GALNT2 (polypeptide N-acetylgalactosaminyltransferase 2)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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2590 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Polypeptide N-acetylgalactosaminyltransferase 2 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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GALNT2 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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CDG2T, GalNAc-T2 |
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Chromosome
Chromosome number
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1 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1q42.13 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hi |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | Q10471 | |||||||||||||||
| Protein name | Polypeptide N-acetylgalactosaminyltransferase 2 (EC 2.4.1.41) (Polypeptide GalNAc transferase 2) (GalNAc-T2) (pp-GaNTase 2) (Protein-UDP acetylgalactosaminyltransferase 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypep | |||||||||||||||
| Protein function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, M | |||||||||||||||
| PDB | 2FFU , 2FFV , 4D0T , 4D0Z , 4D11 , 5AJN , 5AJO , 5AJP , 5FV9 , 5NDF , 6E7I , 6EGS , 6NQT | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Detected in urine (at protein level) (PubMed:37453717). Widely expressed. {ECO:0000269|PubMed:37453717, ECO:0000269|PubMed:7592619}. | |||||||||||||||
| Sequence |
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| Sequence length | 571 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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