Gene Gene information from NCBI Gene database.
Entrez ID 25843
Gene name MOB family member 4, phocein
Gene symbol MOB4
Synonyms (NCBI Gene)
2C4DCGI-95MOB1MOB3MOBKL3PHOCNPREI3
Chromosome 2
Chromosome location 2q33.1
Summary This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alterna
miRNA miRNA information provided by mirtarbase database.
539
miRTarBase ID miRNA Experiments Reference
MIRT023746 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT027305 hsa-miR-101-3p Sequencing 20371350
MIRT031318 hsa-miR-18a-5p Sequencing 20371350
MIRT677739 hsa-miR-3155a HITS-CLIP 23824327
MIRT677738 hsa-miR-3155b HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 18782753, 19156129, 24255178, 24366813, 26496610, 33633399, 33961781
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
GO:0005737 Component Cytoplasm ISS
GO:0005794 Component Golgi apparatus IDA 11251078
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609361 17261 ENSG00000115540
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y3A3
Protein name MOB-like protein phocein (2C4D) (Class II mMOB1) (Mob1 homolog 3) (Mob3) (Mps one binder kinase activator-like 3) (Preimplantation protein 3)
Protein function Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytos
PDB 5YF4 , 7K36
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03637 Mob1_phocein 44 209 Mob1/phocein family Family
Sequence
Sequence length 225
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
9
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANOREXIA NERVOSA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Neoplasms Associate 35046109
★☆☆☆☆
Found in Text Mining only
Pancreatic Neoplasms Stimulate 30072378
★☆☆☆☆
Found in Text Mining only