Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
25827
Gene name Gene Name - the full gene name approved by the HGNC.
F-box and leucine rich repeat protein 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FBXL2
Synonyms (NCBI Gene) Gene synonyms aliases
FBL2, FBL3
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p22.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), w
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT030985 hsa-miR-21-5p Microarray 18591254
MIRT042990 hsa-miR-324-3p CLASH 23622248
MIRT679732 hsa-miR-302a-3p HITS-CLIP 23824327
MIRT679731 hsa-miR-302b-3p HITS-CLIP 23824327
MIRT679730 hsa-miR-302c-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 15893726, 18160438, 19159283, 22939624, 25036637, 26790640, 27705803, 32296183, 32814053, 33961781
GO:0005516 Function Calmodulin binding IEA
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm TAS 10508920
GO:0006508 Process Proteolysis TAS 10531035
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605652 13598 ENSG00000153558
Protein
UniProt ID Q9UKC9
Protein name F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) (F-box protein FBL2/FBL3)
Protein function Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:2202032
PDB 6O60
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00646 F-box 13 57 F-box domain Domain
PF13516 LRR_6 128 152 Leucine Rich repeat Repeat
PF13516 LRR_6 154 178 Leucine Rich repeat Repeat
PF13516 LRR_6 206 230 Leucine Rich repeat Repeat
PF13516 LRR_6 310 334 Leucine Rich repeat Repeat
Tissue specificity TISSUE SPECIFICITY: Expressed in brain, heart, kidney, liver, lung, pancreas and placenta. {ECO:0000269|PubMed:10531037}.
Sequence
MVFSNNDEGLINKKLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFNF
QTDVEGRVVENISKRCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDS
TCYSLSRFCSKLKHLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALVRG
CRGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQALC
LSGCSNLTDASLTALGLNCPRLQILEAARCSHLTDAGFTLLARNCHELEKMDLEECILIT
DSTLIQLSIHCPKLQALSLSHCELITDDGILHLSNSTCGHERLRVLELDNCLLITDVALE
HLENCRGLERLELYDCQQVTRAGIKRMRAQLPHVKVHAYFAPVTPPTAVAGSGQRLCRCC
VIL
Sequence length 423
Interactions View interactions
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