Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	25976
Gene name Gene Name - the full gene name approved by the HGNC.	TCDD inducible poly(ADP-ribose) polymerase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TIPARP
Synonyms (NCBI Gene) Gene synonyms aliases	ARTD14, PARP7, pART14
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3q25.31
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in m

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024175	hsa-miR-221-3p	Sequencing	20371350
MIRT029801	hsa-miR-26b-5p	Microarray	19088304
MIRT208842	hsa-miR-142-3p	Microarray, qRT-PCR	22815788
MIRT437683	hsa-miR-222-3p	Microarray, qRT-PCR	22815788
MIRT237128	hsa-miR-4311	PAR-CLIP	22012620
MIRT237127	hsa-miR-1276	PAR-CLIP	22012620
MIRT237125	hsa-miR-583	PAR-CLIP	22012620
MIRT090928	hsa-miR-5692a	PAR-CLIP	22012620
MIRT237129	hsa-miR-203b-5p	PAR-CLIP	22012620
MIRT237133	hsa-miR-6718-5p	PAR-CLIP	22012620
MIRT531050	hsa-miR-3121-3p	PAR-CLIP	22012620
MIRT531049	hsa-miR-520f-5p	PAR-CLIP	22012620
MIRT531048	hsa-miR-4680-5p	PAR-CLIP	22012620
MIRT531047	hsa-miR-7111-3p	PAR-CLIP	22012620
MIRT531046	hsa-miR-6780a-3p	PAR-CLIP	22012620
MIRT531045	hsa-miR-6881-3p	PAR-CLIP	22012620
MIRT531044	hsa-miR-4799-5p	PAR-CLIP	22012620
MIRT531043	hsa-miR-552-5p	PAR-CLIP	22012620
MIRT237128	hsa-miR-4311	PAR-CLIP	22012620
MIRT237127	hsa-miR-1276	PAR-CLIP	22012620
MIRT237125	hsa-miR-583	PAR-CLIP	22012620
MIRT090928	hsa-miR-5692a	PAR-CLIP	22012620
MIRT237129	hsa-miR-203b-5p	PAR-CLIP	22012620
MIRT237133	hsa-miR-6718-5p	PAR-CLIP	22012620
MIRT531050	hsa-miR-3121-3p	PAR-CLIP	22012620
MIRT531049	hsa-miR-520f-5p	PAR-CLIP	22012620
MIRT531048	hsa-miR-4680-5p	PAR-CLIP	22012620
MIRT531047	hsa-miR-7111-3p	PAR-CLIP	22012620
MIRT531046	hsa-miR-6780a-3p	PAR-CLIP	22012620
MIRT531045	hsa-miR-6881-3p	PAR-CLIP	22012620
MIRT531044	hsa-miR-4799-5p	PAR-CLIP	22012620
MIRT531043	hsa-miR-552-5p	PAR-CLIP	22012620
MIRT1425527	hsa-miR-105	CLIP-seq
MIRT1425528	hsa-miR-1200	CLIP-seq
MIRT1425529	hsa-miR-1283	CLIP-seq
MIRT1425530	hsa-miR-1287	CLIP-seq
MIRT1425531	hsa-miR-1323	CLIP-seq
MIRT1425532	hsa-miR-1911	CLIP-seq
MIRT1425533	hsa-miR-194	CLIP-seq
MIRT1425534	hsa-miR-221	CLIP-seq
MIRT1425535	hsa-miR-222	CLIP-seq
MIRT1425536	hsa-miR-23a	CLIP-seq
MIRT1425537	hsa-miR-23b	CLIP-seq
MIRT1425538	hsa-miR-23c	CLIP-seq
MIRT1425539	hsa-miR-3133	CLIP-seq
MIRT1425540	hsa-miR-3135b	CLIP-seq
MIRT1425541	hsa-miR-3140-5p	CLIP-seq
MIRT1425542	hsa-miR-3187-3p	CLIP-seq
MIRT1425543	hsa-miR-320a	CLIP-seq
MIRT1425544	hsa-miR-320b	CLIP-seq
MIRT1425545	hsa-miR-320c	CLIP-seq
MIRT1425546	hsa-miR-320d	CLIP-seq
MIRT1425547	hsa-miR-34c-3p	CLIP-seq
MIRT1425548	hsa-miR-3908	CLIP-seq
MIRT1425549	hsa-miR-3913-3p	CLIP-seq
MIRT1425550	hsa-miR-3942-5p	CLIP-seq
MIRT1425551	hsa-miR-4329	CLIP-seq
MIRT1425552	hsa-miR-4420	CLIP-seq
MIRT1425553	hsa-miR-4429	CLIP-seq
MIRT1425554	hsa-miR-4435	CLIP-seq
MIRT1425555	hsa-miR-4511	CLIP-seq
MIRT1425556	hsa-miR-4529-5p	CLIP-seq
MIRT1425557	hsa-miR-4670-3p	CLIP-seq
MIRT1425558	hsa-miR-4682	CLIP-seq
MIRT1425559	hsa-miR-4691-3p	CLIP-seq
MIRT1425560	hsa-miR-4701-5p	CLIP-seq
MIRT1425561	hsa-miR-4703-5p	CLIP-seq
MIRT1425562	hsa-miR-4704-5p	CLIP-seq
MIRT1425563	hsa-miR-4715-5p	CLIP-seq
MIRT1425564	hsa-miR-4720-3p	CLIP-seq
MIRT1425565	hsa-miR-4766-3p	CLIP-seq
MIRT1425566	hsa-miR-4804-3p	CLIP-seq
MIRT1425567	hsa-miR-545	CLIP-seq
MIRT1425568	hsa-miR-548c-3p	CLIP-seq
MIRT1425569	hsa-miR-548o	CLIP-seq
MIRT1425570	hsa-miR-548s	CLIP-seq
MIRT1425571	hsa-miR-548v	CLIP-seq
MIRT1425572	hsa-miR-588	CLIP-seq
MIRT1425573	hsa-miR-885-3p	CLIP-seq
MIRT1425533	hsa-miR-194	CLIP-seq
MIRT1425536	hsa-miR-23a	CLIP-seq
MIRT1425537	hsa-miR-23b	CLIP-seq
MIRT1425538	hsa-miR-23c	CLIP-seq
MIRT1425574	hsa-miR-3159	CLIP-seq
MIRT1425542	hsa-miR-3187-3p	CLIP-seq
MIRT1425543	hsa-miR-320a	CLIP-seq
MIRT1425544	hsa-miR-320b	CLIP-seq
MIRT1425545	hsa-miR-320c	CLIP-seq
MIRT1425546	hsa-miR-320d	CLIP-seq
MIRT1425553	hsa-miR-4429	CLIP-seq
MIRT1425554	hsa-miR-4435	CLIP-seq
MIRT1425575	hsa-miR-4436b-3p	CLIP-seq
MIRT1425555	hsa-miR-4511	CLIP-seq
MIRT1425556	hsa-miR-4529-5p	CLIP-seq
MIRT1425557	hsa-miR-4670-3p	CLIP-seq
MIRT1425559	hsa-miR-4691-3p	CLIP-seq
MIRT1425560	hsa-miR-4701-5p	CLIP-seq
MIRT1425563	hsa-miR-4715-5p	CLIP-seq
MIRT1425576	hsa-miR-4761-3p	CLIP-seq
MIRT1425567	hsa-miR-545	CLIP-seq
MIRT1425568	hsa-miR-548c-3p	CLIP-seq
MIRT1425570	hsa-miR-548s	CLIP-seq
MIRT1425572	hsa-miR-588	CLIP-seq
MIRT1425573	hsa-miR-885-3p	CLIP-seq
MIRT2127525	hsa-miR-3157-5p	CLIP-seq
MIRT1425543	hsa-miR-320a	CLIP-seq
MIRT1425544	hsa-miR-320b	CLIP-seq
MIRT1425545	hsa-miR-320c	CLIP-seq
MIRT1425546	hsa-miR-320d	CLIP-seq
MIRT2127526	hsa-miR-3691-3p	CLIP-seq
MIRT2127527	hsa-miR-4280	CLIP-seq
MIRT1425553	hsa-miR-4429	CLIP-seq
MIRT2127528	hsa-miR-4477a	CLIP-seq
MIRT1425559	hsa-miR-4691-3p	CLIP-seq
MIRT2127529	hsa-miR-4797-5p	CLIP-seq
MIRT1425567	hsa-miR-545	CLIP-seq
MIRT2127530	hsa-miR-548ag	CLIP-seq
MIRT2127531	hsa-miR-548ai	CLIP-seq
MIRT2127532	hsa-miR-562	CLIP-seq
MIRT2127533	hsa-miR-599	CLIP-seq
MIRT1425559	hsa-miR-4691-3p	CLIP-seq
MIRT1425567	hsa-miR-545	CLIP-seq
MIRT2127525	hsa-miR-3157-5p	CLIP-seq
MIRT1425559	hsa-miR-4691-3p	CLIP-seq
MIRT2642642	hsa-miR-1278	CLIP-seq
MIRT2642643	hsa-miR-19a	CLIP-seq
MIRT2642644	hsa-miR-19b	CLIP-seq
MIRT2642645	hsa-miR-2113	CLIP-seq
MIRT2642646	hsa-miR-330-3p	CLIP-seq
MIRT2642647	hsa-miR-338-3p	CLIP-seq
MIRT2127526	hsa-miR-3691-3p	CLIP-seq
MIRT1425549	hsa-miR-3913-3p	CLIP-seq
MIRT2127527	hsa-miR-4280	CLIP-seq
MIRT2642648	hsa-miR-4282	CLIP-seq
MIRT2642649	hsa-miR-433	CLIP-seq
MIRT2127528	hsa-miR-4477a	CLIP-seq
MIRT2642650	hsa-miR-4519	CLIP-seq
MIRT2642651	hsa-miR-4530	CLIP-seq
MIRT2642652	hsa-miR-4639-5p	CLIP-seq
MIRT1425564	hsa-miR-4720-3p	CLIP-seq
MIRT2127529	hsa-miR-4797-5p	CLIP-seq
MIRT1425566	hsa-miR-4804-3p	CLIP-seq
MIRT2642653	hsa-miR-513a-3p	CLIP-seq
MIRT1425567	hsa-miR-545	CLIP-seq
MIRT2642654	hsa-miR-548aa	CLIP-seq
MIRT2127530	hsa-miR-548ag	CLIP-seq
MIRT2127531	hsa-miR-548ai	CLIP-seq
MIRT1425568	hsa-miR-548c-3p	CLIP-seq
MIRT2127532	hsa-miR-562	CLIP-seq
MIRT2127533	hsa-miR-599	CLIP-seq
MIRT2693205	hsa-miR-3545-3p	CLIP-seq
MIRT2127526	hsa-miR-3691-3p	CLIP-seq
MIRT1425549	hsa-miR-3913-3p	CLIP-seq
MIRT2693206	hsa-miR-3915	CLIP-seq
MIRT2693207	hsa-miR-3921	CLIP-seq
MIRT2693208	hsa-miR-3928	CLIP-seq
MIRT2693209	hsa-miR-4261	CLIP-seq
MIRT2693210	hsa-miR-4496	CLIP-seq
MIRT2693211	hsa-miR-4539	CLIP-seq
MIRT2693212	hsa-miR-4653-5p	CLIP-seq
MIRT1425564	hsa-miR-4720-3p	CLIP-seq
MIRT1425566	hsa-miR-4804-3p	CLIP-seq
MIRT2127533	hsa-miR-599	CLIP-seq

Show/Hide all(33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000987	Function	Cis-regulatory region sequence-specific DNA binding	IDA	23275542
GO:0001570	Process	Vasculogenesis	IEA
GO:0001822	Process	Kidney development	IEA
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IBA
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IDA	23275542
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	23275542, 30373764
GO:0005634	Component	Nucleus	IEA
GO:0008209	Process	Androgen metabolic process	IEA
GO:0008210	Process	Estrogen metabolic process	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008585	Process	Female gonad development	IEA
GO:0009791	Process	Post-embryonic development	IEA
GO:0010629	Process	Negative regulation of gene expression	IMP	23275542
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0030097	Process	Hemopoiesis	IEA
GO:0045732	Process	Positive regulation of protein catabolic process	IMP	23275542
GO:0046872	Function	Metal ion binding	IEA
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	IEA
GO:0048705	Process	Skeletal system morphogenesis	IEA
GO:0048745	Process	Smooth muscle tissue development	IEA
GO:0060021	Process	Roof of mouth development	IEA
GO:0060325	Process	Face morphogenesis	IEA
GO:0140803	Function	NAD+-protein-cysteine ADP-ribosyltransferase activity	IDA	30373764
GO:0140803	Function	NAD+-protein-cysteine ADP-ribosyltransferase activity	IEA
GO:0140806	Function	NAD+-protein-aspartate ADP-ribosyltransferase activity	IEA
GO:0140807	Function	NAD+-protein-glutamate ADP-ribosyltransferase activity	IEA
GO:1904612	Process	Response to 2,3,7,8-tetrachlorodibenzodioxine	IEA
GO:1990404	Function	NAD+-protein mono-ADP-ribosyltransferase activity	IDA	25043379
GO:1990404	Function	NAD+-protein mono-ADP-ribosyltransferase activity	IEA

MIM	HGNC	e!Ensembl
612480	23696	ENSG00000163659

Protein

UniProt ID

Q7Z3E1

Protein name

Protein mono-ADP-ribosyltransferase TIPARP (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) (TCDD-inducible poly [ADP-ribose] polymerase)

Protein function

ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (PubMed:23275542, PubMed:25043379, PubMed:30373764). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylati

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00644	PARP	471 → 650	Poly(ADP-ribose) polymerase catalytic domain	Family

Sequence

MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPIL
NTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQ
IPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDK
VIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGI
EICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDR
MRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREY
PESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGG
VPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNL
FHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVD
GICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGS
HGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI

Sequence length

657

Interactions

View interactions

Show/Hide Unknown Diseases (7)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma (childhood onset), Asthma (adult onset), Age of onset of childhood onset asthma	N/A	N/A	GWAS
Breast cancer	Breast cancer	N/A	N/A	GWAS
Melanoma	Melanoma	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Ovarian cancer	Epithelial ovarian cancer	N/A	N/A	GWAS
Psoriasis	Psoriasis	N/A	N/A	GWAS
Testicular Germ Cell Tumor	Testicular germ cell tumor	N/A	N/A	GWAS

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Breast Neoplasms	Associate	33799807, 38011562
Bronchiolitis Obliterans Syndrome	Associate	25828101
Carcinoma Ovarian Epithelial	Associate	25173882, 27378695
Hypertension	Associate	28784648
Hypoxia	Associate	33799807
Metabolic Diseases	Associate	37486064
Neoplasm Metastasis	Associate	34434692
Neoplasms	Associate	33475085, 38011562
Ovarian Neoplasms	Associate	20852632, 22235027, 22253144, 23133607, 33475085
Prostatic Neoplasms	Associate	37077937
Pulmonary Disease Chronic Obstructive	Associate	36012391
Thyroid Neoplasms	Associate	37907864
Uveal melanoma	Associate	34434692

TIPARP (TCDD inducible poly(ADP-ribose) polymerase)