Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	259173
Gene name	ALS2 C-terminal like
Gene symbol	ALS2CL
Synonyms (NCBI Gene)	RN49018
Chromosome	3
Chromosome location	3p21.31

106

Show/Hide all (106)

miRTarBase ID	miRNA	Experiments	Reference
MIRT489638	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT489637	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT489636	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT489635	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT489634	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT489633	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT489632	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT489630	hsa-miR-1973	PAR-CLIP	23592263
MIRT489631	hsa-miR-4419a	PAR-CLIP	23592263
MIRT489629	hsa-miR-4510	PAR-CLIP	23592263
MIRT489628	hsa-miR-6127	PAR-CLIP	23592263
MIRT489627	hsa-miR-6129	PAR-CLIP	23592263
MIRT489626	hsa-miR-6130	PAR-CLIP	23592263
MIRT489625	hsa-miR-6133	PAR-CLIP	23592263
MIRT489624	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT489623	hsa-miR-6879-3p	PAR-CLIP	23592263
MIRT489638	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT489637	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT489636	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT489635	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT489634	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT489633	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT489632	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT489630	hsa-miR-1973	PAR-CLIP	23592263
MIRT489631	hsa-miR-4419a	PAR-CLIP	23592263
MIRT489629	hsa-miR-4510	PAR-CLIP	23592263
MIRT489628	hsa-miR-6127	PAR-CLIP	23592263
MIRT489627	hsa-miR-6129	PAR-CLIP	23592263
MIRT489626	hsa-miR-6130	PAR-CLIP	23592263
MIRT489625	hsa-miR-6133	PAR-CLIP	23592263
MIRT489624	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT489623	hsa-miR-6879-3p	PAR-CLIP	23592263
MIRT779243	hsa-miR-125a-3p	CLIP-seq
MIRT779244	hsa-miR-1470	CLIP-seq
MIRT779245	hsa-miR-3150a-5p	CLIP-seq
MIRT779246	hsa-miR-3150b-5p	CLIP-seq
MIRT779247	hsa-miR-3652	CLIP-seq
MIRT779248	hsa-miR-3919	CLIP-seq
MIRT779249	hsa-miR-3934	CLIP-seq
MIRT779250	hsa-miR-4430	CLIP-seq
MIRT779251	hsa-miR-4474-3p	CLIP-seq
MIRT779252	hsa-miR-4505	CLIP-seq
MIRT779253	hsa-miR-4667-3p	CLIP-seq
MIRT779254	hsa-miR-4755-3p	CLIP-seq
MIRT779255	hsa-miR-4772-3p	CLIP-seq
MIRT779256	hsa-miR-510	CLIP-seq
MIRT779257	hsa-miR-539	CLIP-seq
MIRT779258	hsa-miR-551a	CLIP-seq
MIRT779259	hsa-miR-551b	CLIP-seq
MIRT779260	hsa-miR-572	CLIP-seq
MIRT779261	hsa-miR-626	CLIP-seq
MIRT779262	hsa-miR-644	CLIP-seq
MIRT779263	hsa-miR-764	CLIP-seq
MIRT779264	hsa-miR-1182	CLIP-seq
MIRT779265	hsa-miR-140-3p	CLIP-seq
MIRT779266	hsa-miR-142-5p	CLIP-seq
MIRT779267	hsa-miR-150	CLIP-seq
MIRT779268	hsa-miR-329	CLIP-seq
MIRT779269	hsa-miR-362-3p	CLIP-seq
MIRT779270	hsa-miR-3649	CLIP-seq
MIRT779271	hsa-miR-3674	CLIP-seq
MIRT779272	hsa-miR-4269	CLIP-seq
MIRT779273	hsa-miR-4423-5p	CLIP-seq
MIRT779274	hsa-miR-4732-5p	CLIP-seq
MIRT779275	hsa-miR-4781-3p	CLIP-seq
MIRT1930018	hsa-miR-1224-3p	CLIP-seq
MIRT1930019	hsa-miR-1260	CLIP-seq
MIRT1930020	hsa-miR-1260b	CLIP-seq
MIRT1930021	hsa-miR-1280	CLIP-seq
MIRT779266	hsa-miR-142-5p	CLIP-seq
MIRT779267	hsa-miR-150	CLIP-seq
MIRT1930022	hsa-miR-188-3p	CLIP-seq
MIRT1930023	hsa-miR-3156-3p	CLIP-seq
MIRT1930024	hsa-miR-4722-3p	CLIP-seq
MIRT1930025	hsa-miR-4740-3p	CLIP-seq
MIRT779264	hsa-miR-1182	CLIP-seq
MIRT1930018	hsa-miR-1224-3p	CLIP-seq
MIRT1930019	hsa-miR-1260	CLIP-seq
MIRT1930020	hsa-miR-1260b	CLIP-seq
MIRT1930021	hsa-miR-1280	CLIP-seq
MIRT779266	hsa-miR-142-5p	CLIP-seq
MIRT779267	hsa-miR-150	CLIP-seq
MIRT1930022	hsa-miR-188-3p	CLIP-seq
MIRT2170800	hsa-miR-1914	CLIP-seq
MIRT2170801	hsa-miR-19a	CLIP-seq
MIRT2170802	hsa-miR-19b	CLIP-seq
MIRT1930023	hsa-miR-3156-3p	CLIP-seq
MIRT2170803	hsa-miR-335	CLIP-seq
MIRT779270	hsa-miR-3649	CLIP-seq
MIRT2170804	hsa-miR-4279	CLIP-seq
MIRT779273	hsa-miR-4423-5p	CLIP-seq
MIRT2170805	hsa-miR-4691-5p	CLIP-seq
MIRT2170806	hsa-miR-4698	CLIP-seq
MIRT1930025	hsa-miR-4740-3p	CLIP-seq
MIRT779275	hsa-miR-4781-3p	CLIP-seq
MIRT779266	hsa-miR-142-5p	CLIP-seq
MIRT779267	hsa-miR-150	CLIP-seq
MIRT779266	hsa-miR-142-5p	CLIP-seq
MIRT779267	hsa-miR-150	CLIP-seq
MIRT2443598	hsa-miR-4469	CLIP-seq
MIRT2473464	hsa-miR-1343	CLIP-seq
MIRT2473465	hsa-miR-3127-3p	CLIP-seq
MIRT2473466	hsa-miR-3667-3p	CLIP-seq
MIRT2473467	hsa-miR-4277	CLIP-seq
MIRT2473468	hsa-miR-4640-3p	CLIP-seq
MIRT2473469	hsa-miR-637	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0016197	Process	Endosomal transport	IBA
GO:0031267	Function	Small GTPase binding	IBA
GO:0031410	Component	Cytoplasmic vesicle	IBA

MIM	HGNC	e!Ensembl
612402	20605	ENSG00000178038

Q60I27

Protein name

ALS2 C-terminal-like protein

Protein function

Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02493	MORN	358 → 378	MORN repeat	Repeat
PF02493	MORN	409 → 430	MORN repeat	Repeat
PF02493	MORN	432 → 450	MORN repeat	Repeat
PF02493	MORN	459 → 480	MORN repeat	Repeat
PF02493	MORN	483 → 503	MORN repeat	Repeat
PF02493	MORN	506 → 527	MORN repeat	Repeat
PF02204	VPS9	834 → 938	Vacuolar sorting protein 9 (VPS9) domain	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in heart and kidney. {ECO:0000269|PubMed:15388334}.

Sequence

MCNPEEAALLRLEEVFSATLAHVNSLVLQPLLPAAPDPSDPWGRECLRLLQQLHKSSQQL
WEVTEESLHSLQERLRYPDSTGLESLLLLRGADRVLQAHIEYIESYTSCMVVQAFQKAAK
RRSEYWRGQRKALRQLLSGVSSEGSVGASLGQALHQPLAHHVQQYVLLLLSLGDTIGEHH
PTRELVVNAVTLFGNLQSFMKQELDQAVATQALWHTLRGRLRDVLCTPAHRLLQDSQDVP
VTVAPLRAERVLLFDDALVLLQGHNVHTFDLKLVWVDPGQDGCTFHLLTPEEEFSFCAKD
SQGQAVWQWKVTWAVHQALHGKKDFPVLGAGLEPSQPPDCRCAEYTFQAEGRLCQATYEG
EWCRGRPHGKGTLKWPDGRNHVGNFCQGLEHGFGIRLLPQASEDKFDCYKCHWREGSMCG
YGICEYSTDEVYKGYFQEGLRHGFGVLESGPQAPQPFRYTGHWERGQRSGYGIEEDGDRG
ERYIGMWQAGQRHGPGVMVTQAGVCYQGTFQADKTVGPGILLSEDDSLYEGTFTRDLTLM
GKGKVTFPNGFTLEGSFGSGAGRGLHTQGVLDTAALPPDPSSTCKRQLGVGAFPVESRWQ
GVYSPFRDFVCAGCPRDLQEALLGFDVQSSRELRRSQDYLSCERTHPEDSVGSMEDILEE
LLQHREPKALQLYLRKALSNSLHPLGKLLRTLMLTFQATYAGVGANKHLQELAQEEVKQH
AQELWAAYRGLLRVALERKGQALEEDEDTETRDLQVHGLVLPLMLPSFYSELFTLYLLLH
EREDSFYSQGIANLSLFPDTQLLEFLDVQKHLWPLKDLTLTSNQRYSLVRDKCFLSATEC
LQKIMTTVDPREKLEVLERTYGEIEGTVSRVLGREYKLPMDDLLPLLIYVVSRARIQHLG
AEIHLIRDMMDPNHTGGLYDFLLTALESCYEHIQKEDMRLHRLPGHWHSRELW

Sequence length

953

Interactions

View interactions

	Reactome
			RAB GEFs exchange GTP for GDP on RABs

ALS2CL (ALS2 C-terminal like)