Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	26018
Gene name Gene Name - the full gene name approved by the HGNC.	Leucine rich repeats and immunoglobulin like domains 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	LRIG1
Synonyms (NCBI Gene) Gene synonyms aliases	LIG-1, LIG1
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p14.1

Show/Hide all(329)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022896	hsa-miR-124-3p	Microarray	18668037
MIRT024575	hsa-miR-215-5p	Microarray	19074876
MIRT026719	hsa-miR-192-5p	Microarray	19074876
MIRT027745	hsa-miR-98-5p	Microarray	19088304
MIRT049649	hsa-miR-92a-3p	CLASH	23622248
MIRT045526	hsa-miR-149-5p	CLASH	23622248
MIRT054124	hsa-let-7b-5p	Luciferase reporter assay, Microarray, qRT-PCR	22995917
MIRT656648	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT656647	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT656645	hsa-miR-5193	HITS-CLIP	23824327
MIRT656646	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT656644	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT656643	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT656642	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT656641	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT656640	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT656639	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT641461	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT641460	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT641459	hsa-miR-545-5p	HITS-CLIP	23824327
MIRT641457	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT641458	hsa-miR-4797-3p	HITS-CLIP	23824327
MIRT641456	hsa-miR-4287	HITS-CLIP	23824327
MIRT641455	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT641454	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT641453	hsa-miR-3926	HITS-CLIP	23824327
MIRT641452	hsa-miR-4764-3p	HITS-CLIP	23824327
MIRT641451	hsa-miR-548s	HITS-CLIP	23824327
MIRT641450	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT641449	hsa-miR-588	HITS-CLIP	23824327
MIRT641448	hsa-miR-4435	HITS-CLIP	23824327
MIRT641447	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT308266	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT440314	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440314	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT656648	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT656647	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT656645	hsa-miR-5193	HITS-CLIP	23824327
MIRT656646	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT656644	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT656643	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT656642	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT656641	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT656640	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT656639	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT641461	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT641460	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT641459	hsa-miR-545-5p	HITS-CLIP	23824327
MIRT641457	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT641458	hsa-miR-4797-3p	HITS-CLIP	23824327
MIRT641456	hsa-miR-4287	HITS-CLIP	23824327
MIRT641455	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT641454	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT641453	hsa-miR-3926	HITS-CLIP	23824327
MIRT641452	hsa-miR-4764-3p	HITS-CLIP	23824327
MIRT641451	hsa-miR-548s	HITS-CLIP	23824327
MIRT641450	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT641449	hsa-miR-588	HITS-CLIP	23824327
MIRT641448	hsa-miR-4435	HITS-CLIP	23824327
MIRT641447	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT308266	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT1117607	hsa-miR-1238	CLIP-seq
MIRT1117608	hsa-miR-1245b-3p	CLIP-seq
MIRT1117609	hsa-miR-1252	CLIP-seq
MIRT1117610	hsa-miR-1271	CLIP-seq
MIRT1117611	hsa-miR-145	CLIP-seq
MIRT1117612	hsa-miR-15a	CLIP-seq
MIRT1117613	hsa-miR-15b	CLIP-seq
MIRT1117614	hsa-miR-16	CLIP-seq
MIRT1117615	hsa-miR-182	CLIP-seq
MIRT1117616	hsa-miR-195	CLIP-seq
MIRT1117617	hsa-miR-2113	CLIP-seq
MIRT1117618	hsa-miR-23a	CLIP-seq
MIRT1117619	hsa-miR-23b	CLIP-seq
MIRT1117620	hsa-miR-23c	CLIP-seq
MIRT1117621	hsa-miR-3145-5p	CLIP-seq
MIRT1117622	hsa-miR-3152-5p	CLIP-seq
MIRT1117623	hsa-miR-3180-5p	CLIP-seq
MIRT1117624	hsa-miR-3622b-5p	CLIP-seq
MIRT1117625	hsa-miR-3646	CLIP-seq
MIRT1117626	hsa-miR-424	CLIP-seq
MIRT1117627	hsa-miR-425	CLIP-seq
MIRT1117628	hsa-miR-4267	CLIP-seq
MIRT1117629	hsa-miR-4317	CLIP-seq
MIRT1117630	hsa-miR-4328	CLIP-seq
MIRT1117631	hsa-miR-4330	CLIP-seq
MIRT1117632	hsa-miR-4426	CLIP-seq
MIRT1117633	hsa-miR-4470	CLIP-seq
MIRT1117634	hsa-miR-4520a-3p	CLIP-seq
MIRT1117635	hsa-miR-4528	CLIP-seq
MIRT1117636	hsa-miR-4647	CLIP-seq
MIRT1117637	hsa-miR-4650-5p	CLIP-seq
MIRT1117638	hsa-miR-4653-3p	CLIP-seq
MIRT1117639	hsa-miR-4662b	CLIP-seq
MIRT1117640	hsa-miR-4675	CLIP-seq
MIRT1117641	hsa-miR-4717-3p	CLIP-seq
MIRT1117642	hsa-miR-4741	CLIP-seq
MIRT1117643	hsa-miR-4765	CLIP-seq
MIRT1117644	hsa-miR-497	CLIP-seq
MIRT1117645	hsa-miR-508-5p	CLIP-seq
MIRT1117646	hsa-miR-516a-3p	CLIP-seq
MIRT1117647	hsa-miR-545	CLIP-seq
MIRT1117648	hsa-miR-548ad	CLIP-seq
MIRT1117649	hsa-miR-570	CLIP-seq
MIRT1117650	hsa-miR-642b	CLIP-seq
MIRT1117651	hsa-miR-96	CLIP-seq
MIRT1117608	hsa-miR-1245b-3p	CLIP-seq
MIRT1117609	hsa-miR-1252	CLIP-seq
MIRT2033247	hsa-miR-2053	CLIP-seq
MIRT1117621	hsa-miR-3145-5p	CLIP-seq
MIRT2033248	hsa-miR-3622a-3p	CLIP-seq
MIRT2033249	hsa-miR-3622b-3p	CLIP-seq
MIRT2033250	hsa-miR-3660	CLIP-seq
MIRT2033251	hsa-miR-3942-3p	CLIP-seq
MIRT2033252	hsa-miR-4264	CLIP-seq
MIRT2033253	hsa-miR-4526	CLIP-seq
MIRT2033254	hsa-miR-4645-3p	CLIP-seq
MIRT1117638	hsa-miR-4653-3p	CLIP-seq
MIRT1117641	hsa-miR-4717-3p	CLIP-seq
MIRT1117643	hsa-miR-4765	CLIP-seq
MIRT1117645	hsa-miR-508-5p	CLIP-seq
MIRT1117608	hsa-miR-1245b-3p	CLIP-seq
MIRT1117609	hsa-miR-1252	CLIP-seq
MIRT2263569	hsa-miR-1273g	CLIP-seq
MIRT2263570	hsa-miR-1305	CLIP-seq
MIRT2263571	hsa-miR-1324	CLIP-seq
MIRT1117611	hsa-miR-145	CLIP-seq
MIRT1117612	hsa-miR-15a	CLIP-seq
MIRT1117613	hsa-miR-15b	CLIP-seq
MIRT1117614	hsa-miR-16	CLIP-seq
MIRT2263572	hsa-miR-1914	CLIP-seq
MIRT1117616	hsa-miR-195	CLIP-seq
MIRT2263573	hsa-miR-200b	CLIP-seq
MIRT2263574	hsa-miR-200c	CLIP-seq
MIRT2033247	hsa-miR-2053	CLIP-seq
MIRT1117617	hsa-miR-2113	CLIP-seq
MIRT1117618	hsa-miR-23a	CLIP-seq
MIRT1117619	hsa-miR-23b	CLIP-seq
MIRT1117620	hsa-miR-23c	CLIP-seq
MIRT1117621	hsa-miR-3145-5p	CLIP-seq
MIRT1117622	hsa-miR-3152-5p	CLIP-seq
MIRT1117623	hsa-miR-3180-5p	CLIP-seq
MIRT2263575	hsa-miR-3190	CLIP-seq
MIRT2263576	hsa-miR-323b-5p	CLIP-seq
MIRT2263577	hsa-miR-3591-3p	CLIP-seq
MIRT2033248	hsa-miR-3622a-3p	CLIP-seq
MIRT2033249	hsa-miR-3622b-3p	CLIP-seq
MIRT2033250	hsa-miR-3660	CLIP-seq
MIRT2263578	hsa-miR-3714	CLIP-seq
MIRT1117626	hsa-miR-424	CLIP-seq
MIRT2033252	hsa-miR-4264	CLIP-seq
MIRT1117628	hsa-miR-4267	CLIP-seq
MIRT2263579	hsa-miR-4282	CLIP-seq
MIRT2263580	hsa-miR-429	CLIP-seq
MIRT1117629	hsa-miR-4317	CLIP-seq
MIRT1117630	hsa-miR-4328	CLIP-seq
MIRT1117631	hsa-miR-4330	CLIP-seq
MIRT2263581	hsa-miR-4446-3p	CLIP-seq
MIRT2263582	hsa-miR-4477a	CLIP-seq
MIRT2033253	hsa-miR-4526	CLIP-seq
MIRT2033254	hsa-miR-4645-3p	CLIP-seq
MIRT1117638	hsa-miR-4653-3p	CLIP-seq
MIRT2263583	hsa-miR-4666-5p	CLIP-seq
MIRT2263584	hsa-miR-4668-3p	CLIP-seq
MIRT1117640	hsa-miR-4675	CLIP-seq
MIRT1117641	hsa-miR-4717-3p	CLIP-seq
MIRT1117642	hsa-miR-4741	CLIP-seq
MIRT2263585	hsa-miR-4752	CLIP-seq
MIRT1117643	hsa-miR-4765	CLIP-seq
MIRT2263586	hsa-miR-4802-3p	CLIP-seq
MIRT1117644	hsa-miR-497	CLIP-seq
MIRT1117645	hsa-miR-508-5p	CLIP-seq
MIRT2263587	hsa-miR-513a-3p	CLIP-seq
MIRT1117646	hsa-miR-516a-3p	CLIP-seq
MIRT1117647	hsa-miR-545	CLIP-seq
MIRT2263588	hsa-miR-548c-3p	CLIP-seq
MIRT2263589	hsa-miR-548n	CLIP-seq
MIRT2263590	hsa-miR-548t	CLIP-seq
MIRT2263591	hsa-miR-548u	CLIP-seq
MIRT1117608	hsa-miR-1245b-3p	CLIP-seq
MIRT1117621	hsa-miR-3145-5p	CLIP-seq
MIRT1117638	hsa-miR-4653-3p	CLIP-seq
MIRT1117641	hsa-miR-4717-3p	CLIP-seq
MIRT1117645	hsa-miR-508-5p	CLIP-seq
MIRT1117610	hsa-miR-1271	CLIP-seq
MIRT1117627	hsa-miR-425	CLIP-seq
MIRT1117632	hsa-miR-4426	CLIP-seq
MIRT1117636	hsa-miR-4647	CLIP-seq
MIRT1117639	hsa-miR-4662b	CLIP-seq
MIRT1117650	hsa-miR-642b	CLIP-seq
MIRT1117651	hsa-miR-96	CLIP-seq
MIRT2562864	hsa-miR-106a	CLIP-seq
MIRT2562865	hsa-miR-106b	CLIP-seq
MIRT1117607	hsa-miR-1238	CLIP-seq
MIRT1117608	hsa-miR-1245b-3p	CLIP-seq
MIRT2562866	hsa-miR-1253	CLIP-seq
MIRT1117610	hsa-miR-1271	CLIP-seq
MIRT2562867	hsa-miR-130a	CLIP-seq
MIRT2562868	hsa-miR-130b	CLIP-seq
MIRT1117611	hsa-miR-145	CLIP-seq
MIRT2562869	hsa-miR-17	CLIP-seq
MIRT2562870	hsa-miR-1912	CLIP-seq
MIRT2562871	hsa-miR-19a	CLIP-seq
MIRT2562872	hsa-miR-19b	CLIP-seq
MIRT2033247	hsa-miR-2053	CLIP-seq
MIRT2562873	hsa-miR-20a	CLIP-seq
MIRT2562874	hsa-miR-20b	CLIP-seq
MIRT2562875	hsa-miR-2682	CLIP-seq
MIRT2562876	hsa-miR-301a	CLIP-seq
MIRT2562877	hsa-miR-301b	CLIP-seq
MIRT2562878	hsa-miR-3130-5p	CLIP-seq
MIRT2562879	hsa-miR-3144-3p	CLIP-seq
MIRT1117621	hsa-miR-3145-5p	CLIP-seq
MIRT2562880	hsa-miR-3163	CLIP-seq
MIRT1117623	hsa-miR-3180-5p	CLIP-seq
MIRT2562881	hsa-miR-34a	CLIP-seq
MIRT2562882	hsa-miR-34c-5p	CLIP-seq
MIRT2033248	hsa-miR-3622a-3p	CLIP-seq
MIRT2033249	hsa-miR-3622b-3p	CLIP-seq
MIRT2033250	hsa-miR-3660	CLIP-seq
MIRT2562883	hsa-miR-3666	CLIP-seq
MIRT2263578	hsa-miR-3714	CLIP-seq
MIRT2562884	hsa-miR-371-5p	CLIP-seq
MIRT2562885	hsa-miR-371b-5p	CLIP-seq
MIRT2562886	hsa-miR-4251	CLIP-seq
MIRT2562887	hsa-miR-4256	CLIP-seq
MIRT2033252	hsa-miR-4264	CLIP-seq
MIRT1117628	hsa-miR-4267	CLIP-seq
MIRT2562888	hsa-miR-4295	CLIP-seq
MIRT1117630	hsa-miR-4328	CLIP-seq
MIRT2562889	hsa-miR-4420	CLIP-seq
MIRT1117632	hsa-miR-4426	CLIP-seq
MIRT2263581	hsa-miR-4446-3p	CLIP-seq
MIRT2562890	hsa-miR-4482	CLIP-seq
MIRT2562891	hsa-miR-4493	CLIP-seq
MIRT2562892	hsa-miR-449a	CLIP-seq
MIRT2562893	hsa-miR-449b	CLIP-seq
MIRT2562894	hsa-miR-449c	CLIP-seq
MIRT2033253	hsa-miR-4526	CLIP-seq
MIRT2562895	hsa-miR-454	CLIP-seq
MIRT2033254	hsa-miR-4645-3p	CLIP-seq
MIRT1117636	hsa-miR-4647	CLIP-seq
MIRT1117638	hsa-miR-4653-3p	CLIP-seq
MIRT1117639	hsa-miR-4662b	CLIP-seq
MIRT1117640	hsa-miR-4675	CLIP-seq
MIRT1117641	hsa-miR-4717-3p	CLIP-seq
MIRT2562896	hsa-miR-4717-5p	CLIP-seq
MIRT2562897	hsa-miR-4726-3p	CLIP-seq
MIRT1117642	hsa-miR-4741	CLIP-seq
MIRT1117643	hsa-miR-4765	CLIP-seq
MIRT2562898	hsa-miR-487a	CLIP-seq
MIRT1117645	hsa-miR-508-5p	CLIP-seq
MIRT1117646	hsa-miR-516a-3p	CLIP-seq
MIRT2562899	hsa-miR-519a	CLIP-seq
MIRT2562900	hsa-miR-519b-3p	CLIP-seq
MIRT2562901	hsa-miR-519c-3p	CLIP-seq
MIRT2562902	hsa-miR-519d	CLIP-seq
MIRT2562903	hsa-miR-548an	CLIP-seq
MIRT2263590	hsa-miR-548t	CLIP-seq
MIRT1117650	hsa-miR-642b	CLIP-seq
MIRT2562904	hsa-miR-765	CLIP-seq
MIRT2562905	hsa-miR-93	CLIP-seq
MIRT1117651	hsa-miR-96	CLIP-seq
MIRT2562864	hsa-miR-106a	CLIP-seq
MIRT2562865	hsa-miR-106b	CLIP-seq
MIRT1117607	hsa-miR-1238	CLIP-seq
MIRT1117608	hsa-miR-1245b-3p	CLIP-seq
MIRT2562866	hsa-miR-1253	CLIP-seq
MIRT1117610	hsa-miR-1271	CLIP-seq
MIRT2562867	hsa-miR-130a	CLIP-seq
MIRT2562868	hsa-miR-130b	CLIP-seq
MIRT1117611	hsa-miR-145	CLIP-seq
MIRT2562869	hsa-miR-17	CLIP-seq
MIRT2562870	hsa-miR-1912	CLIP-seq
MIRT2562871	hsa-miR-19a	CLIP-seq
MIRT2562872	hsa-miR-19b	CLIP-seq
MIRT2562873	hsa-miR-20a	CLIP-seq
MIRT2562874	hsa-miR-20b	CLIP-seq
MIRT2562875	hsa-miR-2682	CLIP-seq
MIRT2562876	hsa-miR-301a	CLIP-seq
MIRT2562877	hsa-miR-301b	CLIP-seq
MIRT2684122	hsa-miR-3124-3p	CLIP-seq
MIRT2562878	hsa-miR-3130-5p	CLIP-seq
MIRT2562879	hsa-miR-3144-3p	CLIP-seq
MIRT1117621	hsa-miR-3145-5p	CLIP-seq
MIRT2562880	hsa-miR-3163	CLIP-seq
MIRT1117623	hsa-miR-3180-5p	CLIP-seq
MIRT2684123	hsa-miR-3183	CLIP-seq
MIRT2562881	hsa-miR-34a	CLIP-seq
MIRT2562882	hsa-miR-34c-5p	CLIP-seq
MIRT2562883	hsa-miR-3666	CLIP-seq
MIRT2263578	hsa-miR-3714	CLIP-seq
MIRT2562884	hsa-miR-371-5p	CLIP-seq
MIRT2562885	hsa-miR-371b-5p	CLIP-seq
MIRT2562886	hsa-miR-4251	CLIP-seq
MIRT1117628	hsa-miR-4267	CLIP-seq
MIRT2562888	hsa-miR-4295	CLIP-seq
MIRT1117632	hsa-miR-4426	CLIP-seq
MIRT2263581	hsa-miR-4446-3p	CLIP-seq
MIRT2562890	hsa-miR-4482	CLIP-seq
MIRT2562891	hsa-miR-4493	CLIP-seq
MIRT2562892	hsa-miR-449a	CLIP-seq
MIRT2562893	hsa-miR-449b	CLIP-seq
MIRT2562894	hsa-miR-449c	CLIP-seq
MIRT2562895	hsa-miR-454	CLIP-seq
MIRT1117636	hsa-miR-4647	CLIP-seq
MIRT1117638	hsa-miR-4653-3p	CLIP-seq
MIRT1117639	hsa-miR-4662b	CLIP-seq
MIRT1117640	hsa-miR-4675	CLIP-seq
MIRT1117641	hsa-miR-4717-3p	CLIP-seq
MIRT2562896	hsa-miR-4717-5p	CLIP-seq
MIRT2684124	hsa-miR-4723-3p	CLIP-seq
MIRT2562897	hsa-miR-4726-3p	CLIP-seq
MIRT1117642	hsa-miR-4741	CLIP-seq
MIRT2684125	hsa-miR-4753-3p	CLIP-seq
MIRT1117643	hsa-miR-4765	CLIP-seq
MIRT2562898	hsa-miR-487a	CLIP-seq
MIRT1117645	hsa-miR-508-5p	CLIP-seq
MIRT1117646	hsa-miR-516a-3p	CLIP-seq
MIRT2562899	hsa-miR-519a	CLIP-seq
MIRT2562900	hsa-miR-519b-3p	CLIP-seq
MIRT2562901	hsa-miR-519c-3p	CLIP-seq
MIRT2562902	hsa-miR-519d	CLIP-seq
MIRT2562903	hsa-miR-548an	CLIP-seq
MIRT2263590	hsa-miR-548t	CLIP-seq
MIRT1117650	hsa-miR-642b	CLIP-seq
MIRT2562904	hsa-miR-765	CLIP-seq
MIRT2562905	hsa-miR-93	CLIP-seq
MIRT1117651	hsa-miR-96	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15282549, 15345710, 18542056, 23723069, 32296183, 33961781
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007605	Process	Sensory perception of sound	IBA
GO:0007605	Process	Sensory perception of sound	IEA
GO:0016020	Component	Membrane	IEA
GO:0022405	Process	Hair cycle process	IEA
GO:0032474	Process	Otolith morphogenesis	IEA
GO:0038023	Function	Signaling receptor activity	IBA
GO:0060384	Process	Innervation	IEA

MIM	HGNC	e!Ensembl
608868	17360	ENSG00000144749

Protein

UniProt ID

Q96JA1

Protein name

Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1)

Protein function

Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.

PDB

4U7L , 4U7M

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13855	LRR_8	70 → 104	Leucine rich repeat	Repeat
PF13855	LRR_8	140 → 189	Leucine rich repeat	Repeat
PF13855	LRR_8	188 → 247	Leucine rich repeat	Repeat
PF13855	LRR_8	307 → 367	Leucine rich repeat	Repeat
PF13855	LRR_8	382 → 442	Leucine rich repeat	Repeat
PF01463	LRRCT	465 → 490	Leucine rich repeat C-terminal domain	Family
PF13927	Ig_3	494 → 581		Domain
PF07679	I-set	599 → 689	Immunoglobulin I-set domain	Domain
PF07679	I-set	693 → 780	Immunoglobulin I-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11414704}.

Sequence

MARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLA
ALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSL
FLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLEL
GAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVL
KLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHR
KGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVL
DLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRS
VQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIF
SVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNA
DMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPS
FTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFIT
DVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNP
PPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV
LPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVP
SYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAG
SAYHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPS
APNGPEPGGSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGD
SSWTLARLYHPDSTELQPASSLTSGSPERAEAQYLLVSNGHLPKACDASPESTPLTGQLP
GKQRVPLLLAPKS

Sequence length

1093

Interactions

View interactions

	Reactome
			Signaling by EGFR Negative regulation of MET activity

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Atrial Fibrillation	Atrial fibrillation	N/A	N/A	GWAS
Colorectal Cancer	Colorectal cancer	N/A	N/A	GWAS
Hyperuricemia	Hyperuricemia	N/A	N/A	GWAS
Kidney Disease	Chronic kidney disease	N/A	N/A	GWAS

Show/Hide Text Mining Associations (51)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	40269842
Alzheimer Disease	Associate	34151794
Breast Neoplasms	Associate	16168117, 21821674, 24879564, 32448168, 34172056, 35440669, 39491279, 40597935
Breast Neoplasms	Inhibit	26387542, 38376291
Carcinogenesis	Associate	18542056, 20334636
Carcinoma Basal Cell	Inhibit	35440669
Carcinoma Ductal	Inhibit	38376291
Carcinoma Merkel Cell	Associate	34331569
Carcinoma Non Small Cell Lung	Associate	26632716, 28230028
Carcinoma Renal Cell	Inhibit	14520461
Carcinoma Renal Cell	Associate	22554477
Carcinoma Squamous Cell	Associate	22427941
Carcinoma Verrucous	Associate	27509922
Colorectal Neoplasms	Stimulate	21821674
Colorectal Neoplasms	Associate	33461538, 37357017
Colorectal Neoplasms	Inhibit	35440669
Death	Associate	24879564
Death	Inhibit	26387542
Fibroadenoma	Associate	38376291
Glioblastoma	Inhibit	18542056
Glioblastoma	Associate	26097540
Glioma	Associate	25048475, 29745084, 37185361
Glioma	Inhibit	25860915
Growth Disorders	Inhibit	26387542
Hepatitis B	Associate	26387542
Hypoxia	Inhibit	25860915
Hypoxia	Associate	30487162
Leukemia Lymphocytic Chronic B Cell	Associate	19779621
Limbal Stem Cell Deficiency	Associate	23732018
Lung Neoplasms	Inhibit	40269842
Lupus Erythematosus Systemic	Associate	38460891
Lymphatic Metastasis	Associate	28230028
Lymphoma Non Hodgkin	Associate	37185361
Melanoma	Associate	30487162
Meningioma	Associate	22484910
Neoplasm Metastasis	Associate	24879564
Neoplasms	Inhibit	14520461, 17624990, 18542056, 18657901, 21821674, 22427941, 24548859, 25048475, 26097540, 26387542, 26632716, 28841699, 35440669, 37930698
Neoplasms	Stimulate	16168117
Neoplasms	Associate	20334636, 23732018, 24314030, 24879564, 28230028, 30487162, 31358815, 34172056, 37185361, 39491279
Oropharyngeal Neoplasms	Associate	24548859
Pituitary Neoplasms	Associate	27249594
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	32174258
Squamous Cell Carcinoma of Head and Neck	Associate	27509922
Stomach Neoplasms	Associate	29450946, 30320337
Triple Negative Breast Neoplasms	Inhibit	35440669
Tuberculosis Multidrug Resistant	Associate	29450946
Urinary Bladder Neoplasms	Inhibit	24314030
Urinary Bladder Neoplasms	Associate	32065779
Uterine Cervical Neoplasms	Inhibit	17624990
Uterine Cervical Neoplasms	Associate	24998916, 26291246
Vaginitis	Associate	28841699

LRIG1 (leucine rich repeats and immunoglobulin like domains 1)