CLIC4 (chloride intracellular channel 4)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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25932 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Chloride intracellular channel 4 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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CLIC4 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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CLIC4L, H1, MTCLIC, huH1, p64H1 |
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Chromosome
Chromosome number
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1 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1p36.11 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracel |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | Q9Y696 | ||||||||||
| Protein name | Chloride intracellular channel protein 4 (Glutaredoxin-like oxidoreductase CLIC4) (EC 1.8.-.-) (Intracellular chloride ion channel protein p64H1) | ||||||||||
| Protein function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channel | ||||||||||
| PDB | 2AHE , 2D2Z , 3OQS | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. {ECO:0000269|PubMed:10793131, ECO:0000269|PubMed:17200346, ECO:0000269|PubMed:176 | ||||||||||
| Sequence |
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| Sequence length | 253 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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