DNAJB5 (DnaJ heat shock protein family (Hsp40) member B5)

Gene

• Entrez ID: 25822
• Gene name: DnaJ heat shock protein family (Hsp40) member B5
• Gene symbol: DNAJB5
• Synonyms (NCBI Gene): Hsc40
• Chromosome: 9
• Chromosome location: 9p13.3
• Summary: This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins. The encoded protein contains an N-terminal DNAJ domain and a C-terminal substrate binding domain but lacks the cysteine-rich domain found in other DNAJ family me

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024402	hsa-miR-215-5p	Microarray	19074876
MIRT026797	hsa-miR-192-5p	Microarray	19074876
MIRT044713	hsa-miR-320a	CLASH	23622248
MIRT658979	hsa-miR-129-1-3p	HITS-CLIP	19536157
MIRT658978	hsa-miR-129-2-3p	HITS-CLIP	19536157
MIRT658977	hsa-miR-3622a-3p	HITS-CLIP	19536157
MIRT658976	hsa-miR-3622b-3p	HITS-CLIP	19536157
MIRT658975	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT658973	hsa-miR-4750-3p	HITS-CLIP	19536157
MIRT658972	hsa-miR-6859-3p	HITS-CLIP	19536157
MIRT658971	hsa-miR-6846-3p	HITS-CLIP	19536157
MIRT658970	hsa-miR-623	HITS-CLIP	19536157
MIRT658969	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT658968	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT658967	hsa-miR-4755-5p	HITS-CLIP	19536157
MIRT658966	hsa-miR-5006-3p	HITS-CLIP	19536157
MIRT658965	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT658979	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT658978	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT658977	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT658976	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT658975	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT658974	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT668705	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT658973	hsa-miR-4750-3p	HITS-CLIP	23824327
MIRT658972	hsa-miR-6859-3p	HITS-CLIP	23824327
MIRT658971	hsa-miR-6846-3p	HITS-CLIP	23824327
MIRT658970	hsa-miR-623	HITS-CLIP	23824327
MIRT658969	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT658968	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT668704	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT668703	hsa-miR-1200	HITS-CLIP	23824327
MIRT658967	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT658966	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT658965	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT658979	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT658978	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT658977	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT658976	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT658975	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT658974	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT658973	hsa-miR-4750-3p	HITS-CLIP	23824327
MIRT658972	hsa-miR-6859-3p	HITS-CLIP	23824327
MIRT658971	hsa-miR-6846-3p	HITS-CLIP	23824327
MIRT658970	hsa-miR-623	HITS-CLIP	23824327
MIRT658969	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT658968	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT658967	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT658966	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT658965	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT658979	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT658978	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT658977	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT658976	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT658975	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT658974	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT668705	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT658973	hsa-miR-4750-3p	HITS-CLIP	23824327
MIRT658972	hsa-miR-6859-3p	HITS-CLIP	23824327
MIRT658971	hsa-miR-6846-3p	HITS-CLIP	23824327
MIRT658970	hsa-miR-623	HITS-CLIP	23824327
MIRT658969	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT658968	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT668704	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT668703	hsa-miR-1200	HITS-CLIP	23824327
MIRT658967	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT658966	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT658965	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT658979	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT658978	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT658977	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT658976	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT658975	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT658974	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT658973	hsa-miR-4750-3p	HITS-CLIP	23824327
MIRT658972	hsa-miR-6859-3p	HITS-CLIP	23824327
MIRT658971	hsa-miR-6846-3p	HITS-CLIP	23824327
MIRT658970	hsa-miR-623	HITS-CLIP	23824327
MIRT658969	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT658968	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT658967	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT658966	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT658965	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT1978065	hsa-miR-4651	CLIP-seq
MIRT1978066	hsa-miR-608	CLIP-seq
MIRT2213580	hsa-miR-1224-3p	CLIP-seq
MIRT2213581	hsa-miR-1261	CLIP-seq
MIRT2213582	hsa-miR-1297	CLIP-seq
MIRT2213583	hsa-miR-216b	CLIP-seq
MIRT2213584	hsa-miR-26a	CLIP-seq
MIRT2213585	hsa-miR-26b	CLIP-seq
MIRT2213586	hsa-miR-300	CLIP-seq
MIRT2213587	hsa-miR-3126-3p	CLIP-seq
MIRT2213588	hsa-miR-3138	CLIP-seq
MIRT2213589	hsa-miR-320e	CLIP-seq
MIRT2213590	hsa-miR-323b-5p	CLIP-seq
MIRT2213591	hsa-miR-342-5p	CLIP-seq
MIRT2213592	hsa-miR-3609	CLIP-seq
MIRT2213593	hsa-miR-361-3p	CLIP-seq
MIRT2213594	hsa-miR-3622b-5p	CLIP-seq
MIRT2213595	hsa-miR-3675-3p	CLIP-seq
MIRT2213596	hsa-miR-3675-5p	CLIP-seq
MIRT2213597	hsa-miR-377	CLIP-seq
MIRT2213598	hsa-miR-381	CLIP-seq
MIRT2213599	hsa-miR-3913-3p	CLIP-seq
MIRT2213600	hsa-miR-3973	CLIP-seq
MIRT2213601	hsa-miR-412	CLIP-seq
MIRT2213602	hsa-miR-4438	CLIP-seq
MIRT2213603	hsa-miR-4465	CLIP-seq
MIRT2213604	hsa-miR-450b-3p	CLIP-seq
MIRT1978065	hsa-miR-4651	CLIP-seq
MIRT2213605	hsa-miR-4654	CLIP-seq
MIRT2213606	hsa-miR-4664-5p	CLIP-seq
MIRT2213607	hsa-miR-4666-3p	CLIP-seq
MIRT2213608	hsa-miR-4684-5p	CLIP-seq
MIRT2213609	hsa-miR-4713-3p	CLIP-seq
MIRT2213610	hsa-miR-4769-5p	CLIP-seq
MIRT2213611	hsa-miR-4787-5p	CLIP-seq
MIRT2213612	hsa-miR-4789-5p	CLIP-seq
MIRT2213613	hsa-miR-490-5p	CLIP-seq
MIRT2213614	hsa-miR-5095	CLIP-seq
MIRT2213615	hsa-miR-510	CLIP-seq
MIRT2213616	hsa-miR-520g	CLIP-seq
MIRT2213617	hsa-miR-520h	CLIP-seq
MIRT2213618	hsa-miR-539	CLIP-seq
MIRT2213619	hsa-miR-543	CLIP-seq
MIRT2213620	hsa-miR-548ah	CLIP-seq
MIRT2213621	hsa-miR-555	CLIP-seq
MIRT2213622	hsa-miR-562	CLIP-seq
MIRT1978066	hsa-miR-608	CLIP-seq
MIRT2213623	hsa-miR-638	CLIP-seq
MIRT2213624	hsa-miR-769-3p	CLIP-seq
MIRT2213580	hsa-miR-1224-3p	CLIP-seq
MIRT2517406	hsa-miR-1291	CLIP-seq
MIRT2517407	hsa-miR-129-3p	CLIP-seq
MIRT2517408	hsa-miR-146b-3p	CLIP-seq
MIRT2517409	hsa-miR-1972	CLIP-seq
MIRT2517410	hsa-miR-204	CLIP-seq
MIRT2517411	hsa-miR-211	CLIP-seq
MIRT2517412	hsa-miR-2278	CLIP-seq
MIRT2517413	hsa-miR-296-5p	CLIP-seq
MIRT2517414	hsa-miR-3189-5p	CLIP-seq
MIRT2517415	hsa-miR-339-5p	CLIP-seq
MIRT2517416	hsa-miR-3529	CLIP-seq
MIRT2213593	hsa-miR-361-3p	CLIP-seq
MIRT2517417	hsa-miR-3614-3p	CLIP-seq
MIRT2517418	hsa-miR-374c	CLIP-seq
MIRT2517419	hsa-miR-379	CLIP-seq
MIRT2517420	hsa-miR-3938	CLIP-seq
MIRT2517421	hsa-miR-4290	CLIP-seq
MIRT2517422	hsa-miR-4324	CLIP-seq
MIRT2517423	hsa-miR-4451	CLIP-seq
MIRT2517424	hsa-miR-4493	CLIP-seq
MIRT2517425	hsa-miR-4502	CLIP-seq
MIRT2517426	hsa-miR-4650-3p	CLIP-seq
MIRT2517427	hsa-miR-4650-5p	CLIP-seq
MIRT2517428	hsa-miR-4777-3p	CLIP-seq
MIRT2517429	hsa-miR-4780	CLIP-seq
MIRT2517430	hsa-miR-483-3p	CLIP-seq
MIRT2517431	hsa-miR-544b	CLIP-seq
MIRT2517432	hsa-miR-655	CLIP-seq
MIRT2517433	hsa-miR-670	CLIP-seq
MIRT2517434	hsa-miR-875-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0005515	Function	Protein binding	IPI	18457437, 21078624, 22810586, 23414517
GO:0005634	Component	Nucleus	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	21231916
GO:0005829	Component	Cytosol	IEA
GO:0006457	Process	Protein folding	IBA
GO:0006457	Process	Protein folding	IEA
GO:0006986	Process	Response to unfolded protein	IEA
GO:0006986	Process	Response to unfolded protein	IEP	10570961
GO:0051082	Function	Unfolded protein binding	IBA
GO:0051082	Function	Unfolded protein binding	IEA
GO:0051087	Function	Protein-folding chaperone binding	IBA
GO:0051087	Function	Protein-folding chaperone binding	IEA
GO:0051087	Function	Protein-folding chaperone binding	IPI	21231916

Other IDs

• MIM: 611328
• HGNC: 14887
• e!Ensembl: ENSG00000137094

Protein

• UniProt ID: O75953
• Protein name: DnaJ homolog subfamily B member 5 (Heat shock protein Hsp40-2) (Heat shock protein Hsp40-3) (Heat shock protein cognate 40) (Hsc40)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00226	DnaJ	4 → 65	DnaJ domain	Domain
  PF01556	DnaJ_C	171 → 330	DnaJ C terminal domain	Domain

• Sequence:

  MGKDYYKILGIPSGANEDEIKKAYRKMALKYHPDKNKEPNAEEKFKEIAEAYDVLSDPKK
  RGLYDQYGEEGLKTGGGTSGGSSGSFHYTFHGDPHATFASFFGGSNPFDIFFASSRSTRP
  FSGFDPDDMDVDEDEDPFGAFGRFGFNGLSRGPRRAPEPLYPRRKVQDPPVVHELRVSLE
  EIYHGSTKRMKITRRRLNPDGRTVRTEDKILHIVIKRGWKEGTKITFPKEGDATPDNIPA
  DIVFVLKDKPHAHFRRDGTNVLYSALISLKEALCGCTVNIPTIDGRVIPLPCNDVIKPGT
  VKRLRGEGLPFPKVPTQRGDLIVEFKVRFPDRLTPQTRQILKQHLPCS

• Sequence length: 348

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Peripheral neuropathy	Conflicting classifications of pathogenicity	rs774909609	RCV000235050
Skeletal myopathy	Conflicting classifications of pathogenicity	rs774909609	RCV000235050