Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID	259266
Gene name	Assembly factor for spindle microtubules
Gene symbol	ASPM
Synonyms (NCBI Gene)	ASPCalmbp1MCPH5
Chromosome	1
Chromosome location	1q31.3
Summary	This gene is the human ortholog of the Drosophila melanogaster `abnormal spindle` gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation,

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SNP ID	Visualize variation	Clinical significance	Consequence
rs115594989	T>C	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, intron variant, coding sequence variant
rs118010078	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance, benign	Missense variant, intron variant, coding sequence variant
rs137852994	G>A	Pathogenic	Stop gained, coding sequence variant
rs137852995	C>T	Pathogenic	Stop gained, coding sequence variant
rs137852996	G>A	Pathogenic	Stop gained, coding sequence variant
rs137852997	A>C,G	Pathogenic	Stop gained, synonymous variant, intron variant, coding sequence variant
rs139317695	T>A,G	Pathogenic, likely-benign, benign	Stop gained, missense variant, coding sequence variant
rs139367209	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance, benign	Missense variant, intron variant, coding sequence variant
rs140602858	G>A,T	Pathogenic	Coding sequence variant, synonymous variant, stop gained
rs141715950	T>A,C	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Intron variant, coding sequence variant, missense variant
rs142587742	T>C	Conflicting-interpretations-of-pathogenicity	Intron variant, synonymous variant, coding sequence variant
rs142901223	A>C	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, missense variant
rs143822761	C>T	Likely-benign, uncertain-significance, conflicting-interpretations-of-pathogenicity	Intron variant, coding sequence variant, missense variant
rs143931757	A>C,G	Pathogenic, benign	Coding sequence variant, synonymous variant, stop gained
rs145489194	G>A,C	Pathogenic	Coding sequence variant, stop gained, missense variant
rs147160053	T>C	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Intron variant, synonymous variant, coding sequence variant
rs147622433	C>T	Pathogenic	Intron variant, stop gained, coding sequence variant
rs148294838	G>T	Pathogenic	Intron variant, stop gained, coding sequence variant
rs148328539	A>C	Conflicting-interpretations-of-pathogenicity, likely-benign	Intron variant, missense variant, coding sequence variant
rs149228705	A>G,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity, likely-benign	Intron variant, synonymous variant, stop gained, coding sequence variant
rs149303254	T>C	Uncertain-significance, benign, conflicting-interpretations-of-pathogenicity	Intron variant
rs149690383	T>C	Conflicting-interpretations-of-pathogenicity, likely-benign	Missense variant, coding sequence variant
rs150642468	G>A	Benign, conflicting-interpretations-of-pathogenicity	Intron variant, synonymous variant, coding sequence variant
rs151142538	A>G	Conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant
rs183395856	T>C	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, synonymous variant
rs188955444	C>A	Conflicting-interpretations-of-pathogenicity	Missense variant, intron variant, coding sequence variant
rs189678019	A>C,G	Pathogenic, likely-benign	Stop gained, intron variant, coding sequence variant, synonymous variant
rs190693455	T>C	Conflicting-interpretations-of-pathogenicity	Missense variant, intron variant, coding sequence variant
rs199422131	C>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422133	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422134	G>A,C,T	Likely-pathogenic	Stop gained, missense variant, coding sequence variant
rs199422135	AG>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422136	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422137	CT>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422138	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422139	CTTGAGA>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422141	C>A,G	Pathogenic	Stop gained, missense variant, coding sequence variant
rs199422142	TTAGGATT>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422143	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422144	TAAGA>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422146	CT>-	Pathogenic, likely-pathogenic	Frameshift variant, coding sequence variant
rs199422147	GTTT>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422148	G>A	Pathogenic	Stop gained, coding sequence variant
rs199422149	T>C	Pathogenic	Intron variant
rs199422150	C>A,T	Pathogenic, likely-pathogenic	Intron variant
rs199422151	G>A,T	Pathogenic	Stop gained, coding sequence variant, synonymous variant
rs199422152	C>T	Pathogenic	Stop gained, coding sequence variant
rs199422153	G>A	Pathogenic	Stop gained, coding sequence variant
rs199422154	C>T	Pathogenic	Missense variant, coding sequence variant
rs199422155	A>C	Pathogenic	Stop gained, coding sequence variant
rs199422156	AGCGT>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422157	G>C	Pathogenic	Stop gained, coding sequence variant
rs199422158	C>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422159	G>C	Pathogenic	Stop gained, coding sequence variant
rs199422160	C>T	Pathogenic	Splice donor variant
rs199422161	C>A,T	Pathogenic	Stop gained, missense variant, coding sequence variant
rs199422162	C>T	Pathogenic	Stop gained, intron variant, coding sequence variant
rs199422163	->T	Pathogenic	Intron variant, frameshift variant, coding sequence variant
rs199422164	T>-	Pathogenic	Intron variant, frameshift variant, coding sequence variant
rs199422165	G>A	Pathogenic	Stop gained, intron variant, coding sequence variant
rs199422166	TA>-	Pathogenic	Intron variant, frameshift variant, coding sequence variant
rs199422167	T>-,TT	Pathogenic	Stop gained, intron variant, frameshift variant, coding sequence variant
rs199422168	G>A	Pathogenic	Stop gained, intron variant, coding sequence variant
rs199422169	AT>-,ATAT	Pathogenic	Intron variant, frameshift variant, coding sequence variant
rs199422170	GTTT>-	Pathogenic	Intron variant, frameshift variant, coding sequence variant
rs199422171	T>-	Pathogenic	Intron variant, frameshift variant, coding sequence variant
rs199422172	ATATA>-	Pathogenic	Intron variant, frameshift variant, coding sequence variant
rs199422173	CT>-	Pathogenic	Intron variant, frameshift variant, coding sequence variant
rs199422174	CT>-	Pathogenic	Intron variant, frameshift variant, coding sequence variant
rs199422175	G>A	Pathogenic	Stop gained, intron variant, coding sequence variant
rs199422176	TT>-	Pathogenic	Intron variant, frameshift variant, coding sequence variant
rs199422177	CT>-	Pathogenic	Intron variant, frameshift variant, coding sequence variant
rs199422178	A>T	Pathogenic	Stop gained, intron variant, coding sequence variant
rs199422179	A>-	Pathogenic	Intron variant, frameshift variant, coding sequence variant
rs199422180	CT>-	Pathogenic	Intron variant, frameshift variant, coding sequence variant
rs199422181	G>A	Pathogenic	Stop gained, intron variant, coding sequence variant
rs199422182	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422183	->AATG	Pathogenic	Frameshift variant, coding sequence variant
rs199422184	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422185	G>A	Pathogenic	Stop gained, coding sequence variant
rs199422186	T>A	Pathogenic	Stop gained, coding sequence variant
rs199422187	G>A	Pathogenic	Stop gained, coding sequence variant
rs199422188	C>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422189	G>C	Pathogenic	Stop gained, coding sequence variant
rs199422190	T>A	Pathogenic	Stop gained, coding sequence variant
rs199422191	->C	Pathogenic	Frameshift variant, coding sequence variant
rs199422192	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422193	AATTT>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422194	G>A	Pathogenic	Stop gained, coding sequence variant
rs199422195	G>A	Pathogenic	Stop gained, coding sequence variant
rs199422196	AG>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422197	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs199422198	A>G,T	Pathogenic	Stop gained, coding sequence variant, synonymous variant
rs199422199	T>A,C	Pathogenic	Stop gained, missense variant, coding sequence variant
rs199422200	C>A	Pathogenic	Splice donor variant
rs199422201	G>T	Pathogenic	Stop gained, coding sequence variant
rs199910503	G>A	Pathogenic	Stop gained, intron variant, coding sequence variant
rs201362977	C>A,T	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant
rs202193200	C>T	Conflicting-interpretations-of-pathogenicity	Intron variant, missense variant, coding sequence variant
rs370972881	C>T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs374040448	T>C	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Synonymous variant, coding sequence variant, intron variant
rs375911555	T>C	Conflicting-interpretations-of-pathogenicity	Intron variant
rs555866170	G>A,C,T	Pathogenic	Coding sequence variant, missense variant, stop gained
rs563858170	G>C	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, missense variant
rs587783211	G>A	Pathogenic	Stop gained, coding sequence variant
rs587783215	G>A,T	Likely-pathogenic, pathogenic	Stop gained, coding sequence variant, missense variant
rs587783216	CA>-	Pathogenic	Coding sequence variant, frameshift variant
rs587783220	AA>-	Pathogenic	Coding sequence variant, frameshift variant
rs587783221	CTTT>-	Pathogenic	Coding sequence variant, frameshift variant
rs587783225	A>G	Pathogenic	Splice donor variant
rs587783227	G>A	Pathogenic	Stop gained, coding sequence variant
rs587783228	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs587783230	A>C	Pathogenic	Stop gained, coding sequence variant
rs587783238	C>T	Pathogenic	Stop gained, coding sequence variant
rs587783239	CT>-	Pathogenic	Coding sequence variant, frameshift variant
rs587783240	CT>-	Pathogenic	Coding sequence variant, frameshift variant
rs587783245	CT>-	Pathogenic	Coding sequence variant, frameshift variant, intron variant
rs587783247	A>T	Pathogenic	Stop gained, coding sequence variant, intron variant
rs587783248	G>A	Pathogenic	Stop gained, coding sequence variant, intron variant
rs587783258	T>-	Pathogenic	Coding sequence variant, frameshift variant
rs587783259	AGAG>-,AG	Pathogenic	Coding sequence variant, frameshift variant, intron variant
rs587783263	->CAGT	Pathogenic	Coding sequence variant, frameshift variant, intron variant
rs587783265	AG>-	Pathogenic	Coding sequence variant, frameshift variant, intron variant
rs587783268	G>A	Pathogenic	Stop gained, coding sequence variant, intron variant
rs587783269	T>-	Pathogenic	Coding sequence variant, frameshift variant, intron variant
rs587783272	G>A	Pathogenic	Stop gained, coding sequence variant, intron variant
rs587783275	G>A	Pathogenic	Stop gained, coding sequence variant, intron variant
rs587783277	TT>-,T	Pathogenic	Coding sequence variant, frameshift variant
rs587783278	CTTT>-	Pathogenic	Coding sequence variant, frameshift variant, intron variant
rs587783280	GT>-	Pathogenic	Coding sequence variant, frameshift variant, intron variant
rs587783282	G>A,T	Pathogenic	Stop gained, coding sequence variant, missense variant, intron variant
rs587783283	TT>-	Pathogenic	Coding sequence variant, frameshift variant, intron variant
rs587783285	C>T	Pathogenic	Stop gained, coding sequence variant
rs587783287	G>A	Pathogenic	Stop gained, coding sequence variant
rs587783288	A>T	Pathogenic	Stop gained, coding sequence variant
rs587783289	CT>-	Pathogenic	Coding sequence variant, frameshift variant
rs587783292	G>A	Pathogenic	Stop gained, coding sequence variant
rs587783295	G>A	Pathogenic	Stop gained, coding sequence variant
rs730882076	G>A	Pathogenic	Stop gained, coding sequence variant, intron variant
rs745997770	G>A	Likely-pathogenic	Stop gained, coding sequence variant, intron variant
rs748529285	G>A,C	Pathogenic	Stop gained, coding sequence variant, missense variant
rs749462358	C>A,T	Pathogenic	Coding sequence variant, stop gained, missense variant
rs750664956	CT>-	Pathogenic	Frameshift variant, coding sequence variant, intron variant
rs753406334	G>A,C,T	Pathogenic	Coding sequence variant, missense variant, stop gained, synonymous variant, intron variant
rs754909135	G>A	Pathogenic	Coding sequence variant, intron variant, stop gained
rs756879923	A>C	Conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant
rs759632528	->T	Pathogenic	Frameshift variant, coding sequence variant
rs761447719	A>G	Likely-pathogenic	Initiator codon variant, missense variant
rs763800571	TTCT>-	Pathogenic	Frameshift variant, intron variant, coding sequence variant
rs763909256	G>A,T	Pathogenic	Stop gained, intron variant, coding sequence variant, missense variant
rs765275884	AT>-	Likely-pathogenic	Frameshift variant, coding sequence variant
rs765530357	GATAT>-	Pathogenic	Stop gained, inframe indel, intron variant, coding sequence variant
rs769364943	G>A,C	Pathogenic	Stop gained, missense variant, coding sequence variant, intron variant
rs769818500	CA>-	Pathogenic	Coding sequence variant, frameshift variant
rs770540184	TTTC>-	Pathogenic	Coding sequence variant, intron variant, frameshift variant
rs771583813	AACT>-	Pathogenic	Coding sequence variant, intron variant, frameshift variant
rs772050241	G>A	Conflicting-interpretations-of-pathogenicity	Stop gained, coding sequence variant, intron variant
rs774338373	G>A	Pathogenic	Coding sequence variant, stop gained
rs774814318	AAA>-,AA,AAAA	Pathogenic	Coding sequence variant, frameshift variant, inframe deletion, stop gained
rs776034810	G>A,T	Likely-pathogenic	Intron variant, stop gained, missense variant, coding sequence variant
rs786205609	A>-	Likely-pathogenic	Coding sequence variant, intron variant, frameshift variant
rs797045311	->A	Pathogenic	Coding sequence variant, frameshift variant
rs797045313	TTAC>-	Pathogenic	Splice donor variant, intron variant
rs797045314	A>C,G	Likely-pathogenic	Coding sequence variant, intron variant, stop gained, synonymous variant
rs797045315	->A	Pathogenic	Coding sequence variant, intron variant, frameshift variant
rs797045316	TTTT>-,TTTTT	Pathogenic	Coding sequence variant, intron variant, frameshift variant
rs876660959	T>-,TT	Pathogenic	Coding sequence variant, intron variant, frameshift variant
rs876660960	->T	Pathogenic	Coding sequence variant, intron variant, frameshift variant
rs876660961	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs876661036	A>C	Pathogenic	Coding sequence variant, intron variant, stop gained
rs876661154	G>-	Pathogenic	Coding sequence variant, intron variant, frameshift variant
rs886041282	AATCT>-	Pathogenic	Frameshift variant, intron variant, coding sequence variant
rs886041709	C>G	Pathogenic, likely-pathogenic	Splice donor variant
rs886041720	A>T	Pathogenic	Coding sequence variant, stop gained
rs886041721	->A	Pathogenic	Frameshift variant, coding sequence variant
rs886043249	C>T	Pathogenic	Coding sequence variant, stop gained
rs933106143	A>G,T	Likely-pathogenic	Stop gained, coding sequence variant, synonymous variant
rs1057518268	TT>-	Pathogenic	Coding sequence variant, frameshift variant
rs1057518269	C>T	Pathogenic	Stop gained, coding sequence variant
rs1057520873	C>A,G	Pathogenic	Stop gained, missense variant, intron variant, coding sequence variant
rs1060499757	CT>-	Likely-pathogenic	Intron variant, coding sequence variant, frameshift variant
rs1060499758	C>T	Likely-pathogenic	Intron variant
rs1064793707	->C	Pathogenic	Intron variant, coding sequence variant, frameshift variant
rs1064795945	AAGT>-	Likely-pathogenic, pathogenic	Intron variant, coding sequence variant, frameshift variant
rs1163303148	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs1170413397	CT>-	Pathogenic	Frameshift variant, coding sequence variant
rs1189399471	T>-	Pathogenic	Frameshift variant, intron variant, coding sequence variant
rs1226333994	G>A,T	Pathogenic	Synonymous variant, stop gained, coding sequence variant, intron variant
rs1291666293	TTTAC>-	Pathogenic	Coding sequence variant, frameshift variant
rs1321892596	C>A,G	Pathogenic	Splice acceptor variant
rs1334301723	CTTT>-	Likely-pathogenic	Intron variant, coding sequence variant, frameshift variant
rs1334947797	C>A,G	Pathogenic	Intron variant, stop gained, coding sequence variant, missense variant
rs1404276011	CA>-	Pathogenic	Coding sequence variant, frameshift variant
rs1482100822	G>A	Pathogenic	Coding sequence variant, stop gained
rs1553223323	->T	Likely-pathogenic	Intron variant, frameshift variant, coding sequence variant
rs1553223496	G>A	Pathogenic	Intron variant, coding sequence variant, stop gained
rs1553225179	->T	Pathogenic	Coding sequence variant, stop gained
rs1553227015	A>T	Likely-pathogenic	Coding sequence variant, stop gained
rs1553227021	C>T	Pathogenic	Coding sequence variant, stop gained
rs1553227645	TTTT>-	Pathogenic	Frameshift variant, coding sequence variant
rs1553227742	G>C	Pathogenic	Coding sequence variant, stop gained
rs1553228009	->CA	Pathogenic	Frameshift variant, coding sequence variant
rs1553228275	C>G	Pathogenic	Splice donor variant
rs1553325275	T>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1553326645	C>G	Likely-pathogenic	Splice acceptor variant
rs1553326840	C>T	Pathogenic	Splice donor variant
rs1557966012	C>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1558328287	TT>-,T	Pathogenic	Intron variant, frameshift variant, coding sequence variant
rs1571596976	AA>-	Pathogenic	Coding sequence variant, frameshift variant, intron variant
rs1571599902	AGTA>-	Likely-pathogenic	Coding sequence variant, frameshift variant, intron variant
rs1571600045	->T	Pathogenic	Coding sequence variant, frameshift variant, intron variant
rs1571600860	->G	Pathogenic	Coding sequence variant, frameshift variant, intron variant
rs1571601267	AG>-	Pathogenic	Coding sequence variant, frameshift variant, intron variant
rs1571602991	AT>-	Pathogenic	Coding sequence variant, stop gained, intron variant
rs1571616951	C>A	Likely-pathogenic	Coding sequence variant, stop gained
rs1571630284	TAG>AA	Pathogenic	Coding sequence variant, frameshift variant

Show/Hide all (18)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016478	hsa-miR-193b-3p	Microarray	20304954
MIRT024686	hsa-miR-215-5p	Microarray	19074876
MIRT026460	hsa-miR-192-5p	Microarray	19074876
MIRT029549	hsa-miR-26b-5p	Microarray	19088304
MIRT052495	hsa-let-7a-5p	CLASH	23622248
MIRT441168	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT441168	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT803183	hsa-miR-1284	CLIP-seq
MIRT803184	hsa-miR-3119	CLIP-seq
MIRT803185	hsa-miR-34b	CLIP-seq
MIRT803186	hsa-miR-3647-3p	CLIP-seq
MIRT803187	hsa-miR-433	CLIP-seq
MIRT803188	hsa-miR-4704-5p	CLIP-seq
MIRT803189	hsa-miR-4724-5p	CLIP-seq
MIRT803190	hsa-miR-509-3p	CLIP-seq
MIRT803191	hsa-miR-548c-3p	CLIP-seq
MIRT803192	hsa-miR-548p	CLIP-seq
MIRT803193	hsa-miR-889	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
BRCA1	Activation	16123590
FOXJ1	Unknown	16809635

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000922	Component	Spindle pole	IEA
GO:0001764	Process	Neuron migration	IEA
GO:0002052	Process	Positive regulation of neuroblast proliferation	IEA
GO:0005516	Function	Calmodulin binding	IEA
GO:0005634	Component	Nucleus	IDA	21044324
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0007051	Process	Spindle organization	IEA
GO:0007051	Process	Spindle organization	IMP	21044324
GO:0007283	Process	Spermatogenesis	IEA
GO:0007405	Process	Neuroblast proliferation	IEA
GO:0007420	Process	Brain development	IEA
GO:0008356	Process	Asymmetric cell division	IEA
GO:0008584	Process	Male gonad development	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0021873	Process	Forebrain neuroblast division	IEA
GO:0021987	Process	Cerebral cortex development	IEA
GO:0030496	Component	Midbody	IEA
GO:0036449	Component	Microtubule minus-end	IDA	21044324
GO:0045665	Process	Negative regulation of neuron differentiation	IEA
GO:0045769	Process	Negative regulation of asymmetric cell division	IEA
GO:0048477	Process	Oogenesis	IEA
GO:0048589	Process	Developmental growth	IEA
GO:0051301	Process	Cell division	IEA
GO:0051445	Process	Regulation of meiotic cell cycle	IEA
GO:0051653	Process	Spindle localization	IMP	21044324
GO:0051661	Process	Maintenance of centrosome location	IEA
GO:0072687	Component	Meiotic spindle	IEA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IEA
GO:0090306	Process	Meiotic spindle assembly	IEA
GO:0097150	Process	Neuronal stem cell population maintenance	IEA
GO:0097431	Component	Mitotic spindle pole	IDA	15972725, 21044324
GO:0097431	Component	Mitotic spindle pole	IEA

MIM	HGNC	e!Ensembl
605481	19048	ENSG00000066279

Q8IZT6

Protein name

Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog)

Protein function

Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depen

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15780	ASH	37 → 134		Domain
PF00307	CH	1110 → 1261	Calponin homology (CH) domain	Domain
PF00612	IQ	1316 → 1336	IQ calmodulin-binding motif	Motif
PF00612	IQ	1348 → 1368	IQ calmodulin-binding motif	Motif
PF00612	IQ	1394 → 1414	IQ calmodulin-binding motif	Motif
PF00612	IQ	1465 → 1485	IQ calmodulin-binding motif	Motif
PF00612	IQ	1488 → 1508	IQ calmodulin-binding motif	Motif
PF00612	IQ	1560 → 1580	IQ calmodulin-binding motif	Motif
PF00612	IQ	1583 → 1603	IQ calmodulin-binding motif	Motif
PF00612	IQ	1633 → 1652	IQ calmodulin-binding motif	Motif
PF00612	IQ	1656 → 1676	IQ calmodulin-binding motif	Motif
PF00612	IQ	1729 → 1749	IQ calmodulin-binding motif	Motif
PF00612	IQ	1752 → 1772	IQ calmodulin-binding motif	Motif
PF00612	IQ	1802 → 1822	IQ calmodulin-binding motif	Motif
PF00612	IQ	1826 → 1845	IQ calmodulin-binding motif	Motif
PF00612	IQ	1848 → 1865	IQ calmodulin-binding motif	Motif
PF00612	IQ	1875 → 1895	IQ calmodulin-binding motif	Motif
PF00612	IQ	1898 → 1918	IQ calmodulin-binding motif	Motif
PF00612	IQ	1971 → 1991	IQ calmodulin-binding motif	Motif
PF00612	IQ	2021 → 2041	IQ calmodulin-binding motif	Motif
PF00612	IQ	2044 → 2064	IQ calmodulin-binding motif	Motif
PF00612	IQ	2094 → 2114	IQ calmodulin-binding motif	Motif
PF00612	IQ	2190 → 2210	IQ calmodulin-binding motif	Motif
PF00612	IQ	2240 → 2260	IQ calmodulin-binding motif	Motif
PF00612	IQ	2312 → 2332	IQ calmodulin-binding motif	Motif
PF00612	IQ	2335 → 2355	IQ calmodulin-binding motif	Motif
PF00612	IQ	2385 → 2405	IQ calmodulin-binding motif	Motif
PF00612	IQ	2408 → 2428	IQ calmodulin-binding motif	Motif
PF00612	IQ	2458 → 2478	IQ calmodulin-binding motif	Motif
PF00612	IQ	2481 → 2500	IQ calmodulin-binding motif	Motif
PF00612	IQ	2532 → 2551	IQ calmodulin-binding motif	Motif
PF00612	IQ	2625 → 2645	IQ calmodulin-binding motif	Motif
PF00612	IQ	2666 → 2686	IQ calmodulin-binding motif	Motif
PF00612	IQ	2689 → 2709	IQ calmodulin-binding motif	Motif
PF00612	IQ	2739 → 2759	IQ calmodulin-binding motif	Motif
PF00612	IQ	2860 → 2880	IQ calmodulin-binding motif	Motif
PF00612	IQ	2933 → 2953	IQ calmodulin-binding motif	Motif
PF00612	IQ	2955 → 2975	IQ calmodulin-binding motif	Motif
PF00612	IQ	3030 → 3050	IQ calmodulin-binding motif	Motif
PF00612	IQ	3080 → 3100	IQ calmodulin-binding motif	Motif
PF00612	IQ	3182 → 3202	IQ calmodulin-binding motif	Motif
PF00612	IQ	3205 → 3223	IQ calmodulin-binding motif	Motif

Sequence

MANRRVGRGCWEVSPTERRPPAGLRGPAAEEEASSPPVLSLSHFCRSPFLCFGDVLLGAS
RTLSLALDNPNEEVAEVKISHFPAADLGFSVSQRCFVLQPKEKIVISVNWTPLKEGRVRE
IMTFLVNDVLKHQAILLGNAEEQKKKKRSLWDTIKKKKISASTSHNRRVSNIQNVNKTFS
VSQKVDRVRSPLQACENLAMNEGGPPTENNSLILEENKIPISPISPAFNECHGATCLPLS
VRRSTTYSSLHASENRELLNVHSANVSKVSFNEKAVTETSFNSVNVNGQRGENSKLSLTP
NCSSTLNITQSQIHFLSPDSFVNNSHGANNELELVTCLSSDMFMKDNSQPVHLESTIAHE
IYQKILSPDSFIKDNYGLNQDLESESVNPILSPNQFLKDNMAYMCTSQQTCKVPLSNENS
QVPQSPEDWRKSEVSPRIPECQGSKSPKAIFEELVEMKSNYYSFIKQNNPKFSAVQDISS
HSHNKQPKRRPILSATVTKRKATCTRENQTEINKPKAKRCLNSAVGEHEKVINNQKEKED
FHSYLPIIDPILSKSKSYKNEVTPSSTTASVARKRKSDGSMEDANVRVAITEHTEVREIK
RIHFSPSEPKTSAVKKTKNVTTPISKRISNREKLNLKKKTDLSIFRTPISKTNKRTKPII
AVAQSSLTFIKPLKTDIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNFILTPDDFTVKT
NISEVNAATLLLGIENQHKISVPRAPTKEEMSLRAYTARCRLNRLRRAACRLFTSEKMVK
AIKKLEIEIEARRLIVRKDRHLWKDVGERQKVLNWLLSYNPLWLRIGLETTYGELISLED
NSDVTGLAMFILNRLLWNPDIAAEYRHPTVPHLYRDGHEEALSKFTLKKLLLLVCFLDYA
KISRLIDHDPCLFCKDAEFKASKEILLAFSRDFLSGEGDLSRHLGLLGLPVNHVQTPFDE
FDFAVTNLAVDLQCGVRLVRTMELLTQNWDLSKKLRIPAISRLQKMHNVDIVLQVLKSRG
IELSDEHGNTILSKDIVDRHREKTLRLLWKIAFAFQVDISLNLDQLKEEIAFLKHTKSIK
KTISLLSCHSDDLINKKKGKRDSGSFEQYSENIKLLMDWVNAVCAFYNKKVENFTVSFSD
GRVLCYLIHHYHPCYVPFDAICQRTTQTVECTQTGSVVLNSSSESDDSSLDMSLKAFDHE
NTSELYKELLENEKKNFHLVRSAVRDLGGIPAMINHSDMSNTIPDEKVVITYLSFLCARL
LDLRKEIRAARLIQTTWRKYKLKTDLKRHQEREKAARIIQLAVINFLAKQRLRKRVNAAL
VIQKYWRRVLAQRKLLMLKKEKLEKVQNKAASLIQGYWRRYSTRQRFLKLKYYSIILQSR
IRMIIAVTSYKRYLWATVTIQRHWRAYLRRKQDQQRYEMLKSSTLIIQSMFRKWKQRKMQ
SQVKATVILQRAFREWHLRKQAKEENSAIIIQSWYRMHKELRKYIYIRSCVVIIQKRFRC
FQAQKLYKRRKESILTIQKYYKAYLKGKIERTNYLQKRAAAIQLQAAFRRLKAHNLCRQI
RAACVIQSYWRMRQDRVRFLNLKKTIIKFQAHVRKHQQRQKYKKMKKAAVIIQTHFRAYI
FAMKVLASYQKTRSAVIVLQSAYRGMQARKMYIHILTSVIKIQSYYRAYVSKKEFLSLKN
ATIKLQSTVKMKQTRKQYLHLRAAALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVR
GYLVRKQMRLQRKAVISLQSYFRMRKARQYYLKMYKAIIVIQNYYHAYKAQVNQRKNFLQ
VKKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRVKYQSVLQSIIKIQRWYRA
YKTLHDTRTHFLKTKAAVISLQSAYRGWKVRKQIRREHQAALKIQSAFRMAKAQKQFRLF
KTAALVIQQNFRAWTAGRKQCMEYIELRHAVLVLQSMWKGKTLRRQLQRQHKCAIIIQSY
YRMHVQQKKWKIMKKAALLIQKYYRAYSIGREQNHLYLKTKAAVVTLQSAYRGMKVRKRI
KDCNKAAVTIQSKYRAYKTKKKYATYRASAIIIQRWYRGIKITNHQHKEYLNLKKTAIKI
QSVYRGIRVRRHIQHMHRAATFIKAMFKMHQSRISYHTMRKAAIVIQVRCRAYYQGKMQR
EKYLTILKAVKVLQASFRGVRVRRTLRKMQTAATLIQSNYRRYRQQTYFNKLKKITKTVQ
QRYWAMKERNIQFQRYNKLRHSVIYIQAIFRGKKARRHLKMMHIAATLIQRRFRTLMMRR
RFLSLKKTAILIQRKYRAHLCTKHHLQFLQVQNAVIKIQSSYRRWMIRKRMREMHRAATF
IQSTFRMHRLHMRYQALKQASVVIQQQYQANRAAKLQRQHYLRQRHSAVILQAAFRGMKT
RRHLKSMHSSATLIQSRFRSLLVRRRFISLKKATIFVQRKYRATICAKHKLYQFLHLRKA
AITIQSSYRRLMVKKKLQEMQRAAVLIQATFRMYRTYITFQTWKHASILIQQHYRTYRAA
KLQRENYIRQWHSAVVIQAAYKGMKARQLLREKHKASIVIQSTYRMYRQYCFYQKLQWAT
KIIQEKYRANKKKQKVFQHNELKKETCVQAGFQDMNIKKQIQEQHQAAIIIQKHCKAFKI
RKHYLHLRATVVSIQRRYRKLTAVRTQAVICIQSYYRGFKVRKDIQNMHRAATLIQSFYR
MHRAKVDYETKKTAIVVIQNYYRLYVRVKTERKNFLAVQKSVRTIQAAFRGMKVRQKLKN
VSEEKMAAIVNQSALCCYRSKTQYEAVQSEGVMIQEWYKASGLACSQEAEYHSQSRAAVT
IQKAFCRMVTRKLETQKCAALRIQFFLQMAVYRRRFVQQKRAAITLQHYFRTWQTRKQFL
LYRKAAVVLQNHYRAFLSAKHQRQVYLQIRSSVIIIQARSKGFIQKRKFQEIKNSTIKIQ
AMWRRYRAKKYLCKVKAACKIQAWYRCWRAHKEYLAILKAVKIIQGCFYTKLERTRFLNV
RASAIIIQRKWRAILPAKIAHEHFLMIKRHRAACLIQAHYRGYKGRQVFLRQKSAALIIQ
KYIRAREAGKHERIKYIEFKKSTVILQALVRGWLVRKRFLEQRAKIRLLHFTAAAYYHLN
AVRIQRAYKLYLAVKNANKQVNSVICIQRWFRARLQEKRFIQKYHSIKKIEHEGQECLSQ
RNRAASVIQKAVRHFLLRKKQEKFTSGIIKIQALWRGYSWRKKNDCTKIKAIRLSLQVVN
REIREENKLYKRTALALHYLLTYKHLSAILEALKHLEVVTRLSPLCCENMAQSGAISKIF
VLIRSCNRSIPCMEVIRYAVQVLLNVSKYEKTTSAVYDVENCIDILLELLQIYREKPGNK
VADKGGSIFTKTCCLLAILLKTTNRASDVRSRSKVVDRIYSLYKLTAHKHKMNTERILYK
QKKNSSISIPFIPETPVRTRIVSRLKPDWVLRRDNMEEITNPLQAIQMVMDTLGIPY

Sequence length

3477

Interactions

View interactions

960

Show/Hide Causal Diseases (11)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Abnormality of the nervous system	Pathogenic	rs2125095360, rs2125113775, rs2125113873, rs199422147	RCV001814472 RCV001814532 RCV001814471 RCV001814007
Arthrogryposis multiplex congenita	Likely pathogenic; Pathogenic	rs886041709, rs774338373	RCV000855492 RCV000855491
ASPM-related disorder	Likely pathogenic; Pathogenic	rs587783265, rs587783280, rs757252885, rs2527402190, rs199422173	RCV003407562 RCV004752754 RCV003405975 RCV003956654 RCV003421927
Autosomal recessive primary microcephaly	Likely pathogenic; Pathogenic	rs2125096196, rs587783225, rs587783265, rs137852994, rs1558328295, rs199422161, rs555866170, rs776034810, rs772050241	RCV003120842 RCV001193345 RCV003317099 RCV001193347 RCV003330447 RCV001193346 RCV005239098 RCV000605641 RCV003994113
Fetal akinesia deformation sequence 1	Likely pathogenic; Pathogenic	rs886041709, rs774338373	RCV000855492 RCV000855491
Intellectual disability	Likely pathogenic; Pathogenic	rs199422192, rs1245021867	RCV001291087 RCV001252164
Lissencephaly	Likely pathogenic; Pathogenic	rs1163303148	RCV001807346
Microcephaly	Pathogenic; Likely pathogenic	rs1463609963, rs199422161, rs1060499758, rs1060499757, rs199422146, rs1163303148	RCV001526515 RCV001526516 RCV000454144 RCV000454355 RCV000454234 RCV001807346
Microcephaly 1, primary, autosomal recessive	Pathogenic	rs199422151, rs199422152, rs199422155, rs199422173, rs199422195, rs1558328287, rs1571600860	RCV000856770 RCV000856771 RCV006261723 RCV000856804 RCV006261941 RCV000856807 RCV000856794
Microcephaly 5, primary, autosomal recessive	Pathogenic; Likely pathogenic	rs77424753, rs774143329, rs1451306414, rs1240081512, rs2125113873, rs1160186494, rs1353421249, rs2125107877, rs2125093720, rs2125107452, rs368682161, rs2125107857, rs2125096622, rs2125087894, rs2125114846 View all (168 more)	RCV001331028 RCV001331027 RCV001331025 RCV001330824 RCV005635174 RCV001542638 RCV001542639 RCV001844388 RCV001693503 RCV001775252 RCV001775253 RCV001784895 RCV001784898 RCV001784908 RCV001784913 RCV001780650 RCV001780651 RCV003130553 RCV003451968 RCV002290816 RCV003444966 RCV004796126 RCV000145074 RCV002210935 RCV002226919 RCV002227856 RCV000145078 RCV000145079 RCV000145085 RCV000145087 RCV000145099 RCV000145102 RCV000145105 RCV000145111 RCV000145121 RCV000145122 RCV000145124 RCV000145134 RCV000145139 RCV000145142 RCV000145166 RCV000145172 RCV000145177 RCV000145180 RCV000145190 RCV000145191 RCV000145199 RCV000145206 RCV000145208 RCV000145209 RCV000145215 RCV000145218 RCV000145219 RCV000145222 RCV000145225 RCV000145226 RCV000145229 RCV000145235 RCV000145241 RCV002272845 RCV002283606 RCV002283743 RCV002291446 RCV000005244 RCV000005246 RCV000005247 RCV000005248 RCV000005249 RCV000005250 RCV000005251 RCV000005253 RCV000194402 RCV000192379 RCV000193254 RCV000193186 RCV000193074 RCV000194147 RCV000194072 RCV004796750 RCV000490408 RCV004786610 RCV003454673 RCV000235002 RCV003129591 RCV003140416 RCV003225880 RCV003130426 RCV003223468 RCV000020785 RCV002503977 RCV001782765 RCV003338195 RCV003338196 RCV003486303 RCV003486304 RCV003486305 RCV003984991 RCV003988769 RCV003989969 RCV004547268 RCV004547347 RCV004557243 RCV004594892 RCV000020741 RCV000020742 RCV000020744 RCV000020748 RCV000020750 RCV000020759 RCV000020760 RCV000020761 RCV000020764 RCV000020767 RCV000020770 RCV000020771 RCV000020772 RCV000020773 RCV000020777 RCV000020778 RCV000020780 RCV000020782 RCV000020784 RCV000020790 RCV000020796 RCV000020797 RCV000020803 RCV000020807 RCV000020811 RCV000020812 RCV000020813 RCV000020816 RCV000020819 RCV000020822 RCV000020824 RCV000020825 RCV000020826 RCV000020827 RCV000020830 RCV002470853 RCV003449037 RCV000416559 RCV000416534 RCV000502418 RCV000020749 RCV000678376 RCV003449261 RCV000579385 RCV000504160 RCV000501361 RCV000503898 RCV000501645 RCV000503412 RCV000500639 RCV000656088 RCV000656089 RCV003451296 RCV000626188 RCV000762873 RCV003451481 RCV000678244 RCV003453512 RCV000714742 RCV000778956 RCV000778206 RCV000785924 RCV002487668 RCV003453775 RCV001007666 RCV001007661 RCV001007665 RCV001007664 RCV000984489 RCV005633805 RCV003455066 RCV005866898 RCV001255755 RCV001255781 RCV001255762 RCV001255777 RCV001255763 RCV001255776 RCV001255782 RCV001289469 RCV001290380 RCV001507254 RCV001507253 RCV003449885
See cases	Pathogenic; Likely pathogenic	rs199422185, rs199422194	RCV002287340 RCV002251919

Show/Hide Unknown Diseases (24)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
-	no classification for the single variant	rs1658213105	-
Acute myeloid leukemia	Benign; Likely benign	rs41299623, rs41299587	RCV005886615 RCV005887029
Adrenocortical carcinoma, hereditary	Benign; Likely benign	rs41299623	RCV005886617
Cervical cancer	Benign; Likely benign; Conflicting classifications of pathogenicity	rs141402675, rs41299587, rs12025066	RCV005887020 RCV005887030 RCV005887599
Cholangiocarcinoma	Likely benign	rs200839523	RCV005867182
Clear cell carcinoma of kidney	Conflicting classifications of pathogenicity	rs149303254	RCV005887028
Colon adenocarcinoma	Uncertain significance	rs147466865	RCV005889811
Colorectal cancer	Uncertain significance	rs146959075	RCV005913682
EBV-positive nodal T- and NK-cell lymphoma	Uncertain significance	rs143911853	RCV004559994
Familial cancer of breast	Likely benign; Benign; Conflicting classifications of pathogenicity	rs200839523, rs141402675, rs368843607, rs149303254, rs10922162	RCV005867178 RCV005887019 RCV005887025 RCV005887027 RCV005887597
Familial pancreatic carcinoma	Benign; Likely benign	rs141402675	RCV005887021
Gastric cancer	Benign; Likely benign; Uncertain significance; Conflicting classifications of pathogenicity	rs41299623, rs200839523, rs372956877, rs139367209, rs12025066, rs72736482	RCV005886619 RCV005867180 RCV005922478 RCV005887036 RCV005887600 RCV005904056
Hepatocellular carcinoma	Benign	rs4915338	RCV005916664
Lung cancer	Benign; Likely benign	rs141402675	RCV005887023
Malignant lymphoma, large B-cell, diffuse	Likely benign; Benign	rs200839523, rs139367209, rs72736482	RCV005867179 RCV005887034 RCV005904055
Malignant tumor of esophagus	Benign; Likely benign; Conflicting classifications of pathogenicity; Uncertain significance	rs41299623, rs118010078, rs375940182, rs12025066, rs560847421	RCV005886616 RCV005889812 RCV005935100 RCV005887598 RCV005913680
Melanoma	Benign; Likely benign	rs139367209	RCV005887040
Ovarian serous cystadenocarcinoma	Benign; Likely benign	rs41299623, rs41299587, rs139367209	RCV005887616 RCV005887032 RCV005887037
Primary Microcephaly, Recessive	Conflicting classifications of pathogenicity; Uncertain significance	rs186663906, rs748503995, rs745619939, rs780677950, rs886045780, rs886045774	RCV000329933 RCV000375823 RCV000388050 RCV000264918 RCV000362487 RCV000308436
Sarcoma	Benign; Likely benign	rs41299623, rs114695225, rs141402675, rs41299587, rs139367209	RCV005886618 RCV005890575 RCV005887022 RCV005887031 RCV005887035
Thymoma	Benign; Likely benign	rs41299623, rs139367209	RCV005887617 RCV005887038
Thyroid cancer, nonmedullary, 1	Benign; Likely benign	rs139367209	RCV005887039
Uterine carcinosarcoma	Likely benign; Benign	rs200839523, rs61995747	RCV005867181 RCV005887026
Uterine corpus endometrial carcinoma	Benign; Likely benign	rs141402675, rs41299587	RCV005887024 RCV005887033

Show/Hide Text Mining Associations (76)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
AA amyloidosis	Associate	30740936
Adenocarcinoma of Lung	Associate	30587197, 32672359, 33187219, 35810236
Anemia Hemolytic	Associate	2346784
Angelman Syndrome	Associate	21633703
Aphasia	Associate	29243349
Arthritis Rheumatoid	Associate	35200126
Atrial Fibrillation	Associate	35003319
Autosomal Recessive Primary Microcephaly	Associate	11067780, 11078481, 12362027, 14574646, 14704186, 16141009, 19028728, 21044324, 24830737, 27920410, 29058117, 29243349, 29504900, 32677750, 34378666, 34402213, 34507672, 35327983 View all (3 more)
Behcet Syndrome	Associate	37335738
Bohring syndrome	Associate	29058117
Brain Diseases	Associate	29243349
Breast Neoplasms	Associate	27026610, 34384030
Carcinogenesis	Associate	35403252
Carcinoma Adenoid Cystic	Associate	37861550
Carcinoma Hepatocellular	Associate	22539975, 28086821, 31822116, 32046048, 32685486, 33157984, 34315286, 34746301, 36120772, 36882493, 37861550
Carcinoma Non Small Cell Lung	Associate	31805030, 31816603, 34825846
Carcinoma Ovarian Epithelial	Associate	21505456, 24830737, 33726773
Carcinoma Pancreatic Ductal	Associate	31465125
Carcinoma Renal Cell	Associate	23019229, 34606125, 34699322
Carcinoma Renal Cell	Stimulate	37309171
Cataract	Associate	25447692
Cholangiocarcinoma	Associate	32040444
Cognition Disorders	Associate	25447692, 35327983
Communication Disorders	Associate	24849541
Coronary Artery Disease	Associate	24073849
COVID 19	Associate	37335738
Disease	Associate	25447692
Dysfibrinogenemia Congenital	Associate	11071644
Dyslexia Acquired	Associate	24849541
Elliptocytosis 1	Associate	2328319
Elliptocytosis Hereditary	Associate	1679439, 8018926
Endometrial Neoplasms	Associate	29693365, 32555395, 36186000
Ependymoma	Associate	20885975
Epilepsy	Associate	35327983
Esophageal Neoplasms	Associate	32443386
Friedreich Ataxia 1	Associate	40432442
Glioblastoma	Associate	39528802
Hearing Loss Sensorineural	Associate	25447692
Hereditary spinal ataxia	Associate	25447692
HIV Infections	Associate	21929758
Hypertriglyceridemic Waist	Associate	19237736
Inflammation	Associate	37861550
Intellectual Disability	Associate	14574646, 19028728, 30500859, 34507672, 35327983
Language Disorders	Associate	24849541
Liver Cirrhosis	Associate	37861550
Lown Ganong Levine Syndrome	Associate	31091247
Lung Neoplasms	Associate	35608130
Macular Degeneration	Associate	18541031
Melanoma	Associate	20520718
Meniere Disease	Associate	35741759
Mesothelioma Malignant	Associate	33032291
Metabolic Syndrome	Associate	15090635
Microcephaly	Associate	14574646, 14704186, 16141009, 19028728, 21044324, 21633703, 24830737, 26846091, 27920410, 29058117, 29243349, 32677750, 34068194, 34378666, 34507672, 35327983 View all (1 more)
Mitochondrial Diseases	Associate	25447692
Muscular Diseases	Associate	25447692
Myositis Ossificans	Associate	22011642
Necrosis	Associate	37861550
Neoplasm Invasiveness	Associate	32788866
Neoplasms	Associate	21505456, 24074379, 24830737, 29693365, 31091247, 32035007, 32040444, 32685486, 34315286, 34746301, 36637953, 37309171, 37384617, 37861550
Neoplasms	Inhibit	23999847
Neuroblastoma	Associate	39289658
Obesity	Associate	15090635
Oculocerebrorenal Syndrome	Associate	20133602
Osteosarcoma	Associate	33578541
Ovarian Neoplasms	Associate	21505456
Parkinson Disease	Associate	31091247
Pigmentation Disorders	Associate	29974532
Pyropoikilocytosis Hereditary	Associate	2328319
Sarcoma Myeloid	Associate	25877407
Seizures	Associate	16141009
Smoke Inhalation Injury	Associate	32788866
Tertiary Lymphoid Structures	Inhibit	24830737
Thyroid Carcinoma Anaplastic	Associate	27796151
Tissue Adhesions	Associate	34968168
Urinary Bladder Neoplasms	Associate	31828101, 32047816
Varicose Veins	Associate	15744037

ASPM (assembly factor for spindle microtubules)