Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	25816
Gene name Gene Name - the full gene name approved by the HGNC.	TNF alpha induced protein 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TNFAIP8
Synonyms (NCBI Gene) Gene synonyms aliases	GG2-1, MDC-3.13, NDED, SCC-S2, SCCS2
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q23.1

Show/Hide all(180)

miRTarBase ID	miRNA	Experiments	Reference
MIRT053458	hsa-miR-452-5p	Microarray	23807165
MIRT720775	hsa-miR-3614-3p	HITS-CLIP	19536157
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	19536157
MIRT720774	hsa-miR-6884-3p	HITS-CLIP	19536157
MIRT720773	hsa-miR-6787-3p	HITS-CLIP	19536157
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	19536157
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	19536157
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	19536157
MIRT625207	hsa-miR-23c	HITS-CLIP	19536157
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT652329	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT652328	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT652327	hsa-miR-92a-2-5p	HITS-CLIP	23824327
MIRT652326	hsa-miR-6769a-5p	HITS-CLIP	23824327
MIRT652325	hsa-miR-6769b-5p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT652329	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT652328	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT652327	hsa-miR-92a-2-5p	HITS-CLIP	23824327
MIRT652326	hsa-miR-6769a-5p	HITS-CLIP	23824327
MIRT652325	hsa-miR-6769b-5p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT720775	hsa-miR-3614-3p	HITS-CLIP	19536157
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	19536157
MIRT720774	hsa-miR-6884-3p	HITS-CLIP	19536157
MIRT720773	hsa-miR-6787-3p	HITS-CLIP	19536157
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	19536157
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	19536157
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	19536157
MIRT625207	hsa-miR-23c	HITS-CLIP	19536157
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT652329	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT652328	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT652327	hsa-miR-92a-2-5p	HITS-CLIP	23824327
MIRT652326	hsa-miR-6769a-5p	HITS-CLIP	23824327
MIRT652325	hsa-miR-6769b-5p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT652329	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT652328	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT652327	hsa-miR-92a-2-5p	HITS-CLIP	23824327
MIRT652326	hsa-miR-6769a-5p	HITS-CLIP	23824327
MIRT652325	hsa-miR-6769b-5p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT1442280	hsa-miR-1271	CLIP-seq
MIRT1442281	hsa-miR-182	CLIP-seq
MIRT1442282	hsa-miR-2116	CLIP-seq
MIRT1442283	hsa-miR-3140-3p	CLIP-seq
MIRT1442284	hsa-miR-3609	CLIP-seq
MIRT1442285	hsa-miR-3671	CLIP-seq
MIRT1442286	hsa-miR-4274	CLIP-seq
MIRT1442287	hsa-miR-4519	CLIP-seq
MIRT1442288	hsa-miR-4524	CLIP-seq
MIRT1442289	hsa-miR-4659a-3p	CLIP-seq
MIRT1442290	hsa-miR-4659b-3p	CLIP-seq
MIRT1442291	hsa-miR-4677-5p	CLIP-seq
MIRT1442292	hsa-miR-548ah	CLIP-seq
MIRT1442293	hsa-miR-548t	CLIP-seq
MIRT1442294	hsa-miR-607	CLIP-seq
MIRT1442295	hsa-miR-96	CLIP-seq
MIRT1442296	hsa-miR-1227	CLIP-seq
MIRT1442297	hsa-miR-455-5p	CLIP-seq
MIRT1442298	hsa-miR-4715-3p	CLIP-seq
MIRT2132420	hsa-miR-3658	CLIP-seq
MIRT2132421	hsa-miR-376c	CLIP-seq
MIRT2132422	hsa-miR-451b	CLIP-seq
MIRT1442296	hsa-miR-1227	CLIP-seq
MIRT1442297	hsa-miR-455-5p	CLIP-seq
MIRT1442298	hsa-miR-4715-3p	CLIP-seq
MIRT1442296	hsa-miR-1227	CLIP-seq
MIRT1442297	hsa-miR-455-5p	CLIP-seq
MIRT1442298	hsa-miR-4715-3p	CLIP-seq
MIRT1442296	hsa-miR-1227	CLIP-seq
MIRT2647488	hsa-miR-1263	CLIP-seq
MIRT2647489	hsa-miR-146a	CLIP-seq
MIRT2647490	hsa-miR-146b-5p	CLIP-seq
MIRT1442282	hsa-miR-2116	CLIP-seq
MIRT2647491	hsa-miR-3127-3p	CLIP-seq
MIRT2647492	hsa-miR-3137	CLIP-seq
MIRT2647493	hsa-miR-3180-5p	CLIP-seq
MIRT2647494	hsa-miR-329	CLIP-seq
MIRT2647495	hsa-miR-362-3p	CLIP-seq
MIRT2647496	hsa-miR-4251	CLIP-seq
MIRT1442286	hsa-miR-4274	CLIP-seq
MIRT2647497	hsa-miR-4303	CLIP-seq
MIRT2647498	hsa-miR-4329	CLIP-seq
MIRT2647499	hsa-miR-4428	CLIP-seq
MIRT1442287	hsa-miR-4519	CLIP-seq
MIRT1442288	hsa-miR-4524	CLIP-seq
MIRT1442297	hsa-miR-455-5p	CLIP-seq
MIRT1442291	hsa-miR-4677-5p	CLIP-seq
MIRT2647500	hsa-miR-4699-5p	CLIP-seq
MIRT2647501	hsa-miR-4713-5p	CLIP-seq
MIRT1442298	hsa-miR-4715-3p	CLIP-seq
MIRT2647502	hsa-miR-4749-3p	CLIP-seq
MIRT2647503	hsa-miR-4762-3p	CLIP-seq
MIRT2647504	hsa-miR-491-3p	CLIP-seq
MIRT2647505	hsa-miR-520a-5p	CLIP-seq
MIRT2647506	hsa-miR-525-5p	CLIP-seq
MIRT2647507	hsa-miR-539	CLIP-seq
MIRT2647508	hsa-miR-642b	CLIP-seq
MIRT2647509	hsa-miR-885-5p	CLIP-seq
MIRT2647503	hsa-miR-4762-3p	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 21516116, 25416956, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	14724590
GO:0005737	Component	Cytoplasm	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0043027	Function	Cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA
GO:0043027	Function	Cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP	10644768
GO:0043065	Process	Positive regulation of apoptotic process	IMP	10644768
GO:0043066	Process	Negative regulation of apoptotic process	TAS	10644768

MIM	HGNC	e!Ensembl
612111	17260	ENSG00000145779

Protein

UniProt ID

O95379

Protein name

Tumor necrosis factor alpha-induced protein 8 (TNF alpha-induced protein 8) (Head and neck tumor and metastasis-related protein) (MDC-3.13) (NF-kappa-B-inducible DED-containing protein) (NDED) (SCC-S2) (TNF-induced protein GG2-1)

Protein function

Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavag

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05527	DUF758	16 → 196	Domain of unknown function (DUF758)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the s

Sequence

MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTRE
YTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVD
YTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKP
HLQKLCDGINKMLDEENI

Sequence length

198

Interactions

View interactions

	Reactome
			PI Metabolism

Show/Hide Unknown Diseases (6)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma	N/A	N/A	GWAS
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Eczema	Eczema	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Multiple Sclerosis	Multiple sclerosis	N/A	N/A	GWAS
Myocardial Infarction	Myocardial infarction	N/A	N/A	GWAS

Show/Hide Text Mining Associations (43)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Carcinogenesis	Associate	22631659, 31929755
Carcinoma Basal Cell	Stimulate	33707587
Carcinoma Hepatocellular	Associate	28152516
Carcinoma Intraductal Noninfiltrating	Associate	38615592
Carcinoma Non Small Cell Lung	Stimulate	24136748
Carcinoma Non Small Cell Lung	Associate	30647104
Carcinoma Ovarian Epithelial	Associate	23982604
Carcinoma Squamous Cell	Stimulate	33707587
Colorectal Neoplasms	Associate	22886548, 30216108
COVID 19	Associate	36571271
Depressive Disorder	Associate	30216108
Endometrial Neoplasms	Associate	24590269
Esophageal Neoplasms	Associate	32432789
Esophageal Squamous Cell Carcinoma	Associate	26886285
Gastrointestinal Neoplasms	Associate	32883271
Head and Neck Neoplasms	Stimulate	34344926
Hereditary Breast and Ovarian Cancer Syndrome	Inhibit	38615592
Insulin Resistance	Associate	39277575
Intestinal Pseudo Obstruction	Associate	39277575
Lymphatic Diseases	Stimulate	26886285
Lymphatic Metastasis	Associate	22631659
Lymphatic Metastasis	Stimulate	22886548, 24590269, 25936980, 30216108
Lymphoma B Cell	Associate	22666399
Lymphoma Large B Cell Diffuse	Associate	26311899, 32219808
Lymphoma Non Hodgkin	Associate	22666399, 23840460
Melanoma	Stimulate	33707587
Mohr Tranebjaerg syndrome	Associate	32432789
Multiple Myeloma	Associate	33256380
Multiple Sclerosis	Associate	34488019, 36571271
Neoplasm Metastasis	Associate	23982604, 24590269, 28127811, 9307729
Neoplasms	Associate	16207477, 22886548, 23982604, 24590269, 25936980, 26886285, 27341992, 27834950, 28127811, 32432789, 33227392, 33256380, 33707587
Neoplasms	Stimulate	22631659, 24136748, 28152516, 30216108
Overweight	Associate	22666399
Pancreatic Neoplasms	Associate	22631659
Personality Disorders	Stimulate	28152516
Prostatic Neoplasms	Stimulate	33227392
Prostatitis	Associate	16207477
Skin Neoplasms	Associate	33707587
Squamous Cell Carcinoma of Head and Neck	Associate	9307729
Stomach Neoplasms	Stimulate	25936980
Stomach Neoplasms	Associate	28127811, 39294296
Tertiary Lymphoid Structures	Stimulate	23982604
Wounds and Injuries	Associate	40170451

TNFAIP8 (TNF alpha induced protein 8)