SVIP (small VCP interacting protein)

Gene

• Entrez ID: 258010
• Gene name: Small VCP interacting protein
• Gene symbol: SVIP
• Synonyms (NCBI Gene): -
• Chromosome: 11
• Chromosome location: 11p14.3
• Summary: Endoplasmic reticulum-associated degradation (ERAD) is the pathway by which misfolded proteins in the endoplasmic reticulum are targeted to the proteasome for degradation. Multiple specialized proteins interact with one another during ERAD to complete thi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027071	hsa-miR-103a-3p	Sequencing	20371350
MIRT563716	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT563715	hsa-miR-590-3p	HITS-CLIP	21572407
MIRT707379	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT707378	hsa-miR-369-3p	HITS-CLIP	21572407
MIRT707376	hsa-miR-5692b	HITS-CLIP	21572407
MIRT707377	hsa-miR-5692c	HITS-CLIP	21572407
MIRT563714	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT563713	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT563712	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT707375	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT563711	hsa-miR-4775	HITS-CLIP	21572407
MIRT707374	hsa-miR-374a-5p	HITS-CLIP	21572407
MIRT707373	hsa-miR-374b-5p	HITS-CLIP	21572407
MIRT563710	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT630213	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT630212	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630211	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630210	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT630209	hsa-miR-4284	HITS-CLIP	23824327
MIRT630208	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630207	hsa-miR-3178	HITS-CLIP	23824327
MIRT630206	hsa-miR-7977	HITS-CLIP	23824327
MIRT630205	hsa-miR-6511b-5p	HITS-CLIP	23824327
MIRT630204	hsa-miR-6811-5p	HITS-CLIP	23824327
MIRT630203	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630213	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT630212	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630211	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630210	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT630209	hsa-miR-4284	HITS-CLIP	23824327
MIRT630208	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630207	hsa-miR-3178	HITS-CLIP	23824327
MIRT630206	hsa-miR-7977	HITS-CLIP	23824327
MIRT630205	hsa-miR-6511b-5p	HITS-CLIP	23824327
MIRT630204	hsa-miR-6811-5p	HITS-CLIP	23824327
MIRT630203	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630213	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT630212	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630211	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630210	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT630209	hsa-miR-4284	HITS-CLIP	23824327
MIRT630208	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630207	hsa-miR-3178	HITS-CLIP	23824327
MIRT630206	hsa-miR-7977	HITS-CLIP	23824327
MIRT630205	hsa-miR-6511b-5p	HITS-CLIP	23824327
MIRT630204	hsa-miR-6811-5p	HITS-CLIP	23824327
MIRT630203	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630208	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630213	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT630212	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630211	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630210	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT630209	hsa-miR-4284	HITS-CLIP	23824327
MIRT630207	hsa-miR-3178	HITS-CLIP	23824327
MIRT630205	hsa-miR-6511b-5p	HITS-CLIP	23824327
MIRT630204	hsa-miR-6811-5p	HITS-CLIP	23824327
MIRT630203	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630213	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT630212	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630211	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630210	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT630209	hsa-miR-4284	HITS-CLIP	23824327
MIRT630208	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630207	hsa-miR-3178	HITS-CLIP	23824327
MIRT630206	hsa-miR-7977	HITS-CLIP	23824327
MIRT630205	hsa-miR-6511b-5p	HITS-CLIP	23824327
MIRT630204	hsa-miR-6811-5p	HITS-CLIP	23824327
MIRT630203	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT563716	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT563715	hsa-miR-590-3p	PAR-CLIP	20371350
MIRT563714	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT563713	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT563712	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT563711	hsa-miR-4775	PAR-CLIP	20371350
MIRT563710	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT563716	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT563715	hsa-miR-590-3p	HITS-CLIP	21572407
MIRT707379	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT707378	hsa-miR-369-3p	HITS-CLIP	21572407
MIRT707376	hsa-miR-5692b	HITS-CLIP	21572407
MIRT707377	hsa-miR-5692c	HITS-CLIP	21572407
MIRT563714	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT563713	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT563712	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT707375	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT563711	hsa-miR-4775	HITS-CLIP	21572407
MIRT707374	hsa-miR-374a-5p	HITS-CLIP	21572407
MIRT707373	hsa-miR-374b-5p	HITS-CLIP	21572407
MIRT563710	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT630213	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT630212	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630211	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630210	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT630209	hsa-miR-4284	HITS-CLIP	23824327
MIRT630208	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630207	hsa-miR-3178	HITS-CLIP	23824327
MIRT630206	hsa-miR-7977	HITS-CLIP	23824327
MIRT630205	hsa-miR-6511b-5p	HITS-CLIP	23824327
MIRT630204	hsa-miR-6811-5p	HITS-CLIP	23824327
MIRT630203	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630213	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT630212	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630211	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630210	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT630209	hsa-miR-4284	HITS-CLIP	23824327
MIRT630208	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630207	hsa-miR-3178	HITS-CLIP	23824327
MIRT630206	hsa-miR-7977	HITS-CLIP	23824327
MIRT630205	hsa-miR-6511b-5p	HITS-CLIP	23824327
MIRT630204	hsa-miR-6811-5p	HITS-CLIP	23824327
MIRT630203	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630213	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT630212	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630211	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630210	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT630209	hsa-miR-4284	HITS-CLIP	23824327
MIRT630208	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630207	hsa-miR-3178	HITS-CLIP	23824327
MIRT630206	hsa-miR-7977	HITS-CLIP	23824327
MIRT630205	hsa-miR-6511b-5p	HITS-CLIP	23824327
MIRT630204	hsa-miR-6811-5p	HITS-CLIP	23824327
MIRT630203	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630208	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630213	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT630212	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630211	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630210	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT630209	hsa-miR-4284	HITS-CLIP	23824327
MIRT630207	hsa-miR-3178	HITS-CLIP	23824327
MIRT630205	hsa-miR-6511b-5p	HITS-CLIP	23824327
MIRT630204	hsa-miR-6811-5p	HITS-CLIP	23824327
MIRT630203	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630213	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT630212	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630211	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630210	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT630209	hsa-miR-4284	HITS-CLIP	23824327
MIRT630208	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630207	hsa-miR-3178	HITS-CLIP	23824327
MIRT630206	hsa-miR-7977	HITS-CLIP	23824327
MIRT630205	hsa-miR-6511b-5p	HITS-CLIP	23824327
MIRT630204	hsa-miR-6811-5p	HITS-CLIP	23824327
MIRT630203	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT563716	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT563715	hsa-miR-590-3p	PAR-CLIP	20371350
MIRT563714	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT563713	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT563712	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT563711	hsa-miR-4775	PAR-CLIP	20371350
MIRT563710	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT1404712	hsa-miR-101	CLIP-seq
MIRT1404713	hsa-miR-103a	CLIP-seq
MIRT1404714	hsa-miR-107	CLIP-seq
MIRT1404715	hsa-miR-124	CLIP-seq
MIRT1404716	hsa-miR-125a-5p	CLIP-seq
MIRT1404717	hsa-miR-125b	CLIP-seq
MIRT1404718	hsa-miR-1305	CLIP-seq
MIRT1404719	hsa-miR-144	CLIP-seq
MIRT1404720	hsa-miR-181a	CLIP-seq
MIRT1404721	hsa-miR-181b	CLIP-seq
MIRT1404722	hsa-miR-181c	CLIP-seq
MIRT1404723	hsa-miR-181d	CLIP-seq
MIRT1404724	hsa-miR-202	CLIP-seq
MIRT1404725	hsa-miR-2053	CLIP-seq
MIRT1404726	hsa-miR-23a	CLIP-seq
MIRT1404727	hsa-miR-23b	CLIP-seq
MIRT1404728	hsa-miR-23c	CLIP-seq
MIRT1404729	hsa-miR-297	CLIP-seq
MIRT1404730	hsa-miR-298	CLIP-seq
MIRT1404731	hsa-miR-3200-5p	CLIP-seq
MIRT1404732	hsa-miR-33a	CLIP-seq
MIRT1404733	hsa-miR-33b	CLIP-seq
MIRT1404734	hsa-miR-3606	CLIP-seq
MIRT1404735	hsa-miR-3647-3p	CLIP-seq
MIRT1404736	hsa-miR-3682-3p	CLIP-seq
MIRT1404737	hsa-miR-3684	CLIP-seq
MIRT1404738	hsa-miR-383	CLIP-seq
MIRT1404739	hsa-miR-3924	CLIP-seq
MIRT1404740	hsa-miR-411	CLIP-seq
MIRT1404741	hsa-miR-4262	CLIP-seq
MIRT1404742	hsa-miR-4287	CLIP-seq
MIRT1404743	hsa-miR-4297	CLIP-seq
MIRT1404744	hsa-miR-4307	CLIP-seq
MIRT1404745	hsa-miR-4319	CLIP-seq
MIRT1404746	hsa-miR-4328	CLIP-seq
MIRT1404747	hsa-miR-4469	CLIP-seq
MIRT1404748	hsa-miR-4484	CLIP-seq
MIRT1404749	hsa-miR-4496	CLIP-seq
MIRT1404750	hsa-miR-4502	CLIP-seq
MIRT1404751	hsa-miR-4666-5p	CLIP-seq
MIRT1404752	hsa-miR-4684-5p	CLIP-seq
MIRT1404753	hsa-miR-4685-3p	CLIP-seq
MIRT1404754	hsa-miR-4713-5p	CLIP-seq
MIRT1404755	hsa-miR-4719	CLIP-seq
MIRT1404756	hsa-miR-4732-3p	CLIP-seq
MIRT1404757	hsa-miR-4742-3p	CLIP-seq
MIRT1404758	hsa-miR-4772-5p	CLIP-seq
MIRT1404759	hsa-miR-485-3p	CLIP-seq
MIRT1404760	hsa-miR-498	CLIP-seq
MIRT1404761	hsa-miR-506	CLIP-seq
MIRT1404762	hsa-miR-523	CLIP-seq
MIRT1404763	hsa-miR-548ac	CLIP-seq
MIRT1404764	hsa-miR-548ae	CLIP-seq
MIRT1404765	hsa-miR-548aj	CLIP-seq
MIRT1404766	hsa-miR-548am	CLIP-seq
MIRT1404767	hsa-miR-548an	CLIP-seq
MIRT1404768	hsa-miR-548d-3p	CLIP-seq
MIRT1404769	hsa-miR-548x	CLIP-seq
MIRT1404770	hsa-miR-548z	CLIP-seq
MIRT1404771	hsa-miR-567	CLIP-seq
MIRT1404772	hsa-miR-568	CLIP-seq
MIRT1404773	hsa-miR-569	CLIP-seq
MIRT1404774	hsa-miR-586	CLIP-seq
MIRT1404775	hsa-miR-670	CLIP-seq
MIRT1404776	hsa-miR-877	CLIP-seq
MIRT2121417	hsa-miR-141	CLIP-seq
MIRT2121418	hsa-miR-200a	CLIP-seq
MIRT1404729	hsa-miR-297	CLIP-seq
MIRT1404730	hsa-miR-298	CLIP-seq
MIRT1404735	hsa-miR-3647-3p	CLIP-seq
MIRT1404739	hsa-miR-3924	CLIP-seq
MIRT1404751	hsa-miR-4666-5p	CLIP-seq
MIRT1404752	hsa-miR-4684-5p	CLIP-seq
MIRT2121419	hsa-miR-4731-3p	CLIP-seq
MIRT2121420	hsa-miR-4801	CLIP-seq
MIRT1404771	hsa-miR-567	CLIP-seq
MIRT1404713	hsa-miR-103a	CLIP-seq
MIRT1404714	hsa-miR-107	CLIP-seq
MIRT1404715	hsa-miR-124	CLIP-seq
MIRT2121417	hsa-miR-141	CLIP-seq
MIRT1404720	hsa-miR-181a	CLIP-seq
MIRT1404721	hsa-miR-181b	CLIP-seq
MIRT1404722	hsa-miR-181c	CLIP-seq
MIRT1404723	hsa-miR-181d	CLIP-seq
MIRT2121418	hsa-miR-200a	CLIP-seq
MIRT1404726	hsa-miR-23a	CLIP-seq
MIRT1404727	hsa-miR-23b	CLIP-seq
MIRT1404728	hsa-miR-23c	CLIP-seq
MIRT1404729	hsa-miR-297	CLIP-seq
MIRT1404730	hsa-miR-298	CLIP-seq
MIRT2343366	hsa-miR-300	CLIP-seq
MIRT2343367	hsa-miR-3158-5p	CLIP-seq
MIRT2343368	hsa-miR-338-5p	CLIP-seq
MIRT2343369	hsa-miR-34a	CLIP-seq
MIRT2343370	hsa-miR-34c-3p	CLIP-seq
MIRT2343371	hsa-miR-34c-5p	CLIP-seq
MIRT1404734	hsa-miR-3606	CLIP-seq
MIRT2343372	hsa-miR-3678-3p	CLIP-seq
MIRT1404736	hsa-miR-3682-3p	CLIP-seq
MIRT2343373	hsa-miR-376a	CLIP-seq
MIRT2343374	hsa-miR-376b	CLIP-seq
MIRT2343375	hsa-miR-381	CLIP-seq
MIRT1404738	hsa-miR-383	CLIP-seq
MIRT1404739	hsa-miR-3924	CLIP-seq
MIRT1404741	hsa-miR-4262	CLIP-seq
MIRT2343376	hsa-miR-4290	CLIP-seq
MIRT1404743	hsa-miR-4297	CLIP-seq
MIRT2343377	hsa-miR-4301	CLIP-seq
MIRT1404744	hsa-miR-4307	CLIP-seq
MIRT1404746	hsa-miR-4328	CLIP-seq
MIRT2343378	hsa-miR-4418	CLIP-seq
MIRT1404748	hsa-miR-4484	CLIP-seq
MIRT1404749	hsa-miR-4496	CLIP-seq
MIRT2343379	hsa-miR-449a	CLIP-seq
MIRT2343380	hsa-miR-449b	CLIP-seq
MIRT1404750	hsa-miR-4502	CLIP-seq
MIRT2343381	hsa-miR-4637	CLIP-seq
MIRT2343382	hsa-miR-4659a-3p	CLIP-seq
MIRT2343383	hsa-miR-4659b-3p	CLIP-seq
MIRT2343384	hsa-miR-4666-3p	CLIP-seq
MIRT1404751	hsa-miR-4666-5p	CLIP-seq
MIRT1404755	hsa-miR-4719	CLIP-seq
MIRT2121419	hsa-miR-4731-3p	CLIP-seq
MIRT1404757	hsa-miR-4742-3p	CLIP-seq
MIRT1404758	hsa-miR-4772-5p	CLIP-seq
MIRT2343385	hsa-miR-4773	CLIP-seq
MIRT2343386	hsa-miR-4786-3p	CLIP-seq
MIRT2121420	hsa-miR-4801	CLIP-seq
MIRT1404759	hsa-miR-485-3p	CLIP-seq
MIRT2343387	hsa-miR-499-3p	CLIP-seq
MIRT2343388	hsa-miR-499a-3p	CLIP-seq
MIRT1404761	hsa-miR-506	CLIP-seq
MIRT2343389	hsa-miR-509-3-5p	CLIP-seq
MIRT2343390	hsa-miR-509-5p	CLIP-seq
MIRT1404762	hsa-miR-523	CLIP-seq
MIRT1404767	hsa-miR-548an	CLIP-seq
MIRT2343391	hsa-miR-562	CLIP-seq
MIRT1404771	hsa-miR-567	CLIP-seq
MIRT1404772	hsa-miR-568	CLIP-seq
MIRT2343392	hsa-miR-889	CLIP-seq
MIRT2343393	hsa-miR-936	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005515	Function	Protein binding	IPI	17872946, 32296183
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	17872946
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0010508	Process	Positive regulation of autophagy	IBA
GO:0010508	Process	Positive regulation of autophagy	IMP	21909394
GO:0016020	Component	Membrane	IDA	17872946
GO:0016020	Component	Membrane	IEA
GO:0030667	Component	Secretory granule membrane	TAS
GO:0030868	Component	Smooth endoplasmic reticulum membrane	IEA
GO:0031333	Process	Negative regulation of protein-containing complex assembly	IMP	17872946
GO:0051117	Function	ATPase binding	IPI	17872946
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070821	Component	Tertiary granule membrane	TAS
GO:1903061	Process	Positive regulation of protein lipidation	IMP	21909394
GO:1904153	Process	Negative regulation of retrograde protein transport, ER to cytosol	IBA
GO:1904153	Process	Negative regulation of retrograde protein transport, ER to cytosol	IMP	25660456
GO:1904240	Process	Negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly	IBA
GO:1904293	Process	Negative regulation of ERAD pathway	IBA
GO:1904293	Process	Negative regulation of ERAD pathway	IMP	17872946

Other IDs

• MIM: 620965
• HGNC: 25238
• e!Ensembl: ENSG00000198168

Protein

• UniProt ID: Q8NHG7
• Protein name: Small VCP/p97-interacting protein
• Protein function: Negative regulator of the ER-associated degradation pathway (ERAD) of misfolded proteins. It competes with AMFR/gp78 for binding VCP/p97, and inhibits AMFR/gp78-VCP/p97 complex formation that is required for degradation of ERAD substrates (PubMe
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15811	SVIP	1 → 73	Small VCP/p97-interacting protein	Family

• Sequence:

  MGLCFPCPGESAPPTPDLEEKRAKLAEAAERRQKEAASRGILDVQSVQEKRKKKEKIEKQ
  IATSGPPPEGGLRWTVS

• Sequence length: 77

Pathways

KEGG:

Protein processing in endoplasmic reticulum

Reactome:

Neutrophil degranulation