Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
25987
Gene name Gene Name - the full gene name approved by the HGNC.
Tsukushi, small leucine rich proteoglycan
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TSKU
Synonyms (NCBI Gene) Gene synonyms aliases
E2IG4, LRRC54, TSK
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q13.5
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004908 hsa-miR-124-3p Microarray 15685193
MIRT004908 hsa-miR-124-3p Microarray 15685193
MIRT004908 hsa-miR-124-3p Microarray 18668037
MIRT025821 hsa-miR-7-5p Microarray 19073608
MIRT029592 hsa-miR-26b-5p Microarray 19088304
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003431 Process Growth plate cartilage chondrocyte development ISS
GO:0005615 Component Extracellular space ISS
GO:0008203 Process Cholesterol metabolic process ISS
GO:0010468 Process Regulation of gene expression ISS
GO:0010977 Process Negative regulation of neuron projection development ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608015 28850 ENSG00000182704
Protein
UniProt ID Q8WUA8
Protein name Tsukushi (E2-induced gene 4 protein) (Leucine-rich repeat-containing protein 54)
Protein function Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways. Wnt signaling inhibitor which competes with WNT2B for binding to Wnt rec
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13855 LRR_8 60 120 Leucine rich repeat Repeat
PF13855 LRR_8 108 169 Leucine rich repeat Repeat
PF13855 LRR_8 206 265 Leucine rich repeat Repeat
Sequence
MPWPLLLLLAVSGAQTTRPCFPGCQCEVETFGLFDSFSLTRVDCSGLGPHIMPVPIPLDT
AHLDLSSNRLEMVNESVLAGPGYTTLAGLDLSHNLLTSISPTAFSRL
RYLESLDLSHNGL
TALPAESFTSSPLSDVNLSHNQLREVSVSAFTTHSQGRALHVDLSHNLI
HRLVPHPTRAG
LPAPTIQSLNLAWNRLHAVPNLRDLPLRYLSLDGNPLAVIGPGAFAGLGGLTHLSLASLQ
RLPELAPSGFRELPGLQVLDLSGNP
KLNWAGAEVFSGLSSLQELDLSGTNLVPLPEALLL
HLPALQSVSVGQDVRCRRLVREGTYPRRPGSSPKVALHCVDTRDSAARGPTIL
Sequence length 353
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Arthritis Degenerative polyarthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 30664745
Unknown
Disease term Disease name Evidence References Source
Endometriosis Endometriosis GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Diabetes Diabetes GWAS
Gastroesophageal Reflux Disease Gastroesophageal Reflux Disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 36077333
Carcinoma Hepatocellular Associate 34664394
Metabolic Diseases Associate 33860453
Neoplasms Associate 30550571
Neuroblastoma Associate 30550571
Obesity Inhibit 33860453