Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	26011
Gene name Gene Name - the full gene name approved by the HGNC.	Teneurin transmembrane protein 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TENM4
Synonyms (NCBI Gene) Gene synonyms aliases	Doc4, ETM5, ODZ4, TEN4, TNM4, Ten-M4, ten-4
Disease Acronyms (UniProt) Disease acronyms from UniProt database	ETM5
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q14.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]

Show/Hide all(5)

SNP ID	Visualize variation	Clinical significance	Consequence
rs199687168	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs375681722	C>T	Pathogenic	Missense variant, coding sequence variant
rs538881762	C>A,T	Pathogenic	Missense variant, coding sequence variant
rs763485258	G>A,T	Pathogenic	Missense variant, coding sequence variant
rs1555080708	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant, genic upstream transcript variant

Show/Hide all(48)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018799	hsa-miR-335-5p	Microarray	18185580
MIRT041218	hsa-miR-193b-3p	CLASH	23622248
MIRT724252	hsa-miR-532-5p	HITS-CLIP	19536157
MIRT724251	hsa-miR-622	HITS-CLIP	19536157
MIRT724250	hsa-miR-3127-3p	HITS-CLIP	19536157
MIRT724249	hsa-miR-6756-3p	HITS-CLIP	19536157
MIRT724248	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT724247	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT724246	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT724245	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT724244	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT724243	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT652765	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT652764	hsa-miR-1470	HITS-CLIP	23824327
MIRT652763	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT652762	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT652761	hsa-miR-4290	HITS-CLIP	23824327
MIRT652760	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT652759	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT652758	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT652757	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT450387	hsa-miR-3121-3p	PAR-CLIP	22100165
MIRT450386	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT450385	hsa-miR-8063	PAR-CLIP	22100165
MIRT450384	hsa-miR-4698	PAR-CLIP	22100165
MIRT724252	hsa-miR-532-5p	HITS-CLIP	19536157
MIRT724251	hsa-miR-622	HITS-CLIP	19536157
MIRT724250	hsa-miR-3127-3p	HITS-CLIP	19536157
MIRT724249	hsa-miR-6756-3p	HITS-CLIP	19536157
MIRT724248	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT724247	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT724246	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT724245	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT724244	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT724243	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT652765	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT652764	hsa-miR-1470	HITS-CLIP	23824327
MIRT652763	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT652762	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT652761	hsa-miR-4290	HITS-CLIP	23824327
MIRT652760	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT652759	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT652758	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT652757	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT450387	hsa-miR-3121-3p	PAR-CLIP	22100165
MIRT450386	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT450385	hsa-miR-8063	PAR-CLIP	22100165
MIRT450384	hsa-miR-4698	PAR-CLIP	22100165

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001702	Process	Gastrulation with mouth forming second	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	ISS
GO:0005886	Component	Plasma membrane	IDA	26188006
GO:0005887	Component	Integral component of plasma membrane	IEA
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA	21873635
GO:0007165	Process	Signal transduction	IEA
GO:0031641	Process	Regulation of myelination	IMP	26188006
GO:0031643	Process	Positive regulation of myelination	ISS
GO:0032289	Process	Central nervous system myelin formation	IMP	26188006
GO:0032289	Process	Central nervous system myelin formation	ISS
GO:0042803	Function	Protein homodimerization activity	IBA	21873635
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0043005	Component	Neuron projection	ISS
GO:0046982	Function	Protein heterodimerization activity	IBA	21873635
GO:0048666	Process	Neuron development	IBA	21873635
GO:0048666	Process	Neuron development	IMP	26188006
GO:0048714	Process	Positive regulation of oligodendrocyte differentiation	ISS
GO:0050839	Function	Cell adhesion molecule binding	IBA	21873635
GO:0060038	Process	Cardiac muscle cell proliferation	IEA
GO:0060912	Process	Cardiac cell fate specification	IEA
GO:2000543	Process	Positive regulation of gastrulation	ISS

MIM	HGNC	e!Ensembl
610084	29945	ENSG00000149256

Protein

UniProt ID

Q6N022

Protein name

Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4)

Protein function

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular proce

PDB

7BAM , 7BAN , 7BAO , 7PLP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06484	Ten_N	11 → 171	Teneurin Intracellular Region	Family
PF06484	Ten_N	164 → 340	Teneurin Intracellular Region	Family
PF07974	EGF_2	626 → 657	EGF-like domain	Domain
PF07974	EGF_2	729 → 755	EGF-like domain	Domain
PF15636	Tox-GHH	2685 → 2762	GHH signature containing HNH/Endo VII superfamily nuclease toxin	Family

Sequence

MDVKERKPYRSLTRRRDAERRYTSSSADSEEGKAPQKSYSSSETLKAYDQDARLAYGSRV
KDIVPQEAEEFCRTGANFTLRELGLEEVTPPHGTLYRTDIGLPHCGYSMGAGSDADMEAD
TVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENTETDHPGGLQNHARLRTPP
PPLSHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTDHSLSGEPPAGGAQEPAHAQENWL
LNSNIPLETRNLGKQPFLGTLQDNLIEMDILGASRHDGAYSDGHFLFKPGGTSPLFCTTS
PGYPLTSSTVYSPPPRPLPRSTFARPAFNLKKPSKYCNWKCAALSAIVISATLVILLAYF
VAMHLFGLNWHLQPMEGQMYEITEDTASSWPVPTDVSLYPSGGTGLETPDRKGKGTTEGK
PSSFFPEDSFIDSGEIDVGRRASQKIPPGTFWRSQVFIDHPVHLKFNVSLGKAALVGIYG
RKGLPPSHTQFDFVELLDGRRLLTQEARSLEGTPRQSRGTVPPSSHETGFIQYLDSGIWH
LAFYNDGKESEVVSFLTTAIESVDNCPSNCYGNGDCISGTCHCFLGFLGPDCGRASCPVL
CSGNGQYMKGRCLCHSGWKGAECDVPTNQCIDVACSNHGTCITGTCICNPGYKGESCEEV
DCMDPTCSGRGVCVRGECHCSVGWGGTNCETPRATCLDQCSGHGTFLPDTGLCSCDPSWT
GHDCSIEICAADCGGHGVCVGGTCRCEDGWMGAACDQRACHPRCAEHGTCRDGKCECSPG
WNGEHCTIAHYLDRVVKEGCPGLCNGNGRCTLDLNGWHCVCQLGWRGAGCDTSMETACGD
SKDNDGDGLVDCMDPDCCLQPLCHINPLCLGSPNPLDIIQETQVPVSQQNLHSFYDRIKF
LVGRDSTHIIPGENPFDGGHACVIRGQVMTSDGTPLVGVNISFVNNPLFGYTISRQDGSF
DLVTNGGISIILRFERAPFITQEHTLWLPWDRFFVMETIIMRHEENEIPSCDLSNFARPN
PVVSPSPLTSFASSCAEKGPIVPEIQALQEEISISGCKMRLSYLSSRTPGYKSVLRISLT
HPTIPFNLMKVHLMVAVEGRLFRKWFAAAPDLSYYFIWDKTDVYNQKVFGLSEAFVSVGY
EYESCPDLILWEKRTTVLQGYEIDASKLGGWSLDKHHALNIQSGILHKGNGENQFVSQQP
PVIGSIMGNGRRRSISCPSCNGLADGNKLLAPVALTCGSDGSLYVGDFNYIRRIFPSGNV
TNILELRNKDFRHSHSPAHKYYLATDPMSGAVFLSDSNSRRVFKIKSTVVVKDLVKNSEV
VAGTGDQCLPFDDTRCGDGGKATEATLTNPRGITVDKFGLIYFVDGTMIRRIDQNGIIST
LLGSNDLTSARPLSCDSVMDISQVHLEWPTDLAINPMDNSLYVLDNNVVLQISENHQVRI
VAGRPMHCQVPGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEKKINRIRQVTTS
GEISLVAGAPSGCDCKNDANCDCFSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRI
RFIRKNKPFLNTQNMYELSSPIDQELYLFDTTGKHLYTQSLPTGDYLYNFTYTGDGDITL
ITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALKSVTTQGHELAMMTYHGNSG
LLATKSNENGWTTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITT
NLSASGAFYTLLQDQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNV
TLPIDNGLNLVEWRQRKEQARGQVTVFGRRLRVHNRNLLSLDFDRVTRTEKIYDDHRKFT
LRILYDQAGRPSLWSPSSRLNGVNVTYSPGGYIAGIQRGIMSERMEYDQAGRITSRIFAD
GKTWSYTYLEKSMVLLLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQ
PPEGNASVIQDFTEDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGM
LKTINLQNEGFTCTIRYRQIGPLIDRQIFRFTEEGMVNARFDYNYDNSFRVTSMQAVINE
TPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKEVQYEIFR
SLMYWMTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLN
GNLHLLSPGNSARLTPLRYDIRDRITRLGDVQYKMDEDGFLRQRGGDIFEYNSAGLLIKA
YNRAGSWSVRYRYDGLGRRVSSKSSHSHHLQFFYADLTNPTKVTHLYNHSSSEITSLYYD
LQGHLFAMELSSGDEFYIACDNIGTPLAVFSGTGLMIKQILYTAYGEIYMDTNPNFQIII
GYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDHELWKHLSSSNVMPFNLYMFKNNNPISN
SQDIKCFMTDVNSWLLTFGFQLHNVIPGYPKPDMDAMEPSYELIHTQMKTQEWDNSKSIL
GVQCEVQKQLKAFVTLERFDQLYGSTITSCQQAPKTKKFASSGSVFGKGVKFALKDGRVT
TDIISVANEDGRRVAAILNHAHYLENLHFTIDGVDTHYFVKPGPSEGDLAILGLSGGRRT
LENGVNVTVSQINTVLNGRTRRYTDIQLQYGALCLNTRYGTTLDEEKARVLELARQRAVR
QAWAREQQRLREGEEGLRAWTEGEKQQVLSTGRVQGYDGFFVISVEQYPELSDSANNIHF
MRQSEMGRR

Sequence length

2769

Interactions

View interactions

Show/Hide Causal Diseases (5)

Disease term	Disease name	dbSNP ID	References
Causal
Attention deficit hyperactivity disorder	Attention deficit hyperactivity disorder	rs786205019	23453885
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959
Lung carcinoma	Carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355 View all (44 more)	28604730
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	25124521, 23453885
Tremor	TREMOR, HEREDITARY ESSENTIAL, 5	rs387907274, rs763485258, rs551348450	26188006

Show/Hide Unknown Diseases (8)

Disease term	Disease name	Evidence	References	Source
Unknown
Hereditary essential tremor	NON RARE IN EUROPE: Hereditary essential tremor			ClinVar
Mental depression	Major Depressive Disorder		23453885	ClinVar
Bipolar Disorder	Bipolar Disorder			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS
Tourette Syndrome	Tourette Syndrome			GWAS
Oligodendroglioma	Oligodendroglioma			GWAS
Diabetes	Diabetes			GWAS
Prostate cancer	Prostate cancer	Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population.		GWAS, CBGDA

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining
Bipolar Disorder	Associate	21926972, 22892719, 23070075, 24618891, 25304227, 27864917, 28115744, 28199072
Breast Neoplasms	Associate	33413557
Essential Tremor	Associate	32196977
Hypoxia	Inhibit	39236027
Lung Neoplasms	Associate	39236027
Neoplasms	Associate	28472127, 36057880
Neuroblastoma	Associate	23991058
Ovarian Neoplasms	Associate	28472127
Prostatic Neoplasms	Associate	28403887
Schizophrenia	Associate	27864917

TENM4 (teneurin transmembrane protein 4)