Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	25874
Gene name Gene Name - the full gene name approved by the HGNC.	Mitochondrial pyruvate carrier 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MPC2
Synonyms (NCBI Gene) Gene synonyms aliases	BRP44, SLC54A2
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q24.2

Show/Hide all(1)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030303	hsa-miR-26b-5p	Microarray	19088304

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	31145700, 32296183, 32814053, 33961781, 35278701
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IBA
GO:0005743	Component	Mitochondrial inner membrane	IDA	26253029, 32403431
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0006086	Process	Pyruvate decarboxylation to acetyl-CoA	IEA
GO:0006850	Process	Pyruvate import into mitochondria	IBA
GO:0006850	Process	Pyruvate import into mitochondria	IDA	26253029, 27317664, 29472561
GO:0006850	Process	Pyruvate import into mitochondria	IEA
GO:0006850	Process	Pyruvate import into mitochondria	IEA
GO:0006850	Process	Pyruvate import into mitochondria	ISS
GO:0016020	Component	Membrane	IEA
GO:0035774	Process	Positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA
GO:0042802	Function	Identical protein binding	IPI	32296183
GO:0050833	Function	Pyruvate transmembrane transporter activity	IBA
GO:0050833	Function	Pyruvate transmembrane transporter activity	IEA
GO:0098800	Component	Inner mitochondrial membrane protein complex	ISS

MIM	HGNC	e!Ensembl
614737	24515	ENSG00000143158

Protein

UniProt ID

O95563

Protein name

Mitochondrial pyruvate carrier 2 (Brain protein 44)

Protein function

Mediates the uptake of pyruvate into mitochondria.

PDB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03650	MPC	27 → 127	Mitochondrial pyruvate carriers	Family

Sequence

MSAAGARGLRATYHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADM
ARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQE
LKAKAHK

Sequence length

127

Interactions

View interactions

	KEGG
	Diabetic cardiomyopathy

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Metabolic Diseases	metabolic disease	N/A	N/A	GenCC
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Diabetic Nephropathies	Inhibit	32664896
Glioma	Associate	35242216
Infantile Epileptic Dyskinetic Encephalopathy	Associate	36417180
Lymphatic Metastasis	Associate	27852261
Neoplasms	Associate	33243007
Parvovirus antenatal infection	Associate	36417180
Prostatic Neoplasms	Associate	27852261
Pyruvate Metabolism Inborn Errors	Associate	36417180
Schizophrenia	Associate	22037555

MPC2 (mitochondrial pyruvate carrier 2)