ANAPC13 (anaphase promoting complex subunit 13)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 25847 |
| Gene name | Anaphase promoting complex subunit 13 |
| Gene symbol | ANAPC13 |
| Synonyms (NCBI Gene) |
APC13SWM1
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| Chromosome | 3 |
| Chromosome location | 3q22.2 |
| Summary | This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily con |
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miRNA
miRNA information provided by mirtarbase database.
481
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9BS18 | ||||||||||
| Protein name | Anaphase-promoting complex subunit 13 (APC13) (Cyclosome subunit 13) | ||||||||||
| Protein function | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:15060174, PubMed:18485873). The APC/C complex acts by | ||||||||||
| PDB | 4UI9 , 5G04 , 5KHR , 5KHU , 5L9T , 5L9U , 5LCW , 6Q6G , 6Q6H , 6TLJ , 6TM5 , 6TNT , 8PKP , 8TAR , 8TAU , 9GAW | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 74 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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