PRDX5 (peroxiredoxin 5)

Gene

• Entrez ID: 25824
• Gene name: Peroxiredoxin 5
• Gene symbol: PRDX5
• Synonyms (NCBI Gene): ACR1, AOEB166, B166, HEL-S-55, PLP, PMP20, PRDX6, PRXV, SBBI10, prx-V
• Chromosome: 11
• Chromosome location: 11q13.1
• Summary: This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT037717	hsa-miR-744-5p	CLASH	23622248
MIRT470292	hsa-miR-302f	PAR-CLIP	23592263
MIRT470291	hsa-miR-1265	PAR-CLIP	23592263
MIRT470290	hsa-miR-3688-3p	PAR-CLIP	23592263
MIRT470289	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT470288	hsa-miR-1205	PAR-CLIP	23592263
MIRT470287	hsa-miR-570-3p	PAR-CLIP	23592263
MIRT470286	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT470285	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT470284	hsa-miR-1286	PAR-CLIP	23592263
MIRT470282	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT470283	hsa-miR-4764-5p	PAR-CLIP	23592263
MIRT737179	hsa-miR-6855-3p	Luciferase reporter assay, Immunoprecipitaion (IP), Immunofluorescence, qRT-PCR	31987042
MIRT738987	hsa-miR-1909	HITS-CLIP	33718276
MIRT738988	hsa-miR-543	HITS-CLIP	33718276
MIRT470292	hsa-miR-302f	PAR-CLIP	23592263
MIRT470291	hsa-miR-1265	PAR-CLIP	23592263
MIRT470290	hsa-miR-3688-3p	PAR-CLIP	23592263
MIRT470289	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT470288	hsa-miR-1205	PAR-CLIP	23592263
MIRT470287	hsa-miR-570-3p	PAR-CLIP	23592263
MIRT470286	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT470285	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT470284	hsa-miR-1286	PAR-CLIP	23592263
MIRT470282	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT470283	hsa-miR-4764-5p	PAR-CLIP	23592263
MIRT1260545	hsa-miR-125a-3p	CLIP-seq
MIRT1260546	hsa-miR-1285	CLIP-seq
MIRT1260547	hsa-miR-1321	CLIP-seq
MIRT738985	hsa-miR-296-5p	CLIP-seq
MIRT1260548	hsa-miR-3126-3p	CLIP-seq
MIRT1260549	hsa-miR-3162-5p	CLIP-seq
MIRT1260550	hsa-miR-3176	CLIP-seq
MIRT1260551	hsa-miR-3187-5p	CLIP-seq
MIRT1260552	hsa-miR-3665	CLIP-seq
MIRT738986	hsa-miR-3918	CLIP-seq
MIRT1260553	hsa-miR-3922-3p	CLIP-seq
MIRT1260554	hsa-miR-3926	CLIP-seq
MIRT1260555	hsa-miR-4446-3p	CLIP-seq
MIRT1260556	hsa-miR-4492	CLIP-seq
MIRT1260557	hsa-miR-4498	CLIP-seq
MIRT1260558	hsa-miR-4505	CLIP-seq
MIRT1260559	hsa-miR-4736	CLIP-seq
MIRT1260560	hsa-miR-4739	CLIP-seq
MIRT1260561	hsa-miR-4756-5p	CLIP-seq
MIRT1260562	hsa-miR-548s	CLIP-seq
MIRT1260563	hsa-miR-612	CLIP-seq
MIRT1260564	hsa-miR-762	CLIP-seq
MIRT1260565	hsa-miR-137	CLIP-seq
MIRT1260566	hsa-miR-25	CLIP-seq
MIRT738985	hsa-miR-296-5p	CLIP-seq
MIRT1260567	hsa-miR-298	CLIP-seq
MIRT1260548	hsa-miR-3126-3p	CLIP-seq
MIRT1260568	hsa-miR-32	CLIP-seq
MIRT1260569	hsa-miR-363	CLIP-seq
MIRT1260570	hsa-miR-367	CLIP-seq
MIRT1260571	hsa-miR-3678-3p	CLIP-seq
MIRT738986	hsa-miR-3918	CLIP-seq
MIRT1260572	hsa-miR-92a	CLIP-seq
MIRT1260573	hsa-miR-92b	CLIP-seq
MIRT1260545	hsa-miR-125a-3p	CLIP-seq
MIRT1260546	hsa-miR-1285	CLIP-seq
MIRT1260547	hsa-miR-1321	CLIP-seq
MIRT738985	hsa-miR-296-5p	CLIP-seq
MIRT1260549	hsa-miR-3162-5p	CLIP-seq
MIRT1260551	hsa-miR-3187-5p	CLIP-seq
MIRT1260552	hsa-miR-3665	CLIP-seq
MIRT738986	hsa-miR-3918	CLIP-seq
MIRT1260555	hsa-miR-4446-3p	CLIP-seq
MIRT1260556	hsa-miR-4492	CLIP-seq
MIRT1260557	hsa-miR-4498	CLIP-seq
MIRT1260558	hsa-miR-4505	CLIP-seq
MIRT1552551	hsa-miR-4651	CLIP-seq
MIRT1552552	hsa-miR-4728-5p	CLIP-seq
MIRT1260559	hsa-miR-4736	CLIP-seq
MIRT1260560	hsa-miR-4739	CLIP-seq
MIRT1260561	hsa-miR-4756-5p	CLIP-seq
MIRT1552553	hsa-miR-608	CLIP-seq
MIRT1260563	hsa-miR-612	CLIP-seq
MIRT1260564	hsa-miR-762	CLIP-seq
MIRT1552554	hsa-miR-765	CLIP-seq
MIRT738985	hsa-miR-296-5p	CLIP-seq
MIRT738986	hsa-miR-3918	CLIP-seq
MIRT1260545	hsa-miR-125a-3p	CLIP-seq
MIRT1260546	hsa-miR-1285	CLIP-seq
MIRT1260547	hsa-miR-1321	CLIP-seq
MIRT738985	hsa-miR-296-5p	CLIP-seq
MIRT1260548	hsa-miR-3126-3p	CLIP-seq
MIRT1260549	hsa-miR-3162-5p	CLIP-seq
MIRT1260551	hsa-miR-3187-5p	CLIP-seq
MIRT1260552	hsa-miR-3665	CLIP-seq
MIRT738986	hsa-miR-3918	CLIP-seq
MIRT1260555	hsa-miR-4446-3p	CLIP-seq
MIRT1260556	hsa-miR-4492	CLIP-seq
MIRT1260557	hsa-miR-4498	CLIP-seq
MIRT1260558	hsa-miR-4505	CLIP-seq
MIRT1552551	hsa-miR-4651	CLIP-seq
MIRT1552552	hsa-miR-4728-5p	CLIP-seq
MIRT1260559	hsa-miR-4736	CLIP-seq
MIRT1260560	hsa-miR-4739	CLIP-seq
MIRT1260561	hsa-miR-4756-5p	CLIP-seq
MIRT1552553	hsa-miR-608	CLIP-seq
MIRT1260563	hsa-miR-612	CLIP-seq
MIRT1260564	hsa-miR-762	CLIP-seq
MIRT1552554	hsa-miR-765	CLIP-seq
MIRT1260545	hsa-miR-125a-3p	CLIP-seq
MIRT1260546	hsa-miR-1285	CLIP-seq
MIRT1260547	hsa-miR-1321	CLIP-seq
MIRT1260565	hsa-miR-137	CLIP-seq
MIRT1260566	hsa-miR-25	CLIP-seq
MIRT738985	hsa-miR-296-5p	CLIP-seq
MIRT1260567	hsa-miR-298	CLIP-seq
MIRT1260548	hsa-miR-3126-3p	CLIP-seq
MIRT1260549	hsa-miR-3162-5p	CLIP-seq
MIRT1260550	hsa-miR-3176	CLIP-seq
MIRT1260551	hsa-miR-3187-5p	CLIP-seq
MIRT1260568	hsa-miR-32	CLIP-seq
MIRT1260569	hsa-miR-363	CLIP-seq
MIRT1260552	hsa-miR-3665	CLIP-seq
MIRT1260570	hsa-miR-367	CLIP-seq
MIRT1260571	hsa-miR-3678-3p	CLIP-seq
MIRT738986	hsa-miR-3918	CLIP-seq
MIRT1260553	hsa-miR-3922-3p	CLIP-seq
MIRT1260554	hsa-miR-3926	CLIP-seq
MIRT1260555	hsa-miR-4446-3p	CLIP-seq
MIRT1260556	hsa-miR-4492	CLIP-seq
MIRT1260557	hsa-miR-4498	CLIP-seq
MIRT1260558	hsa-miR-4505	CLIP-seq
MIRT1552551	hsa-miR-4651	CLIP-seq
MIRT1552552	hsa-miR-4728-5p	CLIP-seq
MIRT1260559	hsa-miR-4736	CLIP-seq
MIRT1260560	hsa-miR-4739	CLIP-seq
MIRT1260561	hsa-miR-4756-5p	CLIP-seq
MIRT1260562	hsa-miR-548s	CLIP-seq
MIRT1552553	hsa-miR-608	CLIP-seq
MIRT1260563	hsa-miR-612	CLIP-seq
MIRT1260564	hsa-miR-762	CLIP-seq
MIRT1552554	hsa-miR-765	CLIP-seq
MIRT1260572	hsa-miR-92a	CLIP-seq
MIRT1260573	hsa-miR-92b	CLIP-seq
MIRT738985	hsa-miR-296-5p	CLIP-seq
MIRT1260548	hsa-miR-3126-3p	CLIP-seq
MIRT1260550	hsa-miR-3176	CLIP-seq
MIRT738986	hsa-miR-3918	CLIP-seq
MIRT1260553	hsa-miR-3922-3p	CLIP-seq
MIRT1260554	hsa-miR-3926	CLIP-seq
MIRT1260555	hsa-miR-4446-3p	CLIP-seq
MIRT1260562	hsa-miR-548s	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
DEK	Repression	19229864
NRF1	Activation	21051700

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001016	Function	RNA polymerase III transcription regulatory region sequence-specific DNA binding	IDA	10095767
GO:0004601	Function	Peroxidase activity	IDA	10521424
GO:0004601	Function	Peroxidase activity	IEA
GO:0005102	Function	Signaling receptor binding	IPI	10514471
GO:0005515	Function	Protein binding	IPI	10514471, 29128334, 32296183
GO:0005615	Component	Extracellular space	HDA	23580065
GO:0005634	Component	Nucleus	IDA	10095767, 15785239
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10514471, 15785239
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	10521424, 10751410, 18262354, 31740833
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005777	Component	Peroxisome	IBA
GO:0005777	Component	Peroxisome	IDA	10521424, 10751410
GO:0005777	Component	Peroxisome	IEA
GO:0005782	Component	Peroxisomal matrix	IDA	10514471
GO:0005782	Component	Peroxisomal matrix	IEA
GO:0005829	Component	Cytosol	IDA	18262354
GO:0005829	Component	Cytosol	TAS
GO:0006954	Process	Inflammatory response	TAS	10521424
GO:0006979	Process	Response to oxidative stress	IDA	10514471, 10521424
GO:0008379	Function	Thioredoxin peroxidase activity	EXP	15280035
GO:0008379	Function	Thioredoxin peroxidase activity	IBA
GO:0008379	Function	Thioredoxin peroxidase activity	IDA	10751410
GO:0008379	Function	Thioredoxin peroxidase activity	IEA
GO:0016209	Function	Antioxidant activity	IDA	10514471
GO:0016209	Function	Antioxidant activity	IEA
GO:0016480	Process	Negative regulation of transcription by RNA polymerase III	IDA	10095767
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0031410	Component	Cytoplasmic vesicle	IDA	10095767
GO:0032967	Process	Positive regulation of collagen biosynthetic process	IDA	15276323
GO:0034599	Process	Cellular response to oxidative stress	IBA
GO:0034599	Process	Cellular response to oxidative stress	IEA
GO:0034599	Process	Cellular response to oxidative stress	TAS
GO:0034614	Process	Cellular response to reactive oxygen species	IMP	18262354
GO:0042744	Process	Hydrogen peroxide catabolic process	IBA
GO:0042744	Process	Hydrogen peroxide catabolic process	IDA	10514471
GO:0042802	Function	Identical protein binding	IPI	15046979
GO:0043027	Function	Cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP	18262354
GO:0043066	Process	Negative regulation of apoptotic process	IMP	18262354
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA	15785239
GO:0045454	Process	Cell redox homeostasis	IBA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	10095767
GO:0051354	Process	Negative regulation of oxidoreductase activity	IDA	15280035
GO:0060785	Process	Regulation of apoptosis involved in tissue homeostasis	IDA	15276323
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145
GO:0072541	Function	Peroxynitrite reductase activity	IDA	15280035
GO:0098869	Process	Cellular oxidant detoxification	IEA
GO:0140824	Function	Thioredoxin-dependent peroxiredoxin activity	IEA
GO:2001057	Process	Reactive nitrogen species metabolic process	IDA	15280035

Other IDs

• MIM: 606583
• HGNC: 9355
• e!Ensembl: ENSG00000126432

Protein

• UniProt ID: P30044
• Protein name: Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxi
• Protein function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrog
• PDB: 1H4O, 1HD2, 1OC3, 1URM, 2VL2, 2VL3, 2VL9, 3MNG, 4K7I, 4K7N, 4K7O, 4MMM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08534	Redoxin	57 → 211	Redoxin	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10521424}.
• Sequence:

  MGLAGVCALRRSAGYILVGGAGGQSAAAAARRYSEGEWASGGVRSFSRAAAAMAPIKVGD
  AIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAEALKAKGV
  QVVACLSVNDAFVTGEWGRAHKAEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKR
  FSMVVQDGIVKALNVEPDGTGLTCSLAPNIISQL

• Sequence length: 214

Pathways

KEGG:

Peroxisome

Reactome:

Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes