Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	25862
Gene name Gene Name - the full gene name approved by the HGNC.	Ubiquitin specific peptidase 49
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	USP49
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p21.1

Show/Hide all(144)

miRTarBase ID	miRNA	Experiments	Reference
MIRT651829	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT651828	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT651827	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT651825	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT651826	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT651824	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT651823	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT651822	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT651821	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT651820	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT651819	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT651818	hsa-miR-1913	HITS-CLIP	23824327
MIRT651817	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT651816	hsa-miR-4749-3p	HITS-CLIP	23824327
MIRT651815	hsa-miR-210-5p	HITS-CLIP	23824327
MIRT651814	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT651813	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT651811	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT651812	hsa-miR-4284	HITS-CLIP	23824327
MIRT651810	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT651809	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT651808	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT651807	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT651806	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT651805	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT651804	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT651803	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT651829	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT651828	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT651827	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT651825	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT651826	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT651824	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT651823	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT651822	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT651821	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT651820	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT651819	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT651818	hsa-miR-1913	HITS-CLIP	23824327
MIRT651817	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT651816	hsa-miR-4749-3p	HITS-CLIP	23824327
MIRT651815	hsa-miR-210-5p	HITS-CLIP	23824327
MIRT651814	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT651813	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT651811	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT651812	hsa-miR-4284	HITS-CLIP	23824327
MIRT651810	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT651809	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT651808	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT651807	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT651806	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT651805	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT651804	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT651803	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT1480209	hsa-miR-150	CLIP-seq
MIRT1480210	hsa-miR-3159	CLIP-seq
MIRT1480211	hsa-miR-3174	CLIP-seq
MIRT1480212	hsa-miR-3194-3p	CLIP-seq
MIRT1480213	hsa-miR-338-5p	CLIP-seq
MIRT1480214	hsa-miR-3616-5p	CLIP-seq
MIRT1480215	hsa-miR-3647-5p	CLIP-seq
MIRT1480216	hsa-miR-371b-3p	CLIP-seq
MIRT1480217	hsa-miR-3929	CLIP-seq
MIRT1480218	hsa-miR-3934	CLIP-seq
MIRT1480219	hsa-miR-411	CLIP-seq
MIRT1480220	hsa-miR-4419b	CLIP-seq
MIRT1480221	hsa-miR-4478	CLIP-seq
MIRT1480222	hsa-miR-4666-3p	CLIP-seq
MIRT1480223	hsa-miR-4716-5p	CLIP-seq
MIRT1480224	hsa-miR-4735-5p	CLIP-seq
MIRT1480225	hsa-miR-4775	CLIP-seq
MIRT1480226	hsa-miR-4781-3p	CLIP-seq
MIRT1480227	hsa-miR-4795-5p	CLIP-seq
MIRT1480228	hsa-miR-483-5p	CLIP-seq
MIRT1480229	hsa-miR-485-3p	CLIP-seq
MIRT1480230	hsa-miR-5095	CLIP-seq
MIRT1480231	hsa-miR-518a-3p	CLIP-seq
MIRT1480232	hsa-miR-518b	CLIP-seq
MIRT1480233	hsa-miR-518c	CLIP-seq
MIRT1480234	hsa-miR-518d-3p	CLIP-seq
MIRT1480235	hsa-miR-518e	CLIP-seq
MIRT1480236	hsa-miR-518f	CLIP-seq
MIRT1480237	hsa-miR-519a	CLIP-seq
MIRT1480238	hsa-miR-519b-3p	CLIP-seq
MIRT1480239	hsa-miR-519c-3p	CLIP-seq
MIRT1480240	hsa-miR-552	CLIP-seq
MIRT1480241	hsa-miR-573	CLIP-seq
MIRT1480242	hsa-miR-590-3p	CLIP-seq
MIRT1480243	hsa-miR-629	CLIP-seq
MIRT1480244	hsa-miR-921	CLIP-seq
MIRT2144492	hsa-miR-103b	CLIP-seq
MIRT1480209	hsa-miR-150	CLIP-seq
MIRT2144493	hsa-miR-1915	CLIP-seq
MIRT2144494	hsa-miR-24	CLIP-seq
MIRT2144495	hsa-miR-3673	CLIP-seq
MIRT2144496	hsa-miR-4258	CLIP-seq
MIRT2144497	hsa-miR-4317	CLIP-seq
MIRT2144498	hsa-miR-4726-3p	CLIP-seq
MIRT2144499	hsa-miR-4772-3p	CLIP-seq
MIRT2144500	hsa-miR-520g	CLIP-seq
MIRT2144501	hsa-miR-520h	CLIP-seq
MIRT2144502	hsa-miR-891b	CLIP-seq
MIRT1480209	hsa-miR-150	CLIP-seq
MIRT2144493	hsa-miR-1915	CLIP-seq
MIRT2144494	hsa-miR-24	CLIP-seq
MIRT1480214	hsa-miR-3616-5p	CLIP-seq
MIRT1480215	hsa-miR-3647-5p	CLIP-seq
MIRT1480217	hsa-miR-3929	CLIP-seq
MIRT1480220	hsa-miR-4419b	CLIP-seq
MIRT1480221	hsa-miR-4478	CLIP-seq
MIRT2144498	hsa-miR-4726-3p	CLIP-seq
MIRT2144499	hsa-miR-4772-3p	CLIP-seq
MIRT1480227	hsa-miR-4795-5p	CLIP-seq
MIRT2364788	hsa-miR-498	CLIP-seq
MIRT1480237	hsa-miR-519a	CLIP-seq
MIRT1480238	hsa-miR-519b-3p	CLIP-seq
MIRT1480239	hsa-miR-519c-3p	CLIP-seq
MIRT1480241	hsa-miR-573	CLIP-seq
MIRT2364789	hsa-miR-764	CLIP-seq
MIRT2396764	hsa-miR-4263	CLIP-seq
MIRT2396765	hsa-miR-4666-5p	CLIP-seq
MIRT2463112	hsa-miR-1267	CLIP-seq
MIRT2463113	hsa-miR-3664-5p	CLIP-seq
MIRT2463114	hsa-miR-4423-5p	CLIP-seq
MIRT2463115	hsa-miR-4639-3p	CLIP-seq
MIRT2463116	hsa-miR-4695-3p	CLIP-seq
MIRT2463112	hsa-miR-1267	CLIP-seq
MIRT2463113	hsa-miR-3664-5p	CLIP-seq
MIRT2463114	hsa-miR-4423-5p	CLIP-seq
MIRT2463115	hsa-miR-4639-3p	CLIP-seq
MIRT2463116	hsa-miR-4695-3p	CLIP-seq
MIRT2463112	hsa-miR-1267	CLIP-seq
MIRT2463113	hsa-miR-3664-5p	CLIP-seq
MIRT1480216	hsa-miR-371b-3p	CLIP-seq
MIRT2463114	hsa-miR-4423-5p	CLIP-seq
MIRT2463115	hsa-miR-4639-3p	CLIP-seq
MIRT2463116	hsa-miR-4695-3p	CLIP-seq
MIRT1480224	hsa-miR-4735-5p	CLIP-seq
MIRT1480225	hsa-miR-4775	CLIP-seq
MIRT1480242	hsa-miR-590-3p	CLIP-seq
MIRT2144493	hsa-miR-1915	CLIP-seq
MIRT2144494	hsa-miR-24	CLIP-seq
MIRT2144498	hsa-miR-4726-3p	CLIP-seq
MIRT2144499	hsa-miR-4772-3p	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IMP	23824326
GO:0004197	Function	Cysteine-type endopeptidase activity	IMP	23824326
GO:0004843	Function	Thiol-dependent ubiquitin-specific protease activity	IDA	14715245, 23824326
GO:0005515	Function	Protein binding	IPI	19615732, 23824326, 25036637
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016579	Process	Protein deubiquitination	IDA	14715245
GO:0016579	Process	Protein deubiquitination	TAS
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0035616	Process	Histone H2B conserved C-terminal lysine deubiquitination	IDA	23824326
GO:0042393	Function	Histone binding	IDA	23824326

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Protein

UniProt ID

Q70CQ1

Protein name

Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.4.19.12) (Deubiquitinating enzyme 49) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49)

Protein function

Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub), a specific tag for epigenetic tran

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02148	zf-UBP	25 → 88	Zn-finger in ubiquitin-hydrolases and other protein	Domain
PF00443	UCH	253 → 654	Ubiquitin carboxyl-terminal hydrolase	Family

Sequence

MDRCKHVGRLRLAQDHSILNPQKWCCLECATTESVWACLKCSHVACGRYIEDHALKHFEE
TGHPLAMEVRDLYVFCYLCKDYVLNDNPEGDLKLLRSSLLAVRGQKQDTPVRRGRTLRSM
ASGEDVVLPQRAPQGQPQMLTALWYRRQRLLARTLRLWFEKSSRGQAKLEQRRQEEALER
KKEEARRRRREVKRRLLEELASTPPRKSARLLLHTPRDAGPAASRPAALPTSRRVPAATL
KLRRQPAMAPGVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGK
TQLSGKPTNSSATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRE
LHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGT
TRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYH
CIEKGFVPLNQTECLLTEMLAKFTETEALEGRIYACDQCNSKRRKSNPKPLVLSEARKQL
MIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQVLTMEPYCCRDMLSSLDKETFAYDL
SAVVMHHGKGFGSGHYTAYCYNTEGGFWVHCNDSKLNVCSVEEVCKTQAYILFYTQRTVQ
GNARISETHLQAQVQSSNNDEGRPQTFS

Sequence length

688

Interactions

View interactions

	Reactome
			Ub-specific processing proteases

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	26626624

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Evidence	Source
Unknown
Diabetes	Diabetes		GWAS
Oligodendroglioma	Oligodendroglioma		GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587	GWAS, CBGDA
Insomnia	Insomnia		GWAS

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	18507837
Carcinogenesis	Associate	28363942
Carcinoma Non Small Cell Lung	Associate	31001918
Neoplasms	Inhibit	31001918
Obesity	Associate	27421018
Pancreatic Neoplasms	Inhibit	28363942
Primary Ovarian Insufficiency	Associate	32143396
Pulmonary Disease Chronic Obstructive	Associate	33116468

USP49 (ubiquitin specific peptidase 49)