Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	2585
Gene name	Galactokinase 2
Gene symbol	GALK2
Synonyms (NCBI Gene)	GK2
Chromosome	15
Chromosome location	15q21.1-q21.2
Summary	This gene encodes a highly efficient N-acetylgalactosamine (GalNAc) kinase, which has galactokinase activity when galactose is present at high concentrations. The encoded protein is a member of the GHMP kinase family. Alternative splicing results in multi

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miRTarBase ID	miRNA	Experiments	Reference
MIRT038704	hsa-miR-148a-5p	CLASH	23622248
MIRT509609	hsa-miR-548c-3p	HITS-CLIP	19536157
MIRT509608	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT509607	hsa-miR-500a-5p	HITS-CLIP	19536157
MIRT509606	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT509605	hsa-miR-4474-5p	HITS-CLIP	19536157
MIRT509609	hsa-miR-548c-3p	HITS-CLIP	21572407
MIRT509608	hsa-miR-4668-3p	HITS-CLIP	21572407
MIRT509607	hsa-miR-500a-5p	HITS-CLIP	21572407
MIRT509606	hsa-miR-3613-3p	HITS-CLIP	21572407
MIRT509605	hsa-miR-4474-5p	HITS-CLIP	21572407
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	20371350
MIRT509611	hsa-miR-4709-5p	PAR-CLIP	20371350
MIRT509610	hsa-miR-421	PAR-CLIP	20371350
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	20371350
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	20371350
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	23446348
MIRT509612	hsa-miR-34c-3p	PAR-CLIP	23446348
MIRT509611	hsa-miR-4709-5p	PAR-CLIP	23446348
MIRT509610	hsa-miR-421	PAR-CLIP	23446348
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	23446348
MIRT509609	hsa-miR-548c-3p	HITS-CLIP	19536157
MIRT509608	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT509607	hsa-miR-500a-5p	HITS-CLIP	19536157
MIRT509606	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT509605	hsa-miR-4474-5p	HITS-CLIP	19536157
MIRT509609	hsa-miR-548c-3p	HITS-CLIP	21572407
MIRT509608	hsa-miR-4668-3p	HITS-CLIP	21572407
MIRT509607	hsa-miR-500a-5p	HITS-CLIP	21572407
MIRT509606	hsa-miR-3613-3p	HITS-CLIP	21572407
MIRT509605	hsa-miR-4474-5p	HITS-CLIP	21572407
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	20371350
MIRT509611	hsa-miR-4709-5p	PAR-CLIP	20371350
MIRT509610	hsa-miR-421	PAR-CLIP	20371350
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	20371350
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	20371350
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	23446348
MIRT509612	hsa-miR-34c-3p	PAR-CLIP	23446348
MIRT509611	hsa-miR-4709-5p	PAR-CLIP	23446348
MIRT509610	hsa-miR-421	PAR-CLIP	23446348
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	23446348
MIRT1010544	hsa-miR-3647-3p	CLIP-seq
MIRT1010545	hsa-miR-369-3p	CLIP-seq
MIRT1010546	hsa-miR-374a	CLIP-seq
MIRT1010547	hsa-miR-374b	CLIP-seq
MIRT1010548	hsa-miR-4676-5p	CLIP-seq
MIRT1010549	hsa-miR-574-5p	CLIP-seq
MIRT1010550	hsa-miR-575	CLIP-seq
MIRT1010551	hsa-miR-579	CLIP-seq
MIRT1010545	hsa-miR-369-3p	CLIP-seq
MIRT1010545	hsa-miR-369-3p	CLIP-seq
MIRT2536667	hsa-miR-1	CLIP-seq
MIRT2536668	hsa-miR-1244	CLIP-seq
MIRT2536669	hsa-miR-1303	CLIP-seq
MIRT2536670	hsa-miR-147	CLIP-seq
MIRT2536671	hsa-miR-202	CLIP-seq
MIRT2536672	hsa-miR-206	CLIP-seq
MIRT2536673	hsa-miR-300	CLIP-seq
MIRT2536674	hsa-miR-302a	CLIP-seq
MIRT2536675	hsa-miR-302b	CLIP-seq
MIRT2536676	hsa-miR-302c	CLIP-seq
MIRT2536677	hsa-miR-302d	CLIP-seq
MIRT2536678	hsa-miR-302e	CLIP-seq
MIRT2536679	hsa-miR-3157-3p	CLIP-seq
MIRT2536680	hsa-miR-3190	CLIP-seq
MIRT2536681	hsa-miR-371b-3p	CLIP-seq
MIRT2536682	hsa-miR-371b-5p	CLIP-seq
MIRT2536683	hsa-miR-372	CLIP-seq
MIRT2536684	hsa-miR-373	CLIP-seq
MIRT2536685	hsa-miR-381	CLIP-seq
MIRT2536686	hsa-miR-3911	CLIP-seq
MIRT2536687	hsa-miR-4305	CLIP-seq
MIRT2536688	hsa-miR-432	CLIP-seq
MIRT2536689	hsa-miR-4666-3p	CLIP-seq
MIRT2536690	hsa-miR-4678	CLIP-seq
MIRT2536691	hsa-miR-4698	CLIP-seq
MIRT2536692	hsa-miR-4722-3p	CLIP-seq
MIRT2536693	hsa-miR-495	CLIP-seq
MIRT2536694	hsa-miR-515-3p	CLIP-seq
MIRT2536695	hsa-miR-519a	CLIP-seq
MIRT2536696	hsa-miR-519b-3p	CLIP-seq
MIRT2536697	hsa-miR-519c-3p	CLIP-seq
MIRT2536698	hsa-miR-519e	CLIP-seq
MIRT2536699	hsa-miR-520a-3p	CLIP-seq
MIRT2536700	hsa-miR-520b	CLIP-seq
MIRT2536701	hsa-miR-520c-3p	CLIP-seq
MIRT2536702	hsa-miR-520d-3p	CLIP-seq
MIRT2536703	hsa-miR-520e	CLIP-seq
MIRT2536704	hsa-miR-539	CLIP-seq
MIRT2536705	hsa-miR-548p	CLIP-seq
MIRT2536706	hsa-miR-562	CLIP-seq
MIRT2536707	hsa-miR-578	CLIP-seq
MIRT2536708	hsa-miR-580	CLIP-seq
MIRT2536709	hsa-miR-613	CLIP-seq
MIRT2536710	hsa-miR-644	CLIP-seq
MIRT2536711	hsa-miR-888	CLIP-seq
MIRT2536667	hsa-miR-1	CLIP-seq
MIRT2536668	hsa-miR-1244	CLIP-seq
MIRT2536669	hsa-miR-1303	CLIP-seq
MIRT2536670	hsa-miR-147	CLIP-seq
MIRT2536672	hsa-miR-206	CLIP-seq
MIRT2536673	hsa-miR-300	CLIP-seq
MIRT2536674	hsa-miR-302a	CLIP-seq
MIRT2536675	hsa-miR-302b	CLIP-seq
MIRT2536676	hsa-miR-302c	CLIP-seq
MIRT2536677	hsa-miR-302d	CLIP-seq
MIRT2536678	hsa-miR-302e	CLIP-seq
MIRT2536679	hsa-miR-3157-3p	CLIP-seq
MIRT2536680	hsa-miR-3190	CLIP-seq
MIRT2536681	hsa-miR-371b-3p	CLIP-seq
MIRT2536683	hsa-miR-372	CLIP-seq
MIRT2536684	hsa-miR-373	CLIP-seq
MIRT2536685	hsa-miR-381	CLIP-seq
MIRT2536686	hsa-miR-3911	CLIP-seq
MIRT2536687	hsa-miR-4305	CLIP-seq
MIRT2536688	hsa-miR-432	CLIP-seq
MIRT2536689	hsa-miR-4666-3p	CLIP-seq
MIRT2536692	hsa-miR-4722-3p	CLIP-seq
MIRT2681335	hsa-miR-4768-5p	CLIP-seq
MIRT2536694	hsa-miR-515-3p	CLIP-seq
MIRT2536695	hsa-miR-519a	CLIP-seq
MIRT2536696	hsa-miR-519b-3p	CLIP-seq
MIRT2536697	hsa-miR-519c-3p	CLIP-seq
MIRT2536698	hsa-miR-519e	CLIP-seq
MIRT2536699	hsa-miR-520a-3p	CLIP-seq
MIRT2536700	hsa-miR-520b	CLIP-seq
MIRT2536701	hsa-miR-520c-3p	CLIP-seq
MIRT2536702	hsa-miR-520d-3p	CLIP-seq
MIRT2536703	hsa-miR-520e	CLIP-seq
MIRT2536705	hsa-miR-548p	CLIP-seq
MIRT2536706	hsa-miR-562	CLIP-seq
MIRT2536707	hsa-miR-578	CLIP-seq
MIRT2536709	hsa-miR-613	CLIP-seq
MIRT2536710	hsa-miR-644	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004335	Function	Galactokinase activity	IBA
GO:0004335	Function	Galactokinase activity	IDA	7542884
GO:0004335	Function	Galactokinase activity	IEA
GO:0004335	Function	Galactokinase activity	TAS	8798585
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005975	Process	Carbohydrate metabolic process	TAS	8798585
GO:0006012	Process	Galactose metabolic process	IBA
GO:0006012	Process	Galactose metabolic process	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016773	Function	Phosphotransferase activity, alcohol group as acceptor	IEA
GO:0033858	Function	N-acetylgalactosamine kinase activity	IEA
GO:0046835	Process	Carbohydrate phosphorylation	IEA

MIM	HGNC	e!Ensembl
137028	4119	ENSG00000156958

Q01415

Protein name

N-acetylgalactosamine kinase (EC 2.7.1.157) (GalNAc kinase) (Galactokinase 2)

Protein function

Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates. {ECO:0000269|PubMed:1

PDB

2A2C , 2A2D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10509	GalKase_gal_bdg	24 → 73	Galactokinase galactose-binding signature	Domain
PF00288	GHMP_kinases_N	131 → 198	GHMP kinases N terminal domain	Family
PF08544	GHMP_kinases_C	345 → 430	GHMP kinases C terminal	Family

Sequence

MATESPATRRVQVAEHPRLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLP
MAVEQDVLIAVEPVKTYALQLANTNPLYPDFSTSANNIQIDKTKPLWHNYFLCGLKGIQE
HFGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSER
YIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSHF
NIRVMECRLAAKLLAKYKSLQWDKVLRLEEVQAKLGISLEEMLLVTEDALHPEPYNPEEI
CRCLGISLEELRTQILSPNTQDVLIFKLYQRAKHVYSEAARVLQFKKICEEAPENMVQLL
GELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSF
LANVHKAYYQRSDGSLAPEKQSLFATKPGGGALVLLEA

Sequence length

458

Interactions

View interactions

	KEGG
	Amino sugar and nucleotide sugar metabolism Metabolic pathways Biosynthesis of nucleotide sugars

GALK2 (galactokinase 2)