Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	25878
Gene name Gene Name - the full gene name approved by the HGNC.	Matrix remodeling associated 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MXRA5
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Xp22.33
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y. [provided by RefSeq, Mar 2010]

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miRTarBase ID	miRNA	Experiments
MIRT1551464	hsa-miR-4680-3p	CLIP-seq
MIRT2277187	hsa-miR-144	CLIP-seq
MIRT2277188	hsa-miR-2110	CLIP-seq
MIRT2277189	hsa-miR-3185	CLIP-seq
MIRT2277190	hsa-miR-345	CLIP-seq
MIRT2277191	hsa-miR-3652	CLIP-seq
MIRT2277192	hsa-miR-3684	CLIP-seq
MIRT2277193	hsa-miR-4271	CLIP-seq
MIRT2277194	hsa-miR-4430	CLIP-seq
MIRT2277195	hsa-miR-4505	CLIP-seq
MIRT2277196	hsa-miR-4667-5p	CLIP-seq
MIRT2277197	hsa-miR-4691-3p	CLIP-seq
MIRT2277198	hsa-miR-4700-5p	CLIP-seq
MIRT2277199	hsa-miR-4725-3p	CLIP-seq
MIRT2277200	hsa-miR-4731-5p	CLIP-seq
MIRT2576027	hsa-miR-1225-3p	CLIP-seq
MIRT2576028	hsa-miR-1233	CLIP-seq
MIRT2576029	hsa-miR-1237	CLIP-seq
MIRT2576030	hsa-miR-1248	CLIP-seq
MIRT2277188	hsa-miR-2110	CLIP-seq
MIRT2576031	hsa-miR-2355-5p	CLIP-seq
MIRT2576032	hsa-miR-30a	CLIP-seq
MIRT2576033	hsa-miR-30b	CLIP-seq
MIRT2576034	hsa-miR-30c	CLIP-seq
MIRT2576035	hsa-miR-30d	CLIP-seq
MIRT2576036	hsa-miR-30e	CLIP-seq
MIRT2576037	hsa-miR-3140-5p	CLIP-seq
MIRT2576038	hsa-miR-3171	CLIP-seq
MIRT2277189	hsa-miR-3185	CLIP-seq
MIRT2576039	hsa-miR-331-3p	CLIP-seq
MIRT2576040	hsa-miR-3620	CLIP-seq
MIRT2576041	hsa-miR-3622b-5p	CLIP-seq
MIRT2277191	hsa-miR-3652	CLIP-seq
MIRT2576042	hsa-miR-3658	CLIP-seq
MIRT2277192	hsa-miR-3684	CLIP-seq
MIRT2576043	hsa-miR-3929	CLIP-seq
MIRT2576044	hsa-miR-3938	CLIP-seq
MIRT2277193	hsa-miR-4271	CLIP-seq
MIRT2576045	hsa-miR-4290	CLIP-seq
MIRT2576046	hsa-miR-4419b	CLIP-seq
MIRT2277194	hsa-miR-4430	CLIP-seq
MIRT2576047	hsa-miR-4478	CLIP-seq
MIRT2576048	hsa-miR-4495	CLIP-seq
MIRT2277195	hsa-miR-4505	CLIP-seq
MIRT2576049	hsa-miR-4663	CLIP-seq
MIRT2576050	hsa-miR-4667-3p	CLIP-seq
MIRT2277196	hsa-miR-4667-5p	CLIP-seq
MIRT2576051	hsa-miR-4687-5p	CLIP-seq
MIRT2277197	hsa-miR-4691-3p	CLIP-seq
MIRT2277198	hsa-miR-4700-5p	CLIP-seq
MIRT2576052	hsa-miR-4708-3p	CLIP-seq
MIRT2576053	hsa-miR-4720-5p	CLIP-seq
MIRT2277199	hsa-miR-4725-3p	CLIP-seq
MIRT2277200	hsa-miR-4731-5p	CLIP-seq
MIRT2576054	hsa-miR-4786-3p	CLIP-seq
MIRT2576055	hsa-miR-4799-3p	CLIP-seq
MIRT2576056	hsa-miR-545	CLIP-seq
MIRT2576057	hsa-miR-642b	CLIP-seq
MIRT2685600	hsa-miR-1206	CLIP-seq
MIRT2685601	hsa-miR-1294	CLIP-seq
MIRT2685602	hsa-miR-204	CLIP-seq
MIRT2685603	hsa-miR-211	CLIP-seq
MIRT2277188	hsa-miR-2110	CLIP-seq
MIRT2576031	hsa-miR-2355-5p	CLIP-seq
MIRT2576032	hsa-miR-30a	CLIP-seq
MIRT2576033	hsa-miR-30b	CLIP-seq
MIRT2576034	hsa-miR-30c	CLIP-seq
MIRT2576035	hsa-miR-30d	CLIP-seq
MIRT2576036	hsa-miR-30e	CLIP-seq
MIRT2576037	hsa-miR-3140-5p	CLIP-seq
MIRT2576038	hsa-miR-3171	CLIP-seq
MIRT2685604	hsa-miR-3174	CLIP-seq
MIRT2277189	hsa-miR-3185	CLIP-seq
MIRT2576039	hsa-miR-331-3p	CLIP-seq
MIRT2576040	hsa-miR-3620	CLIP-seq
MIRT2576041	hsa-miR-3622b-5p	CLIP-seq
MIRT2277191	hsa-miR-3652	CLIP-seq
MIRT2576042	hsa-miR-3658	CLIP-seq
MIRT2277192	hsa-miR-3684	CLIP-seq
MIRT2277193	hsa-miR-4271	CLIP-seq
MIRT2277194	hsa-miR-4430	CLIP-seq
MIRT2576048	hsa-miR-4495	CLIP-seq
MIRT2277195	hsa-miR-4505	CLIP-seq
MIRT2277196	hsa-miR-4667-5p	CLIP-seq
MIRT2277197	hsa-miR-4691-3p	CLIP-seq
MIRT2277198	hsa-miR-4700-5p	CLIP-seq
MIRT2576053	hsa-miR-4720-5p	CLIP-seq
MIRT2277199	hsa-miR-4725-3p	CLIP-seq
MIRT2277200	hsa-miR-4731-5p	CLIP-seq
MIRT2685605	hsa-miR-4755-5p	CLIP-seq
MIRT2576054	hsa-miR-4786-3p	CLIP-seq
MIRT2685606	hsa-miR-4796-5p	CLIP-seq
MIRT2576055	hsa-miR-4799-3p	CLIP-seq
MIRT2685607	hsa-miR-490-3p	CLIP-seq
MIRT2685608	hsa-miR-520d-5p	CLIP-seq
MIRT2685609	hsa-miR-524-5p	CLIP-seq
MIRT2685610	hsa-miR-623	CLIP-seq
MIRT2576057	hsa-miR-642b	CLIP-seq
MIRT2685611	hsa-miR-921	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005201	Function	Extracellular matrix structural constituent	HDA	28344315
GO:0005201	Function	Extracellular matrix structural constituent	RCA	28327460
GO:0005576	Component	Extracellular region	IEA
GO:0031012	Component	Extracellular matrix	HDA	28327460, 28344315
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0071559	Process	Response to transforming growth factor beta	IBA
GO:0071559	Process	Response to transforming growth factor beta	IMP	27599751

MIM	HGNC	e!Ensembl
300938	7539	ENSG00000101825

Protein

UniProt ID

Q9NR99

Protein name

Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican)

Protein function

In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13855	LRR_8	55 → 115	Leucine rich repeat	Repeat
PF13855	LRR_8	80 → 130	Leucine rich repeat	Repeat
PF13855	LRR_8	103 → 163	Leucine rich repeat	Repeat
PF13855	LRR_8	127 → 184	Leucine rich repeat	Repeat
PF13927	Ig_3	480 → 558		Domain
PF13927	Ig_3	575 → 655		Domain
PF13927	Ig_3	1852 → 1932		Domain
PF07679	I-set	1950 → 2042	Immunoglobulin I-set domain	Domain
PF07679	I-set	2047 → 2139	Immunoglobulin I-set domain	Domain
PF13927	Ig_3	2147 → 2225		Domain
PF07679	I-set	2244 → 2341	Immunoglobulin I-set domain	Domain
PF07679	I-set	2348 → 2435	Immunoglobulin I-set domain	Domain
PF13927	Ig_3	2439 → 2522		Domain
PF07679	I-set	2542 → 2633	Immunoglobulin I-set domain	Domain
PF13927	Ig_3	2732 → 2814		Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in placenta (at protein level) (PubMed:32337544). Detected in cerebrospinal fluid and fibroblasts (at protein level) (PubMed:25326458, PubMed:36213313). Highly expressed in kidney, also detected on liver and spleen (PubMed:275

Sequence

MPKRAHWGALSVVLILLWGHPRVALACPHPCACYVPSEVHCTFRSLASVPAGIAKHVERI
NLGFNSIQALSETSFAGLTKLELLMIHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITG
QTLQGLSNLMRLHIDHNKIEFIHPQAFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYF
RLSTIRHLYLAENMVRTLPASMLRNMPLLENLYLQGNPWTCDCEMRWFLEWDAKSRGILK
CKKDKAYEGGQLCAMCFSPKKLYKHEIHKLKDMTCLKPSIESPLRQNRSRSIEEEQEQEE
DGGSQLILEKFQLPQWSISLNMTDEHGNMVNLVCDIKKPMDVYKIHLNQTDPPDIDINAT
VALDFECPMTRENYEKLWKLIAYYSEVPVKLHRELMLSKDPRVSYQYRQDADEEALYYTG
VRAQILAEPEWVMQPSIDIQLNRRQSTAKKVLLSYYTQYSQTISTKDTRQARGRSWVMIE
PSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWL
RIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCN
ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGAD
HFTVGITVTKKGSGLPSKRGRRPGAKALSRVREDIVEDEGGSGMGDEENTSRRLLHPKDQ
EVFLKTKDDAINGDKKAKKGRRKLKLWKHSEKEPETNVAEGRRVFESRRRINMANKQINP
ERWADILAKVRGKNLPKGTEVPPLIKTTSPPSLSLEVTPPFPAISPPSASPVQTVTSAEE
SSADVPLLGEEEHVLGTISSASMGLEHNHNGVILVEPEVTSTPLEEVVDDLSEKTEEITS
TEGDLKGTAAPTLISEPYEPSPTLHTLDTVYEKPTHEETATEGWSAADVGSSPEPTSSEY
EPPLDAVSLAESEPMQYFDPDLETKSQPDEDKMKEDTFAHLTPTPTIWVNDSSTSQLFED
STIGEPGVPGQSHLQGLTDNIHLVKSSLSTQDTLLIKKGMKEMSQTLQGGNMLEGDPTHS
RSSESEGQESKSITLPDSTLGIMSSMSPVKKPAETTVGTLLDKDTTTATTTPRQKVAPSS
TMSTHPSRRRPNGRRRLRPNKFRHRHKQTPPTTFAPSETFSTQPTQAPDIKISSQVESSL
VPTAWVDNTVNTPKQLEMEKNAEPTSKGTPRRKHGKRPNKHRYTPSTVSSRASGSKPSPS
PENKHRNIVTPSSETILLPRTVSLKTEGPYDSLDYMTTTRKIYSSYPKVQETLPVTYKPT
SDGKEIKDDVATNVDKHKSDILVTGESITNAIPTSRSLVSTMGEFKEESSPVGFPGTPTW
NPSRTAQPGRLQTGIPVTTSGENLTDPPLLKELEDVDFTSEFLSSLTVSTPFHQEEAGSS
TTLSSIKVEVASSQAETTTLDQDHLETTVAILLSETRPQNHTPTAARMKEPASSSPSTIL
MSLGQTTTTKPALPSPRISQASRDSKENVFLNYVGNPETEATPVNNEGTQHMSGPNELST
PSSDQDAFNLSTKLELEKQVFGSRSLPRGPDSQRQDGRVHASHQLTRVPAKPILPTATVR
LPEMSTQSASRYFVTSQSPRHWTNKPEITTYPSGALPENKQFTTPRLSSTTIPLPLHMSK
PSIPSKFTDRRTDQFNGYSKVFGNNNIPEARNPVGKPPSPRIPHYSNGRLPFFTNKTLSF
PQLGVTRRPQIPTSPAPVMRERKVIPGSYNRIHSHSTFHLDFGPPAPPLLHTPQTTGSPS
TNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSP
QTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQV
QDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAP
QISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRL
HVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLF
VFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRY
GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYL
CVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLP
DGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVK
VVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQD
GTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGS
RKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMA
RNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPN
GTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEAN
KQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVRE
ASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGI
PKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDS
KTTYIHVF

Sequence length

2828

Interactions

View interactions

MXRA5 (matrix remodeling associated 5)