MPC2 (mitochondrial pyruvate carrier 2)

Gene

• Entrez ID: 25874
• Gene name: Mitochondrial pyruvate carrier 2
• Gene symbol: MPC2
• Synonyms (NCBI Gene): BRP44, SLC54A2
• Chromosome: 1
• Chromosome location: 1q24.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030303	hsa-miR-26b-5p	Microarray	19088304

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	31145700, 32296183, 32814053, 33961781, 35278701
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IBA
GO:0005743	Component	Mitochondrial inner membrane	IDA	26253029, 32403431
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0006086	Process	Pyruvate decarboxylation to acetyl-CoA	IEA
GO:0006850	Process	Pyruvate import into mitochondria	IBA
GO:0006850	Process	Pyruvate import into mitochondria	IDA	26253029, 27317664, 29472561
GO:0006850	Process	Pyruvate import into mitochondria	IEA
GO:0006850	Process	Pyruvate import into mitochondria	IEA
GO:0006850	Process	Pyruvate import into mitochondria	ISS
GO:0016020	Component	Membrane	IEA
GO:0035774	Process	Positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA
GO:0042802	Function	Identical protein binding	IPI	32296183
GO:0050833	Function	Pyruvate transmembrane transporter activity	IBA
GO:0050833	Function	Pyruvate transmembrane transporter activity	IEA
GO:0098800	Component	Inner mitochondrial membrane protein complex	ISS

Other IDs

• MIM: 614737
• HGNC: 24515
• e!Ensembl: ENSG00000143158

Protein

• UniProt ID: O95563
• Protein name: Mitochondrial pyruvate carrier 2 (Brain protein 44)
• Protein function: Mediates the uptake of pyruvate into mitochondria.
• PDB: 8YW6, 8YW8, 8YW9, 9KNW, 9KNX, 9KNY, 9MNW, 9MNX, 9MNY, 9MNZ, 9MO0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03650	MPC	27 → 127	Mitochondrial pyruvate carriers	Family

• Sequence:

  MSAAGARGLRATYHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADM
  ARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQE
  LKAKAHK

• Sequence length: 127

Pathways

KEGG:

Diabetic cardiomyopathy