Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	25976
Gene name	TCDD inducible poly(ADP-ribose) polymerase
Gene symbol	TIPARP
Synonyms (NCBI Gene)	ARTD14PARP7pART14
Chromosome	3
Chromosome location	3q25.31
Summary	This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in m

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024175	hsa-miR-221-3p	Sequencing	20371350
MIRT029801	hsa-miR-26b-5p	Microarray	19088304
MIRT208842	hsa-miR-142-3p	MicroarrayqRT-PCR	22815788
MIRT437683	hsa-miR-222-3p	MicroarrayqRT-PCR	22815788
MIRT237128	hsa-miR-4311	PAR-CLIP	22012620
MIRT237127	hsa-miR-1276	PAR-CLIP	22012620
MIRT237125	hsa-miR-583	PAR-CLIP	22012620
MIRT090928	hsa-miR-5692a	PAR-CLIP	22012620
MIRT237129	hsa-miR-203b-5p	PAR-CLIP	22012620
MIRT237133	hsa-miR-6718-5p	PAR-CLIP	22012620
MIRT531050	hsa-miR-3121-3p	PAR-CLIP	22012620
MIRT531049	hsa-miR-520f-5p	PAR-CLIP	22012620
MIRT531048	hsa-miR-4680-5p	PAR-CLIP	22012620
MIRT531047	hsa-miR-7111-3p	PAR-CLIP	22012620
MIRT531046	hsa-miR-6780a-3p	PAR-CLIP	22012620
MIRT531045	hsa-miR-6881-3p	PAR-CLIP	22012620
MIRT531044	hsa-miR-4799-5p	PAR-CLIP	22012620
MIRT531043	hsa-miR-552-5p	PAR-CLIP	22012620
MIRT237128	hsa-miR-4311	PAR-CLIP	22012620
MIRT237127	hsa-miR-1276	PAR-CLIP	22012620
MIRT237125	hsa-miR-583	PAR-CLIP	22012620
MIRT090928	hsa-miR-5692a	PAR-CLIP	22012620
MIRT237129	hsa-miR-203b-5p	PAR-CLIP	22012620
MIRT237133	hsa-miR-6718-5p	PAR-CLIP	22012620
MIRT531050	hsa-miR-3121-3p	PAR-CLIP	22012620
MIRT531049	hsa-miR-520f-5p	PAR-CLIP	22012620
MIRT531048	hsa-miR-4680-5p	PAR-CLIP	22012620
MIRT531047	hsa-miR-7111-3p	PAR-CLIP	22012620
MIRT531046	hsa-miR-6780a-3p	PAR-CLIP	22012620
MIRT531045	hsa-miR-6881-3p	PAR-CLIP	22012620
MIRT531044	hsa-miR-4799-5p	PAR-CLIP	22012620
MIRT531043	hsa-miR-552-5p	PAR-CLIP	22012620
MIRT1425527	hsa-miR-105	CLIP-seq
MIRT1425528	hsa-miR-1200	CLIP-seq
MIRT1425529	hsa-miR-1283	CLIP-seq
MIRT1425530	hsa-miR-1287	CLIP-seq
MIRT1425531	hsa-miR-1323	CLIP-seq
MIRT1425532	hsa-miR-1911	CLIP-seq
MIRT1425533	hsa-miR-194	CLIP-seq
MIRT1425534	hsa-miR-221	CLIP-seq
MIRT1425535	hsa-miR-222	CLIP-seq
MIRT1425536	hsa-miR-23a	CLIP-seq
MIRT1425537	hsa-miR-23b	CLIP-seq
MIRT1425538	hsa-miR-23c	CLIP-seq
MIRT1425539	hsa-miR-3133	CLIP-seq
MIRT1425540	hsa-miR-3135b	CLIP-seq
MIRT1425541	hsa-miR-3140-5p	CLIP-seq
MIRT1425542	hsa-miR-3187-3p	CLIP-seq
MIRT1425543	hsa-miR-320a	CLIP-seq
MIRT1425544	hsa-miR-320b	CLIP-seq
MIRT1425545	hsa-miR-320c	CLIP-seq
MIRT1425546	hsa-miR-320d	CLIP-seq
MIRT1425547	hsa-miR-34c-3p	CLIP-seq
MIRT1425548	hsa-miR-3908	CLIP-seq
MIRT1425549	hsa-miR-3913-3p	CLIP-seq
MIRT1425550	hsa-miR-3942-5p	CLIP-seq
MIRT1425551	hsa-miR-4329	CLIP-seq
MIRT1425552	hsa-miR-4420	CLIP-seq
MIRT1425553	hsa-miR-4429	CLIP-seq
MIRT1425554	hsa-miR-4435	CLIP-seq
MIRT1425555	hsa-miR-4511	CLIP-seq
MIRT1425556	hsa-miR-4529-5p	CLIP-seq
MIRT1425557	hsa-miR-4670-3p	CLIP-seq
MIRT1425558	hsa-miR-4682	CLIP-seq
MIRT1425559	hsa-miR-4691-3p	CLIP-seq
MIRT1425560	hsa-miR-4701-5p	CLIP-seq
MIRT1425561	hsa-miR-4703-5p	CLIP-seq
MIRT1425562	hsa-miR-4704-5p	CLIP-seq
MIRT1425563	hsa-miR-4715-5p	CLIP-seq
MIRT1425564	hsa-miR-4720-3p	CLIP-seq
MIRT1425565	hsa-miR-4766-3p	CLIP-seq
MIRT1425566	hsa-miR-4804-3p	CLIP-seq
MIRT1425567	hsa-miR-545	CLIP-seq
MIRT1425568	hsa-miR-548c-3p	CLIP-seq
MIRT1425569	hsa-miR-548o	CLIP-seq
MIRT1425570	hsa-miR-548s	CLIP-seq
MIRT1425571	hsa-miR-548v	CLIP-seq
MIRT1425572	hsa-miR-588	CLIP-seq
MIRT1425573	hsa-miR-885-3p	CLIP-seq
MIRT1425533	hsa-miR-194	CLIP-seq
MIRT1425536	hsa-miR-23a	CLIP-seq
MIRT1425537	hsa-miR-23b	CLIP-seq
MIRT1425538	hsa-miR-23c	CLIP-seq
MIRT1425574	hsa-miR-3159	CLIP-seq
MIRT1425542	hsa-miR-3187-3p	CLIP-seq
MIRT1425543	hsa-miR-320a	CLIP-seq
MIRT1425544	hsa-miR-320b	CLIP-seq
MIRT1425545	hsa-miR-320c	CLIP-seq
MIRT1425546	hsa-miR-320d	CLIP-seq
MIRT1425553	hsa-miR-4429	CLIP-seq
MIRT1425554	hsa-miR-4435	CLIP-seq
MIRT1425575	hsa-miR-4436b-3p	CLIP-seq
MIRT1425555	hsa-miR-4511	CLIP-seq
MIRT1425556	hsa-miR-4529-5p	CLIP-seq
MIRT1425557	hsa-miR-4670-3p	CLIP-seq
MIRT1425559	hsa-miR-4691-3p	CLIP-seq
MIRT1425560	hsa-miR-4701-5p	CLIP-seq
MIRT1425563	hsa-miR-4715-5p	CLIP-seq
MIRT1425576	hsa-miR-4761-3p	CLIP-seq
MIRT1425567	hsa-miR-545	CLIP-seq
MIRT1425568	hsa-miR-548c-3p	CLIP-seq
MIRT1425570	hsa-miR-548s	CLIP-seq
MIRT1425572	hsa-miR-588	CLIP-seq
MIRT1425573	hsa-miR-885-3p	CLIP-seq
MIRT2127525	hsa-miR-3157-5p	CLIP-seq
MIRT1425543	hsa-miR-320a	CLIP-seq
MIRT1425544	hsa-miR-320b	CLIP-seq
MIRT1425545	hsa-miR-320c	CLIP-seq
MIRT1425546	hsa-miR-320d	CLIP-seq
MIRT2127526	hsa-miR-3691-3p	CLIP-seq
MIRT2127527	hsa-miR-4280	CLIP-seq
MIRT1425553	hsa-miR-4429	CLIP-seq
MIRT2127528	hsa-miR-4477a	CLIP-seq
MIRT1425559	hsa-miR-4691-3p	CLIP-seq
MIRT2127529	hsa-miR-4797-5p	CLIP-seq
MIRT1425567	hsa-miR-545	CLIP-seq
MIRT2127530	hsa-miR-548ag	CLIP-seq
MIRT2127531	hsa-miR-548ai	CLIP-seq
MIRT2127532	hsa-miR-562	CLIP-seq
MIRT2127533	hsa-miR-599	CLIP-seq
MIRT1425559	hsa-miR-4691-3p	CLIP-seq
MIRT1425567	hsa-miR-545	CLIP-seq
MIRT2127525	hsa-miR-3157-5p	CLIP-seq
MIRT1425559	hsa-miR-4691-3p	CLIP-seq
MIRT2642642	hsa-miR-1278	CLIP-seq
MIRT2642643	hsa-miR-19a	CLIP-seq
MIRT2642644	hsa-miR-19b	CLIP-seq
MIRT2642645	hsa-miR-2113	CLIP-seq
MIRT2642646	hsa-miR-330-3p	CLIP-seq
MIRT2642647	hsa-miR-338-3p	CLIP-seq
MIRT2127526	hsa-miR-3691-3p	CLIP-seq
MIRT1425549	hsa-miR-3913-3p	CLIP-seq
MIRT2127527	hsa-miR-4280	CLIP-seq
MIRT2642648	hsa-miR-4282	CLIP-seq
MIRT2642649	hsa-miR-433	CLIP-seq
MIRT2127528	hsa-miR-4477a	CLIP-seq
MIRT2642650	hsa-miR-4519	CLIP-seq
MIRT2642651	hsa-miR-4530	CLIP-seq
MIRT2642652	hsa-miR-4639-5p	CLIP-seq
MIRT1425564	hsa-miR-4720-3p	CLIP-seq
MIRT2127529	hsa-miR-4797-5p	CLIP-seq
MIRT1425566	hsa-miR-4804-3p	CLIP-seq
MIRT2642653	hsa-miR-513a-3p	CLIP-seq
MIRT1425567	hsa-miR-545	CLIP-seq
MIRT2642654	hsa-miR-548aa	CLIP-seq
MIRT2127530	hsa-miR-548ag	CLIP-seq
MIRT2127531	hsa-miR-548ai	CLIP-seq
MIRT1425568	hsa-miR-548c-3p	CLIP-seq
MIRT2127532	hsa-miR-562	CLIP-seq
MIRT2127533	hsa-miR-599	CLIP-seq
MIRT2693205	hsa-miR-3545-3p	CLIP-seq
MIRT2127526	hsa-miR-3691-3p	CLIP-seq
MIRT1425549	hsa-miR-3913-3p	CLIP-seq
MIRT2693206	hsa-miR-3915	CLIP-seq
MIRT2693207	hsa-miR-3921	CLIP-seq
MIRT2693208	hsa-miR-3928	CLIP-seq
MIRT2693209	hsa-miR-4261	CLIP-seq
MIRT2693210	hsa-miR-4496	CLIP-seq
MIRT2693211	hsa-miR-4539	CLIP-seq
MIRT2693212	hsa-miR-4653-5p	CLIP-seq
MIRT1425564	hsa-miR-4720-3p	CLIP-seq
MIRT1425566	hsa-miR-4804-3p	CLIP-seq
MIRT2127533	hsa-miR-599	CLIP-seq

Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000987	Function	Cis-regulatory region sequence-specific DNA binding	IDA	23275542
GO:0001570	Process	Vasculogenesis	IEA
GO:0001822	Process	Kidney development	IEA
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IBA
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IDA	23275542
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	23275542, 30373764
GO:0005634	Component	Nucleus	IEA
GO:0008209	Process	Androgen metabolic process	IEA
GO:0008210	Process	Estrogen metabolic process	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008585	Process	Female gonad development	IEA
GO:0009791	Process	Post-embryonic development	IEA
GO:0010629	Process	Negative regulation of gene expression	IMP	23275542
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0030097	Process	Hemopoiesis	IEA
GO:0045732	Process	Positive regulation of protein catabolic process	IMP	23275542
GO:0046872	Function	Metal ion binding	IEA
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	IEA
GO:0048705	Process	Skeletal system morphogenesis	IEA
GO:0048745	Process	Smooth muscle tissue development	IEA
GO:0060021	Process	Roof of mouth development	IEA
GO:0060325	Process	Face morphogenesis	IEA
GO:0140803	Function	NAD+-protein-cysteine ADP-ribosyltransferase activity	IDA	30373764
GO:0140803	Function	NAD+-protein-cysteine ADP-ribosyltransferase activity	IEA
GO:0140806	Function	NAD+-protein-aspartate ADP-ribosyltransferase activity	IEA
GO:0140807	Function	NAD+-protein-glutamate ADP-ribosyltransferase activity	IEA
GO:1904612	Process	Response to 2,3,7,8-tetrachlorodibenzodioxine	IEA
GO:1990404	Function	NAD+-protein mono-ADP-ribosyltransferase activity	IDA	25043379
GO:1990404	Function	NAD+-protein mono-ADP-ribosyltransferase activity	IEA

MIM	HGNC	e!Ensembl
612480	23696	ENSG00000163659

Q7Z3E1

Protein name

Protein mono-ADP-ribosyltransferase TIPARP (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) (TCDD-inducible poly [ADP-ribose] polymerase)

Protein function

ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (PubMed:23275542, PubMed:25043379, PubMed:30373764). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylati

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00644	PARP	471 → 650	Poly(ADP-ribose) polymerase catalytic domain	Family

Sequence

MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPIL
NTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQ
IPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDK
VIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGI
EICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDR
MRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREY
PESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGG
VPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNL
FHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVD
GICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGS
HGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI

Sequence length

657

Interactions

View interactions

TIPARP (TCDD inducible poly(ADP-ribose) polymerase)