Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	25830
Gene name Gene Name - the full gene name approved by the HGNC.	Sulfotransferase family 4A member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SULT4A1
Synonyms (NCBI Gene) Gene synonyms aliases	BR-STL-1, BRSTL1, DJ388M5.3, NST, SULTX3, hBR-STL-1
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q13.31
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizop

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miRTarBase ID	miRNA	Experiments
MIRT1402934	hsa-miR-146a	CLIP-seq
MIRT1402935	hsa-miR-146b-5p	CLIP-seq
MIRT1402936	hsa-miR-298	CLIP-seq
MIRT1402937	hsa-miR-3128	CLIP-seq
MIRT1402938	hsa-miR-326	CLIP-seq
MIRT1402939	hsa-miR-330-5p	CLIP-seq
MIRT1402940	hsa-miR-4330	CLIP-seq
MIRT1402941	hsa-miR-4632	CLIP-seq
MIRT1402942	hsa-miR-4720-5p	CLIP-seq
MIRT1402943	hsa-miR-4773	CLIP-seq
MIRT1402944	hsa-miR-4799-3p	CLIP-seq
MIRT1402945	hsa-miR-589	CLIP-seq
MIRT1402946	hsa-miR-593	CLIP-seq
MIRT1402937	hsa-miR-3128	CLIP-seq
MIRT1402938	hsa-miR-326	CLIP-seq
MIRT1402939	hsa-miR-330-5p	CLIP-seq
MIRT1402941	hsa-miR-4632	CLIP-seq
MIRT1402942	hsa-miR-4720-5p	CLIP-seq
MIRT1402944	hsa-miR-4799-3p	CLIP-seq
MIRT1402946	hsa-miR-593	CLIP-seq
MIRT2120791	hsa-miR-153	CLIP-seq
MIRT1402937	hsa-miR-3128	CLIP-seq
MIRT2120792	hsa-miR-3180-5p	CLIP-seq
MIRT1402938	hsa-miR-326	CLIP-seq
MIRT1402939	hsa-miR-330-5p	CLIP-seq
MIRT2120793	hsa-miR-448	CLIP-seq
MIRT1402941	hsa-miR-4632	CLIP-seq
MIRT1402942	hsa-miR-4720-5p	CLIP-seq
MIRT1402944	hsa-miR-4799-3p	CLIP-seq
MIRT1402946	hsa-miR-593	CLIP-seq
MIRT2120794	hsa-miR-656	CLIP-seq
MIRT2342814	hsa-miR-1229	CLIP-seq
MIRT2342815	hsa-miR-197	CLIP-seq
MIRT2342816	hsa-miR-2117	CLIP-seq
MIRT1402937	hsa-miR-3128	CLIP-seq
MIRT2120792	hsa-miR-3180-5p	CLIP-seq
MIRT1402938	hsa-miR-326	CLIP-seq
MIRT1402939	hsa-miR-330-5p	CLIP-seq
MIRT2342817	hsa-miR-4273	CLIP-seq
MIRT1402941	hsa-miR-4632	CLIP-seq
MIRT1402942	hsa-miR-4720-5p	CLIP-seq
MIRT1402944	hsa-miR-4799-3p	CLIP-seq
MIRT1402946	hsa-miR-593	CLIP-seq
MIRT1402937	hsa-miR-3128	CLIP-seq
MIRT1402938	hsa-miR-326	CLIP-seq
MIRT1402939	hsa-miR-330-5p	CLIP-seq
MIRT1402941	hsa-miR-4632	CLIP-seq
MIRT1402942	hsa-miR-4720-5p	CLIP-seq
MIRT1402944	hsa-miR-4799-3p	CLIP-seq
MIRT1402946	hsa-miR-593	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19439498, 21044950, 32296183
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0008146	Function	Sulfotransferase activity	IBA	21873635
GO:0008146	Function	Sulfotransferase activity	NAS	10698717
GO:0008150	Process	Biological_process	ND
GO:0008202	Process	Steroid metabolic process	IEA
GO:0042802	Function	Identical protein binding	IPI	19439498, 32296183
GO:0050427	Process	3'-phosphoadenosine 5'-phosphosulfate metabolic process	TAS
GO:0051923	Process	Sulfation	IBA	21873635

MIM	HGNC	e!Ensembl
608359	14903	ENSG00000130540

Protein

UniProt ID

Q9BR01

Protein name

Sulfotransferase 4A1 (ST4A1) (EC 2.8.2.-) (Brain sulfotransferase-like protein) (hBR-STL) (hBR-STL-1) (Nervous system sulfotransferase) (NST)

Protein function

Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May hav

PDB

1ZD1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00685	Sulfotransfer_1	45 → 277	Sulfotransferase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in the cerebral cortex and frontal lobe, slightly less in the cerebellum, occipital and temporal lobes, relatively low in the medulla and putamen, and lowest in the spinal cord. No expression detected in the pancreas (

Sequence

MAESEAETPSTPGEFESKYFEFHGVRLPPFCRGKMEEIANFPVRPSDVWIVTYPKSGTSL
LQEVVYLVSQGADPDEIGLMNIDEQLPVLEYPQPGLDIIKELTSPRLIKSHLPYRFLPSD
LHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQ
EFWEHRMDSNVLFLKYEDMHRDLVTMVEQLARFLGVSCDKAQLEALTEHCHQLVDQCCNA
EALPVGRGRVGLWKDIFTVSMNEKFDLVYKQKMGKCDLTFDFYL

Sequence length

284

Interactions

View interactions

	Reactome
			Cytosolic sulfonation of small molecules

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	19125109, 16152568, 18823757, 17728668

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Diabetes	Diabetes			GWAS

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	37589509
Glioblastoma	Associate	33423377
Parkinson Disease	Associate	32348865
Telomeric 22q13 Monosomy Syndrome	Associate	30875393
Thymoma	Associate	34104648

SULT4A1 (sulfotransferase family 4A member 1)