Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	26011
Gene name	Teneurin transmembrane protein 4
Gene symbol	TENM4
Synonyms (NCBI Gene)	Doc4ETM5ODZ4TEN4TNM4Ten-M4ten-4
Chromosome	11
Chromosome location	11q14.1
Summary	The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]

Show/Hide all (5)

SNP ID	Visualize variation	Clinical significance	Consequence
rs199687168	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs375681722	C>T	Pathogenic	Missense variant, coding sequence variant
rs538881762	C>A,T	Pathogenic	Missense variant, coding sequence variant
rs763485258	G>A,T	Pathogenic	Missense variant, coding sequence variant
rs1555080708	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant, genic upstream transcript variant

Show/Hide all (48)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018799	hsa-miR-335-5p	Microarray	18185580
MIRT041218	hsa-miR-193b-3p	CLASH	23622248
MIRT724252	hsa-miR-532-5p	HITS-CLIP	19536157
MIRT724251	hsa-miR-622	HITS-CLIP	19536157
MIRT724250	hsa-miR-3127-3p	HITS-CLIP	19536157
MIRT724249	hsa-miR-6756-3p	HITS-CLIP	19536157
MIRT724248	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT724247	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT724246	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT724245	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT724244	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT724243	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT652765	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT652764	hsa-miR-1470	HITS-CLIP	23824327
MIRT652763	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT652762	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT652761	hsa-miR-4290	HITS-CLIP	23824327
MIRT652760	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT652759	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT652758	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT652757	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT450387	hsa-miR-3121-3p	PAR-CLIP	22100165
MIRT450386	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT450385	hsa-miR-8063	PAR-CLIP	22100165
MIRT450384	hsa-miR-4698	PAR-CLIP	22100165
MIRT724252	hsa-miR-532-5p	HITS-CLIP	19536157
MIRT724251	hsa-miR-622	HITS-CLIP	19536157
MIRT724250	hsa-miR-3127-3p	HITS-CLIP	19536157
MIRT724249	hsa-miR-6756-3p	HITS-CLIP	19536157
MIRT724248	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT724247	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT724246	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT724245	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT724244	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT724243	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT652765	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT652764	hsa-miR-1470	HITS-CLIP	23824327
MIRT652763	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT652762	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT652761	hsa-miR-4290	HITS-CLIP	23824327
MIRT652760	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT652759	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT652758	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT652757	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT450387	hsa-miR-3121-3p	PAR-CLIP	22100165
MIRT450386	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT450385	hsa-miR-8063	PAR-CLIP	22100165
MIRT450384	hsa-miR-4698	PAR-CLIP	22100165

Show/Hide all (38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001702	Process	Gastrulation with mouth forming second	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005886	Component	Plasma membrane	IDA	26188006
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0016020	Component	Membrane	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0031641	Process	Regulation of myelination	IEA
GO:0031641	Process	Regulation of myelination	IMP	26188006
GO:0031643	Process	Positive regulation of myelination	IEA
GO:0031643	Process	Positive regulation of myelination	ISS
GO:0032289	Process	Central nervous system myelin formation	IEA
GO:0032289	Process	Central nervous system myelin formation	IMP	26188006
GO:0032289	Process	Central nervous system myelin formation	ISS
GO:0042802	Function	Identical protein binding	IEA
GO:0042803	Function	Protein homodimerization activity	IBA
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IBA
GO:0043005	Component	Neuron projection	IEA
GO:0043005	Component	Neuron projection	ISS
GO:0046982	Function	Protein heterodimerization activity	IBA
GO:0048666	Process	Neuron development	IBA
GO:0048666	Process	Neuron development	IMP	26188006
GO:0048714	Process	Positive regulation of oligodendrocyte differentiation	IEA
GO:0048714	Process	Positive regulation of oligodendrocyte differentiation	ISS
GO:0050839	Function	Cell adhesion molecule binding	IBA
GO:0060038	Process	Cardiac muscle cell proliferation	IEA
GO:0060912	Process	Cardiac cell fate specification	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099560	Process	Synaptic membrane adhesion	IEA
GO:2000543	Process	Positive regulation of gastrulation	IEA
GO:2000543	Process	Positive regulation of gastrulation	ISS

MIM	HGNC	e!Ensembl
610084	29945	ENSG00000149256

Q6N022

Protein name

Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4)

Protein function

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular proce

PDB

7BAM , 7BAN , 7BAO , 7PLP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06484	Ten_N	11 → 171	Teneurin Intracellular Region	Family
PF06484	Ten_N	164 → 340	Teneurin Intracellular Region	Family
PF07974	EGF_2	626 → 657	EGF-like domain	Domain
PF07974	EGF_2	729 → 755	EGF-like domain	Domain
PF15636	Tox-GHH	2685 → 2762	GHH signature containing HNH/Endo VII superfamily nuclease toxin	Family

Sequence

MDVKERKPYRSLTRRRDAERRYTSSSADSEEGKAPQKSYSSSETLKAYDQDARLAYGSRV
KDIVPQEAEEFCRTGANFTLRELGLEEVTPPHGTLYRTDIGLPHCGYSMGAGSDADMEAD
TVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENTETDHPGGLQNHARLRTPP
PPLSHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTDHSLSGEPPAGGAQEPAHAQENWL
LNSNIPLETRNLGKQPFLGTLQDNLIEMDILGASRHDGAYSDGHFLFKPGGTSPLFCTTS
PGYPLTSSTVYSPPPRPLPRSTFARPAFNLKKPSKYCNWKCAALSAIVISATLVILLAYF
VAMHLFGLNWHLQPMEGQMYEITEDTASSWPVPTDVSLYPSGGTGLETPDRKGKGTTEGK
PSSFFPEDSFIDSGEIDVGRRASQKIPPGTFWRSQVFIDHPVHLKFNVSLGKAALVGIYG
RKGLPPSHTQFDFVELLDGRRLLTQEARSLEGTPRQSRGTVPPSSHETGFIQYLDSGIWH
LAFYNDGKESEVVSFLTTAIESVDNCPSNCYGNGDCISGTCHCFLGFLGPDCGRASCPVL
CSGNGQYMKGRCLCHSGWKGAECDVPTNQCIDVACSNHGTCITGTCICNPGYKGESCEEV
DCMDPTCSGRGVCVRGECHCSVGWGGTNCETPRATCLDQCSGHGTFLPDTGLCSCDPSWT
GHDCSIEICAADCGGHGVCVGGTCRCEDGWMGAACDQRACHPRCAEHGTCRDGKCECSPG
WNGEHCTIAHYLDRVVKEGCPGLCNGNGRCTLDLNGWHCVCQLGWRGAGCDTSMETACGD
SKDNDGDGLVDCMDPDCCLQPLCHINPLCLGSPNPLDIIQETQVPVSQQNLHSFYDRIKF
LVGRDSTHIIPGENPFDGGHACVIRGQVMTSDGTPLVGVNISFVNNPLFGYTISRQDGSF
DLVTNGGISIILRFERAPFITQEHTLWLPWDRFFVMETIIMRHEENEIPSCDLSNFARPN
PVVSPSPLTSFASSCAEKGPIVPEIQALQEEISISGCKMRLSYLSSRTPGYKSVLRISLT
HPTIPFNLMKVHLMVAVEGRLFRKWFAAAPDLSYYFIWDKTDVYNQKVFGLSEAFVSVGY
EYESCPDLILWEKRTTVLQGYEIDASKLGGWSLDKHHALNIQSGILHKGNGENQFVSQQP
PVIGSIMGNGRRRSISCPSCNGLADGNKLLAPVALTCGSDGSLYVGDFNYIRRIFPSGNV
TNILELRNKDFRHSHSPAHKYYLATDPMSGAVFLSDSNSRRVFKIKSTVVVKDLVKNSEV
VAGTGDQCLPFDDTRCGDGGKATEATLTNPRGITVDKFGLIYFVDGTMIRRIDQNGIIST
LLGSNDLTSARPLSCDSVMDISQVHLEWPTDLAINPMDNSLYVLDNNVVLQISENHQVRI
VAGRPMHCQVPGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEKKINRIRQVTTS
GEISLVAGAPSGCDCKNDANCDCFSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRI
RFIRKNKPFLNTQNMYELSSPIDQELYLFDTTGKHLYTQSLPTGDYLYNFTYTGDGDITL
ITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALKSVTTQGHELAMMTYHGNSG
LLATKSNENGWTTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITT
NLSASGAFYTLLQDQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNV
TLPIDNGLNLVEWRQRKEQARGQVTVFGRRLRVHNRNLLSLDFDRVTRTEKIYDDHRKFT
LRILYDQAGRPSLWSPSSRLNGVNVTYSPGGYIAGIQRGIMSERMEYDQAGRITSRIFAD
GKTWSYTYLEKSMVLLLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQ
PPEGNASVIQDFTEDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGM
LKTINLQNEGFTCTIRYRQIGPLIDRQIFRFTEEGMVNARFDYNYDNSFRVTSMQAVINE
TPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKEVQYEIFR
SLMYWMTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLN
GNLHLLSPGNSARLTPLRYDIRDRITRLGDVQYKMDEDGFLRQRGGDIFEYNSAGLLIKA
YNRAGSWSVRYRYDGLGRRVSSKSSHSHHLQFFYADLTNPTKVTHLYNHSSSEITSLYYD
LQGHLFAMELSSGDEFYIACDNIGTPLAVFSGTGLMIKQILYTAYGEIYMDTNPNFQIII
GYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDHELWKHLSSSNVMPFNLYMFKNNNPISN
SQDIKCFMTDVNSWLLTFGFQLHNVIPGYPKPDMDAMEPSYELIHTQMKTQEWDNSKSIL
GVQCEVQKQLKAFVTLERFDQLYGSTITSCQQAPKTKKFASSGSVFGKGVKFALKDGRVT
TDIISVANEDGRRVAAILNHAHYLENLHFTIDGVDTHYFVKPGPSEGDLAILGLSGGRRT
LENGVNVTVSQINTVLNGRTRRYTDIQLQYGALCLNTRYGTTLDEEKARVLELARQRAVR
QAWAREQQRLREGEEGLRAWTEGEKQQVLSTGRVQGYDGFFVISVEQYPELSDSANNIHF
MRQSEMGRR

Sequence length

2769

Interactions

View interactions

100

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Tremor, hereditary essential, 5	Pathogenic	rs2136208238, rs763485258	RCV001848594 RCV000203504

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cleft palate	Likely benign	rs1591072819	RCV000824806
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs1855975579, rs1855507156	RCV004557986 RCV004557987
Ovarian serous cystadenocarcinoma	Uncertain significance	rs2496387394	RCV005936768
Retinal disorder	Likely benign	rs1591072819	RCV000824806
TENM4-related disorder	Uncertain significance; Conflicting classifications of pathogenicity; Benign; Likely benign	rs748691958, rs201960718, rs200271895, rs75922333, rs200318543, rs1463723707, rs748314290, rs189655072, rs377415389, rs201811725, rs370715239, rs79508298, rs564607395, rs750652207, rs759485865 View all (47 more)	RCV004749890 RCV003946361 RCV003936679 RCV003973778 RCV003906685 RCV003412020 RCV003399810 RCV003919102 RCV003946520 RCV003906733 RCV004750377 RCV003981194 RCV003894669 RCV003921550 RCV003981589 RCV003983345 RCV003893991 RCV003904260 RCV003901671 RCV003901724 RCV003901784 RCV003911742 RCV003912056 RCV003916888 RCV003973918 RCV003899339 RCV003911673 RCV003909546 RCV003962110 RCV003931461 RCV003931759 RCV003941659 RCV003939708 RCV003934466 RCV003949635 RCV003959295 RCV003937188 RCV003947116 RCV003949471 RCV003932133 RCV003956846 RCV003964716 RCV003983666 RCV003966813 RCV003925984 RCV003925964 RCV003933304 RCV003962859 RCV003978353 RCV003906015 RCV003936033 RCV003910391 RCV003910481 RCV003950400 RCV003948326 RCV003920833 RCV003968297 RCV003902878 RCV003925878 RCV004749571 RCV003972987 RCV003938438
Thyroid cancer, nonmedullary, 1	Uncertain significance	rs377317773	RCV005939257

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Bipolar Disorder	Associate	21926972, 22892719, 23070075, 24618891, 25304227, 27864917, 28115744, 28199072
Breast Neoplasms	Associate	33413557
Essential Tremor	Associate	32196977
Hypoxia	Inhibit	39236027
Lung Neoplasms	Associate	39236027
Neoplasms	Associate	28472127, 36057880
Neuroblastoma	Associate	23991058
Ovarian Neoplasms	Associate	28472127
Prostatic Neoplasms	Associate	28403887
Schizophrenia	Associate	27864917

TENM4 (teneurin transmembrane protein 4)