Gene Gene information from NCBI Gene database.
Entrez ID 25847
Gene name Anaphase promoting complex subunit 13
Gene symbol ANAPC13
Synonyms (NCBI Gene)
APC13SWM1
Chromosome 3
Chromosome location 3q22.2
Summary This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily con
miRNA miRNA information provided by mirtarbase database.
481
miRTarBase ID miRNA Experiments Reference
MIRT029001 hsa-miR-26b-5p Microarray 19088304
MIRT031495 hsa-miR-16-5p Microarray 21199864
MIRT043053 hsa-miR-324-5p CLASH 23622248
MIRT543415 hsa-miR-4428 PAR-CLIP 21572407
MIRT543414 hsa-miR-3173-3p PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 20360068, 26496610, 28514442, 32296183, 32814053, 33961781, 35271311
GO:0005634 Component Nucleus IEA
GO:0005680 Component Anaphase-promoting complex IBA
GO:0005680 Component Anaphase-promoting complex IDA 16364912
GO:0005680 Component Anaphase-promoting complex IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
614484 24540 ENSG00000129055
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BS18
Protein name Anaphase-promoting complex subunit 13 (APC13) (Cyclosome subunit 13)
Protein function Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:15060174, PubMed:18485873). The APC/C complex acts by
PDB 4UI9 , 5G04 , 5KHR , 5KHU , 5L9T , 5L9U , 5LCW , 6Q6G , 6Q6H , 6TLJ , 6TM5 , 6TNT , 8PKP , 8TAR , 8TAU , 9GAW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05839 Apc13p 1 74 Apc13p protein Family
Sequence
Sequence length 74
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cell cycle
Oocyte meiosis
Ubiquitin mediated proteolysis
Progesterone-mediated oocyte maturation
Human T-cell leukemia virus 1 infection
  Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CHOLELITHIASIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Mouth Neoplasms Associate 32887903
★☆☆☆☆
Found in Text Mining only