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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q10471 |
| Protein name |
Polypeptide N-acetylgalactosaminyltransferase 2 (EC 2.4.1.41) (Polypeptide GalNAc transferase 2) (GalNAc-T2) (pp-GaNTase 2) (Protein-UDP acetylgalactosaminyltransferase 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypep |
| Protein function |
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, M |
| PDB |
2FFU
, 2FFV
, 4D0T
, 4D0Z
, 4D11
, 5AJN
, 5AJO
, 5AJP
, 5FV9
, 5NDF
, 6E7I
, 6EGS
, 6NQT
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| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
| PF00535 |
Glycos_transf_2 |
139 → 322 |
Glycosyl transferase family 2 |
Family |
| PF00652 |
Ricin_B_lectin |
446 → 563 |
Ricin-type beta-trefoil lectin domain |
Domain |
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| Tissue specificity |
TISSUE SPECIFICITY: Detected in urine (at protein level) (PubMed:37453717). Widely expressed. {ECO:0000269|PubMed:37453717, ECO:0000269|PubMed:7592619}. |
| Sequence |
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| Sequence length |
571 |
| Interactions |
View interactions |
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| Phenotype Name |
Clinical Significance |
dbSNP ID |
RCV Accession |
| Cervical cancer |
Benign |
rs16851310 |
RCV005928100 |
| Clear cell carcinoma of kidney |
Benign |
rs16851310 |
RCV005928101 |
| Colon adenocarcinoma |
Benign |
rs16851310 |
RCV005928099 |
| GALNT2-related disorder |
Benign; Uncertain significance; Likely benign |
rs2273970, rs1923950, rs72646701, rs3748006, rs142736956, rs200837962, rs151097882, rs34897003, rs147354186, rs58148281 |
RCV003968466 RCV003978812 RCV003970909 RCV003984201 RCV003916696 RCV003954302 RCV003939299 RCV003970689 RCV003943167 RCV003928420 |
| Gastric cancer |
Benign |
rs16851310 |
RCV005928102 |
| Lung cancer |
Benign |
rs16851310 |
RCV005928106 |
| Melanoma |
Benign |
rs16851310 |
RCV005928105 |
| Thyroid cancer, nonmedullary, 1 |
Benign |
rs16851310 |
RCV005928104 |
| Uterine carcinosarcoma |
Benign |
rs16851310 |
RCV005928103 |
| Uterine corpus endometrial carcinoma |
Benign |
rs16851310 |
RCV005928107 |
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