Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2587
Gene name Gene Name - the full gene name approved by the HGNC.	Galanin receptor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GALR1
Synonyms (NCBI Gene) Gene synonyms aliases	GALNR, GALNR1
Chromosome Chromosome number	18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	18q23
Summary Summary of gene provided in NCBI Entrez Gene.	The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inh

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miRTarBase ID	miRNA	Experiments	Reference
MIRT718909	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT718908	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT718907	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT718906	hsa-miR-411-5p	HITS-CLIP	19536157
MIRT718905	hsa-miR-452-3p	HITS-CLIP	19536157
MIRT718904	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT718903	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT718902	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT718909	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT718908	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT718907	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT718906	hsa-miR-411-5p	HITS-CLIP	19536157
MIRT718905	hsa-miR-452-3p	HITS-CLIP	19536157
MIRT718904	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT718903	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT718902	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT1011690	hsa-miR-1226	CLIP-seq
MIRT1011691	hsa-miR-1915	CLIP-seq
MIRT1011692	hsa-miR-204	CLIP-seq
MIRT1011693	hsa-miR-211	CLIP-seq
MIRT1011694	hsa-miR-217	CLIP-seq
MIRT1011695	hsa-miR-3125	CLIP-seq
MIRT1011696	hsa-miR-324-5p	CLIP-seq
MIRT1011697	hsa-miR-3916	CLIP-seq
MIRT1011698	hsa-miR-4418	CLIP-seq
MIRT1011699	hsa-miR-4709-3p	CLIP-seq
MIRT1011700	hsa-miR-4712-5p	CLIP-seq
MIRT1011701	hsa-miR-4726-3p	CLIP-seq
MIRT1011702	hsa-miR-4733-3p	CLIP-seq
MIRT1011703	hsa-miR-4755-5p	CLIP-seq
MIRT1011704	hsa-miR-509-3-5p	CLIP-seq
MIRT1011705	hsa-miR-509-5p	CLIP-seq
MIRT1011706	hsa-miR-623	CLIP-seq
MIRT1011707	hsa-miR-654-3p	CLIP-seq
MIRT1011708	hsa-miR-770-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004966	Function	Galanin receptor activity	IBA
GO:0004966	Function	Galanin receptor activity	IDA	24517231
GO:0004966	Function	Galanin receptor activity	IEA
GO:0004966	Function	Galanin receptor activity	TAS	7524088
GO:0005515	Function	Protein binding	IPI	23597562, 25691535, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7524088
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0007194	Process	Negative regulation of adenylate cyclase activity	TAS	7524088
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0007218	Process	Neuropeptide signaling pathway	IBA
GO:0007218	Process	Neuropeptide signaling pathway	TAS	7524088
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	7524088
GO:0017046	Function	Peptide hormone binding	IDA	24517231
GO:0042923	Function	Neuropeptide binding	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	24517231
GO:0051464	Process	Positive regulation of cortisol secretion	IMP	17982695

MIM	HGNC	e!Ensembl
600377	4132	ENSG00000166573

Protein

UniProt ID

P47211

Protein name

Galanin receptor type 1 (GAL1-R) (GALR-1)

Protein function

Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

PDB

7WQ3 , 7XJJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	50 → 303	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLAR
SKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSML
VSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPR
ASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEA
SKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNP
IIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV

Sequence length

349

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction		Peptide ligand-binding receptors G alpha (i) signalling events

GALR1 (galanin receptor 1)