Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	25816
Gene name	TNF alpha induced protein 8
Gene symbol	TNFAIP8
Synonyms (NCBI Gene)	GG2-1MDC-3.13NDEDSCC-S2SCCS2
Chromosome	5
Chromosome location	5q23.1

180

Show/Hide all (180)

miRTarBase ID	miRNA	Experiments	Reference
MIRT053458	hsa-miR-452-5p	Microarray	23807165
MIRT720775	hsa-miR-3614-3p	HITS-CLIP	19536157
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	19536157
MIRT720774	hsa-miR-6884-3p	HITS-CLIP	19536157
MIRT720773	hsa-miR-6787-3p	HITS-CLIP	19536157
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	19536157
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	19536157
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	19536157
MIRT625207	hsa-miR-23c	HITS-CLIP	19536157
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT652329	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT652328	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT652327	hsa-miR-92a-2-5p	HITS-CLIP	23824327
MIRT652326	hsa-miR-6769a-5p	HITS-CLIP	23824327
MIRT652325	hsa-miR-6769b-5p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT652329	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT652328	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT652327	hsa-miR-92a-2-5p	HITS-CLIP	23824327
MIRT652326	hsa-miR-6769a-5p	HITS-CLIP	23824327
MIRT652325	hsa-miR-6769b-5p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT720775	hsa-miR-3614-3p	HITS-CLIP	19536157
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	19536157
MIRT720774	hsa-miR-6884-3p	HITS-CLIP	19536157
MIRT720773	hsa-miR-6787-3p	HITS-CLIP	19536157
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	19536157
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	19536157
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	19536157
MIRT625207	hsa-miR-23c	HITS-CLIP	19536157
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT652329	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT652328	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT652327	hsa-miR-92a-2-5p	HITS-CLIP	23824327
MIRT652326	hsa-miR-6769a-5p	HITS-CLIP	23824327
MIRT652325	hsa-miR-6769b-5p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT652329	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT652328	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT652327	hsa-miR-92a-2-5p	HITS-CLIP	23824327
MIRT652326	hsa-miR-6769a-5p	HITS-CLIP	23824327
MIRT652325	hsa-miR-6769b-5p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT1442280	hsa-miR-1271	CLIP-seq
MIRT1442281	hsa-miR-182	CLIP-seq
MIRT1442282	hsa-miR-2116	CLIP-seq
MIRT1442283	hsa-miR-3140-3p	CLIP-seq
MIRT1442284	hsa-miR-3609	CLIP-seq
MIRT1442285	hsa-miR-3671	CLIP-seq
MIRT1442286	hsa-miR-4274	CLIP-seq
MIRT1442287	hsa-miR-4519	CLIP-seq
MIRT1442288	hsa-miR-4524	CLIP-seq
MIRT1442289	hsa-miR-4659a-3p	CLIP-seq
MIRT1442290	hsa-miR-4659b-3p	CLIP-seq
MIRT1442291	hsa-miR-4677-5p	CLIP-seq
MIRT1442292	hsa-miR-548ah	CLIP-seq
MIRT1442293	hsa-miR-548t	CLIP-seq
MIRT1442294	hsa-miR-607	CLIP-seq
MIRT1442295	hsa-miR-96	CLIP-seq
MIRT1442296	hsa-miR-1227	CLIP-seq
MIRT1442297	hsa-miR-455-5p	CLIP-seq
MIRT1442298	hsa-miR-4715-3p	CLIP-seq
MIRT2132420	hsa-miR-3658	CLIP-seq
MIRT2132421	hsa-miR-376c	CLIP-seq
MIRT2132422	hsa-miR-451b	CLIP-seq
MIRT1442296	hsa-miR-1227	CLIP-seq
MIRT1442297	hsa-miR-455-5p	CLIP-seq
MIRT1442298	hsa-miR-4715-3p	CLIP-seq
MIRT1442296	hsa-miR-1227	CLIP-seq
MIRT1442297	hsa-miR-455-5p	CLIP-seq
MIRT1442298	hsa-miR-4715-3p	CLIP-seq
MIRT1442296	hsa-miR-1227	CLIP-seq
MIRT2647488	hsa-miR-1263	CLIP-seq
MIRT2647489	hsa-miR-146a	CLIP-seq
MIRT2647490	hsa-miR-146b-5p	CLIP-seq
MIRT1442282	hsa-miR-2116	CLIP-seq
MIRT2647491	hsa-miR-3127-3p	CLIP-seq
MIRT2647492	hsa-miR-3137	CLIP-seq
MIRT2647493	hsa-miR-3180-5p	CLIP-seq
MIRT2647494	hsa-miR-329	CLIP-seq
MIRT2647495	hsa-miR-362-3p	CLIP-seq
MIRT2647496	hsa-miR-4251	CLIP-seq
MIRT1442286	hsa-miR-4274	CLIP-seq
MIRT2647497	hsa-miR-4303	CLIP-seq
MIRT2647498	hsa-miR-4329	CLIP-seq
MIRT2647499	hsa-miR-4428	CLIP-seq
MIRT1442287	hsa-miR-4519	CLIP-seq
MIRT1442288	hsa-miR-4524	CLIP-seq
MIRT1442297	hsa-miR-455-5p	CLIP-seq
MIRT1442291	hsa-miR-4677-5p	CLIP-seq
MIRT2647500	hsa-miR-4699-5p	CLIP-seq
MIRT2647501	hsa-miR-4713-5p	CLIP-seq
MIRT1442298	hsa-miR-4715-3p	CLIP-seq
MIRT2647502	hsa-miR-4749-3p	CLIP-seq
MIRT2647503	hsa-miR-4762-3p	CLIP-seq
MIRT2647504	hsa-miR-491-3p	CLIP-seq
MIRT2647505	hsa-miR-520a-5p	CLIP-seq
MIRT2647506	hsa-miR-525-5p	CLIP-seq
MIRT2647507	hsa-miR-539	CLIP-seq
MIRT2647508	hsa-miR-642b	CLIP-seq
MIRT2647509	hsa-miR-885-5p	CLIP-seq
MIRT2647503	hsa-miR-4762-3p	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 21516116, 25416956, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	14724590
GO:0005737	Component	Cytoplasm	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0043027	Function	Cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA
GO:0043027	Function	Cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP	10644768
GO:0043065	Process	Positive regulation of apoptotic process	IMP	10644768
GO:0043066	Process	Negative regulation of apoptotic process	TAS	10644768

MIM	HGNC	e!Ensembl
612111	17260	ENSG00000145779

O95379

Protein name

Tumor necrosis factor alpha-induced protein 8 (TNF alpha-induced protein 8) (Head and neck tumor and metastasis-related protein) (MDC-3.13) (NF-kappa-B-inducible DED-containing protein) (NDED) (SCC-S2) (TNF-induced protein GG2-1)

Protein function

Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavag

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05527	DUF758	16 → 196	Domain of unknown function (DUF758)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the s

Sequence

MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTRE
YTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVD
YTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKP
HLQKLCDGINKMLDEENI

Sequence length

198

Interactions

View interactions

	Reactome
			PI Metabolism

TNFAIP8 (TNF alpha induced protein 8)