Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	25880
Gene name	Transmembrane protein 186
Gene symbol	TMEM186
Synonyms (NCBI Gene)	C16orf51
Chromosome	16
Chromosome location	16p13.2
Summary	This gene encodes a potential transmembrane protein. [provided by RefSeq, Dec 2012]

192

Show/Hide all (192)

miRTarBase ID	miRNA	Experiments	Reference
MIRT706384	hsa-miR-2392	HITS-CLIP	22927820
MIRT706383	hsa-miR-1976	HITS-CLIP	22927820
MIRT706382	hsa-miR-6790-3p	HITS-CLIP	22927820
MIRT706380	hsa-miR-6821-3p	HITS-CLIP	22927820
MIRT706381	hsa-miR-3605-5p	HITS-CLIP	22927820
MIRT706379	hsa-miR-4454	HITS-CLIP	22927820
MIRT706378	hsa-miR-4757-5p	HITS-CLIP	22927820
MIRT706377	hsa-miR-6744-3p	HITS-CLIP	22927820
MIRT706376	hsa-miR-6084	HITS-CLIP	22927820
MIRT706375	hsa-miR-6878-3p	HITS-CLIP	22927820
MIRT706384	hsa-miR-2392	HITS-CLIP	22927820
MIRT706383	hsa-miR-1976	HITS-CLIP	22927820
MIRT706382	hsa-miR-6790-3p	HITS-CLIP	22927820
MIRT706380	hsa-miR-6821-3p	HITS-CLIP	22927820
MIRT706381	hsa-miR-3605-5p	HITS-CLIP	22927820
MIRT706379	hsa-miR-4454	HITS-CLIP	22927820
MIRT706378	hsa-miR-4757-5p	HITS-CLIP	22927820
MIRT706377	hsa-miR-6744-3p	HITS-CLIP	22927820
MIRT706376	hsa-miR-6084	HITS-CLIP	22927820
MIRT706375	hsa-miR-6878-3p	HITS-CLIP	22927820
MIRT1433830	hsa-miR-1226	CLIP-seq
MIRT1433831	hsa-miR-1257	CLIP-seq
MIRT1433832	hsa-miR-1260	CLIP-seq
MIRT1433833	hsa-miR-1260b	CLIP-seq
MIRT1433834	hsa-miR-1286	CLIP-seq
MIRT1433835	hsa-miR-188-3p	CLIP-seq
MIRT1433836	hsa-miR-302a	CLIP-seq
MIRT1433837	hsa-miR-302b	CLIP-seq
MIRT1433838	hsa-miR-302c	CLIP-seq
MIRT1433839	hsa-miR-302d	CLIP-seq
MIRT1433840	hsa-miR-302e	CLIP-seq
MIRT1433841	hsa-miR-3145-5p	CLIP-seq
MIRT1433842	hsa-miR-3156-3p	CLIP-seq
MIRT1433843	hsa-miR-345	CLIP-seq
MIRT1433844	hsa-miR-3611	CLIP-seq
MIRT1433845	hsa-miR-3672	CLIP-seq
MIRT1433846	hsa-miR-3685	CLIP-seq
MIRT1433847	hsa-miR-372	CLIP-seq
MIRT1433848	hsa-miR-373	CLIP-seq
MIRT1433849	hsa-miR-384	CLIP-seq
MIRT1433850	hsa-miR-3938	CLIP-seq
MIRT1433851	hsa-miR-4256	CLIP-seq
MIRT1433852	hsa-miR-4267	CLIP-seq
MIRT1433853	hsa-miR-4312	CLIP-seq
MIRT1433854	hsa-miR-4329	CLIP-seq
MIRT1433855	hsa-miR-4511	CLIP-seq
MIRT1433856	hsa-miR-4718	CLIP-seq
MIRT1433857	hsa-miR-4719	CLIP-seq
MIRT1433858	hsa-miR-4729	CLIP-seq
MIRT1433859	hsa-miR-4762-5p	CLIP-seq
MIRT1433860	hsa-miR-486-5p	CLIP-seq
MIRT1433861	hsa-miR-489	CLIP-seq
MIRT1433862	hsa-miR-494	CLIP-seq
MIRT1433863	hsa-miR-512-3p	CLIP-seq
MIRT1433864	hsa-miR-514	CLIP-seq
MIRT1433865	hsa-miR-514b-3p	CLIP-seq
MIRT1433866	hsa-miR-520a-3p	CLIP-seq
MIRT1433867	hsa-miR-520b	CLIP-seq
MIRT1433868	hsa-miR-520c-3p	CLIP-seq
MIRT1433869	hsa-miR-520d-3p	CLIP-seq
MIRT1433870	hsa-miR-520e	CLIP-seq
MIRT1433871	hsa-miR-548aa	CLIP-seq
MIRT1433872	hsa-miR-548b-3p	CLIP-seq
MIRT1433873	hsa-miR-570	CLIP-seq
MIRT1433874	hsa-miR-576-3p	CLIP-seq
MIRT1433875	hsa-miR-587	CLIP-seq
MIRT1433876	hsa-miR-649	CLIP-seq
MIRT2130161	hsa-miR-1267	CLIP-seq
MIRT2130162	hsa-miR-216a	CLIP-seq
MIRT2130163	hsa-miR-3929	CLIP-seq
MIRT2130164	hsa-miR-4419b	CLIP-seq
MIRT2130165	hsa-miR-4478	CLIP-seq
MIRT2130166	hsa-miR-4686	CLIP-seq
MIRT2130167	hsa-miR-4687-3p	CLIP-seq
MIRT1433856	hsa-miR-4718	CLIP-seq
MIRT1433859	hsa-miR-4762-5p	CLIP-seq
MIRT2130168	hsa-miR-627	CLIP-seq
MIRT2130169	hsa-miR-924	CLIP-seq
MIRT1433841	hsa-miR-3145-5p	CLIP-seq
MIRT1433843	hsa-miR-345	CLIP-seq
MIRT1433845	hsa-miR-3672	CLIP-seq
MIRT1433851	hsa-miR-4256	CLIP-seq
MIRT1433854	hsa-miR-4329	CLIP-seq
MIRT1433855	hsa-miR-4511	CLIP-seq
MIRT1433859	hsa-miR-4762-5p	CLIP-seq
MIRT1433872	hsa-miR-548b-3p	CLIP-seq
MIRT1433845	hsa-miR-3672	CLIP-seq
MIRT1433851	hsa-miR-4256	CLIP-seq
MIRT1433854	hsa-miR-4329	CLIP-seq
MIRT1433830	hsa-miR-1226	CLIP-seq
MIRT2645176	hsa-miR-1228	CLIP-seq
MIRT1433831	hsa-miR-1257	CLIP-seq
MIRT2645177	hsa-miR-1262	CLIP-seq
MIRT2645178	hsa-miR-197	CLIP-seq
MIRT1433836	hsa-miR-302a	CLIP-seq
MIRT1433837	hsa-miR-302b	CLIP-seq
MIRT1433838	hsa-miR-302c	CLIP-seq
MIRT1433839	hsa-miR-302d	CLIP-seq
MIRT1433840	hsa-miR-302e	CLIP-seq
MIRT2645179	hsa-miR-3115	CLIP-seq
MIRT1433841	hsa-miR-3145-5p	CLIP-seq
MIRT2645180	hsa-miR-3152-5p	CLIP-seq
MIRT1433843	hsa-miR-345	CLIP-seq
MIRT1433844	hsa-miR-3611	CLIP-seq
MIRT1433845	hsa-miR-3672	CLIP-seq
MIRT1433846	hsa-miR-3685	CLIP-seq
MIRT1433847	hsa-miR-372	CLIP-seq
MIRT1433848	hsa-miR-373	CLIP-seq
MIRT2645181	hsa-miR-377	CLIP-seq
MIRT1433849	hsa-miR-384	CLIP-seq
MIRT1433851	hsa-miR-4256	CLIP-seq
MIRT2645182	hsa-miR-4258	CLIP-seq
MIRT1433852	hsa-miR-4267	CLIP-seq
MIRT1433853	hsa-miR-4312	CLIP-seq
MIRT1433855	hsa-miR-4511	CLIP-seq
MIRT2645183	hsa-miR-4642	CLIP-seq
MIRT2645184	hsa-miR-4643	CLIP-seq
MIRT2645185	hsa-miR-4659a-3p	CLIP-seq
MIRT2645186	hsa-miR-4659b-3p	CLIP-seq
MIRT2645187	hsa-miR-4701-3p	CLIP-seq
MIRT1433856	hsa-miR-4718	CLIP-seq
MIRT1433857	hsa-miR-4719	CLIP-seq
MIRT2645188	hsa-miR-4753-3p	CLIP-seq
MIRT1433859	hsa-miR-4762-5p	CLIP-seq
MIRT2645189	hsa-miR-4768-5p	CLIP-seq
MIRT2645190	hsa-miR-4774-3p	CLIP-seq
MIRT1433860	hsa-miR-486-5p	CLIP-seq
MIRT1433862	hsa-miR-494	CLIP-seq
MIRT1433863	hsa-miR-512-3p	CLIP-seq
MIRT1433866	hsa-miR-520a-3p	CLIP-seq
MIRT1433867	hsa-miR-520b	CLIP-seq
MIRT1433868	hsa-miR-520c-3p	CLIP-seq
MIRT1433869	hsa-miR-520d-3p	CLIP-seq
MIRT1433870	hsa-miR-520e	CLIP-seq
MIRT1433872	hsa-miR-548b-3p	CLIP-seq
MIRT2645191	hsa-miR-574-3p	CLIP-seq
MIRT1433876	hsa-miR-649	CLIP-seq
MIRT1433830	hsa-miR-1226	CLIP-seq
MIRT2645176	hsa-miR-1228	CLIP-seq
MIRT1433831	hsa-miR-1257	CLIP-seq
MIRT2645177	hsa-miR-1262	CLIP-seq
MIRT1433834	hsa-miR-1286	CLIP-seq
MIRT2693452	hsa-miR-1293	CLIP-seq
MIRT2645178	hsa-miR-197	CLIP-seq
MIRT2130162	hsa-miR-216a	CLIP-seq
MIRT1433836	hsa-miR-302a	CLIP-seq
MIRT1433837	hsa-miR-302b	CLIP-seq
MIRT1433838	hsa-miR-302c	CLIP-seq
MIRT1433839	hsa-miR-302d	CLIP-seq
MIRT1433840	hsa-miR-302e	CLIP-seq
MIRT2645179	hsa-miR-3115	CLIP-seq
MIRT1433841	hsa-miR-3145-5p	CLIP-seq
MIRT2645180	hsa-miR-3152-5p	CLIP-seq
MIRT1433843	hsa-miR-345	CLIP-seq
MIRT1433844	hsa-miR-3611	CLIP-seq
MIRT1433845	hsa-miR-3672	CLIP-seq
MIRT1433846	hsa-miR-3685	CLIP-seq
MIRT1433847	hsa-miR-372	CLIP-seq
MIRT1433848	hsa-miR-373	CLIP-seq
MIRT2645181	hsa-miR-377	CLIP-seq
MIRT1433849	hsa-miR-384	CLIP-seq
MIRT1433851	hsa-miR-4256	CLIP-seq
MIRT2645182	hsa-miR-4258	CLIP-seq
MIRT1433852	hsa-miR-4267	CLIP-seq
MIRT1433853	hsa-miR-4312	CLIP-seq
MIRT2693453	hsa-miR-4483	CLIP-seq
MIRT1433855	hsa-miR-4511	CLIP-seq
MIRT2645183	hsa-miR-4642	CLIP-seq
MIRT2645184	hsa-miR-4643	CLIP-seq
MIRT2645187	hsa-miR-4701-3p	CLIP-seq
MIRT1433856	hsa-miR-4718	CLIP-seq
MIRT1433857	hsa-miR-4719	CLIP-seq
MIRT2645188	hsa-miR-4753-3p	CLIP-seq
MIRT1433859	hsa-miR-4762-5p	CLIP-seq
MIRT2645189	hsa-miR-4768-5p	CLIP-seq
MIRT2645190	hsa-miR-4774-3p	CLIP-seq
MIRT1433860	hsa-miR-486-5p	CLIP-seq
MIRT1433862	hsa-miR-494	CLIP-seq
MIRT1433863	hsa-miR-512-3p	CLIP-seq
MIRT1433866	hsa-miR-520a-3p	CLIP-seq
MIRT1433867	hsa-miR-520b	CLIP-seq
MIRT1433868	hsa-miR-520c-3p	CLIP-seq
MIRT1433869	hsa-miR-520d-3p	CLIP-seq
MIRT1433870	hsa-miR-520e	CLIP-seq
MIRT1433871	hsa-miR-548aa	CLIP-seq
MIRT1433872	hsa-miR-548b-3p	CLIP-seq
MIRT1433873	hsa-miR-570	CLIP-seq
MIRT2645191	hsa-miR-574-3p	CLIP-seq
MIRT1433874	hsa-miR-576-3p	CLIP-seq
MIRT1433875	hsa-miR-587	CLIP-seq
MIRT1433876	hsa-miR-649	CLIP-seq
MIRT2693454	hsa-miR-760	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32320651, 32814053
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	32275929
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	32320651
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0032981	Process	Mitochondrial respiratory chain complex I assembly	IMP	32320651
GO:0032981	Process	Mitochondrial respiratory chain complex I assembly	NAS	32320651

MIM	HGNC	e!Ensembl
620433	24530	ENSG00000184857

Q96B77

Protein name

Transmembrane protein 186

Protein function

As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14640	TMEM223	52 → 210		Family

Sequence

MAALLRAVRRFRGKAVWERPLHGLWCCSGQEDPKRWVGSSSPISKEKLPNAETEKFWMFY
RFDAIRTFGFLSRLKLAQTALTVVALPPGYYLYSQGLLTLNTVCLMSGISGFALTMLCWM
SYFLRRLVGILYLNESGTMLRVAHLNFWGWRQDTYCPMADVIPLTETKDRPQEMFVRIQR
YSGKQTFYVTLRYGRILDRERFTQVFGVHQMLK

Sequence length

213

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	35779338	★★★★★ ★☆☆☆☆ Found in Text Mining only

TMEM186 (transmembrane protein 186)