Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
25932
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Chloride intracellular channel 4 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
CLIC4 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
CLIC4L, H1, MTCLIC, huH1, p64H1 |
Chromosome
Chromosome number
|
1 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
1p36.11 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracel |
UniProt ID |
Q9Y696
|
Protein name |
Chloride intracellular channel protein 4 (Glutaredoxin-like oxidoreductase CLIC4) (EC 1.8.-.-) (Intracellular chloride ion channel protein p64H1) |
Protein function |
In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channel |
PDB |
2AHE
,
2D2Z
,
3OQS
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF13410
|
GST_C_2 |
134 → 223 |
|
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. {ECO:0000269|PubMed:10793131, ECO:0000269|PubMed:17200346, ECO:0000269|PubMed:176 |
Sequence |
|
Sequence length |
253 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Arthritis |
Degenerative polyarthritis |
rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 |
18784066 |
Prostate cancer |
Malignant neoplasm of prostate |
rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 |
17199135 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Hypertension |
Hypertension |
|
|
GWAS |
Alzheimer disease |
Alzheimer disease |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Adenocarcinoma Mucinous |
Inhibit
|
24503901 |
Adenocarcinoma of Lung |
Associate
|
24503901 |
Breast Neoplasms |
Associate
|
12163372 |
Carcinogenesis |
Associate
|
24503901, 32667519 |
Carcinoma Hepatocellular |
Associate
|
34766585 |
Carcinoma Merkel Cell |
Associate
|
29462791 |
Carcinoma Ovarian Epithelial |
Stimulate
|
30282979 |
Carcinoma Pancreatic Ductal |
Associate
|
28205343 |
Carcinoma Renal Cell |
Associate
|
37689589 |
Carcinoma Verrucous |
Associate
|
37026609 |
Colorectal Neoplasms |
Associate
|
34697147, 35732323 |
Corneal Endothelial Cell Loss |
Associate
|
35081862 |
Lung Neoplasms |
Associate
|
24503901 |
Lymphatic Metastasis |
Associate
|
28205343, 32667519 |
Mitochondrial Diseases |
Associate
|
22761775, 36264759 |
Neoplasm Metastasis |
Associate
|
28205343 |
Neoplasms |
Associate
|
16239224, 19781102, 28205343, 30201851, 30282979, 32667519, 34697147, 35732323, 36264759, 37026609 |
Neoplasms Cystic Mucinous and Serous |
Associate
|
30282979 |
Ovarian Neoplasms |
Associate
|
19781102 |
Prostatic Neoplasms |
Associate
|
37298233 |
Pulmonary Arterial Hypertension |
Associate
|
36264759 |
Squamous Cell Carcinoma of Head and Neck |
Associate
|
37026609 |
|