GO:1900181	Process	Negative regulation of protein localization to nucleus	IEA

MIM	HGNC	e!Ensembl
615949	24529	ENSG00000006042

Protein

UniProt ID

Q9Y2Y6

Protein name

Transmembrane protein 98 (Protein TADA1)

Protein function

Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13324	GCIP	41 → 170		Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with high expression in the ovary, pancreas and prostate (PubMed:25946230). Expressed in the eye, particularly in corneal endothelium, iris, ciliary body, sclera, optic nerve, optic nerve head, and retina (PubMed:24852

Sequence

METVVIVAIGVLATIFLASFAALVLVCRQRYCRPRDLLQRYDSKPIVDLIGAMETQSEPS
ELELDDVVITNPHIEAILENEDWIEDASGLMSHCIAILKICHTLTEKLVAMTMGSGAKMK
TSASVSDIIVVAKRISPRVDDVVKSMYPPLDPKLLDARTTALLLSVSHLVLVTRNACHLT
GGLDWIDQSLSAAEEHLEVLREAALASEPDKGLPGPEGFLQEQSAI

Sequence length

226

Interactions

View interactions

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Glaucoma	Glaucoma	rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328 View all (29 more)
Microphthalmos	Microphthalmos	rs794726862, rs1329285216	24852644
Nanophthalmos	NANOPHTHALMOS 4, Nanophthalmos	rs587776595, rs121908189, rs587776596, rs121908190, rs587777690, rs869312733, rs869312734, rs1591137064	26392740, 24852644

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Myopia	Myopia	GWAS
Oligodendroglioma	Oligodendroglioma	GWAS

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Associate	20855955
Aicardi Goutieres syndrome	Associate	32996714
Carcinoma Non Small Cell Lung	Associate	26884835
Hyperopia	Associate	33203948
Lung Neoplasms	Inhibit	26884835
Microphthalmos	Associate	32052405
Nanophthalmos 1	Associate	26392740, 32052405, 33004036, 33203948
Neoplasms	Inhibit	35866395
Ovarian Neoplasms	Inhibit	35866395

TMEM98 (transmembrane protein 98)