Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
25824
Gene name Gene Name - the full gene name approved by the HGNC.
Peroxiredoxin 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PRDX5
Synonyms (NCBI Gene) Gene synonyms aliases
ACR1, AOEB166, B166, HEL-S-55, PLP, PMP20, PRDX6, PRXV, SBBI10, prx-V
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q13.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT037717 hsa-miR-744-5p CLASH 23622248
MIRT470292 hsa-miR-302f PAR-CLIP 23592263
MIRT470291 hsa-miR-1265 PAR-CLIP 23592263
MIRT470290 hsa-miR-3688-3p PAR-CLIP 23592263
MIRT470289 hsa-miR-4733-3p PAR-CLIP 23592263
Transcription factors
Transcription factor Regulation Reference
DEK Repression 19229864
NRF1 Activation 21051700
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001016 Function RNA polymerase III transcription regulatory region sequence-specific DNA binding IDA 10095767
GO:0004601 Function Peroxidase activity IDA 10521424
GO:0005515 Function Protein binding IPI 10514471, 29128334, 32296183
GO:0005615 Component Extracellular space HDA 23580065
GO:0005634 Component Nucleus IDA 10095767, 15785239
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606583 9355 ENSG00000126432
Protein
UniProt ID P30044
Protein name Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxi
Protein function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrog
PDB 1H4O , 1HD2 , 1OC3 , 1URM , 2VL2 , 2VL3 , 2VL9 , 3MNG , 4K7I , 4K7N , 4K7O , 4MMM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08534 Redoxin 57 211 Redoxin Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10521424}.
Sequence
Sequence length 214
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Peroxisome   Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
19424620
Unknown
Disease term Disease name Evidence References Source
Alopecia Areata Alopecia Areata GWAS
Hypothyroidism Hypothyroidism GWAS
Crohn Disease Crohn Disease GWAS
Sarcoidosis Sarcoidosis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 10833265, 9177183
Adrenocortical Carcinoma Associate 20231622
Alopecia Areata Associate 20596022
Aneurysm Associate 37445606
Aortic Aneurysm Thoracic Associate 32273946, 37445606
Arthritis Rheumatoid Associate 10555039
Autistic Disorder Associate 22051046
Breast Neoplasms Associate 19620238, 22975630, 33768386, 9774665
Carcinoma Adenoid Cystic Associate 26847304
Carcinoma Non Small Cell Lung Stimulate 31899687